The research of organic luminescent materials in aggregate has drawn more and more attention for their wide applications.To adjust the luminescent properties for aggregates,a deep understanding of the corresponding in...The research of organic luminescent materials in aggregate has drawn more and more attention for their wide applications.To adjust the luminescent properties for aggregates,a deep understanding of the corresponding internal mechanism is needed.In this short review,a brief introduction of aggregation-induced emission(AIE)and some other solid state luminescence behaviors derived from or parallel to AIE is presented.Particularly,the relationship between emission property and intermolecular/intramolecular interactions is summarized,with the aim to guide the further development of organic optoelectronic materials in aggregate.展开更多
J-aggregation and H-aggregation are identified as two classical models of function-ally oriented non-covalent interactions,and significant attention has been drawn by researchers.However,due to the scarcity of single-cr...J-aggregation and H-aggregation are identified as two classical models of function-ally oriented non-covalent interactions,and significant attention has been drawn by researchers.However,due to the scarcity of single-crystal examples of H-aggregation,a comprehensive understanding of the relationship between its stacking mode and optical behaviour has been hindered.In recent studies,two polyaromatic Schiff base compounds,Cl-Salmphen and H-Salmphen,were successfully synthe-sized,and both were found to exhibit H-aggregation.In thefindings,H-Salmphen was shown to display typical C─H···πinteractions,characteristic of Aggregation-Induced Emission(AIE)active molecules,whereas its halogenated counterpart was identified as behaving similar to Aggregation-Caused Quenching(ACQ)active molecules.These types of results suggest that identical intermolecular interactions can produce differing optical behaviours.Light was shed,at least in part,on the for-mation mechanisms of H-type aggregates and their luminescence properties from these observations.Additionally,the high optical signal-to-noise ratio inherent to H-aggregates was utilized for the exploration of water content detection.As an outcome,a high-performancefluorescentfilter paper was developed,enabling easy real-time detection using a smartphone.展开更多
The presence of protein aggregates in numerous human diseases underscores the significance of detecting these aggregates to comprehend disease mechanisms and develop novel therapeutic approaches for combating these di...The presence of protein aggregates in numerous human diseases underscores the significance of detecting these aggregates to comprehend disease mechanisms and develop novel therapeutic approaches for combating these disorders.Despite the development of various biosensors and fluorescent probes that selectively target amyloid fibers or amorphous aggregates,there is still a lack of tools capable of simultaneously detecting both types of aggregates.Herein,we demonstrate the quantitative discernment of amorphous aggregates by QM-FN-SO3,an aggregationinduced emission(AIE)probe initially designed for detecting amyloid fibers.This probe easily penetrates the membranes of the widely-used prokaryotic model organism Escherichia coli,enabling the visualization of both amorphous aggregates and amyloid fibers through near-infrared fluorescence.Notably,the probe exhibits sensitivity in distinguishing the varying aggregation propensities of proteins,regardless of whether they form amorphous aggregates or amyloid fibers in vivo.These properties contribute to the successful application of the QM-FN-SO3 probe in the subsequent investigation of the antiaggregation activities of two outer membrane protein(OMP)chaperones,both in vitro and in their physiological environment.Overall,our work introduces a near-infrared fluorescent chemical probe that can quantitatively detect amyloid fibers and amorphous aggregates with high sensitivity in vitro and in vivo.Furthermore,it demonstrates the applicability of the probe in chaperone biology and its potential as a high-throughput screening tool for protein aggregation inhibitors and folding factors.展开更多
