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缩短骨科择期全麻手术患者术前禁食时间的最佳证据实践 被引量:26
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作者 田梅梅 尹小兵 +3 位作者 施雁 周英凤 刘海俐 赵宏程 《护理学杂志》 CSCD 2017年第20期4-8,共5页
目的遴选骨科择期全麻手术患者术前禁食最佳证据,以缩短术前禁食时间,改善手术相关指标结局。方法参照澳大利亚乔安娜布里格斯研究中心(Joanna Briggs Institute)临床证据实践方法,查找最佳证据,制定7条审查标准,制订患者术前个性化禁... 目的遴选骨科择期全麻手术患者术前禁食最佳证据,以缩短术前禁食时间,改善手术相关指标结局。方法参照澳大利亚乔安娜布里格斯研究中心(Joanna Briggs Institute)临床证据实践方法,查找最佳证据,制定7条审查标准,制订患者术前个性化禁食方案,修订术前工作流程,将最佳证据嵌入到临床实践中,实施6个月后评价效果。结果第2轮审查,7条审查指标执行率从基线审查的0~20.0%提高至85.0%~92.5%;医务人员术前禁食最佳证据知识回答正确率从13.3%~80.0%提高至90.0%~100%;患者术前禁食、禁饮时间显著缩短,中重度口渴、饥饿发生率及术后24h内恶心呕吐发生率显著降低(P<0.05,P<0.01);两组均无误吸发生。结论骨科择期手术患者术前个性化禁食及麻醉开始前2h进食清流质安全有效,对医务人员和患者进行针对性培训及教育有利于提高执行率。 展开更多
关键词 骨科 择期全麻手术 术前禁食 口渴 饥饿 恶心呕吐 误吸 循证护理
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饥饿和食物单宁酸对东方田鼠(Microtus fortis)食物摄入量和觅食行为的影响 被引量:17
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作者 李俊年 刘季科 陶双伦 《生态学报》 CAS CSCD 北大核心 2007年第11期4478-4484,共7页
实验室条件下,测定饥饿和食物单宁酸对东方田鼠食物摄入量和觅食行为的影响。结果表明,饥饿使实验个体的食物总摄入量增加,食物摄入率及口量大小随饥饿强度的增大而增加,而觅食频次则无显著改变,实验个体每取食回合的觅食时间呈缓慢增... 实验室条件下,测定饥饿和食物单宁酸对东方田鼠食物摄入量和觅食行为的影响。结果表明,饥饿使实验个体的食物总摄入量增加,食物摄入率及口量大小随饥饿强度的增大而增加,而觅食频次则无显著改变,实验个体每取食回合的觅食时间呈缓慢增加的趋势,与对照组比较,觅食时间差异不显著。东方田鼠优先选择0%单宁酸食物,次为3%单宁酸食物,而对6%单宁酸食物的摄入量最少。在饥饿条件下,东方田鼠食物摄入率的增加主要源于其口量大小,觅食频次和觅摄食时间对食物摄入量增加的贡献不显著。在饥饿条件下,植食性小哺乳动物并未通过延长觅食时间,降低用于防卫、繁殖活动时间来增加食物摄入量,而是通过增加口量大小,提高其食物摄入率来满足其营养需要。验证了饥饿与植物次生化合物共同作用引起田鼠类动物生理的改变,能影响其食物摄入量及觅食行为的假设。 展开更多
关键词 饥饿 东方田鼠 食物摄入量 觅食行为 单宁酸
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细胞自噬对饥饿环境下椎间盘髓核细胞的保护作用 被引量:18
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作者 江立波 张小磊 +5 位作者 徐华梓 吴瑞凯 杨光永 吴畏 胡旭琪 郑旭浩 《中国病理生理杂志》 CAS CSCD 北大核心 2012年第7期1302-1307,共6页
目的:探讨饥饿条件下椎间盘髓核细胞是否发生自噬及自噬对髓核细胞的作用。方法:原代培养SD大鼠髓核细胞,对细胞表型进行鉴定后,将细胞分为正常对照组、3-甲基腺嘌呤(3-methyladenine,3-MA)加DMEM培养基组、3-MA加EBSS培养基组和EBSS饥... 目的:探讨饥饿条件下椎间盘髓核细胞是否发生自噬及自噬对髓核细胞的作用。方法:原代培养SD大鼠髓核细胞,对细胞表型进行鉴定后,将细胞分为正常对照组、3-甲基腺嘌呤(3-methyladenine,3-MA)加DMEM培养基组、3-MA加EBSS培养基组和EBSS饥饿组,接着用单丹磺酰戊二胺(monodansylcadaverine,MDC)染色、透射电镜和Western blotting观察各组细胞的自噬差异,最后采用CCK-8法测定细胞生长抑制率以及TUNEL法测定细胞凋亡率。结果:成功培养出SD大鼠髓核细胞。与对照组相比,电镜和荧光显微镜下观察到EBSS培养基诱导的髓核细胞出现自噬囊泡,但是3-MA抑制后细胞自噬泡明显减少;Western blotting检测发现LC3-II/LC3-I和Beclin-1/β-actin在EBSS处理组明显大于3-MA+EBSS处理组和对照组(P<0.05),而3-MA+EBSS处理组的细胞抑制率和凋亡率明显高于EBSS处理组(P<0.05)。结论:饥饿可以诱导大鼠椎间盘髓核细胞发生自噬,并且3-MA能抑制自噬发生。自噬对饥饿环境下的髓核细胞可能具有一定的保护作用。 展开更多
关键词 髓核细胞 自噬 细胞凋亡 饥饿
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Sun, climate, hunger, and mass migration 被引量:13
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作者 KennethJ.Hsu 《Science China Earth Sciences》 SCIE EI CAS 1998年第5期449-472,共24页
Paleoclimatic studies indicate four epochs of global cooling during the last 4 000 years, i.e. during the few centuries before and after 2000 BC, 800 BC, 400 AD, and 1 600 AD; the quasiperiodicity corresponds to cycli... Paleoclimatic studies indicate four epochs of global cooling during the last 4 000 years, i.e. during the few centuries before and after 2000 BC, 800 BC, 400 AD, and 1 600 AD; the quasiperiodicity corresponds to cyclic variation of solar activity. Global temperature changes influenced regional precipitation patterns: Northern Europe was wetter while the middle and low latitude lands were more arid during colder epochs. Both sets of cold climatical conditions were unfavorable for agricultural production. Historical records show that large demographic movements in history took place because of crop failures and mass starvation, rather than escaping from war zones. The "wandering" of the Germanic tribes during the first two or three centuries of the Christian Era is one example. Whereas the accelerated release of