Objective:Ipomoea batatas(L.)Lam.is a food plant used in African traditional medicine to treat cardiovascular diseases and related conditions.We assessed the hypolipidemic and anti-atherosclerogenic properties of the ...Objective:Ipomoea batatas(L.)Lam.is a food plant used in African traditional medicine to treat cardiovascular diseases and related conditions.We assessed the hypolipidemic and anti-atherosclerogenic properties of the aqueous extract of I.batatas leaves in a rat model of diet-induced hypercholesterolemia.Methods:Hypercholesterolemia was induced in male Wistar rats by exclusive feeding with a cholesterolenriched(1%)standard diet for four weeks.Then,rats were treated once daily(per os)with I.batatas extract at doses of 400,500 and 600 mg/kg or with atorvastatin(2 mg/kg),for four weeks.Following treatment,animals were observed for another four weeks and then sacrificed.Aortas were excised and processed for histopathological studies,and blood glucose level and lipid profile were measured.Results:Hypercholesterolemic animals experienced a 21.5%faster increase in body weight,significant increases in blood glucose and blood lipids(148.94%triglycerides,196.97%high-density lipoprotein cholesterol,773.04%low-density lipoprotein cholesterol,148.93%very low-density lipoprotein cholesterol and 210.42%total cholesterol),and increases in aorta thickness and atherosclerotic plaque sizes compared to rats fed standard diet.Treatment of hypercholesterolemic rats with the extract mitigated these alterations and restored blood glucose and blood lipid levels to normocholesterolemic values.Conclusion:Our findings suggest that I.batatas leaves have hypolipidemic and anti-atherosclerogenic properties and justify their use in traditional medicine.展开更多
Background: Today’s lifestyle changes have resulted in changes in the pattern of diseases from infectious diseases to non-communicable diseases. One disease that threatens the community is hypercholesterolemia. Pharm...Background: Today’s lifestyle changes have resulted in changes in the pattern of diseases from infectious diseases to non-communicable diseases. One disease that threatens the community is hypercholesterolemia. Pharmacological therapy was performed often fails due to non-compliance hypercholesterolemia patients. One of the complementary therapies that can be done is by implementing reimprinting. Reimprinting is a development of the SEFT method (Spiritual Emotional Freedom Technique). Reimprinting is the implementation of SEFT therapy independently. Methods: The research design used was quasy experimental with a Randomized Pretest and Posttest Control Group Design. The variables observed in this study were cholesterol levels (total cholesterol, HDL (High Density Lipoprotein), LDL (Low Density Lipoprotein), triglycerides). The group of respondents in this study was divided into 2 groups, namely group 1 (not given an intervention) and group 2 (the group given the reimprinting intervention). To find out the effectiveness of the reimprinting method, a paired-samples t test was used with a significance of 0.05. Result: The results of the study showed that the administration of reimprinting intervention in hypercholesterolemia patients was effective in reducing total cholesterol levels, increasing HDL (High Density Lipoprotein) cholesterol levels and lowering LDL (Low Density Lipoprotein) cholesterol levels. Conclusion: Reimprinting is one type of complementary therapy that can be done as a support for pharmacological therapy given to hypercholesterolemia patients to improve the success of the therapy. To get optimal results, an active role is needed from health personnel to be able to apply reimprinting therapy, obedience of hypercholesterolemia patients to attend each therapy session, active hypercholesterolemia patients should perform therapy independently and obey any advice has been given by health workers to consume drugs routinely and adopt a healthy lifestyle.展开更多
The effect of dietary supplementation with mango (Mangifera indica L.) powder obtained by microwave dehydration was studied in normal and hypercholesterolemic mice. The phenolic profiles in methanolic extracts and ant...The effect of dietary supplementation with mango (Mangifera indica L.) powder obtained by microwave dehydration was studied in normal and hypercholesterolemic mice. The phenolic profiles in methanolic extracts and antioxidant activities were determined using high-performance liquid chromatography and DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis-3-ethyl-benzothiazoline-6-sulphonic acid) assays, respectively. The total phenolic content of microwave-dehydrated mango powder was 1451.7 ± 26.7 μggallic acid equivalents/g dry weight. The main phenolic compounds identified were gallic acid, epicatechin, ferulic acid, and catechin. The anti-oxidant activity was 14.6% higher in microwave-dehydrated mango powder than in conventional mango powder. Mice were fed a hypercholesterolemic diet (1 g cholesterol/100g over 7 days). The hypercholesterolemic mice whose diets were supplemented with microwave-dehydrated mango powder showed a significant decrease (P ≤ 0.05) in total serum cholesterol compared to the hypercholesterolemic mice and the mice fed with conventional dehydrated mango powder. We observed a significant increase (P ≤ 0.05) in HDL-c levels in the microwave-dehydrated mango powder group mice (12.4 ± 1.3 mmol/L) compared to the hypercholesterolemic group (8.6 ± 1.4 mmol/L) and the conventional-dehydrated mango powder group (10.9 ± 1.3 mmol/L). The mice provided with microwave-dehydrated mango powder had significantly lower (P ≤ 0.05) levels of serum LDL-c (36.0%) and total cholesterol (43.3%) compared to the mice in hypercholesterolemic group. Notably, the atherogenic index was 72% lower in the microwave-dehydrated mango powder group compared to the hypercholesterolemic group. These results suggest that the biocompounds, such as polyphenols and dietary fiber, found in mango pulp might improve the lipid profile in mice fed a hypercholesterolemic diet.展开更多