Nucleophilic substitution reaction and 1,3-dicarbonyl compounds play significant roles in organic chemistry, and non-traditional intrinsic luminescence (NTIL) has become an emerging research area. Here, we demonstrate...Nucleophilic substitution reaction and 1,3-dicarbonyl compounds play significant roles in organic chemistry, and non-traditional intrinsic luminescence (NTIL) has become an emerging research area. Here, we demonstrate the successful nucleophilic substitution polymerization of 1,3-dicarbonyl compounds, including acetylacetone, 3,5-heptanedione, methyl acetoacetate, cyclopentane-1,3-dione, 1,3-indandione, 1-phenyl-1,3-butanedione and dibenzoylmethane, where reactive hydrogens at α position of 1,3-dicarbonyl compounds are involved. Through this base catalyzed nucleophilic substitution polycondensation between 1,3-dicarbonyl compounds and α,α’-dibromo xylene, a series of nonconjugated poly(1,3-dicarbonyl)s have been successfully prepared with high yield (up to >99%) under mild conditions. Investigations reveal that this nucleophilic substitution polycondensation exhibits self-accelerating effect and flexible stoichiometry characteristics, which exhibits advantages over traditional polycondensation methods. This polymerization also exhibits intriguing polymerization-induced emission (PIE) characteristics, where nonconjugated poly(1,3-dicarbonyl)s exhibit intriguing chemical structure dependent aggregation-induced emission (AIE) type NTIL. This work therefore expands the monomer, method, chemical structure and property libraries of polymer chemistry, which may cause inspirations to polymerization methodology, PIE, AIE and NTIL.展开更多
Since the first report of aggregation-induced emission(AIE)concept in 2001,it has received intense attentions from academy and industry because of its important applications in diverse research fronts.Up to now,the lu...Since the first report of aggregation-induced emission(AIE)concept in 2001,it has received intense attentions from academy and industry because of its important applications in diverse research fronts.Up to now,the luminogens with AIE property(AIEgens)have been widely used in optoelectronic devices,fluorescent bioprobes and chemosensors,and researchers have also committed to exploring the potentials of AIEgens in other cross-cutting areas.The AIEgens have shown superior advantages such as highly efficient emissions in the aggregated state and thus exhibited better performances in comparison with traditional luminescent materials whose emissions are usually quenched upon aggregate formation.In view of the significant achievements of AIEgens in recent years,this review presents representative advancements of AIEgens for the applications in organic optoelectronic devices,mainly including organic light-emitting diodes(OLEDs),circularly polarized luminescence(CPL)devices,electrofluorochromic(EFC)devices,luminescent solar concentrators(LSCs),and liquid crystal displays(LCDs).Not only the design strategies of AIEgens for these optoelectronic devices are analyzed,but also their structureproperty relationship and working mechanism are elucidated.It is foreseeable that robust AIEgens with specific functionalities will find more and more applications in various research fields and play an increasingly important role in high-tech devices.展开更多
In this paper,a decision-making problem with a q-rung orthopair fuzzy hypersoft environment is developed,and two operators of ordered weighted average and induced ordered weighted average are developed.Several fundame...In this paper,a decision-making problem with a q-rung orthopair fuzzy hypersoft environment is developed,and two operators of ordered weighted average and induced ordered weighted average are developed.Several fundamental features are also derived.The induced ordered weighted average operator is essential in a q-ROFH environment as the induced ordered aggregation operators are special cases of the existing aggregation operators that already exist in q-ROFH environments.The main function of these operators is to help decision-makers gain a complete understanding of uncertain facts.The proposed aggregation operator is applied to a decision-making problem,with the aim of selecting the most promising real estate project for investment.展开更多
Organic fluorophores play essential roles in both academic and applied fields.Most of the fluorescent molecules can be divided into aggregation-caused quenching(ACQ)and aggregation-induced emission(AIE)types based on ...Organic fluorophores play essential roles in both academic and applied fields.Most of the fluorescent molecules can be divided into aggregation-caused quenching(ACQ)and aggregation-induced emission(AIE)types based on the diverse emission properties in solution and aggregated states.Currently,a large part of studies focuses on the ACQ-to-AIE one-way transformation and the complex synthesis of chemical bonds is inevitable in all existing methods.To maximize the advantages of ACQ and AIE types fluorophores and avoid complex chemosynthesis,we propose a facile strategy first realizing the reversible ACQAIE transformation with the dynamic Diels-Alder(DA)reactions.Besides,the fluorescent platform can monitor DA reactions in microscale ultra-sensitively and quantitively.The dynamic covalent bonds can help to develop novel fluorophores creatively,and the reversible ACQ-AIE platform is expected to offer fresh insights into the dynamic covalent chemistry.展开更多