carbon dioxide from the burning of fossil fuels is ultimately to cause global warming, historical evidence indicates, however, that global warming has been on the whole a blessing to mankind. Global cooling, on the other hand, has curtailed agricultural production and has led to famines and mass migrations of people. Perhaps the most important task at the present is not so much computer modelling of greenhouse effect on global climate, but water management and agricultural researches to insure food supply for an everincreasing world population. 展开更多
关键词 SUN CLIMATE hunger MASS migration.
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Research progress of gut flora in improving human wellness 被引量:11
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作者 Chenggang Zhang Wenjing Gong +2 位作者 Zhihui Li Dawen Gao Yan Gao 《Food Science and Human Wellness》 SCIE 2019年第2期102-105,共4页
Human wellness is the ultimate goal of our efforts in improving the human life.Special foods are undoubtedly important in achieving human wellness.However,overeating significantly leads to obesity and diabetes.These c... Human wellness is the ultimate goal of our efforts in improving the human life.Special foods are undoubtedly important in achieving human wellness.However,overeating significantly leads to obesity and diabetes.These chronic diseases will in turn affect the human wellness.Therefore,“dietary restriction and proper exercise”were introduced in the human daily life.Different foods cause various effects on the human health.The diversification of diet is a priority for nutritionists to keep our body healthy.To avoid diabetes mellitus,special foods for ketogenic diet,low-carbon diet,and low-calorie intake are also gradually attracting attention.In addition,the hypothesis that“hunger sensation comes from gut flora”brings new light to the research on the biological motivation for humans to eat food.This hypothesis has been gradually demonstrated using the flexible fasting technology by providing special foods,such as plant polysaccharides and dietary fibers.The response to food-needing signals from the gut flora to these foods demonstrates the importance of the gut flora in improving human wellness.The gut flora is probably an essential factor for translating the food-eating signals and converting the nutrition to our body.Therefore,“gut flora priority principle”is developed to guarantee human wellness.The 16S rRNA sequencing and mass spectrometric techniques can be used to identify the gut flora,which may guide us to a new era of human wellness based on gut flora wellness. 展开更多
关键词 hunger sensation comes from gut flora Gut flora-centric theory Flexible fasting Gut flora priority principle Universal reproducing power of the microbiota Gut flora wellness Human wellness
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饥饿诱导增生性瘢痕成纤维细胞自噬发生 被引量:10
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作者 吕雷 林康 +4 位作者 高伟阳 何智灵 高自勉 李浙峰 李俊杰 《中国病理生理杂志》 CAS CSCD 北大核心 2013年第2期330-333,共4页
目的:探讨饥饿诱导的增生性瘢痕成纤维细胞自噬的发生。方法:原代培养增生性瘢痕成纤维细胞至对数生长期,用EBSS(Earle’s balanced salt solution)代替培养液,分别饥饿0 h、1 h、2 h、3 h,应用Western blot-ting和定量PCR(qRT-PCR)方... 目的:探讨饥饿诱导的增生性瘢痕成纤维细胞自噬的发生。方法:原代培养增生性瘢痕成纤维细胞至对数生长期,用EBSS(Earle’s balanced salt solution)代替培养液,分别饥饿0 h、1 h、2 h、3 h,应用Western blot-ting和定量PCR(qRT-PCR)方法分别检测成纤维细胞微管相关蛋白1轻链3(microtubule-associated protein 1 lightchain 3,LC-3)和自噬相关蛋白Beclin-1的蛋白和mRNA表达,单丹磺酰戊二胺(monodansylcadaverine,MDC)染色和透射电镜观察自噬体。结果:Western blotting和qRT-PCR检测LC3和Beclin-1蛋白和mRNA表达在饥饿1 h开始增加,2 h达到高峰,3 h逐渐下降,均明显大于对照组(P<0.05)。荧光显微镜和电镜下观察到饥饿2 h诱导的成纤维细胞出现自噬囊泡。结论:饥饿可诱导增生性瘢痕成纤维细胞发生自噬,可能与增生性瘢痕的形成有关。 展开更多
关键词 瘢痕 增生性 成纤维细胞 自噬 饥饿
