OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with ea...OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and depression.METHODS:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data entry.Patients with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant chemotherapy.Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation.In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this study.RESULTS:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment.Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly.Unfortunately,we do not have effective pharmacological interventions yet.And clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been reported.CONCLUSION:The findings of the trial will allow us to determine the effects of acupuncture treatment approach.We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments.展开更多
Seawater is a dense microbial suspension with >106 prokaryotic and >104 eukaryotic propagules per milliliter. Hence, submerged surfaces get immediately covered by biofilm-forming colonizers upon contact with sea...Seawater is a dense microbial suspension with >106 prokaryotic and >104 eukaryotic propagules per milliliter. Hence, submerged surfaces get immediately covered by biofilm-forming colonizers upon contact with seawater. Since biofilms may reduce individual fitness through decreasing motility and attractiveness or increasing shearing stress by water currents and infection risk by pathogens, marine organisms have evolved countermeasures to regulate the number of surface-colonizers;alternatively they tolerate settlement and biofilm-formation. Antimicrobial defense mechanisms co-evolved with potentially colonizing microbes. By contrast, non-native animals (neozoa) are confronted with novel microbial colonizers upon colonizing a new habitat, and are expected to be less well protected against surface-colonization. Here we present results of a thorough screening of the epithelial surface of the ctenophore Mnemiopsis leidyi, being non-native in European marine environments, for epithelial bacteria and archaea. Neither light- and electron-microscopic inspection nor PCR-screening for bacterial and archaeal DNA of 134 adult specimens from different collection sites in the Western Baltic revealed any presence of prokaryotes on the surface epithelium of comb jellies in a recently invaded environment. A limited number of bacterial associates became evident from whole-body extracts of both juvenile and adult comb jellies. Their taxonomic diversity, however, was significantly lower in adult than in juvenile specimens, suggesting a maturation of anti-microbial defense upon ontogenetic development. The mechanisms underlying the effective defense of Mnemiopsisagainst microbial colonization, however, remain unknown. Based on our findings, we propose 1) to make use of invasion events as natural space-for-time experiments on how symbiotic interactions change upon environmental change;and 2) to study basal metazoan animals, such as ctenophores, to understand the evolutionary basics of symbiont-host interactions.展开更多
BACKGROUND Solitary necrotic nodule of the liver(SNNL)is a rare benign lesion with a complete necrotic core and a clear fibrous capsule containing elastic fibers.We present the case of a patient with a radiographic co...BACKGROUND Solitary necrotic nodule of the liver(SNNL)is a rare benign lesion with a complete necrotic core and a clear fibrous capsule containing elastic fibers.We present the case of a patient with a radiographic computed tomography(CT)finding of"ring"-like annular calcification within the lesion and postoperative pathologic diagnosis of necrotic nodules wrapped by dense fibers in liver tissue,as well as the patient's subsequent management and outcome.CASE SUMMARY A 38-year-old Chinese woman with a history of systemic lupus erythematosus treated with prednisone and hydroxychloroquine,without any symptoms,was found to have hepatic space-occupying lesions by imaging examination at a health examination.A subsequent CT scan suggested a space-occupying lesion of the liver with annular calcification,which was not defined to be benign or malignant.After that,a laparoscopic hepatic space-occupying resection was performed.The postoperative pathological diagnosis was necrotic nodules wrapped by dense fibers in the liver tissue,and the final diagnosis was SNNL.The patient had an uneventful postoperative recovery.CONCLUSION There is a"ring"-like calcification in SNNL.This patient had a history of systemic lupus erythematosus,without a history of parasite infection,trauma,or tumor.Therefore,whether the etiology and pathological changes of SNNL are related to rheumatic immune diseases remains to be investigated.展开更多
基金Supported by PreciMed Platform Europe,a Financial Support from France Ruban Rose,the Pilot Clinical Study at Kunming Site was Granted By Yunnan Provincial Science and Technology Department Funding(No.2018IA059)。
文摘OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and depression.METHODS:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data entry.Patients with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant chemotherapy.Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation.In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this study.RESULTS:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment.Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly.Unfortunately,we do not have effective pharmacological interventions yet.And clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been reported.CONCLUSION:The findings of the trial will allow us to determine the effects of acupuncture treatment approach.We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments.
文摘Seawater is a dense microbial suspension with >106 prokaryotic and >104 eukaryotic propagules per milliliter. Hence, submerged surfaces get immediately covered by biofilm-forming colonizers upon contact with seawater. Since biofilms may reduce individual fitness through decreasing motility and attractiveness or increasing shearing stress by water currents and infection risk by pathogens, marine organisms have evolved countermeasures to regulate the number of surface-colonizers;alternatively they tolerate settlement and biofilm-formation. Antimicrobial defense mechanisms co-evolved with potentially colonizing microbes. By contrast, non-native animals (neozoa) are confronted with novel microbial colonizers upon colonizing a new habitat, and are expected to be less well protected against surface-colonization. Here we present results of a thorough screening of the epithelial surface of the ctenophore Mnemiopsis leidyi, being non-native in European marine environments, for epithelial bacteria and archaea. Neither light- and electron-microscopic inspection nor PCR-screening for bacterial and archaeal DNA of 134 adult specimens from different collection sites in the Western Baltic revealed any presence of prokaryotes on the surface epithelium of comb jellies in a recently invaded environment. A limited number of bacterial associates became evident from whole-body extracts of both juvenile and adult comb jellies. Their taxonomic diversity, however, was significantly lower in adult than in juvenile specimens, suggesting a maturation of anti-microbial defense upon ontogenetic development. The mechanisms underlying the effective defense of Mnemiopsisagainst microbial colonization, however, remain unknown. Based on our findings, we propose 1) to make use of invasion events as natural space-for-time experiments on how symbiotic interactions change upon environmental change;and 2) to study basal metazoan animals, such as ctenophores, to understand the evolutionary basics of symbiont-host interactions.
文摘BACKGROUND Solitary necrotic nodule of the liver(SNNL)is a rare benign lesion with a complete necrotic core and a clear fibrous capsule containing elastic fibers.We present the case of a patient with a radiographic computed tomography(CT)finding of"ring"-like annular calcification within the lesion and postoperative pathologic diagnosis of necrotic nodules wrapped by dense fibers in liver tissue,as well as the patient's subsequent management and outcome.CASE SUMMARY A 38-year-old Chinese woman with a history of systemic lupus erythematosus treated with prednisone and hydroxychloroquine,without any symptoms,was found to have hepatic space-occupying lesions by imaging examination at a health examination.A subsequent CT scan suggested a space-occupying lesion of the liver with annular calcification,which was not defined to be benign or malignant.After that,a laparoscopic hepatic space-occupying resection was performed.The postoperative pathological diagnosis was necrotic nodules wrapped by dense fibers in the liver tissue,and the final diagnosis was SNNL.The patient had an uneventful postoperative recovery.CONCLUSION There is a"ring"-like calcification in SNNL.This patient had a history of systemic lupus erythematosus,without a history of parasite infection,trauma,or tumor.Therefore,whether the etiology and pathological changes of SNNL are related to rheumatic immune diseases remains to be investigated.