For cases in which a robot with installed solar cells and a sensor operates in a nuclear reactor building or in space for extravehicular activity, we require elastic and extensible solar cells. More than two different...For cases in which a robot with installed solar cells and a sensor operates in a nuclear reactor building or in space for extravehicular activity, we require elastic and extensible solar cells. More than two different types of sensing are also required, minimally with photovoltaics and built-in electricity. Magnetic compound fluid (MCF) rubber solar cells are made of rubber, so they are elastic and extensible as well as sensitive. To achieve flexibility and an effective photovoltaic effect, MCF rubber solar cells must include both soluble and insoluble rubbers, Fe<sub>3</sub>O<sub>4</sub>, TiO<sub>2</sub>, Na<sub>2</sub>WO<sub>4</sub>∙2H<sub>2</sub>O, etc. On the basis of this constitution, we propose a consummate fabrication process for MCF rubber solar cells. The characteristics of these cells result from the semiconductor-like role of the molecules of TiO<sub>2</sub>, Fe<sub>3</sub>O<sub>4</sub>, Ni, Na<sub>2</sub>WO<sub>4</sub>∙2H<sub>2</sub>O, polydimethylsiloxane (PDMS), natural rubber (NR), oleic acid, polyvinyl alcohol (PVA), water and magnetic cluster involved in the MCF rubber. Their tendencies can be deduced by synthesizing knowledge about the enhancement of the reverse-bias saturation current <em>I</em><sub><em>S</em></sub> and the diode ideality factor <em>N</em>, with conventional knowledge about the semiconductor affected by <em>γ</em>-irradiation and the attenuation of the photon energy of <em>γ</em>-rays.展开更多
The development of fluorescent nanocrystals based on organic small molecules is of great importance in bioimaging due to the merits of easy modification,high brightness and excellent photostability,however suffering f...The development of fluorescent nanocrystals based on organic small molecules is of great importance in bioimaging due to the merits of easy modification,high brightness and excellent photostability,however suffering from the emission-detrimental aggregation-caused quenching(ACQ)effect.Herein,we successfully designed and synthesized an AIE-active di(N,N-dimethylaniline)-dibenzofulvene(named as NFTPE),which exhibits the crystallization-induced emission enhancement(CIEE)effect.Interestingly,two types of yellow-and orange-emissive crystals for NFTPE were obtained,exhibiting aggregation microenvironment-dependent emission tuning in the solid state.Single-crystal analysis and density functional theory(DFT)calculations reveal that different aggregation microenvironments result in the distinct molecular conformation for various emission.Excitingly,the crystallization of NFTPE in an aqueous solution under the assistance of amphiphilic PEG polymer matrices could be monitored in situ by the fluorescence changes,facilitating the preparation of NFTPE nanocrystals(NFTPE-NCs)by adjusting the aggregation microenvironment.The obtained NFTPE-NCs exhibit the superior performance in cell imaging in respect to high brightness,photostability,and biocompatibility,thus demonstrating the potential in bioimaging applications.展开更多
Recently we have reported our study on the J-aggregate formation of an anionic cyanine promoted by the counterions of added salts under environmental conditions. The result showed that the counterions are bound to the...Recently we have reported our study on the J-aggregate formation of an anionic cyanine promoted by the counterions of added salts under environmental conditions. The result showed that the counterions are bound to the dye ion J-stacks in 'stoichiometric' relation. Concerning the fact that polyeletrolytes could promote the formation of J-aggregate of cyanine dye ions, the authors suggested that the J-aggregates of an ionic cyanine might more easily induce the J-aggregation of other cyanine ions with opposite charges. The two展开更多
In this work,a facile and sensitive colorimetric detection method was firstly reported for RNase A activity detection based on target regulated protection effect of chimeric DNA probe on the salt-induced aggregation o...In this work,a facile and sensitive colorimetric detection method was firstly reported for RNase A activity detection based on target regulated protection effect of chimeric DNA probe on the salt-induced aggregation of plasmonic gold nanoparticles.Compared with previous works of RNase A activity detection,this colorimetric assay integrated the advantages of sensitive,low cost,facile operation,rapid response and low biological toxicity.展开更多