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不同饥饿时段对常规及高脂饮食大鼠胃壁组织胃促生长素(ghrelin)表达的影响 被引量:7
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作者 邵莉 李荣英 +4 位作者 张一波 赵双霞 乔洁 朱鋐达 陈名道 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2005年第3期265-268,共4页
目的探讨不同饥饿时段及长期高脂饮食对大鼠胃壁组织胃促生长素(ghrelin)表达的影响。方法应用Northern印迹法观察不同饥饿时段及长期高脂饮食时大鼠胃壁组织ghrelin表达的变化。结果在常规饮食喂养大鼠饥饿72 h以内(短期饥饿),其胃壁组... 目的探讨不同饥饿时段及长期高脂饮食对大鼠胃壁组织胃促生长素(ghrelin)表达的影响。方法应用Northern印迹法观察不同饥饿时段及长期高脂饮食时大鼠胃壁组织ghrelin表达的变化。结果在常规饮食喂养大鼠饥饿72 h以内(短期饥饿),其胃壁组织ghrelin表达升高(24 hP<0.05,72 hP<0.01),饥饿持续时间达120 h(长期饥饿)时,大鼠胃壁组织ghrelin表达又下调(P<0.01),但长期高脂饮食喂养的肥胖的大鼠模型,其胃壁组织ghrelin表达不受饥饿时段的影响。此外,在非饥饿状态,高脂大鼠胃壁组织ghrelin表达低于常规饮食组(P<0.01)。结论常规饮食大鼠ghrelin表达随饥饿时段延长先升后降;高脂组ghrelin表达不随饥饿时段而改变。推测肥胖时Ghrelin表达的下降及不受饥饿时段的影响可能是机体自发降低食欲,控制体重增加的机制之一。 展开更多
关键词 饥饿时段 高脂饮食 大鼠 胃壁组织 胃促生长素 基因表达 肥胖症
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An Analysis of Liberia’s Vulnerability to Climate Change in the Context of Least Developed Countries (LDCs): A Review
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作者 Charles Flomo Togbah 《American Journal of Climate Change》 2024年第2期230-250,共21页
Climate change is an alarming global challenge, particularly affecting the least developed countries (LDCs) including Liberia. These countries, located in regions prone to unpredictable temperature and precipitation c... Climate change is an alarming global challenge, particularly affecting the least developed countries (LDCs) including Liberia. These countries, located in regions prone to unpredictable temperature and precipitation changes, are facing significant challenges, particularly in climate-sensitive sectors such as mining and agriculture. LDCs need more resilience to adverse climate shocks but have limited capacity for adaptation compared to other developed and developing nations. This paper examines Liberia’s susceptibility to climate change as a least developed country, focusing on its exposure, sensitivity, and adaptive capacity. It provides an overview of LDCs and outlines the global distribution of carbon dioxide emissions. The paper also evaluates specific challenges that amplify Liberia’s vulnerability and constrain sustainable adaptation, providing insight into climate change’s existing and potential effects. The paper emphasizes the urgency of addressing climate impacts on Liberia and calls for concerted local and international efforts for effective and sustainable mitigation efforts. It provides recommendations for policy decisions and calls for further research on climate change mitigation and adaptation. 展开更多
关键词 Least Developed Countries LIBERIA Climate Change VULNERABILITY POVERTY hunger Disease Research and Development (R&D) Adaptation
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谷氨酰胺对饥饿大鼠肠黏膜屏障功能的保护作用 被引量:6
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作者 张小平 杨拔贤 +4 位作者 夏萍 程爱国 乔玉涛 李克伟 陈玉宏 《中华麻醉学杂志》 CAS CSCD 北大核心 2006年第7期642-645,共4页
目的探讨谷氨酰胺对饥饿大鼠肠黏膜屏障功能的保护作用。方法90只健康雄性SD大鼠,随机分为正常对照组(C组,n=10)、全饥饿组(S组,n=40)和谷氨酰胺组(G组,n=40),S、G组随机分为为饥饿3、5、7、9d亚组(n=10)。实验期间无饲料供应,自由摄水... 目的探讨谷氨酰胺对饥饿大鼠肠黏膜屏障功能的保护作用。方法90只健康雄性SD大鼠,随机分为正常对照组(C组,n=10)、全饥饿组(S组,n=40)和谷氨酰胺组(G组,n=40),S、G组随机分为为饥饿3、5、7、9d亚组(n=10)。实验期间无饲料供应,自由摄水。G组给予谷氨酰胺1.0 g·kg-1·d-1水溶液灌胃,每天一次。取小肠组织,光镜下观察肠黏膜的形态改变,并观察细胞凋亡情况,测定小肠组织匀浆中一氧化化氮(NO)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果饥饿可以导致小肠黏膜损伤,凋亡细胞增加,小肠NO、MDA含量增加,SOD活性降低,谷氨酰胺可减弱饥饿诱导的上述改变(P<0.05或0.01)。结论谷氨酰胺对饥饿大鼠肠黏膜屏障功能有保护作用。 展开更多
关键词 谷氨酰胺 饥饿 肠黏膜
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A possible mechanism of mineral responses to elevated atmospheric CO_2 in rice grains 被引量:5
