The global energy cycle is a diagnostic metric widely used to gauge the quality of datasets. In this paper, the "Mixed Space-Time Domain" method for diagnosis of energy cycle is evaluated by using newly deve...The global energy cycle is a diagnostic metric widely used to gauge the quality of datasets. In this paper, the "Mixed Space-Time Domain" method for diagnosis of energy cycle is evaluated by using newly developed datasets-the Chinese Reanalysis Interim (CRAI) and ECMWF Reanalysis version 5 (ERA5), over a 7-yr period (2010-16) on seasonal and monthly timescales. The results show that the energy components calculated from the two reanalysis datasets are highly consistent;however, some components in the global energy integral from CRAI are slightly larger than those from ERA5. The main discrepancy in the energy components stems from the conversion of baroclinic process, whereas the dominant difference originates from the conversion from stationary eddy available potential energy to stationary eddy kinetic energy (CES), which is caused by systematic differences in the temperature and vertical velocity in low-mid latitudes of the Northern Hemisphere and near the Antarctic, where there exist complex terrains. Furthermore, the monthly analysis reveals that the general discrepancy in the temporal variation between the two datasets also lie mainly in the CES as well as corresponding generation and dissipation rates.展开更多
The China Meteorological Administration(CMA)recently produced a CMA Global Atmospheric Interim Reanalysis(CRAI)dataset for the years 2007–2016.A comprehensive evaluation of the ability of CRAI to capture the spatiote...The China Meteorological Administration(CMA)recently produced a CMA Global Atmospheric Interim Reanalysis(CRAI)dataset for the years 2007–2016.A comprehensive evaluation of the ability of CRAI to capture the spatiotemporal variability of observed precipitation,in terms of both mean states and extreme indicators over China,is performed.Comparisons are made with other current reanalysis datasets,namely,the ECMWF interim reanalysis(ERAI),Japanese 55-yr reanalysis(JRA55),NCEP Climate Forecast System Reanalysis(CFSR),and NASA Modern-Era Retrospective analysis for Research and Applications version 2(MERRA2),as well as NCEP Climate Prediction Center(CPC)observations.The results show that,for daily variations of rainfall during warm seasons in eastern China,CRAI and CFSR overestimate the precipitation of the main rain belt,while the overestimation is confined to the area south of 25°N in JRA55 but north of 24°N in MERRA2;whereas ERAI tends to underestimate the precipitation in most regions of eastern China.Two extreme metrics,the total amount of precipitation on days where daily precipitation exceeds the 95 th percentile(R95 pTOT)and the number of consecutive dry days(CDDs)in one month,are examined to assess the performance of reanalysis datasets.In terms of extreme events,CRAI,ERAI,and JRA55 tend to underestimate the R95 pTOT in most of eastern China,whereas more frequent extreme rainfall can be found in most regions of China in both CFSR and MERRA2;and all of the reanalyses underestimate the CDDs.Among the reanalysis products,CRAI and JRA55 show better agreement with the observed R95 pTOT than the other datasets,with fewer biases,higher correlation coefficients,and much more similar linear trend patterns,while ERAI stands out in better capturing the amount and temporal variations of the observed CDDs.展开更多
Wideband IMT-Advanced mobile communication systems tend to operate in the high frequency bands due to a relatively large capacity available. Thus, Measurement and modelling methods of radio propaga- tion eharaeteristi...Wideband IMT-Advanced mobile communication systems tend to operate in the high frequency bands due to a relatively large capacity available. Thus, Measurement and modelling methods of radio propaga- tion eharaeteristics are proposed for the field test of Chinese 4th generation （4G） trial system. The mea- surement system is established for 3.5GHz based on the sophistieated measurement instruments and the virtual instrument teehnology. The characteristic parameters of radio propagation sueh as path loss （PL） exponent and shadow fading standard deviation are extracted from measurement data, which result in the path loss model finally. The comparisons with other existing international models results validate our mea- surement in terms of path loss model. Based on the analysis of the existing extension model assumed for the microwave frequency at 3.5GHz, we find that the Stanford University Interim （SUI） model fits very well with the measurement result in the hotspot scenario, while the COST 231 model is closer to the mea- surement result in the suburban scenario. This result provides a measurement-based channel referenee for the development of the future IMT-Advanced systems in China.展开更多