基金partly funded by the Faculty of Science,University of Ngaoundere。
文摘Objective:Ipomoea batatas(L.)Lam.is a food plant used in African traditional medicine to treat cardiovascular diseases and related conditions.We assessed the hypolipidemic and anti-atherosclerogenic properties of the aqueous extract of I.batatas leaves in a rat model of diet-induced hypercholesterolemia.Methods:Hypercholesterolemia was induced in male Wistar rats by exclusive feeding with a cholesterolenriched(1%)standard diet for four weeks.Then,rats were treated once daily(per os)with I.batatas extract at doses of 400,500 and 600 mg/kg or with atorvastatin(2 mg/kg),for four weeks.Following treatment,animals were observed for another four weeks and then sacrificed.Aortas were excised and processed for histopathological studies,and blood glucose level and lipid profile were measured.Results:Hypercholesterolemic animals experienced a 21.5%faster increase in body weight,significant increases in blood glucose and blood lipids(148.94%triglycerides,196.97%high-density lipoprotein cholesterol,773.04%low-density lipoprotein cholesterol,148.93%very low-density lipoprotein cholesterol and 210.42%total cholesterol),and increases in aorta thickness and atherosclerotic plaque sizes compared to rats fed standard diet.Treatment of hypercholesterolemic rats with the extract mitigated these alterations and restored blood glucose and blood lipid levels to normocholesterolemic values.Conclusion:Our findings suggest that I.batatas leaves have hypolipidemic and anti-atherosclerogenic properties and justify their use in traditional medicine.
文摘Background: Today’s lifestyle changes have resulted in changes in the pattern of diseases from infectious diseases to non-communicable diseases. One disease that threatens the community is hypercholesterolemia. Pharmacological therapy was performed often fails due to non-compliance hypercholesterolemia patients. One of the complementary therapies that can be done is by implementing reimprinting. Reimprinting is a development of the SEFT method (Spiritual Emotional Freedom Technique). Reimprinting is the implementation of SEFT therapy independently. Methods: The research design used was quasy experimental with a Randomized Pretest and Posttest Control Group Design. The variables observed in this study were cholesterol levels (total cholesterol, HDL (High Density Lipoprotein), LDL (Low Density Lipoprotein), triglycerides). The group of respondents in this study was divided into 2 groups, namely group 1 (not given an intervention) and group 2 (the group given the reimprinting intervention). To find out the effectiveness of the reimprinting method, a paired-samples t test was used with a significance of 0.05. Result: The results of the study showed that the administration of reimprinting intervention in hypercholesterolemia patients was effective in reducing total cholesterol levels, increasing HDL (High Density Lipoprotein) cholesterol levels and lowering LDL (Low Density Lipoprotein) cholesterol levels. Conclusion: Reimprinting is one type of complementary therapy that can be done as a support for pharmacological therapy given to hypercholesterolemia patients to improve the success of the therapy. To get optimal results, an active role is needed from health personnel to be able to apply reimprinting therapy, obedience of hypercholesterolemia patients to attend each therapy session, active hypercholesterolemia patients should perform therapy independently and obey any advice has been given by health workers to consume drugs routinely and adopt a healthy lifestyle.
文摘The effect of dietary supplementation with mango (Mangifera indica L.) powder obtained by microwave dehydration was studied in normal and hypercholesterolemic mice. The phenolic profiles in methanolic extracts and antioxidant activities were determined using high-performance liquid chromatography and DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2'-azino-bis-3-ethyl-benzothiazoline-6-sulphonic acid) assays, respectively. The total phenolic content of microwave-dehydrated mango powder was 1451.7 ± 26.7 μggallic acid equivalents/g dry weight. The main phenolic compounds identified were gallic acid, epicatechin, ferulic acid, and catechin. The anti-oxidant activity was 14.6% higher in microwave-dehydrated mango powder than in conventional mango powder. Mice were fed a hypercholesterolemic diet (1 g cholesterol/100g over 7 days). The hypercholesterolemic mice whose diets were supplemented with microwave-dehydrated mango powder showed a significant decrease (P ≤ 0.05) in total serum cholesterol compared to the hypercholesterolemic mice and the mice fed with conventional dehydrated mango powder. We observed a significant increase (P ≤ 0.05) in HDL-c levels in the microwave-dehydrated mango powder group mice (12.4 ± 1.3 mmol/L) compared to the hypercholesterolemic group (8.6 ± 1.4 mmol/L) and the conventional-dehydrated mango powder group (10.9 ± 1.3 mmol/L). The mice provided with microwave-dehydrated mango powder had significantly lower (P ≤ 0.05) levels of serum LDL-c (36.0%) and total cholesterol (43.3%) compared to the mice in hypercholesterolemic group. Notably, the atherogenic index was 72% lower in the microwave-dehydrated mango powder group compared to the hypercholesterolemic group. These results suggest that the biocompounds, such as polyphenols and dietary fiber, found in mango pulp might improve the lipid profile in mice fed a hypercholesterolemic diet.