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作者 GUO Jia ZHANG Ming-qian +1 位作者 WANG Xiao-wen ZHANG Wei-jian 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2015年第1期50-57,共8页
Increasing attentions have been paid to mineral concentration decrease in milled rice grains caused by CO2 enrichment, but the mechanisms still remain unclear. Therefore, mineral (Ca, Mg, Fe, Zn and Mn) translocatio... Increasing attentions have been paid to mineral concentration decrease in milled rice grains caused by CO2 enrichment, but the mechanisms still remain unclear. Therefore, mineral (Ca, Mg, Fe, Zn and Mn) translocation in plant-soil system with a FACE (Free-air CO2 enrichment) experiment were investigated in Eastern China after 4-yr operation. Results mainly showed that: (1) elevated CO2 significantly increased the biomass of stem and panicle by 21.9 and 24.0%, respectively, but did not affect the leaf biomass. (2) Elevated CO2 significantly increased the contents of Ca, Mg, Fe, Zn, and Mn in panicle by 61.2, 28.9, 87.0, 36.7, and 66.0%, respectively, and in stem by 13.2, 21.3, 47.2, 91.8, and 25.2%, respectively, but did not affect them in leaf. (3) Elevated CO2 had positive effects on the weight ratio of mineral/biomass in stem and panicle. Our results suggest that elevated CO2 can favor the translocation of Ca, Mg, Fe, Zn, and Mn from soil to stem and panicle. The CO2-led mineral decline in milled rice grains may mainly attribute to the CO2-1ed unbalanced stimulations on the translocations of minerals and carbohydrates from vegetative parts (e.g., leaf, stem, branch and husk) to the grains. 展开更多
关键词 climate change free-air CO2 enrichment (FACE) hidden hunger nutritional quality paddy field rice
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The Importance of Agricultural Development Projects: A Focus on Sustenance and Employment Creation in Kenya, Malawi, Namibia, Rwanda, and Uganda
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作者 Benonia Mwahafa Rafael 《Journal of Agricultural Chemistry and Environment》 CAS 2023年第2期152-170,共19页
The paper on the importance of Agricultural Development Projects focuses on different projects implemented in Kenya, Malawi, Namibia, Rwanda, and Uganda. The paper presents the significance of agriculture in these 5 A... The paper on the importance of Agricultural Development Projects focuses on different projects implemented in Kenya, Malawi, Namibia, Rwanda, and Uganda. The paper presents the significance of agriculture in these 5 African economies in its ability to provide job opportunities and sustenance. A large portion of the African population in their different countries resides in rural areas and is fully dependent on agriculture for food and income. Subsequently, the development of many developing economies relies heavily on agriculture, the sector is the highest employer in the region with 60 percent of the total labor force being employed in agriculture and agriculture-related sectors such as manufacturing. The success of the sector means that people will have sufficient food, jobs will be created, and standards of living will be improved. The different projects implemented by local governments in the 5 countries and by the development partners have attained plausible results in providing job opportunities, increasing yield, providing food security, and creating a market for small-holder farmers. Despite these remarkable achievements, the agriculture sector in Africa as a whole is faced with many challenges that hinder its success, such as lack of funding, lack of infrastructure, limited land for farming, and climate change. To overcome these challenges and enable the sector to transform, bold policies need to be implemented. This study recommends that African countries create favorable business environments to attract investment, encourage youth participation in agricultural activities, and employ modern farming practices to increase agricultural productivity. 展开更多
