Based on the platform of Matlab and the theory of digital signal processing, we propose a method in the cepstrum domain for dynamic load spectra identification of machinery. We demonstrate that the dynamic load spectr...Based on the platform of Matlab and the theory of digital signal processing, we propose a method in the cepstrum domain for dynamic load spectra identification of machinery. We demonstrate that the dynamic load spectra can be identified from the response signal of the system, based on cepstra. An ARMA model is built based on the harmonic retrieval by high-order spectra. The coefficients of a Green function are determined and the window width can be estimated. Finally the effectiveness of the method is validated by simulation results.展开更多
Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex diseases.Simulation data is crucial for evaluating epistasis de...Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex diseases.Simulation data is crucial for evaluating epistasis detection tools in genome-wide association studies(GWAS).Existing simulators normally suffer from two limitations:absence of support for high-order epistasis models containing multiple single nucleotide polymorphisms(SNPs),and inability to generate simulation SNP data independently.In this study,we proposed a simulator SimHOEPI,which is capable of calculating penetrance tables of high-order epistasis models depending on either prevalence or heritability,and uses a resampling strategy to generate simulation data independently.Highlights of SimHOEPI are the preservation of realistic minor allele frequencies in sampling data,the accurate calculation and embedding of high-order epistasis models,and acceptable simulation time.A series of experiments were carried out to verify these properties from different aspects.Experimental results show that SimHOEPI can generate simulation SNP data independently with high-order epistasis models,implying that it might be an alternative simulator for GWAS.展开更多
There has been an intensive international effort to develop high-order Computational Fluid Dynamics(CFD) methods into design tools in aerospace engineering during the last one and half decades. These methods offer the...There has been an intensive international effort to develop high-order Computational Fluid Dynamics(CFD) methods into design tools in aerospace engineering during the last one and half decades. These methods offer the potential to significantly improve solution accuracy and efficiency for vortex dominated turbulent flows. Enough progresses have been made in algorithm development, mesh generation and parallel computing that these methods are on the verge of being applied in a production design environment. Since many review papers have been written on the subject, I decide to offer a personal perspective on the state-of-the-art in high-order CFD methods and the challenges that must be overcome.展开更多
基金Project 59775004 supported by National Natural Science Foundation of China
文摘Based on the platform of Matlab and the theory of digital signal processing, we propose a method in the cepstrum domain for dynamic load spectra identification of machinery. We demonstrate that the dynamic load spectra can be identified from the response signal of the system, based on cepstra. An ARMA model is built based on the harmonic retrieval by high-order spectra. The coefficients of a Green function are determined and the window width can be estimated. Finally the effectiveness of the method is validated by simulation results.
基金This work was supported by the National Natural Science Foundation of China(Nos.61972226 and 62172254).
文摘Epistasis is a ubiquitous phenomenon in genetics,and is considered to be one of main factors in current efforts to unveil missing heritability of complex diseases.Simulation data is crucial for evaluating epistasis detection tools in genome-wide association studies(GWAS).Existing simulators normally suffer from two limitations:absence of support for high-order epistasis models containing multiple single nucleotide polymorphisms(SNPs),and inability to generate simulation SNP data independently.In this study,we proposed a simulator SimHOEPI,which is capable of calculating penetrance tables of high-order epistasis models depending on either prevalence or heritability,and uses a resampling strategy to generate simulation data independently.Highlights of SimHOEPI are the preservation of realistic minor allele frequencies in sampling data,the accurate calculation and embedding of high-order epistasis models,and acceptable simulation time.A series of experiments were carried out to verify these properties from different aspects.Experimental results show that SimHOEPI can generate simulation SNP data independently with high-order epistasis models,implying that it might be an alternative simulator for GWAS.
基金supported by Air Force Office of Scientific ResearchNational Aeronautics and Space Administration+7 种基金Department of Energy, U.S. NavyNational Science FoundationDefense Advanced Research Project AgencyOffice of Naval ResearchArmy Research OfficeMichigan State UniversityIowa State Universitythe University of Kansas
文摘There has been an intensive international effort to develop high-order Computational Fluid Dynamics(CFD) methods into design tools in aerospace engineering during the last one and half decades. These methods offer the potential to significantly improve solution accuracy and efficiency for vortex dominated turbulent flows. Enough progresses have been made in algorithm development, mesh generation and parallel computing that these methods are on the verge of being applied in a production design environment. Since many review papers have been written on the subject, I decide to offer a personal perspective on the state-of-the-art in high-order CFD methods and the challenges that must be overcome.
