Background Acute exacerbation of chronic obstructive pulmonary disease （AECOPD） is a common condition,which affects not only the quality of life of patients but also their prognosis.The purpose of this study was to ...Background Acute exacerbation of chronic obstructive pulmonary disease （AECOPD） is a common condition,which affects not only the quality of life of patients but also their prognosis.The purpose of this study was to explore the effects of an inhaled salbutamol sulfate solution and an inhalation suspension of the glucocorticoid budesonide that were atomized with heliox to treat patients with AECOPD.Methods Twenty-three patients with AECOPD were divided into a treatment group （He/O2=70％/30％） and a control group （N2/O2=70％/30％）.The salbutamol sulfate and budesonide were administered by inhalation twice a day for 7 days.Vital signs,arterial blood gas levels,pulmonary function and the levels of serum myostatin （sMSTN） were measured and lung vibration imaging was performed.Results We found that the PaO2 and PaCO2 values were not significantly different between the two groups at the various time points （P ＞0.05）.There were also no significant differences in any of the parameters of pulmonary function between the two groups.However,after baseline correction,the increase rate of the forced expiratory volume in one second （FEV1）,the forced vital capacity （FVC）,and the maximum minute ventilation （MW） appeared to be significantly increased at some time points compared with the baseline （before treatment） in both groups （P ＜0.05）.Although the values of quantitative lung distribution （QLD） for different regions and the levels of sMSTN were slightly different between the two groups,the repeated measures analysis of variance （ANOVA） revealed that there were no significant differences between the two groups or within any group （P ＞0.05）.Conclusion Although the use of heliox as a driving gas can improve symptoms and benefit patients with AECOPD,the heliox treatment group did not have significant differences in arterial blood gases,lung function,lung vibration response imaging or the levels of sMSTN compared with the control group.（Chinese Clinical Trial Register Ce展开更多
Objective To evaluate the effectiveness of a helium oxygen mixture (79%He 21%O 2) as an aerosolizing compressed gas for β 2 agonist therapy in patients with an asthma exacerbation Methods Twenty four pat...Objective To evaluate the effectiveness of a helium oxygen mixture (79%He 21%O 2) as an aerosolizing compressed gas for β 2 agonist therapy in patients with an asthma exacerbation Methods Twenty four patients in the outpatient department with a mild to moderate exacerbation of asthma were enrolled The patients were randomly divided into an experimental group (13 cases) and a control group (11 cases) The experimental group inhaled Berotec with heliox driven, and the control group inhaled Berotec with compressed air driven Eight hospitalized patients in the respiratory department with severe exacerbation of asthma were enrolled The patients inhaled Berotec with heliox driven or compressed air driven in a random order Results The results of spirometric parameters and arterial blood gas analysis were measured In the mild to moderate asthma patients, no statistical differences between the two groups for forced vital capacity (FVC), forced expired volume in one second (FEV 1), and expiratory flow in 50% forced vital capacity (FEF 50 ) were presented But the severe patients showed significant differences between heliox driven and compressed air driven for FVC, FEV 1, FEF 50 and partial pressure of oxygen (PaO 2) Conclusions Compared with the traditional inhalation of β 2 agonist therapy using compressed air driven, the method of inhaling β 2 agonist with heliox driven has more obvious benefits for those suffering from severe asthma This is likely due to the cooperative effects between inhaling heliox on its physical gas properties and improving delivery of β 2 agonist in the treatment of exacerbation of severe asthma展开更多
-The chief purpose of the research was to understand the physiological function change regularity, performance and adaptability of the human body living and working under high pressure for prolonged time.In January 19...