关键词 Agriculture Development EMPLOYMENT hunger Food Security INVESTMENT AFRICA
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Effect of Low and High Glycemic Index Meals on Hunger and Satiety
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作者 Noorah Saleh Al-Sowayan Bushra Almeneay Tahiyat Al Othaim 《Advances in Bioscience and Biotechnology》 2023年第9期409-418,共10页
Recently, people suffer from the inability to maintain weight with an increasing body mass, and this may be due to several reasons, including the type and quantity of food. In current study, the effect of the glycemic... Recently, people suffer from the inability to maintain weight with an increasing body mass, and this may be due to several reasons, including the type and quantity of food. In current study, the effect of the glycemic index of foods (high-low-medium) on the speed of return of hunger in adult women was discussed. Non-pregnant or lactating women who do not suffer from chronic diseases such as diabetes and pressure, for three days in a row for breakfast, lunch, and dinner, by calculating the number of hours preceding the feeling of hunger, as the results showed that the least hours of hunger were after eating foods with a low glycemic index and then followed by foods with a medium glycemic index, and the number of hours of starvation after eating foods with a high glycemic index was the least, and this leads to an increase in subsequent food intake and an increase in calories during the day. The results indicated: first day that are high in the glycemic index (breakfast). Highest percentage of feeling hungry was 30% after 4 h (lunch). The highest percentage of feeling hungry was 30% after 3 h, (dinner), the highest percentage of not feeling hungry by 50%. The second day with a low glycemic index (breakfast). The highest percentage of feeling hungry after 4 h was 30%, (lunch). The highest percentage of feeling hungry after 4 h was 30%, (dinner). The highest percentage of not feeling hungry was 80%. Third day with a medium glycemic index (breakfast). The highest percentage of feeling hungry was after 3 h and 4 h, with a percentage of 30%, (lunch), the highest percentage of feeling hungry after 4 h, with a percentage of 30%, (dinner), the highest percentage of not feeling hungry by 70%, which increases body mass and weight continuously, and this leads to an increase in vulnerability to chronic diseases. Therefore, it is important to preserve and be careful to eat meals with a low and medium glycemic index in the diets, with the addition of foods with a high glycemic index, without negligence or excess, and we look forw 展开更多
关键词 Increase in Body Mass Feeling of hunger Medium Glycemic Index Pressure DIABETES
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Hungry and Angry Society: Implications for Sustainable Development in Nigeria
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作者 Lawrence Udisi 《Journalism and Mass Communication》 2024年第2期140-154,共15页
