Background： Marker detection is an important task in complex disease studies. Here we provide an association rule mining （ARM） based approach for identifying integrated markers through mutual information （MI） bas...Background： Marker detection is an important task in complex disease studies. Here we provide an association rule mining （ARM） based approach for identifying integrated markers through mutual information （MI） based statistically significant feature extraction, and apply it to acute myeloid leukemia （AML） and prostate carcinoma （PC） gene expression and methylation profiles. Methods： We first collect the genes having both expression and methylation values in AML as well as PC. Next, we run Jarque-Bera normality test on the expression/methylation data to divide the whole dataset into two parts： one that follows normal distribution and the other that does not follow normal distribution. Thus, we have now four parts of the dataset： normally distributed expression data, normally distributed methylation data, non-normally distributed expression data, and non-normally distributed methylated data. A feature-extraction technique, ＂mRMR＂ is then utilized on each part. This results in a list of top-ranked genes. Next, we apply Welch t-test （parametric test） and Shrink t-test （non-parametric test） on the expression/methylation data for the top selected normally distributed genes and non-normally distributed genes, respectively. We then use a recent weighted ARM method, ＂RANWAR＂ to combine all/specific resultant genes to generate top oncogenic rules along with respective integrated markers. Finally, we perform literature search as well as KEGG pathway and Gene-Ontology （GO） analyses using Enrichr database for in silico validation of the prioritized oncogenes as the markers and labeling the markers as existing or novel. Results： The novel markers of AML are {ABCB11↑ U KRT17↓} （i.e., ABCBll as up-regulated, ＆ KRT17 as down- regulated）, and {AP1SI-UKRT17↓ U NEIL2-UDYDC1↓}） （i.e., AP1S1 and NEIL2 both as hypo-methylated, ＆ KRT17 and DYDC1 both as down-regulated）. The novel marker of PC is {UBIAD1 ｜｜U APBA2 U C4orf31： （i.e., UBIAD1 as up-regulated and hypo-展开更多
Based on the idea of fusing modeling, an integrated prediction model for sintering process was proposed. A framework for sulfur content prediction was established, which integrated multi modeling ways together, includ...Based on the idea of fusing modeling, an integrated prediction model for sintering process was proposed. A framework for sulfur content prediction was established, which integrated multi modeling ways together, including mathematical model combined with neural network(NN), rule model based on empirical knowledge and model-choosing coordinator. Via metallurgic mechanism analysis and material balance computation, a mathematical model calculated the sulfur content in agglomerate by the material balance equation with some parameters predicted by NN method. In the other model, the relationship between sulfur content and key factors was described in the form of expert rules. The model-choosing coordinator based on fuzzy logic was introduced to decide the weight of result of each model according to process conditions. The model was tested by industrial application data and produced a relatively satisfactory prediction error. The model also preferably reflected the varying tendency of sulfur content in agglomerate as the evidence of its prediction performance.展开更多
针对现有三阶段装配集成调度问题模型将各工件在运输阶段的运输时间简化设定为相同常量,未考虑运输车辆数量和车载重量有限会导致工件需按批量分别运输的实际情况,研究以最小化总完工时间为目标的带工件批量运输的加工、运输、装配三阶...针对现有三阶段装配集成调度问题模型将各工件在运输阶段的运输时间简化设定为相同常量,未考虑运输车辆数量和车载重量有限会导致工件需按批量分别运输的实际情况,研究以最小化总完工时间为目标的带工件批量运输的加工、运输、装配三阶段装配集成调度问题(three-stage assembly integrated scheduling problem with job batch transportation,3sAISPJBT)和求解算法.首先,分阶段建立3sAISPJBT的数学模型;其次,分别提出求解运输、装配阶段对应子问题的先完工先运输(first completed first transported,FCFT)规则和先到先装配(first come first assembly,FCFA)规则,以降低求解3sAISPJBT的整体计算复杂度;再次,提出一种融合多种规则的混合分布估计算法(hybrid estimation of distribution algorithm with rules,HEDAR)求解3sAISPJBT;最后,通过仿真实验和算法比较验证了所提出算法的有效性.展开更多
A complex optical model potential modified by incorporating the concept of bonded atom, which takes into consideration the overlapping effect of electron clouds between atoms in a molecule, is firstly employed to calc...A complex optical model potential modified by incorporating the concept of bonded atom, which takes into consideration the overlapping effect of electron clouds between atoms in a molecule, is firstly employed to calculate the absolute differential, elastic integrated and moment transfer cross sections for electron scattering by OCS over the incident energy range from 200 to 1000 eV using the additivity rule model at Hartree-Fock level. The calculated results are compared with those obtained by experiment and other theories wherever available, and good agreement is obtained over a wide energy range. It is shown that the additivity rule model together with the modified potential is completely suitable for calculating the absolute differential, elastic integrated and moment transfer cross sections of electron scattering by molecules such as OCS.展开更多
This paper presents a two-agent framework to build a natural langua g e query interface for IC information system, focusing more on scope queries in a single English sentence. The first agent, parsing agent, syntact...This paper presents a two-agent framework to build a natural langua g e query interface for IC information system, focusing more on scope queries in a single English sentence. The first agent, parsing agent, syntactically p rocesses and semantically interprets natural language sentence to construct a fu zzy structured query language (SQL) statement. The second agent, defuzzif ying agent, defuzzifies the imprecise part of the fuzzy SQL statement into its e quivalent executable precise SQL statement based on fuzzy rules. The first agent can also actively ask the user some necessary questions when it manages to disa mbiguate the vague retrieval requirements. The adaptive defuzzification approach employed in the defuzzifying agent is discussed in detail. A prototype interface has been implemented to demonstrate the effectiveness.展开更多
