Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been d...Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been devel- oped for asymmetric hydrogenation of benzils with Ru（OTf）（TsDPEN）（rl6-cymene） as a pre-catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to moderate diastereoselectiv- ities and good to excellent enantioselectivities.展开更多
基金Acknowledgement We are grateful for financial support from the Na- tional Natural Science Foundation of China （NSFC） （21072145）, the Foundation for the Authors of National Excellent Doctoral Dissertations of PR China （200931）, and the Natural Science Foundation of Jiangsu Province of China （BK2009115）. This project was also funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.
文摘Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been devel- oped for asymmetric hydrogenation of benzils with Ru（OTf）（TsDPEN）（rl6-cymene） as a pre-catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to moderate diastereoselectiv- ities and good to excellent enantioselectivities.