Aim: To test the hypothesis that antimicrobial agents can be incorporated into bis-acryl resin and that the material will inhibit bacterial growth in vitro. Materials and Methods: 0.5%, 1% and 2% triclosan (5-chloro-2...Aim: To test the hypothesis that antimicrobial agents can be incorporated into bis-acryl resin and that the material will inhibit bacterial growth in vitro. Materials and Methods: 0.5%, 1% and 2% triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) and 0.05% 0.01% and 0.15% cetylpyridinium chloride were incorporated into bis-acryl resins and molded into 1 mm × 10 mm discs. The discs were placed on bacterial culture media inoculated with Aggregatibacter actinomycetemcomitans strain Y4, Porphyromonas gingivalis strain SUNYaB A7A1-28 or Streptococcus gordonii strain 10558, incubated and examined for growth inhibition. Results: Triclosan-containing bisacryl resin discs produced dose-dependent zones of growth inhibition for A. actinomycetemcomitans but not S. gordonii or P. gingivalis. Cetylpyridinium chloride-containing discs produced dose-dependent zones of growth inhibition for Porphyromonas gingivalis and Streptococcus gordonii but not A. actinomycetemcomitans. Conclusion: Triclosan and cetylpyridinium chloride can be incorporated into bis-acryl resin and can inhibit the growth of plaque bacteria in a dose dependent manner. Bis-acryl resin containing antimicrobial agents may inhibit in vivo plaque accumulation and gingival inflammation.展开更多
Clinical trials are usually long term studies and it seems impossible to reach all required subjects at the same time. Performing interim analyses and monitoring results may provide early termination of trial after ob...Clinical trials are usually long term studies and it seems impossible to reach all required subjects at the same time. Performing interim analyses and monitoring results may provide early termination of trial after obtaining significant results. The aim of this study is comparing group sequential tests in respect to advantage of sample size reduction and early termination. In this study, 4 test types used in group sequential designs were compared with fixed sample size design test and each other. Comparisons were done according to two-sided tests for comparing two treatments. In this sense, 1080 models were performed. In models, 2 different Type I errors, 2 different powers, 5 different analysis groups, 6 different effect sizes and 9 different variances selections were considered. All test types increased the maximum sample size in different manner, compared with fixed sample size design. Each test had different critical values to reject H0 hypothesis, at the same type I error rate and number of analyses conditions. Selection of test type used in group sequential designs depends on a few characteristics, as reducing sample size, early termination and detecting minimal effect size. Test performance is highly related with selected Type I error rate, power and number of analyses. In addition to these statistical characteristics, researchers should decide test type with respect to other trial conditions as the issue of trial, reaching subjects easy or not and importance of early termination.展开更多
In this paper a frequency offset estimation technique for Wireless Local Area and Wireless Metropolitan Ar- ea Networks is presented. For frequency offset estimation, we have applied a low-complexity frequency offset ...In this paper a frequency offset estimation technique for Wireless Local Area and Wireless Metropolitan Ar- ea Networks is presented. For frequency offset estimation, we have applied a low-complexity frequency offset estimator for simple AWGN channels to fading channels for MIMO-OFDM systems. Simulation results have shown that the performance of the proposed estimator is better than the low complexity frequency offset estimator designed for AWGN channels.展开更多
