目的探究极低出生体重(very low birth weight,VLBW)早产儿校正月龄12个月内体重、身长、头围追赶生长特征及相关影响因素,为临床干预提供依据。方法采用回顾性研究,摘录2014年1月—2016年3月就诊于上海市某妇婴保健院新生儿重症监护室(...目的探究极低出生体重(very low birth weight,VLBW)早产儿校正月龄12个月内体重、身长、头围追赶生长特征及相关影响因素,为临床干预提供依据。方法采用回顾性研究,摘录2014年1月—2016年3月就诊于上海市某妇婴保健院新生儿重症监护室(neonatal intensive care unit,NICU)符合纳入和排除标准的VLBW早产儿的临床资料。分别与Fenton(2003)早产儿生长曲线及疾病预防控制中心(Centers for Disease Control and Prevention,CDC)足月儿生长曲线进行比较,探究VLBW早产儿校正月龄6个月及12个月体格生长发育的影响因素。结果共纳入113例VLBW早产儿,其中106例随访至校正月龄3个月及以上。与早产儿及足月儿相比,VLBW早产儿的身长、体重、头围差异均有统计学意义(P<0.05)。单因素分析显示,校正月龄6个月时,VLBW男婴身长发育不良与住院时间长、开始经口喂养月龄大、全经口喂养月龄大、开始经口母乳喂养月龄大相关,其体重发育不理想与住院时间长、开始经口母乳喂养月龄大相关(P<0.05)。校正月龄12个月时,VLBW女婴头围发育与母亲年龄和校正月龄6个月纯配方奶喂养有关,其体重发育不良与母亲年龄有关(P<0.05)。VLBW男婴头围发育不良与开始经口喂养及全经口喂养胎龄大有关,其身长发育不良与住院期间纯母乳喂养有关(P<0.05)。结论尽早过渡到全经口喂养,住院及随访期间母乳和早产儿配方奶混合喂养对VLBW早产儿体格生长起积极作用,提示患儿NICU住院期间及随访期间喂养指导的重要性。展开更多
Background： With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight （ELBW） survived all over the world. This study was designed to investigate the short-term ontcome...Background： With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight （ELBW） survived all over the world. This study was designed to investigate the short-term ontcomes of ELBW infants during their Neonatal Intensive Care Unit （NICU） stay in the mainland of China. Methods： All infants admitted to 26 NICUs with a birth weight （BW） 〈1000 g were included between January 1,2011 and December 31,2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results： A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age （GA） was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants （23.3%） died and another 69 infants （26.7%） died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas （53.6% vs. 35.3%, P = 0.019）. BW 〈750 g and GA 〈28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions： Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.展开更多
目的研究极低出生体重儿（VLBWI）住院期间的生长发育状态及相关影响因素。方法回顾性调查广东省珠江三角洲地区9个城市的9家医院新生儿科于2010年7月1日至2011年6月30日，出院的VLBWI的住院资料，根据出生体重，分为宫内生长发育迟缓[I...目的研究极低出生体重儿（VLBWI）住院期间的生长发育状态及相关影响因素。方法回顾性调查广东省珠江三角洲地区9个城市的9家医院新生儿科于2010年7月1日至2011年6月30日，出院的VLBWI的住院资料，根据出生体重，分为宫内生长发育迟缓[IUGR组（n=63）]和非IUGR组（n=120），非IUGR组又根据其出院时是否发展为宫外生长发育迟缓（EUGR）而分为EUGR组（n=71）和非EUGR组（n=49），对比性研究IUGR组和非IUGtl组住院期间的日均体重增长速度和出院时EUGR的发生率，及各组的院内营养摄入情况、生长速度和相关疾病因素的影响。结果（1）出生时IUGR和出院时EUGR的发生率分别为34．4％和72．1％，IUGR组的日均体重增长速度高于非IUGR组[（12．5±2．7）g/k vs（11．3±2．5）g/kg，t=3．068，P=0．002]，但IUGt／组发展为EUGR的比例明显高于非IUGR组（96．8％vs59．2％，X^2=29．145，P=0．000）。（2）IUGR组在生后1、2、4周、达完全经口喂养前和住院期间的日均热卡摄入[62（51，69）kcal／kg vs 56（45，64）kcal／kg、83（71，94）keal／kg vs 76（66，88）keal／kg、107（94，120）keal／kg vs 95（85，108）kcal／kg；103（96，110）keal／kg vs 97（89，106）kcal／kg、121（111，131）keal／kg vs 111（101，119）kcal／kg]（1kcal=4．1840kJ）。蛋白质摄入[1．7（1．3，2．0）g／kg vs 1．6（1．2，1．8）g／kg、2．6（2．1，2．9）g／kg vs 2．3（1．9，2．7）g／kg、3．3（2．7，3．6）g/kg vs 2．7（2．4，3．2）g/kg、3．1（2．6，3．4）g／kg vs 2．8（2．4，3．3）g／k、3．4（3．1，3．8）g／kg vs 3．1（2．8，3．5）g／k]均高于非IUGR组（P〈0．05）。热卡累积损失[407（360，483）kca]／kg vs 448（393，527）keal／kg、534（369，689）kcal／kgw612（453，758）keal／kg、367（12，724）kcal／kg vs 718（330，996）kcal／kg、381（231，609）kcal／kg vs 656（394，959）keal�展开更多