Background:Investigations of the pathogenic mechanisms in motor neurons(MNs)derived from amyotrophic lateral sclerosis(ALS)disease-specific induced pluripotent stem(iPS)cell lines could improve understanding of the is...Background:Investigations of the pathogenic mechanisms in motor neurons(MNs)derived from amyotrophic lateral sclerosis(ALS)disease-specific induced pluripotent stem(iPS)cell lines could improve understanding of the issues affecting MNs.Therefore,in this study we explored mutant superoxide dismutase 1(SOD1)protein expression in MNs derived from the iPS cell lines of ALS patients carrying different SOD1 mutations.Methods:We generated induced pluripotent stem cell(iPSC)lines from two familial ALS(FALS)patients withSOD1-V14M andSOD1-C111Y mutations,and then differentiated them into MNs.We investigated levels of the SOD1 protein in iPSCs and MNs,the intracellular Ca2+levels in MNs,and the lactate dehydrogenase(LDH)activity in the process of differentiation into the MNs derived from the controls and ALS patients’iPSCs.Results:The iPSCs from the two FALS patients were capable of differentiation into MNs carrying different SOD1 mutations and differentially expressed MN markers.We detected high SOD1 protein expression and high intracellular calcium levels in both the MN and iPSCs that were derived from the twoSOD1 mutant patients.However,at no time did we observe stronger LDH activity in the patient lines compared with the control lines.Conclusions:MNs derived from patient-specific iPSC lines can recapitulate key aspects of ALS pathogenesis,providing a cell-based disease model to further elucidate disease pathogenesis and explore gene repair coupled with cell-replacement therapy.Incremental mutant expressions of SOD1 in MNs may have disrupted MN function,either causing or contributing to the intracellular calcium disturbances,which could lead to the occurrence and development of the disease.展开更多
Molecular ordering within the photoactive layer plays a crucial role in determining the device performance of organic solar cells(OSCs).However,the simultaneous molecular ordering processes of polymer donors and non-f...Molecular ordering within the photoactive layer plays a crucial role in determining the device performance of organic solar cells(OSCs).However,the simultaneous molecular ordering processes of polymer donors and non-fullerene acceptors(NFAs)during solution casting usually bring confinement effect,leading to insufficient structural order of photovoltaic components.Herein,the molecular packing of mINPOIC NFA is effectively formed through a heating induced aggregation strategy,with the aggregation of PBDB-T,which has a strong temperature dependence,is retarded by casting on a preheated substrate to reduce its interference toward m-INPOIC.A sequent thermal annealing treatment is then applied to promote the ordering of PBDB-T and achieve balanced aggregation of both donors and acceptors,resulting in the achievement of a maximum efficiency of 13.9% of PBDB-T:m-INPOIC binary OSCs.This work disentangles the interactions of donor polymer and NFA during the solution casting process and develops a rational strategy to enhance the molecular packing of NFAs to boost device performance.展开更多
Aggregation-induced emission(AIE) has drawn great attention worldwide for its unique optical phenomenon and huge potential applications. Since coined by Ben Zhong Tang et al. in 2001, AIE has been deeply investigated ...Aggregation-induced emission(AIE) has drawn great attention worldwide for its unique optical phenomenon and huge potential applications. Since coined by Ben Zhong Tang et al. in 2001, AIE has been deeply investigated and widely utilized in many important areas, such as organic light-emitting diode(OLED), sensor, and bio-imaging. Herein, we highlight some important progress of AIE in these eighteen years, including the exploration of internal mechanism and potential applications. Furthermore,some other interestingly emissive behaviors, originating but distinguishing from the AIE concept, are presented. It is anticipated an overall understanding about AIE could be easily caught from this short review for scientists, no matter whether they are involved in this exciting and rising research area or not.展开更多
基金National Natural Science Foundation of China,Grant/Award Number:51903188Natural Science Foundation ofTianjin City,Grant/Award Number:19JCQNJC04500。
文摘The research of organic luminescent materials in aggregate has drawn more and more attention for their wide applications.To adjust the luminescent properties for aggregates,a deep understanding of the corresponding internal mechanism is needed.In this short review,a brief introduction of aggregation-induced emission(AIE)and some other solid state luminescence behaviors derived from or parallel to AIE is presented.Particularly,the relationship between emission property and intermolecular/intramolecular interactions is summarized,with the aim to guide the further development of organic optoelectronic materials in aggregate.