A multiple-input multiple-output interleave division multiple access (MIMO-IDMA) system with Triple Polarized Division Multiplexing (TPDM) is presented in this paper. The present methodology replaces three indepe...A multiple-input multiple-output interleave division multiple access (MIMO-IDMA) system with Triple Polarized Division Multiplexing (TPDM) is presented in this paper. The present methodology replaces three independent linearly polarized antennas with a single triple polarized antenna at both the transmitter and receiver. The users in the communication link are accommodated and separated using a user-specific interleaver combined with low rate spreading sequence. To eliminate the effects of multi-stream interference (MSI), minimum mean square error (MMSE) algorithm based on successive interference cancellation (SIC) Multi-user detection (MUD) technique is employed at the receiver. Furthermore, log-maximum a posteriori probability (MAPP) decoding algorithm is implemented at the mobile stations (MSs) to overcome the effects of multi-user interference (MUI) effects. The paper also evaluates the effects of coded MIMO-IDMA in the downlink communication by adopting the Stanford University Interim (SUI) and Long-term Evolution (LTE)channel model specifications. In comparison with the traditional uncoded system, the present solution considering turbo coded triple-polarized MIMO-IDMA system with iterative decoding algorithm provides better bit error rate (BER) with reduced signal to noise ratio (SNR). The simulation results also show that though the SNR requirement is higher for the proposed technique compared to the conventional uni-polarized antenna based MIMO-IDMA system, it gives the advantages of achieving higher data rate with reduced cost and space requirements in the context of a downlink (DL).展开更多
Interim Positron-Emission Tomography (int-PET) and the peripheral blood absolute lymphocyte/monocyte ratio at di- agnosis (ALC/AMC-DX) have been shown to be predictors for progression-free survival (PFS) and time to p...Interim Positron-Emission Tomography (int-PET) and the peripheral blood absolute lymphocyte/monocyte ratio at di- agnosis (ALC/AMC-DX) have been shown to be predictors for progression-free survival (PFS) and time to progression (TTP) in classical Hodgkin lymphoma (cHL). Therefore, we studied if the combination of ALC/AMC-DX and the (int-PET) can further stratified PFS and TTP in cHL patients. Patients were required to be diagnosed, treated, and followed with int-PET at Mayo Clinic, Rochester, Minnesota. From 2000 until 2008, 111 cHL patients qualified for the study. The median follow-up was 2.8 years (range: 0.3 - 10.4 years). Patients with a negative int-PET (N = 98) pre- sented with a higher ALC/AMC-DX (median of 2.32, range: 0.26 - 37.5) compared with patients with a positive int-PET (N = 13) (median of 0.9, range: 0.29 - 3.10), p 1.1. Group 1 experienced superior PFS and TTP in comparison with the other groups. In conclusion, the combination of ALC/AMC-DX and the int-PET provides a simple model to assess clinical outcomes in cHL.展开更多
Based on the actual demand of project Management (PM) and the traditional conceptof Project Evaluation (PE), we extend the concept and connotation of PE In this paper, wepresent the concept of PE corresponding to the ...Based on the actual demand of project Management (PM) and the traditional conceptof Project Evaluation (PE), we extend the concept and connotation of PE In this paper, wepresent the concept of PE corresponding to the whole project life cycle, and divide it into ProjectEx Ante Evaluation (PAE), Project lnterim Evaluation (PIE) and Project Ex Post Evaluation(PPE), and mainly analyze PIE.展开更多
基金Supported by the China Meteorological Administration(CMA)Special Public Welfare Research Fund(GYHY201506002)National Key Research and Development Program of China(2017YFA0604500)+1 种基金CMA Special Project for Developing Key Techniques for Operational Meteorological Forecast(YBGJXM201706)National Natural Science Foundation of China(41305091)
文摘The global energy cycle is a diagnostic metric widely used to gauge the quality of datasets. In this paper, the "Mixed Space-Time Domain" method for diagnosis of energy cycle is evaluated by using newly developed datasets-the Chinese Reanalysis Interim (CRAI) and ECMWF Reanalysis version 5 (ERA5), over a 7-yr period (2010-16) on seasonal and monthly timescales. The results show that the energy components calculated from the two reanalysis datasets are highly consistent;however, some components in the global energy integral from CRAI are slightly larger than those from ERA5. The main discrepancy in the energy components stems from the conversion of baroclinic process, whereas the dominant difference originates from the conversion from stationary eddy available potential energy to stationary eddy kinetic energy (CES), which is caused by systematic differences in the temperature and vertical velocity in low-mid latitudes of the Northern Hemisphere and near the Antarctic, where there exist complex terrains. Furthermore, the monthly analysis reveals that the general discrepancy in the temporal variation between the two datasets also lie mainly in the CES as well as corresponding generation and dissipation rates.
基金Supported by the China Meteorological Administration Special Public Welfare Research Fund(GYHY201506002)National Natural Science Foundation of China(41790475,41675094,and 41605066).