Hunger is a physiological need,but the production and consumption of adequate and balanced food is a function of social forces.At every point,social,political,and economic processes intervene,for better or(more common... Hunger is a physiological need,but the production and consumption of adequate and balanced food is a function of social forces.At every point,social,political,and economic processes intervene,for better or(more common)for worse.Food is one fundamental need of human beings for survival.But in Nigeria there is widespread food shortage and hunger.Development scholars have put forward reasons why poverty,hunger persists in the country,from the platitudes about population growth,inadequate implementation of agricultural policies,and neglect of agriculture,bad leadership,corruption,and the issue of distribution.Nigeria is richly blessed with arable land and citizens eager to unlock its food potentials.Unfortunately,this is far from being realized as the country depends on foreign countries for food,a situation that is tragic and sad.She spends about$10 billion a year importing food and agricultural products,the majority of which are wheat,rice,poultry,fish,and consumer-oriented foods.The pressure on the exchange rate results in devaluation-triggered inflation and food costs that fly up beyond the grasp of people at the bottom of the ladder as it is now is one of the negative repercussions of high food importation bills.Examining the effects of hunger is one of this paper’s key concerns and goals,and anger crisis for achieving sustainable development in the country using the Frustration-Aggression Theory,The Relative Deprivation and Political Economy Approach as guide. 展开更多
关键词 hunger and angry society POVERTY sustainable development frustration-aggression theory political economy
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在象征中触摸原乡——评美国华裔女作家张岚小说集《饥饿》 被引量:4
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作者 魏全凤 《海南大学学报(人文社会科学版)》 CSSCI 2008年第5期569-572,共4页
身处边缘空间引发的身份焦虑,导致华裔作品对身份认同的关注。在美国华裔女作家张岚的小说集《饥饿》中,对原乡的向往诉诸对文化象征的想象和与文化象征的纠葛。在象征中触摸原乡,模糊且又顾虑重重,不过通过对原乡的象征性想象与叙述,... 身处边缘空间引发的身份焦虑,导致华裔作品对身份认同的关注。在美国华裔女作家张岚的小说集《饥饿》中,对原乡的向往诉诸对文化象征的想象和与文化象征的纠葛。在象征中触摸原乡,模糊且又顾虑重重,不过通过对原乡的象征性想象与叙述,身份追寻由焦虑升华为审美,从而实现了自我建构的诗性超越。 展开更多
关键词 张岚 《饥饿》 象征 原乡
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Nesfatin-1对饥饿小鼠氧化应激及自噬的影响
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作者 王铭 玉斯日古楞 +3 位作者 陈宇飞 谢志凤 罗雨晨 么宏强 《黑龙江畜牧兽医》 CAS 北大核心 2024年第3期10-15,共6页
为了研究在急性禁食状态下Nesfatin-1对机体氧化应激及自噬的影响,试验构建小鼠饥饿模型,将50只小鼠随机均分为阴性对照组、禁食24 h组、禁食48 h组、Nesfatin-1+禁食24 h组、Nesfatin-1+禁食48 h组。禁食24,48 h组小鼠分别禁食24 h及48... 为了研究在急性禁食状态下Nesfatin-1对机体氧化应激及自噬的影响,试验构建小鼠饥饿模型,将50只小鼠随机均分为阴性对照组、禁食24 h组、禁食48 h组、Nesfatin-1+禁食24 h组、Nesfatin-1+禁食48 h组。禁食24,48 h组小鼠分别禁食24 h及48 h;Nesfatin-1+禁食24 h组及Nesfatin-1+禁食48 h组分别在禁食24,48 h基础上按每20 g体重腹腔注射1.25 nmol/g Nesfatin-1 0.26 mL;阴性对照组腹腔注射同等剂量PBS。对各组小鼠进行眼球采血,处死后解剖取脑、肝脏组织。采用化学荧光法测定各组小鼠肝脏氧化基因指标活性氧(reactive oxygen species,ROS)荧光强度,采用ELISA方法测定各组小鼠血清丙二醛(malonaldehyde,MDA)和Nesfatin-1含量,运用实时荧光定量PCR方法测定各组自噬相关基因Beclin-1、LC3、P62 mRNA相对表达量。结果表明:与阴性对照组相比,禁食24 h组及禁食48 h组小鼠ROS荧光强度、MDA含量极显著升高(P<0.01),脑组织Beclin-1、LC3 mRNA相对表达量显著或极显著上调(P<0.05或P<0.01),P62 mRNA相对表达量极显著降低(P<0.01);在禁食24,48 h后,小鼠血清Nesfatin-1含量显著降低(P<0.05),使用Nesfatin-1干预后,其含量极显著升高(P<0.01);与禁食24 h组相比,Nesfatin-1+禁食24 h组小鼠的ROS、MDA含量和Beclin-1、LC3 mRNA相对表达量极显著降低(P<0.01),P62 mRNA相对表达量显著升高(P<0.05);与禁食48 h组相比,Nesfatin-1+禁食48 h组小鼠的ROS、MDA含量和Beclin-1、LC3 mRNA相对表达量极显著降低(P<0.01),P62 mRNA相对表达量极显著升高(P<0.01)。说明急性禁食会使小鼠体内Nesfatin-1含量降低,氧化应激与自噬水平上调,Nesfatin-1能增强细胞活力,注射Nesfatin-1后可以降低小鼠体内的氧化应激水平,也能够降低小鼠在急性禁食状态下上调的自噬水平。 展开更多
关键词 NESFATIN-1 饥饿 氧化应激 活性氧 自噬
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艺术家的生存困境——论卡夫卡的《饥饿艺术家》 被引量:6
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作者 侯相琪 《河池学院学报》 2010年第1期29-31,共3页
小说《饥饿艺术家》写了艺术家从受欢迎到被人遗忘的过程,铁笼是饥饿艺术家的生活的空间,他拒绝与外在的世界交流,孤独地进行着饥饿表演。他的艺术得不到人们的认同,一直处于生存的被遗忘状态。艺术家坚持自己的选择,他的这一选择充满... 小说《饥饿艺术家》写了艺术家从受欢迎到被人遗忘的过程,铁笼是饥饿艺术家的生活的空间,他拒绝与外在的世界交流,孤独地进行着饥饿表演。他的艺术得不到人们的认同,一直处于生存的被遗忘状态。艺术家坚持自己的选择,他的这一选择充满了荒诞性,同时也注定了他的悲剧命运。 展开更多