基金the Program for Innovative Research Team(in Science and Technology)in Universities of Yunnan Province(IRTSTYN),the Recruitment Program of Yunnan Province Experts Provincial Young Talents(2019HB098)the Ten-Thousand Talents Program of Yunnan Province(YNWR-QNBJ-2018-273).
文摘J-aggregation and H-aggregation are identified as two classical models of function-ally oriented non-covalent interactions,and significant attention has been drawn by researchers.However,due to the scarcity of single-crystal examples of H-aggregation,a comprehensive understanding of the relationship between its stacking mode and optical behaviour has been hindered.In recent studies,two polyaromatic Schiff base compounds,Cl-Salmphen and H-Salmphen,were successfully synthe-sized,and both were found to exhibit H-aggregation.In thefindings,H-Salmphen was shown to display typical C─H···πinteractions,characteristic of Aggregation-Induced Emission(AIE)active molecules,whereas its halogenated counterpart was identified as behaving similar to Aggregation-Caused Quenching(ACQ)active molecules.These types of results suggest that identical intermolecular interactions can produce differing optical behaviours.Light was shed,at least in part,on the for-mation mechanisms of H-type aggregates and their luminescence properties from these observations.Additionally,the high optical signal-to-noise ratio inherent to H-aggregates was utilized for the exploration of water content detection.As an outcome,a high-performancefluorescentfilter paper was developed,enabling easy real-time detection using a smartphone.
基金Natural Science Foundation of Shanghai,Grant/Award Number:23ZR1415300National Natural Science Foundation of China,Grant/Award Numbers:32222049,31661143021,32171269,32201043+1 种基金National Key Research and Development Program of China,Grant/Award Number:2022YFF1102900Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism Shanghai Municipal Education Commission,Grant/Award Number:2021Sci&Tech0328。
文摘The presence of protein aggregates in numerous human diseases underscores the significance of detecting these aggregates to comprehend disease mechanisms and develop novel therapeutic approaches for combating these disorders.Despite the development of various biosensors and fluorescent probes that selectively target amyloid fibers or amorphous aggregates,there is still a lack of tools capable of simultaneously detecting both types of aggregates.Herein,we demonstrate the quantitative discernment of amorphous aggregates by QM-FN-SO3,an aggregationinduced emission(AIE)probe initially designed for detecting amyloid fibers.This probe easily penetrates the membranes of the widely-used prokaryotic model organism Escherichia coli,enabling the visualization of both amorphous aggregates and amyloid fibers through near-infrared fluorescence.Notably,the probe exhibits sensitivity in distinguishing the varying aggregation propensities of proteins,regardless of whether they form amorphous aggregates or amyloid fibers in vivo.These properties contribute to the successful application of the QM-FN-SO3 probe in the subsequent investigation of the antiaggregation activities of two outer membrane protein(OMP)chaperones,both in vitro and in their physiological environment.Overall,our work introduces a near-infrared fluorescent chemical probe that can quantitatively detect amyloid fibers and amorphous aggregates with high sensitivity in vitro and in vivo.Furthermore,it demonstrates the applicability of the probe in chaperone biology and its potential as a high-throughput screening tool for protein aggregation inhibitors and folding factors.
