It has been expected that chemotherapy,as one of the major modalities in the management of cancer,would exert some beneficial effects on head and neck tumors.However,most of the pathologic types of head and neck solid...It has been expected that chemotherapy,as one of the major modalities in the management of cancer,would exert some beneficial effects on head and neck tumors.However,most of the pathologic types of head and neck solid carcinoma are of squamous cell variety,which seems no long-term radical response to any regimens of chemotherapy so far,according to the literature reports since the advent of chemotherapy.It is suggested at present no chemotherapy be applied to head and neck cancer patients for the purpose of a radical cure,which could be brought about by surgery or radiotherapy.Some of the literature that advocated chemotherapy on head and neck cancer is unjustifiable,not without personal bias.Clinical investigation should be further conducted on a small scale and in a rigorous way at research units in order to find a curative and treatment advice for head and neck oncologists in future.展开更多
The management of locally advanced unresectable head and neck squamous cell cancer(HNSCC) continues to improve. One of the major advances in the treatment of HNSCC was the addition of chemotherapy to radiation in the ...The management of locally advanced unresectable head and neck squamous cell cancer(HNSCC) continues to improve. One of the major advances in the treatment of HNSCC was the addition of chemotherapy to radiation in the treatment of non-surgical patients. The majority of the data regarding chemotherapy in HNSCC involve cisplatin chemotherapy with concurrent radiation. However, several new approaches have included targeted therapy against epidermal growth factor receptor and several recent studies have explored the role of induction chemotherapy in the treatment of HNSCC. The purpose of this article is to provide an overview of the role of chemotherapy in the treatment of locally advanced HNSCC.展开更多
文摘It has been expected that chemotherapy,as one of the major modalities in the management of cancer,would exert some beneficial effects on head and neck tumors.However,most of the pathologic types of head and neck solid carcinoma are of squamous cell variety,which seems no long-term radical response to any regimens of chemotherapy so far,according to the literature reports since the advent of chemotherapy.It is suggested at present no chemotherapy be applied to head and neck cancer patients for the purpose of a radical cure,which could be brought about by surgery or radiotherapy.Some of the literature that advocated chemotherapy on head and neck cancer is unjustifiable,not without personal bias.Clinical investigation should be further conducted on a small scale and in a rigorous way at research units in order to find a curative and treatment advice for head and neck oncologists in future.
文摘The management of locally advanced unresectable head and neck squamous cell cancer(HNSCC) continues to improve. One of the major advances in the treatment of HNSCC was the addition of chemotherapy to radiation in the treatment of non-surgical patients. The majority of the data regarding chemotherapy in HNSCC involve cisplatin chemotherapy with concurrent radiation. However, several new approaches have included targeted therapy against epidermal growth factor receptor and several recent studies have explored the role of induction chemotherapy in the treatment of HNSCC. The purpose of this article is to provide an overview of the role of chemotherapy in the treatment of locally advanced HNSCC.