关键词 铁笼 饥饿 孤独 遗忘
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饮食种类及时间对肠道准备质量和患者舒适度的影响 被引量:5
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作者 周梁云 俞亚萍 +1 位作者 陆群 姜鑫 《中华护理教育》 CSCD 2020年第9期842-844,共3页
目的探讨不同饮食种类及时间对肠道准备质量和患者舒适度的影响。方法选择本院消化内镜中心行肠镜检查的患者600例,随机分为3组,每组200例。A组,检查前3 d进食无渣或低渣半流质饮食,前1 d进流质饮食;B组,检查前3 d进食低渣饮食;C组,检查... 目的探讨不同饮食种类及时间对肠道准备质量和患者舒适度的影响。方法选择本院消化内镜中心行肠镜检查的患者600例,随机分为3组,每组200例。A组,检查前3 d进食无渣或低渣半流质饮食,前1 d进流质饮食;B组,检查前3 d进食低渣饮食;C组,检查前1 d进食低渣饮食。3组患者肠道清洁剂均选用复方聚乙二醇电解质散。比较3组患者在肠道准备清洁度和患者舒适度的差异。结果3组患者在肠道准备清洁度方面效果相当,差异无统计学意义(P>0.05);B、C组在饥饿感、疲惫感、肠道不适反应等舒适度方面均优于A组(P<0.05)。结论目前临床上常用的几种饮食种类均可以获得满意的肠道准备质量,采用检查前1 d进食低渣饮食的方法可以提高患者舒适度。 展开更多
关键词 结肠镜检查 饥饿 低渣饮食 肠道准备
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非低血糖状态下饥饿感对2型糖尿病患者睡眠质量、生活质量的影响 被引量:5
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作者 付利丽 郭强 +2 位作者 喻国 周晋霜 张明峰 《四川医学》 CAS 2020年第7期696-700,共5页
目的探究非低血糖状态下饥饿感与2型糖尿病(T2DM)患者低血糖恐惧、睡眠质量、生活质量关系以及高纤低糖食物对患者干预效果。方法选取2019年5至11月150例饥饿感视觉模拟评分(VAS)≥1分的T2DM患者为研究对象,另选50例VAS评分为0分的T2DM... 目的探究非低血糖状态下饥饿感与2型糖尿病(T2DM)患者低血糖恐惧、睡眠质量、生活质量关系以及高纤低糖食物对患者干预效果。方法选取2019年5至11月150例饥饿感视觉模拟评分(VAS)≥1分的T2DM患者为研究对象,另选50例VAS评分为0分的T2DM患者进行对照,比较饥饿组与非饥饿组入院时低血糖恐惧量表(FH-15)、匹兹堡睡眠质量指数(PSQI)及糖尿病患者生存质量量表(DSQL)得分,并分析饥饿组VAS评分与FH-15、PSQI及DSQL得分相关性;饥饿组根据是否进食高纤低糖食物分为观察组73例、对照组77例,观察组在原饮食结构基础上,每日补充2次新鲜黄瓜或西红柿,每次100 g,对照组维持原饮食结构不变,连续干预1个月,比较两组干预前、后夜间(22:00)血糖值、每日饥饿VAS评分>3分次数、夜间饥饿VAS评分、FH-15、PSQI、DSQL得分。结果饥饿组入院时FH-15、PSQI、DSQL得分均显著高于非饥饿组(P<0.05),饥饿组饥饿VAS评分与FH-15、PSQI、DSQL得分均呈正相关(P<0.05),且FH-15、PSQI、DSQL得分互呈正相关(P<0.05);干预后,两组夜间血糖值比较差异无统计学意义(P>0.05),但观察组每日饥饿VAS评分>3分次数、夜间VAS评分、FH-15、PSQI、DSQL得分均显著低于对照组(P<0.05)。结论T2DM非低血糖状态下饥饿感可增加患者低血糖恐惧、影响其睡眠质量及生存质量,给予高纤维低糖食物干预有利于改善患者饥饿感、降低其低血糖恐惧,同时提高患者睡眠质量及生活质量,且不升高夜间血糖。 展开更多
关键词 二型糖尿病 饥饿感 非低血糖状态 睡眠质量 生活质量 高纤低糖食物
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New Sustainable Market Opportunities for Surplus Food: A Food System-Sensitive Methodology (FSSM) 被引量:2
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作者 Thomas H. O’Donnell Jonathan Deutsch +2 位作者 Cathy Yungmann Alexandra Zeitz Solomon H. Katz 《Food and Nutrition Sciences》 2015年第10期883-892,共10页
An important way to address global food security is to make better use of the food already produced. Since at least one third of global food is wasted before consumption, there are enormous incentives to cut this wast... An important way to address global food security is to make better use of the food already produced. Since at least one third of global food is wasted before consumption, there are enormous incentives to cut this waste and create a more sustainable food system. This paper focuses upon saving food loss at the supermarket level in the US and channeling this food stream in new and efficient ways to those in hunger. A more comprehensive Food System-Sensitive Methodology has been used to pilot and evaluate a surplus food management program that diverts culled fresh fruits and vegetables from grocery stores that would otherwise be disposed of in landfills. Instead, produce is processed for donation or for new businesses. Nearly 35,000 pounds of produce was culled from a grocery store chain in Philadelphia. Twenty-five percent of this was not suitable for culinary uses, ten percent consisted of relatively small quantities of food that did not warrant further research, and about 33 percent is suitable for use at area food shelters and pantries. An experimental sample taken from the remaining 15,000 pounds was used for recipe research and development for diversion to new commercial enterprises. We analyzed a scenario where a supermarket receives $0.25 per pound for culled produce, generating about $8700 dollars in average monthly revenue while eliminating disposal costs. New commercial possibilities for the unused food were then explored. The scenario included community-based enterprises that could process the produce into value-added products that could be wholesaled back to the store at sufficient profits to support 2 - 4 community employees. Extrapolating these results to the approximately 38,000 large supermarkets in the United States suggests that much of the 1,100,000,000 pounds of produce that is currently sent to landfills can be repurposed. If diverted to new foods each of the 46.1 million SNAP recipients could figuratively receive an equivalent of 24 pounds of fruit and vegetable products per annum. This initial 展开更多
关键词 MARKET SUSTAINABILITY FOOD Waste hunger
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Reliability and validity of the hidden hunger assessment scale in China-revised for high school students
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作者 Ning Zhang Minao Wang +6 位作者 Yuchen Zhang Huake Cao Yang Yang Yuhang Shi Yang Pei Feixiang Yang Yinan Du 《Global Health Journal》 2023年第2期110-116,共7页
Objective:Hidden hunger remains a severe public health problem that affects millions of people worldwide.In China,challenges related to dietary imbalance and hidden hunger persist.Micronutrient inadequacy deserves mor... Objective:Hidden hunger remains a severe public health problem that affects millions of people worldwide.In China,challenges related to dietary imbalance and hidden hunger persist.Micronutrient inadequacy deserves more attention among adolescents,given its vital role in their growth and development;however,this problem appears to have been largely ignored.High school students,in particular,are often at a high risk of hidden hunger but have limited assessment tools available.Therefore,this study aims to revise the hidden hunger assessment scale for high school students(HHAS-HSS)in China and assess its reliability and validity.Methods:Based on a literature review,expert consultation,pre-experiment,and formal survey,a hidden hunger assessment scale was revised for high school students.The formal survey involved 9336 high school students in 11 of the 16 cities in Anhui Province,China,and 9038 valid questionnaires were collected and included in the analysis.The item analysis,internal consistency reliability,test-retest reliability,content validity,exploratory factor analysis,and confirmatory factor analysis of the HHAS-HSS were examined.Results:The HHAS-HSS included a total of 4 dimensions and 12 items:"vegetables and food diversity"(three items),"fruits and dairy products"(three items),"micronutrient-dense foods"(four items),and"health condition and eating habits"(two items).The results showed a Cronbach's alpha of 0.758,a split-half reliability of 0.829,and a test-retest reliability of o.793,indicating good internal consistency.Using the Bartlett's test and Kaiser-Meyer-Olkin test(KMO)to test the exploratory factor analysis presented a four-factor model of the HHAS-HSS,the KMO0 value was 0.820(P<0.001),which indicated the possibility for factor confirmatory factor analysis.Using the maximum variance rotation method,four factors were obtained,and the cumulative variance explained rate was 57.974%.Confirmatory factor analysis also supported the division of the scale into four dimensions,and the fitting indices were x^ 展开更多
关键词 Hidden hunger Reliability and validity Assessment scale High school student MICRONUTRIENTS
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