文摘Background： Marker detection is an important task in complex disease studies. Here we provide an association rule mining （ARM） based approach for identifying integrated markers through mutual information （MI） based statistically significant feature extraction, and apply it to acute myeloid leukemia （AML） and prostate carcinoma （PC） gene expression and methylation profiles. Methods： We first collect the genes having both expression and methylation values in AML as well as PC. Next, we run Jarque-Bera normality test on the expression/methylation data to divide the whole dataset into two parts： one that follows normal distribution and the other that does not follow normal distribution. Thus, we have now four parts of the dataset： normally distributed expression data, normally distributed methylation data, non-normally distributed expression data, and non-normally distributed methylated data. A feature-extraction technique, ＂mRMR＂ is then utilized on each part. This results in a list of top-ranked genes. Next, we apply Welch t-test （parametric test） and Shrink t-test （non-parametric test） on the expression/methylation data for the top selected normally distributed genes and non-normally distributed genes, respectively. We then use a recent weighted ARM method, ＂RANWAR＂ to combine all/specific resultant genes to generate top oncogenic rules along with respective integrated markers. Finally, we perform literature search as well as KEGG pathway and Gene-Ontology （GO） analyses using Enrichr database for in silico validation of the prioritized oncogenes as the markers and labeling the markers as existing or novel. Results： The novel markers of AML are {ABCB11↑ U KRT17↓} （i.e., ABCBll as up-regulated, ＆ KRT17 as down- regulated）, and {AP1SI-UKRT17↓ U NEIL2-UDYDC1↓}） （i.e., AP1S1 and NEIL2 both as hypo-methylated, ＆ KRT17 and DYDC1 both as down-regulated）. The novel marker of PC is {UBIAD1 ｜｜U APBA2 U C4orf31： （i.e., UBIAD1 as up-regulated and hypo-
文摘Based on the idea of fusing modeling, an integrated prediction model for sintering process was proposed. A framework for sulfur content prediction was established, which integrated multi modeling ways together, including mathematical model combined with neural network(NN), rule model based on empirical knowledge and model-choosing coordinator. Via metallurgic mechanism analysis and material balance computation, a mathematical model calculated the sulfur content in agglomerate by the material balance equation with some parameters predicted by NN method. In the other model, the relationship between sulfur content and key factors was described in the form of expert rules. The model-choosing coordinator based on fuzzy logic was introduced to decide the weight of result of each model according to process conditions. The model was tested by industrial application data and produced a relatively satisfactory prediction error. The model also preferably reflected the varying tendency of sulfur content in agglomerate as the evidence of its prediction performance.
文摘针对现有三阶段装配集成调度问题模型将各工件在运输阶段的运输时间简化设定为相同常量,未考虑运输车辆数量和车载重量有限会导致工件需按批量分别运输的实际情况,研究以最小化总完工时间为目标的带工件批量运输的加工、运输、装配三阶段装配集成调度问题(three-stage assembly integrated scheduling problem with job batch transportation,3sAISPJBT)和求解算法.首先,分阶段建立3sAISPJBT的数学模型;其次,分别提出求解运输、装配阶段对应子问题的先完工先运输(first completed first transported,FCFT)规则和先到先装配(first come first assembly,FCFA)规则,以降低求解3sAISPJBT的整体计算复杂度;再次,提出一种融合多种规则的混合分布估计算法(hybrid estimation of distribution algorithm with rules,HEDAR)求解3sAISPJBT;最后,通过仿真实验和算法比较验证了所提出算法的有效性.
基金Project supported by the National Natural Science Foundation of China （Grant No 10574039）
文摘A complex optical model potential modified by incorporating the concept of bonded atom, which takes into consideration the overlapping effect of electron clouds between atoms in a molecule, is firstly employed to calculate the absolute differential, elastic integrated and moment transfer cross sections for electron scattering by OCS over the incident energy range from 200 to 1000 eV using the additivity rule model at Hartree-Fock level. The calculated results are compared with those obtained by experiment and other theories wherever available, and good agreement is obtained over a wide energy range. It is shown that the additivity rule model together with the modified potential is completely suitable for calculating the absolute differential, elastic integrated and moment transfer cross sections of electron scattering by molecules such as OCS.
文摘This paper presents a two-agent framework to build a natural langua g e query interface for IC information system, focusing more on scope queries in a single English sentence. The first agent, parsing agent, syntactically p rocesses and semantically interprets natural language sentence to construct a fu zzy structured query language (SQL) statement. The second agent, defuzzif ying agent, defuzzifies the imprecise part of the fuzzy SQL statement into its e quivalent executable precise SQL statement based on fuzzy rules. The first agent can also actively ask the user some necessary questions when it manages to disa mbiguate the vague retrieval requirements. The adaptive defuzzification approach employed in the defuzzifying agent is discussed in detail. A prototype interface has been implemented to demonstrate the effectiveness.