文摘目的探究极低出生体重(very low birth weight,VLBW)早产儿校正月龄12个月内体重、身长、头围追赶生长特征及相关影响因素,为临床干预提供依据。方法采用回顾性研究,摘录2014年1月—2016年3月就诊于上海市某妇婴保健院新生儿重症监护室(neonatal intensive care unit,NICU)符合纳入和排除标准的VLBW早产儿的临床资料。分别与Fenton(2003)早产儿生长曲线及疾病预防控制中心(Centers for Disease Control and Prevention,CDC)足月儿生长曲线进行比较,探究VLBW早产儿校正月龄6个月及12个月体格生长发育的影响因素。结果共纳入113例VLBW早产儿,其中106例随访至校正月龄3个月及以上。与早产儿及足月儿相比,VLBW早产儿的身长、体重、头围差异均有统计学意义(P<0.05)。单因素分析显示,校正月龄6个月时,VLBW男婴身长发育不良与住院时间长、开始经口喂养月龄大、全经口喂养月龄大、开始经口母乳喂养月龄大相关,其体重发育不理想与住院时间长、开始经口母乳喂养月龄大相关(P<0.05)。校正月龄12个月时,VLBW女婴头围发育与母亲年龄和校正月龄6个月纯配方奶喂养有关,其体重发育不良与母亲年龄有关(P<0.05)。VLBW男婴头围发育不良与开始经口喂养及全经口喂养胎龄大有关,其身长发育不良与住院期间纯母乳喂养有关(P<0.05)。结论尽早过渡到全经口喂养,住院及随访期间母乳和早产儿配方奶混合喂养对VLBW早产儿体格生长起积极作用,提示患儿NICU住院期间及随访期间喂养指导的重要性。
文摘Background： With the progress ofperinatal medicine and neonatal technology, more and more extremely low birth weight （ELBW） survived all over the world. This study was designed to investigate the short-term ontcomes of ELBW infants during their Neonatal Intensive Care Unit （NICU） stay in the mainland of China. Methods： All infants admitted to 26 NICUs with a birth weight （BW） 〈1000 g were included between January 1,2011 and December 31,2011. All the data were collected retrospectively from clinical records by a prospectively designed questionnaire. The data collected from each NICU transmitted to the main institution where the results were aggregated and analyzed. Categorical variables were performed with Pearson Chi-square test. Binary Logistic regression analysis was used to detect risk factors. Results： A total of 258 ELBW infants were admitted to 26 NICUs, of whom the mean gestational age （GA） was 28.1 ± 2.2 weeks, and the mean BW was 868 ± 97 g. The overall survival rate at discharge was 50.0%. Despite aggressive treatment 60 infants （23.3%） died and another 69 infants （26.7%） died after medical care withdrawal. Furthermore, the survival rate was significantly higher in coastal areas than inland areas （53.6% vs. 35.3%, P = 0.019）. BW 〈750 g and GA 〈28 weeks were the largest risk factors, and being small for gestational age was a protective factor related to mortality. Respiratory distress syndrome was the most common complication. The incidence of patent ductus arteriosus, intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, retinopathy of prematurity was 26.2%, 33.7%, 6.7%, 48.1%, and 41.4%, respectively. Ventilator associated pneumonia was the most common hospital acquired infection during hospitalization. Conclusions： Our study was the first survey that revealed the present status of ELBW infants in the mainland of China. The mortality and morbidity of ELBW infants remained high as compared to other developed countries.
文摘目的研究极低出生体重儿（VLBWI）住院期间的生长发育状态及相关影响因素。方法回顾性调查广东省珠江三角洲地区9个城市的9家医院新生儿科于2010年7月1日至2011年6月30日，出院的VLBWI的住院资料，根据出生体重，分为宫内生长发育迟缓[IUGR组（n=63）]和非IUGR组（n=120），非IUGR组又根据其出院时是否发展为宫外生长发育迟缓（EUGR）而分为EUGR组（n=71）和非EUGR组（n=49），对比性研究IUGR组和非IUGtl组住院期间的日均体重增长速度和出院时EUGR的发生率，及各组的院内营养摄入情况、生长速度和相关疾病因素的影响。结果（1）出生时IUGR和出院时EUGR的发生率分别为34．4％和72．1％，IUGR组的日均体重增长速度高于非IUGR组[（12．5±2．7）g/k vs（11．3±2．5）g/kg，t=3．068，P=0．002]，但IUGt／组发展为EUGR的比例明显高于非IUGR组（96．8％vs59．2％，X^2=29．145，P=0．000）。（2）IUGR组在生后1、2、4周、达完全经口喂养前和住院期间的日均热卡摄入[62（51，69）kcal／kg vs 56（45，64）kcal／kg、83（71，94）keal／kg vs 76（66，88）keal／kg、107（94，120）keal／kg vs 95（85，108）kcal／kg；103（96，110）keal／kg vs 97（89，106）kcal／kg、121（111，131）keal／kg vs 111（101，119）kcal／kg]（1kcal=4．1840kJ）。蛋白质摄入[1．7（1．3，2．0）g／kg vs 1．6（1．2，1．8）g／kg、2．6（2．1，2．9）g／kg vs 2．3（1．9，2．7）g／kg、3．3（2．7，3．6）g/kg vs 2．7（2．4，3．2）g/kg、3．1（2．6，3．4）g／kg vs 2．8（2．4，3．3）g／k、3．4（3．1，3．8）g／kg vs 3．1（2．8，3．5）g／k]均高于非IUGR组（P〈0．05）。热卡累积损失[407（360，483）kca]／kg vs 448（393，527）keal／kg、534（369，689）kcal／kgw612（453，758）keal／kg、367（12，724）kcal／kg vs 718（330，996）kcal／kg、381（231，609）kcal／kg vs 656（394，959）keal�
