Mucormycosis is a rare fungal infection which is largely diagnosed in immune-compromised patients. The infection can cause pulmonary, rhinocerebral, skin and soft tissue, central nervous system and gastrointestinal sy...Mucormycosis is a rare fungal infection which is largely diagnosed in immune-compromised patients. The infection can cause pulmonary, rhinocerebral, skin and soft tissue, central nervous system and gastrointestinal system. The gastrointestinal involvement is the rarest presentation, especially the stomach. We present a 38 years old HIV positive female seen in Steve Biko Academic Hospital with 2 wk history of cough, shortness of breath and lethargy. She was clinically found to be pale, pyrexial, dyspnoea and had severe oral thrush. Blood tests revealed hemoglobin of 6 g/dL CD4 count of 63 cells/uL. Chest X-ray showed multi-lobe pneumonia and gastroscopy confirmed esophageal candidiasis and nodular gastritis. She continued to deteriorate despite antibiotics, antifungal and antituberculous treatment. She developed upper gastrointestinal bleed on day 34, and gastroscopy showed a plaque like lesion in the stomach, histology of which confirmed mucormycosis. She improved on Amphotericin B but subsequently deteriorated and demised a few days later. These cases illustrate the occurrence of a rare fungal infection of the stomach and the poor mortality when diagnosis is delayed. Mucormycosis can co-exist with candidiasis and clinicians should have a high index of suspicion especially in patients not responding to appropriate treatment.展开更多
目的研究获得性免疫缺陷综合征(AIDS)患者颈动脉弹性功能的改变及其影响因素。方法随机选取符合入选标准的河南省AIDS患者50例为AIDS组,人类免疫缺陷病毒(HIV)感染病程平均(14.93±3.82)年,均未接受过抗病毒治疗,按照随机对照的原...目的研究获得性免疫缺陷综合征(AIDS)患者颈动脉弹性功能的改变及其影响因素。方法随机选取符合入选标准的河南省AIDS患者50例为AIDS组,人类免疫缺陷病毒(HIV)感染病程平均(14.93±3.82)年,均未接受过抗病毒治疗,按照随机对照的原则选取当地健康村民50名为对照组,采用内-中膜自动测量(QIMT)及血管弹性功能定量(QAS)技术检测受试者右侧颈动脉,获得颈动脉内-中膜厚度(IMT)、顺应性系数(CC)、僵硬度(β)和脉搏波传导速度(PWV)。2组间比较采用非配对t检验,相关性分析采用Pearson线性相关分析。结果 AIDS组与对照组受试者颈动脉IMT比较,差异无统计学意义(P>0.05)。与对照组比较,AIDS组颈动脉CC降低[(0.59±0.21)mm2/k Pa vs(1.04±0.41)mm2/k Pa)]、β升高(13.01±6.10 vs 8.14±1.37)、PWV升高[(8.70±1.65)m/s vs(6.81±1.37)m/s)],差异均具有统计学意义(P值均<0.05)。HIV感染时间与颈动脉IMT无相关性(r=0.191,P>0.05),与颈动脉弹性参数CC呈负相关,与β、PWV呈正相关(r=-0.575、0.380、0.417,P值均<0.05)。CD4+、CD8+细胞计数与颈动脉IMT、CC、β、PWV均无相关性(r=0.000、1.012,r=-0.093、-0.097,r=0.096、0.012,r=0.056、0.024,P值均>0.05)。结论 AIDS患者颈动脉弹性功能较正常人减低,且与HIV感谢染时间呈弱的正相关,提示HIV可能在AIDS患者颈动脉弹性功能减低中起一定作用。展开更多
文摘Mucormycosis is a rare fungal infection which is largely diagnosed in immune-compromised patients. The infection can cause pulmonary, rhinocerebral, skin and soft tissue, central nervous system and gastrointestinal system. The gastrointestinal involvement is the rarest presentation, especially the stomach. We present a 38 years old HIV positive female seen in Steve Biko Academic Hospital with 2 wk history of cough, shortness of breath and lethargy. She was clinically found to be pale, pyrexial, dyspnoea and had severe oral thrush. Blood tests revealed hemoglobin of 6 g/dL CD4 count of 63 cells/uL. Chest X-ray showed multi-lobe pneumonia and gastroscopy confirmed esophageal candidiasis and nodular gastritis. She continued to deteriorate despite antibiotics, antifungal and antituberculous treatment. She developed upper gastrointestinal bleed on day 34, and gastroscopy showed a plaque like lesion in the stomach, histology of which confirmed mucormycosis. She improved on Amphotericin B but subsequently deteriorated and demised a few days later. These cases illustrate the occurrence of a rare fungal infection of the stomach and the poor mortality when diagnosis is delayed. Mucormycosis can co-exist with candidiasis and clinicians should have a high index of suspicion especially in patients not responding to appropriate treatment.
文摘目的研究获得性免疫缺陷综合征(AIDS)患者颈动脉弹性功能的改变及其影响因素。方法随机选取符合入选标准的河南省AIDS患者50例为AIDS组,人类免疫缺陷病毒(HIV)感染病程平均(14.93±3.82)年,均未接受过抗病毒治疗,按照随机对照的原则选取当地健康村民50名为对照组,采用内-中膜自动测量(QIMT)及血管弹性功能定量(QAS)技术检测受试者右侧颈动脉,获得颈动脉内-中膜厚度(IMT)、顺应性系数(CC)、僵硬度(β)和脉搏波传导速度(PWV)。2组间比较采用非配对t检验,相关性分析采用Pearson线性相关分析。结果 AIDS组与对照组受试者颈动脉IMT比较,差异无统计学意义(P>0.05)。与对照组比较,AIDS组颈动脉CC降低[(0.59±0.21)mm2/k Pa vs(1.04±0.41)mm2/k Pa)]、β升高(13.01±6.10 vs 8.14±1.37)、PWV升高[(8.70±1.65)m/s vs(6.81±1.37)m/s)],差异均具有统计学意义(P值均<0.05)。HIV感染时间与颈动脉IMT无相关性(r=0.191,P>0.05),与颈动脉弹性参数CC呈负相关,与β、PWV呈正相关(r=-0.575、0.380、0.417,P值均<0.05)。CD4+、CD8+细胞计数与颈动脉IMT、CC、β、PWV均无相关性(r=0.000、1.012,r=-0.093、-0.097,r=0.096、0.012,r=0.056、0.024,P值均>0.05)。结论 AIDS患者颈动脉弹性功能较正常人减低,且与HIV感谢染时间呈弱的正相关,提示HIV可能在AIDS患者颈动脉弹性功能减低中起一定作用。