基金funding support from NSFC(Nos.22271286,21971236).
文摘Nucleophilic substitution reaction and 1,3-dicarbonyl compounds play significant roles in organic chemistry, and non-traditional intrinsic luminescence (NTIL) has become an emerging research area. Here, we demonstrate the successful nucleophilic substitution polymerization of 1,3-dicarbonyl compounds, including acetylacetone, 3,5-heptanedione, methyl acetoacetate, cyclopentane-1,3-dione, 1,3-indandione, 1-phenyl-1,3-butanedione and dibenzoylmethane, where reactive hydrogens at α position of 1,3-dicarbonyl compounds are involved. Through this base catalyzed nucleophilic substitution polycondensation between 1,3-dicarbonyl compounds and α,α’-dibromo xylene, a series of nonconjugated poly(1,3-dicarbonyl)s have been successfully prepared with high yield (up to >99%) under mild conditions. Investigations reveal that this nucleophilic substitution polycondensation exhibits self-accelerating effect and flexible stoichiometry characteristics, which exhibits advantages over traditional polycondensation methods. This polymerization also exhibits intriguing polymerization-induced emission (PIE) characteristics, where nonconjugated poly(1,3-dicarbonyl)s exhibit intriguing chemical structure dependent aggregation-induced emission (AIE) type NTIL. This work therefore expands the monomer, method, chemical structure and property libraries of polymer chemistry, which may cause inspirations to polymerization methodology, PIE, AIE and NTIL.
基金National Natural Science Foundation of China(21788102)Natural Science Foundation of Guangdong Province(2019B030301003)Science and Technology Program of Guangzhou(201804020027).
文摘Since the first report of aggregation-induced emission(AIE)concept in 2001,it has received intense attentions from academy and industry because of its important applications in diverse research fronts.Up to now,the luminogens with AIE property(AIEgens)have been widely used in optoelectronic devices,fluorescent bioprobes and chemosensors,and researchers have also committed to exploring the potentials of AIEgens in other cross-cutting areas.The AIEgens have shown superior advantages such as highly efficient emissions in the aggregated state and thus exhibited better performances in comparison with traditional luminescent materials whose emissions are usually quenched upon aggregate formation.In view of the significant achievements of AIEgens in recent years,this review presents representative advancements of AIEgens for the applications in organic optoelectronic devices,mainly including organic light-emitting diodes(OLEDs),circularly polarized luminescence(CPL)devices,electrofluorochromic(EFC)devices,luminescent solar concentrators(LSCs),and liquid crystal displays(LCDs).Not only the design strategies of AIEgens for these optoelectronic devices are analyzed,but also their structureproperty relationship and working mechanism are elucidated.It is foreseeable that robust AIEgens with specific functionalities will find more and more applications in various research fields and play an increasingly important role in high-tech devices.
文摘In this paper,a decision-making problem with a q-rung orthopair fuzzy hypersoft environment is developed,and two operators of ordered weighted average and induced ordered weighted average are developed.Several fundamental features are also derived.The induced ordered weighted average operator is essential in a q-ROFH environment as the induced ordered aggregation operators are special cases of the existing aggregation operators that already exist in q-ROFH environments.The main function of these operators is to help decision-makers gain a complete understanding of uncertain facts.The proposed aggregation operator is applied to a decision-making problem,with the aim of selecting the most promising real estate project for investment.
基金supported by the National Natural Science Foundation of China(21788102)。
文摘Organic fluorophores play essential roles in both academic and applied fields.Most of the fluorescent molecules can be divided into aggregation-caused quenching(ACQ)and aggregation-induced emission(AIE)types based on the diverse emission properties in solution and aggregated states.Currently,a large part of studies focuses on the ACQ-to-AIE one-way transformation and the complex synthesis of chemical bonds is inevitable in all existing methods.To maximize the advantages of ACQ and AIE types fluorophores and avoid complex chemosynthesis,we propose a facile strategy first realizing the reversible ACQAIE transformation with the dynamic Diels-Alder(DA)reactions.Besides,the fluorescent platform can monitor DA reactions in microscale ultra-sensitively and quantitively.The dynamic covalent bonds can help to develop novel fluorophores creatively,and the reversible ACQ-AIE platform is expected to offer fresh insights into the dynamic covalent chemistry.
文摘For cases in which a robot with installed solar cells and a sensor operates in a nuclear reactor building or in space for extravehicular activity, we require elastic and extensible solar cells. More than two different types of sensing are also required, minimally with photovoltaics and built-in electricity. Magnetic compound fluid (MCF) rubber solar cells are made of rubber, so they are elastic and extensible as well as sensitive. To achieve flexibility and an effective photovoltaic effect, MCF rubber solar cells must include both soluble and insoluble rubbers, Fe<sub>3</sub>O<sub>4</sub>, TiO<sub>2</sub>, Na<sub>2</sub>WO<sub>4</sub>∙2H<sub>2</sub>O, etc. On the basis of this constitution, we propose a consummate fabrication process for MCF rubber solar cells. The characteristics of these cells result from the semiconductor-like role of the molecules of TiO<sub>2</sub>, Fe<sub>3</sub>O<sub>4</sub>, Ni, Na<sub>2</sub>WO<sub>4</sub>∙2H<sub>2</sub>O, polydimethylsiloxane (PDMS), natural rubber (NR), oleic acid, polyvinyl alcohol (PVA), water and magnetic cluster involved in the MCF rubber. Their tendencies can be deduced by synthesizing knowledge about the enhancement of the reverse-bias saturation current <em>I</em><sub><em>S</em></sub> and the diode ideality factor <em>N</em>, with conventional knowledge about the semiconductor affected by <em>γ</em>-irradiation and the attenuation of the photon energy of <em>γ</em>-rays.
基金This work was partially supported by the National Natural Science Foundation of China(Nos.21702016,21905015 and 52003023)the Fund of the Beijing National Laboratory for Molecular Sciences,China(No.BNLMS201813).B.Z.Tang acknowledges the financial support from the National Natural Science Foundation of China(No.21788102)+1 种基金the Research Grants Council of Hong Kong(Nos.N_HKUT609/19,16305518,and C6009-17G)the Innovation and Technology Commission(No.ITC-CNERC14SC01).
文摘The development of fluorescent nanocrystals based on organic small molecules is of great importance in bioimaging due to the merits of easy modification,high brightness and excellent photostability,however suffering from the emission-detrimental aggregation-caused quenching(ACQ)effect.Herein,we successfully designed and synthesized an AIE-active di(N,N-dimethylaniline)-dibenzofulvene(named as NFTPE),which exhibits the crystallization-induced emission enhancement(CIEE)effect.Interestingly,two types of yellow-and orange-emissive crystals for NFTPE were obtained,exhibiting aggregation microenvironment-dependent emission tuning in the solid state.Single-crystal analysis and density functional theory(DFT)calculations reveal that different aggregation microenvironments result in the distinct molecular conformation for various emission.Excitingly,the crystallization of NFTPE in an aqueous solution under the assistance of amphiphilic PEG polymer matrices could be monitored in situ by the fluorescence changes,facilitating the preparation of NFTPE nanocrystals(NFTPE-NCs)by adjusting the aggregation microenvironment.The obtained NFTPE-NCs exhibit the superior performance in cell imaging in respect to high brightness,photostability,and biocompatibility,thus demonstrating the potential in bioimaging applications.
文摘Recently we have reported our study on the J-aggregate formation of an anionic cyanine promoted by the counterions of added salts under environmental conditions. The result showed that the counterions are bound to the dye ion J-stacks in 'stoichiometric' relation. Concerning the fact that polyeletrolytes could promote the formation of J-aggregate of cyanine dye ions, the authors suggested that the J-aggregates of an ionic cyanine might more easily induce the J-aggregation of other cyanine ions with opposite charges. The two
基金supported by the National Natural Science Foundation of China(21625502、21974070)。
文摘In this work,a facile and sensitive colorimetric detection method was firstly reported for RNase A activity detection based on target regulated protection effect of chimeric DNA probe on the salt-induced aggregation of plasmonic gold nanoparticles.Compared with previous works of RNase A activity detection,this colorimetric assay integrated the advantages of sensitive,low cost,facile operation,rapid response and low biological toxicity.
