The integrated lipopeptide(RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment.After self-assembling and target coating modification,the poly(γ-glutamic acid)(γ-PGA...The integrated lipopeptide(RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment.After self-assembling and target coating modification,the poly(γ-glutamic acid)(γ-PGA)/RVA nano-vectors can sequentially respond to pH&redox stimuli,and guarantee efficient therapeutic gene delivery and control release of all-trans retinoic acid.The design provides a facile but promising strategy to treat refractory cancers.展开更多
With the extensive integration of high-penetration renewable energy resources,more fast-response frequency regulation(FR)providers are required to eliminate the impact of uncertainties from loads and distributed gener...With the extensive integration of high-penetration renewable energy resources,more fast-response frequency regulation(FR)providers are required to eliminate the impact of uncertainties from loads and distributed generators(DGs)on system security and stability.As a high-quality FR resource,community integrated energy station(CIES)can effectively respond to frequency deviation caused by renewable energy generation,helping to solve the frequency problem of power system.This paper proposes an optimal planning model of CIES considering FR service.First,the model of FR service is established to unify the time scale of FR service and economic operation.Then,an optimal planning model of CIES considering FR service is proposed,with which the revenue of participating in the FR service is obtained under market mechanism.The flexible electricity pricing model is introduced to flatten the peak tieline power of CIES.Case studies are conducted to analyze the annual cost and the revenue of CIES participating in FR service,which suggest that providing ancillary services can bring potential revenue.展开更多
基金financially supported by National Natural Science Foundation of China(NSFC,Nos.81873921 and 51903174)Sino-German Cooperation Group Project(No.GZ1512)+2 种基金China Postdoctoral Science Foundation(No.2021M702772)Chengdu Science and Technology Program(No.2020-GH02-00007-HZ)Sichuan University Postdoctoral Interdisciplinary Innovation Startup Foundation and the Fundamental Research Funds for Central Universities(No.2021SCU12070)。
文摘The integrated lipopeptide(RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment.After self-assembling and target coating modification,the poly(γ-glutamic acid)(γ-PGA)/RVA nano-vectors can sequentially respond to pH&redox stimuli,and guarantee efficient therapeutic gene delivery and control release of all-trans retinoic acid.The design provides a facile but promising strategy to treat refractory cancers.
基金supported by the National Key R&D Program of China(No.2018YFB0905000)National Natural Science Foundation of China(No.51961135101)。
文摘With the extensive integration of high-penetration renewable energy resources,more fast-response frequency regulation(FR)providers are required to eliminate the impact of uncertainties from loads and distributed generators(DGs)on system security and stability.As a high-quality FR resource,community integrated energy station(CIES)can effectively respond to frequency deviation caused by renewable energy generation,helping to solve the frequency problem of power system.This paper proposes an optimal planning model of CIES considering FR service.First,the model of FR service is established to unify the time scale of FR service and economic operation.Then,an optimal planning model of CIES considering FR service is proposed,with which the revenue of participating in the FR service is obtained under market mechanism.The flexible electricity pricing model is introduced to flatten the peak tieline power of CIES.Case studies are conducted to analyze the annual cost and the revenue of CIES participating in FR service,which suggest that providing ancillary services can bring potential revenue.