文摘The China Meteorological Administration(CMA)recently produced a CMA Global Atmospheric Interim Reanalysis(CRAI)dataset for the years 2007–2016.A comprehensive evaluation of the ability of CRAI to capture the spatiotemporal variability of observed precipitation,in terms of both mean states and extreme indicators over China,is performed.Comparisons are made with other current reanalysis datasets,namely,the ECMWF interim reanalysis(ERAI),Japanese 55-yr reanalysis(JRA55),NCEP Climate Forecast System Reanalysis(CFSR),and NASA Modern-Era Retrospective analysis for Research and Applications version 2(MERRA2),as well as NCEP Climate Prediction Center(CPC)observations.The results show that,for daily variations of rainfall during warm seasons in eastern China,CRAI and CFSR overestimate the precipitation of the main rain belt,while the overestimation is confined to the area south of 25°N in JRA55 but north of 24°N in MERRA2;whereas ERAI tends to underestimate the precipitation in most regions of eastern China.Two extreme metrics,the total amount of precipitation on days where daily precipitation exceeds the 95 th percentile(R95 pTOT)and the number of consecutive dry days(CDDs)in one month,are examined to assess the performance of reanalysis datasets.In terms of extreme events,CRAI,ERAI,and JRA55 tend to underestimate the R95 pTOT in most of eastern China,whereas more frequent extreme rainfall can be found in most regions of China in both CFSR and MERRA2;and all of the reanalyses underestimate the CDDs.Among the reanalysis products,CRAI and JRA55 show better agreement with the observed R95 pTOT than the other datasets,with fewer biases,higher correlation coefficients,and much more similar linear trend patterns,while ERAI stands out in better capturing the amount and temporal variations of the observed CDDs.
基金supported by the High Technology Research and Development Programme of China(2007AA01Z278)
文摘Wideband IMT-Advanced mobile communication systems tend to operate in the high frequency bands due to a relatively large capacity available. Thus, Measurement and modelling methods of radio propaga- tion eharaeteristics are proposed for the field test of Chinese 4th generation （4G） trial system. The mea- surement system is established for 3.5GHz based on the sophistieated measurement instruments and the virtual instrument teehnology. The characteristic parameters of radio propagation sueh as path loss （PL） exponent and shadow fading standard deviation are extracted from measurement data, which result in the path loss model finally. The comparisons with other existing international models results validate our mea- surement in terms of path loss model. Based on the analysis of the existing extension model assumed for the microwave frequency at 3.5GHz, we find that the Stanford University Interim （SUI） model fits very well with the measurement result in the hotspot scenario, while the COST 231 model is closer to the mea- surement result in the suburban scenario. This result provides a measurement-based channel referenee for the development of the future IMT-Advanced systems in China.
文摘Aim: To test the hypothesis that antimicrobial agents can be incorporated into bis-acryl resin and that the material will inhibit bacterial growth in vitro. Materials and Methods: 0.5%, 1% and 2% triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) and 0.05% 0.01% and 0.15% cetylpyridinium chloride were incorporated into bis-acryl resins and molded into 1 mm × 10 mm discs. The discs were placed on bacterial culture media inoculated with Aggregatibacter actinomycetemcomitans strain Y4, Porphyromonas gingivalis strain SUNYaB A7A1-28 or Streptococcus gordonii strain 10558, incubated and examined for growth inhibition. Results: Triclosan-containing bisacryl resin discs produced dose-dependent zones of growth inhibition for A. actinomycetemcomitans but not S. gordonii or P. gingivalis. Cetylpyridinium chloride-containing discs produced dose-dependent zones of growth inhibition for Porphyromonas gingivalis and Streptococcus gordonii but not A. actinomycetemcomitans. Conclusion: Triclosan and cetylpyridinium chloride can be incorporated into bis-acryl resin and can inhibit the growth of plaque bacteria in a dose dependent manner. Bis-acryl resin containing antimicrobial agents may inhibit in vivo plaque accumulation and gingival inflammation.
