Background Obesity is the most common metabolic disease in the world. However, the relationship between obesity and lung function is not fully understood. Although several longitudinal studies have shown that increase...Background Obesity is the most common metabolic disease in the world. However, the relationship between obesity and lung function is not fully understood. Although several longitudinal studies have shown that increases in body weight can lead to reductions in pulmonary function, whether this is the case with the Japanese population and whether high body mass index （BMI） status alone represents an appropriate predictor of obstructive lung dysfunction remains unclear.The purpose of present study was to estimate the effect of BMI on lung function measured by spirometry of Japanese patients in general clinics. We measured BMI and performed spirometry on screening patients who had consulted general clinics.Methods Subjects comprised 1231 patients ≥40 years of age （mean age （65.0±12.0） years, 525 men, 706 women） who had consulted clinics in Nagasaki Prefecture, Japan, for non-respiratory disease. BMI was calculated and lung function was measured by spirometry.Results BMI was found to be positively correlated with forced expiratory volume in 1 second （FEV1）/forced vital capacity （FVC） in men and with maximum mid-expiratory flow （MMF） in all subjects. Following adjustment for relevant factors, a significant positive correlation between BMI and FEV1/FVC was identified for all subjects. Comparison between subjects with normal BMI （18.5-25.0） and higher BMI （25.1-30.0） also demonstrated that FEV1/FVC and percentage of predicted maximum mid-expiratory flow （%MMF） were significantly higher in the latter subjects.Conclusions In a population without marked respiratory disease, higher BMI subjects showed less obstructive pulmonary dysfunction compared to normal BMI subjects. High BMI status alone may be inappropriate as a predictor of obstructive lung dysfunction, particularly in populations with a low prevalence of obesity.展开更多
目的 :回顾性评价体外膈肌起搏(external diaphragm pacing, EDP)对不同体质量指数(body mass index,BMI)的慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的康复疗效。方法:52例COPD患者入选, BMI≥24者23例入高BM...目的 :回顾性评价体外膈肌起搏(external diaphragm pacing, EDP)对不同体质量指数(body mass index,BMI)的慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的康复疗效。方法:52例COPD患者入选, BMI≥24者23例入高BMI组,BMI<24者29例入低BMI组,均给予20周的EDP治疗,比较治疗前后2组患者BODE指数及其分项、动脉血气分析、急性发作次数、心理状态、主观用力程度计分(rate of perceived exertion,RPE)、日常生活活动能力(activities of daily living,ADL)的差异。结果:①20周EDP干预后,高BMI组在BODE指数及其分项、急性发作次数、动脉血气分析、心理状态、RPE、ADL较低BMI组有明显改善(均P<0.05)。②高BMI组治疗前后自身比较,在一秒钟用力呼气肺活量预计值(forced expiratory vital capacity in one second expected,FEV1%)、6 min步行距离(6 minutes walking distance,6MWD)、改良的英国医学研究委员会呼吸困难量表(modified Medical Research Council dyspnea scale,MMRC)、BMI、BODE、pH、动脉氧分压(arterial oxygen pressure,PaO_2)、汉密尔顿抑郁量表(Hamilton depression rating scale for depression,HRSD)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、急性发作次数、RPE、ADL明显改善(均P<0.05)。③低BMI组治疗前后自身比较,在MMRC、BODE、HRSD、HAMA、RPE、ADL明显改善(均P<0.05)。结论:对于20周的EDP治疗,高BMI的COPD患者较低BMI患者在BODE指数及其分项、动脉血气分析、急性发作次数、RPE、ADL的疗效明显。展开更多
文摘Background Obesity is the most common metabolic disease in the world. However, the relationship between obesity and lung function is not fully understood. Although several longitudinal studies have shown that increases in body weight can lead to reductions in pulmonary function, whether this is the case with the Japanese population and whether high body mass index （BMI） status alone represents an appropriate predictor of obstructive lung dysfunction remains unclear.The purpose of present study was to estimate the effect of BMI on lung function measured by spirometry of Japanese patients in general clinics. We measured BMI and performed spirometry on screening patients who had consulted general clinics.Methods Subjects comprised 1231 patients ≥40 years of age （mean age （65.0±12.0） years, 525 men, 706 women） who had consulted clinics in Nagasaki Prefecture, Japan, for non-respiratory disease. BMI was calculated and lung function was measured by spirometry.Results BMI was found to be positively correlated with forced expiratory volume in 1 second （FEV1）/forced vital capacity （FVC） in men and with maximum mid-expiratory flow （MMF） in all subjects. Following adjustment for relevant factors, a significant positive correlation between BMI and FEV1/FVC was identified for all subjects. Comparison between subjects with normal BMI （18.5-25.0） and higher BMI （25.1-30.0） also demonstrated that FEV1/FVC and percentage of predicted maximum mid-expiratory flow （%MMF） were significantly higher in the latter subjects.Conclusions In a population without marked respiratory disease, higher BMI subjects showed less obstructive pulmonary dysfunction compared to normal BMI subjects. High BMI status alone may be inappropriate as a predictor of obstructive lung dysfunction, particularly in populations with a low prevalence of obesity.
文摘目的 :回顾性评价体外膈肌起搏(external diaphragm pacing, EDP)对不同体质量指数(body mass index,BMI)的慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者的康复疗效。方法:52例COPD患者入选, BMI≥24者23例入高BMI组,BMI<24者29例入低BMI组,均给予20周的EDP治疗,比较治疗前后2组患者BODE指数及其分项、动脉血气分析、急性发作次数、心理状态、主观用力程度计分(rate of perceived exertion,RPE)、日常生活活动能力(activities of daily living,ADL)的差异。结果:①20周EDP干预后,高BMI组在BODE指数及其分项、急性发作次数、动脉血气分析、心理状态、RPE、ADL较低BMI组有明显改善(均P<0.05)。②高BMI组治疗前后自身比较,在一秒钟用力呼气肺活量预计值(forced expiratory vital capacity in one second expected,FEV1%)、6 min步行距离(6 minutes walking distance,6MWD)、改良的英国医学研究委员会呼吸困难量表(modified Medical Research Council dyspnea scale,MMRC)、BMI、BODE、pH、动脉氧分压(arterial oxygen pressure,PaO_2)、汉密尔顿抑郁量表(Hamilton depression rating scale for depression,HRSD)、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、急性发作次数、RPE、ADL明显改善(均P<0.05)。③低BMI组治疗前后自身比较,在MMRC、BODE、HRSD、HAMA、RPE、ADL明显改善(均P<0.05)。结论:对于20周的EDP治疗,高BMI的COPD患者较低BMI患者在BODE指数及其分项、动脉血气分析、急性发作次数、RPE、ADL的疗效明显。