基金supported by grants from National Natural Science Foundation of China(No.31670987)Beijing Science Foundation(No.7192223)。
文摘Background:Investigations of the pathogenic mechanisms in motor neurons(MNs)derived from amyotrophic lateral sclerosis(ALS)disease-specific induced pluripotent stem(iPS)cell lines could improve understanding of the issues affecting MNs.Therefore,in this study we explored mutant superoxide dismutase 1(SOD1)protein expression in MNs derived from the iPS cell lines of ALS patients carrying different SOD1 mutations.Methods:We generated induced pluripotent stem cell(iPSC)lines from two familial ALS(FALS)patients withSOD1-V14M andSOD1-C111Y mutations,and then differentiated them into MNs.We investigated levels of the SOD1 protein in iPSCs and MNs,the intracellular Ca2+levels in MNs,and the lactate dehydrogenase(LDH)activity in the process of differentiation into the MNs derived from the controls and ALS patients’iPSCs.Results:The iPSCs from the two FALS patients were capable of differentiation into MNs carrying different SOD1 mutations and differentially expressed MN markers.We detected high SOD1 protein expression and high intracellular calcium levels in both the MN and iPSCs that were derived from the twoSOD1 mutant patients.However,at no time did we observe stronger LDH activity in the patient lines compared with the control lines.Conclusions:MNs derived from patient-specific iPSC lines can recapitulate key aspects of ALS pathogenesis,providing a cell-based disease model to further elucidate disease pathogenesis and explore gene repair coupled with cell-replacement therapy.Incremental mutant expressions of SOD1 in MNs may have disrupted MN function,either causing or contributing to the intracellular calcium disturbances,which could lead to the occurrence and development of the disease.
基金supported by the Natural Science Foundation of Hubei Province(Grant No.2018CFA055)of Chinathe National Natural Science Foundation of China(Grant No.21774097)the ACAP fellowship supported by the Australian government through the Australian Renewable Energy Agency(ARENA)。
文摘Molecular ordering within the photoactive layer plays a crucial role in determining the device performance of organic solar cells(OSCs).However,the simultaneous molecular ordering processes of polymer donors and non-fullerene acceptors(NFAs)during solution casting usually bring confinement effect,leading to insufficient structural order of photovoltaic components.Herein,the molecular packing of mINPOIC NFA is effectively formed through a heating induced aggregation strategy,with the aggregation of PBDB-T,which has a strong temperature dependence,is retarded by casting on a preheated substrate to reduce its interference toward m-INPOIC.A sequent thermal annealing treatment is then applied to promote the ordering of PBDB-T and achieve balanced aggregation of both donors and acceptors,resulting in the achievement of a maximum efficiency of 13.9% of PBDB-T:m-INPOIC binary OSCs.This work disentangles the interactions of donor polymer and NFA during the solution casting process and develops a rational strategy to enhance the molecular packing of NFAs to boost device performance.
基金supported by the Starting Grants of Tianjin University and Tianjin Government
文摘Aggregation-induced emission(AIE) has drawn great attention worldwide for its unique optical phenomenon and huge potential applications. Since coined by Ben Zhong Tang et al. in 2001, AIE has been deeply investigated and widely utilized in many important areas, such as organic light-emitting diode(OLED), sensor, and bio-imaging. Herein, we highlight some important progress of AIE in these eighteen years, including the exploration of internal mechanism and potential applications. Furthermore,some other interestingly emissive behaviors, originating but distinguishing from the AIE concept, are presented. It is anticipated an overall understanding about AIE could be easily caught from this short review for scientists, no matter whether they are involved in this exciting and rising research area or not.