文摘Clinical trials are usually long term studies and it seems impossible to reach all required subjects at the same time. Performing interim analyses and monitoring results may provide early termination of trial after obtaining significant results. The aim of this study is comparing group sequential tests in respect to advantage of sample size reduction and early termination. In this study, 4 test types used in group sequential designs were compared with fixed sample size design test and each other. Comparisons were done according to two-sided tests for comparing two treatments. In this sense, 1080 models were performed. In models, 2 different Type I errors, 2 different powers, 5 different analysis groups, 6 different effect sizes and 9 different variances selections were considered. All test types increased the maximum sample size in different manner, compared with fixed sample size design. Each test had different critical values to reject H0 hypothesis, at the same type I error rate and number of analyses conditions. Selection of test type used in group sequential designs depends on a few characteristics, as reducing sample size, early termination and detecting minimal effect size. Test performance is highly related with selected Type I error rate, power and number of analyses. In addition to these statistical characteristics, researchers should decide test type with respect to other trial conditions as the issue of trial, reaching subjects easy or not and importance of early termination.
文摘In this paper a frequency offset estimation technique for Wireless Local Area and Wireless Metropolitan Ar- ea Networks is presented. For frequency offset estimation, we have applied a low-complexity frequency offset estimator for simple AWGN channels to fading channels for MIMO-OFDM systems. Simulation results have shown that the performance of the proposed estimator is better than the low complexity frequency offset estimator designed for AWGN channels.
文摘A multiple-input multiple-output interleave division multiple access (MIMO-IDMA) system with Triple Polarized Division Multiplexing (TPDM) is presented in this paper. The present methodology replaces three independent linearly polarized antennas with a single triple polarized antenna at both the transmitter and receiver. The users in the communication link are accommodated and separated using a user-specific interleaver combined with low rate spreading sequence. To eliminate the effects of multi-stream interference (MSI), minimum mean square error (MMSE) algorithm based on successive interference cancellation (SIC) Multi-user detection (MUD) technique is employed at the receiver. Furthermore, log-maximum a posteriori probability (MAPP) decoding algorithm is implemented at the mobile stations (MSs) to overcome the effects of multi-user interference (MUI) effects. The paper also evaluates the effects of coded MIMO-IDMA in the downlink communication by adopting the Stanford University Interim (SUI) and Long-term Evolution (LTE)channel model specifications. In comparison with the traditional uncoded system, the present solution considering turbo coded triple-polarized MIMO-IDMA system with iterative decoding algorithm provides better bit error rate (BER) with reduced signal to noise ratio (SNR). The simulation results also show that though the SNR requirement is higher for the proposed technique compared to the conventional uni-polarized antenna based MIMO-IDMA system, it gives the advantages of achieving higher data rate with reduced cost and space requirements in the context of a downlink (DL).
文摘Interim Positron-Emission Tomography (int-PET) and the peripheral blood absolute lymphocyte/monocyte ratio at di- agnosis (ALC/AMC-DX) have been shown to be predictors for progression-free survival (PFS) and time to progression (TTP) in classical Hodgkin lymphoma (cHL). Therefore, we studied if the combination of ALC/AMC-DX and the (int-PET) can further stratified PFS and TTP in cHL patients. Patients were required to be diagnosed, treated, and followed with int-PET at Mayo Clinic, Rochester, Minnesota. From 2000 until 2008, 111 cHL patients qualified for the study. The median follow-up was 2.8 years (range: 0.3 - 10.4 years). Patients with a negative int-PET (N = 98) pre- sented with a higher ALC/AMC-DX (median of 2.32, range: 0.26 - 37.5) compared with patients with a positive int-PET (N = 13) (median of 0.9, range: 0.29 - 3.10), p 1.1. Group 1 experienced superior PFS and TTP in comparison with the other groups. In conclusion, the combination of ALC/AMC-DX and the int-PET provides a simple model to assess clinical outcomes in cHL.
文摘Based on the actual demand of project Management (PM) and the traditional conceptof Project Evaluation (PE), we extend the concept and connotation of PE In this paper, wepresent the concept of PE corresponding to the whole project life cycle, and divide it into ProjectEx Ante Evaluation (PAE), Project lnterim Evaluation (PIE) and Project Ex Post Evaluation(PPE), and mainly analyze PIE.
