Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were sele...Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were selected as the study sample, and all patients were randomly and evenly divided into the study group (n = 100) and the control group (n = 100), and the serum inflammatory factors and the disappearance time of symptoms were compared. Results: After treatment, the serum inflammatory factors in the observation group were better than those in the control group, and the time of belching and burning sensation in the observation group was shorter than that in the control group, all of which were statistically significant (P Conclusion: Ilaprazole enteric-coated tablets in the treatment of peptic ulcer have a good effect and can effectively improve the symptoms of patients with clinical signs, with reference significance.展开更多
文摘目的：观察艾普拉唑联合铋剂10 d 标准四联方案及序贯方案治疗H ．pylori 感染慢性胃炎患者的临床疗效。方法经胃镜、快速尿素酶试验确诊的H ．pylori 阳性慢性胃炎初治患者200例，按区组随机化分组法分为标准四联方案组和序贯疗法方案组，每组100例，分别接受艾普拉唑＋枸橼酸铋钾＋阿莫西林克拉维酸钾＋左氧氟沙星的10 d 标准四联方案或艾普拉唑＋阿莫西林克拉维酸钾＋左氧氟沙星＋呋喃唑酮的10 d 序贯疗法方案。疗程结束后4～6周内行14 C尿素呼气试验检测H ．pylori根除情况，并观察临床症状改善及不良反应发生情况。符合正态分布、方差齐性的计量资料比较采用t 检验，无序分类资料比较用卡方检验或 Fisher 确切概率法，有序分类资料比较采用两独立样本比较的秩和检验。结果标准四联方案组和序贯疗法方案组H ．pylori 根除率符合方案数据分析分别为88．54％（85/96）和87．23％（82/94）；意向性分析分别为85．00％（85/100）和82．00％（82/100）。标准四联方案组和序贯疗法方案组对上腹痛、反酸、烧心等临床症状缓解有效率分别达95．83％（92/96）和95．74％（90/94），不良反应发生率分别为6．25％（6/96）和7．44％（7/94），且轻微。两组患者在上述3个方面差异均无统计学意义（P 均＞0．05）。结论艾普拉唑联合铋剂10 d 标准四联方案或10 d 序贯疗法方案治疗H ．pylori阳性慢性胃炎患者均可取得临床症状改善率高、不良反应轻、H ．pylori根除率高的疗效。
文摘Objective: To discuss the actual effect of ilaprazole enteric-coated tablets in the treatment of peptic ulcer patients. Methods: 200 peptic ulcer patients who received treatment from January to December 2023 were selected as the study sample, and all patients were randomly and evenly divided into the study group (n = 100) and the control group (n = 100), and the serum inflammatory factors and the disappearance time of symptoms were compared. Results: After treatment, the serum inflammatory factors in the observation group were better than those in the control group, and the time of belching and burning sensation in the observation group was shorter than that in the control group, all of which were statistically significant (P Conclusion: Ilaprazole enteric-coated tablets in the treatment of peptic ulcer have a good effect and can effectively improve the symptoms of patients with clinical signs, with reference significance.
