One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isola...One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isolated from the solid cultures of the endophytic fungus,Penicillium brefeidianum.The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism（CD） exciton chirality method.All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines.Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC（50） values of 14.1 μmol/L and 35.5μmol/L,respectively.Compound 3 showed moderate activity against HepG2 cells with IC（50） values of 36.6 μmol/L.展开更多
基金funded by the National Natural Science Foundation of China(No.81503218)the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Fundamental Research Funds for the Central Universities(No.2016ZZD010)
文摘One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isolated from the solid cultures of the endophytic fungus,Penicillium brefeidianum.The structures and absolute configurations of compounds 1-3 were elucidated by comprehensive spectroscopic analysis and the circular dichroism（CD） exciton chirality method.All the metablites were evaluated for their cytotoxic activites against three human tumor cell lines.Compound 2 exhibited cytotoxicities against HepG2 and MDA-MB-231 cells with IC（50） values of 14.1 μmol/L and 35.5μmol/L,respectively.Compound 3 showed moderate activity against HepG2 cells with IC（50） values of 36.6 μmol/L.