-The chief purpose of the research was to understand the physiological function change regularity, performance and adaptability of the human body living and working under high pressure for prolonged time.In January 1989, 4 naval divers entered the habital of NMRI's 500 msw saturation diving system after a series of adaptive diving training. The breathing mixture was helium-oxygen. After 55 h compression (including intermediate stages) the 350 msw depth was reached, where the divers lived and worked for 72 h 10 min. No sign of discomfort or significant HPNS was found in the 4 divers.The second and third day of the saturation exposure, the divers carried out 370 msw dry and wet chamber excursion diving 2 man-time each, the divers effectively carried out operational work under water, the total excursion time was 1 h each excursion dive.Saturation decompression started after 3-day storage exposure, the divers were gradually brought toward the surface 25 msw a day on the average by employing the linear steady rate of decompression. During decompression, no case of DCS occurred. Immediate post-dive medical check-ups shows that they were physically normal.More than 120 biomedical indices were monitored and measured on the divers at different period of the experiment. The organisms showed a good adaptability and certain operating capability, and both the compression and decompression profiles were proved to be satisfactory.The detailed experimental data obtained provided sound scientific basis for the practical application of future great depth open sea saturation diving.展开更多
Four divers were compressed to 350 m to observe changes in hearing threshold, brainstem evoked response and acoustic impedance. The divers experienced no tinnitus, impairment of bearing, earache daring compression. Ex...Four divers were compressed to 350 m to observe changes in hearing threshold, brainstem evoked response and acoustic impedance. The divers experienced no tinnitus, impairment of bearing, earache daring compression. Examination showed that the threshold of tower frequency range of hearing was elevated because of the masking effect of the noise in the hyperbaric chamber. Changes in waveform and latency of brainstem evoked response were due to changes in sound wave transmission affected by the chamber pressure and a poor ratio of signal to noise in the hyperbaric environment with heliox. All these changes were transient After leaving the chamber, the hearing threshold and brainstem evoked response returned to normal. Besides, there were no changes in tympanogram, acoustic compliance and stapedius reflex before and after diving. This indicated the designed speed of compression and decompression in the experiment caused no damage to the divers' acoustic system, and the functions of their Eustachain tubes, middle and inner ears were normal during the diving test展开更多
文摘Background Acute exacerbation of chronic obstructive pulmonary disease （AECOPD） is a common condition,which affects not only the quality of life of patients but also their prognosis.The purpose of this study was to explore the effects of an inhaled salbutamol sulfate solution and an inhalation suspension of the glucocorticoid budesonide that were atomized with heliox to treat patients with AECOPD.Methods Twenty-three patients with AECOPD were divided into a treatment group （He/O2=70％/30％） and a control group （N2/O2=70％/30％）.The salbutamol sulfate and budesonide were administered by inhalation twice a day for 7 days.Vital signs,arterial blood gas levels,pulmonary function and the levels of serum myostatin （sMSTN） were measured and lung vibration imaging was performed.Results We found that the PaO2 and PaCO2 values were not significantly different between the two groups at the various time points （P ＞0.05）.There were also no significant differences in any of the parameters of pulmonary function between the two groups.However,after baseline correction,the increase rate of the forced expiratory volume in one second （FEV1）,the forced vital capacity （FVC）,and the maximum minute ventilation （MW） appeared to be significantly increased at some time points compared with the baseline （before treatment） in both groups （P ＜0.05）.Although the values of quantitative lung distribution （QLD） for different regions and the levels of sMSTN were slightly different between the two groups,the repeated measures analysis of variance （ANOVA） revealed that there were no significant differences between the two groups or within any group （P ＞0.05）.Conclusion Although the use of heliox as a driving gas can improve symptoms and benefit patients with AECOPD,the heliox treatment group did not have significant differences in arterial blood gases,lung function,lung vibration response imaging or the levels of sMSTN compared with the control group.（Chinese Clinical Trial Register Ce
文摘Objective To evaluate the effectiveness of a helium oxygen mixture (79%He 21%O 2) as an aerosolizing compressed gas for β 2 agonist therapy in patients with an asthma exacerbation Methods Twenty four patients in the outpatient department with a mild to moderate exacerbation of asthma were enrolled The patients were randomly divided into an experimental group (13 cases) and a control group (11 cases) The experimental group inhaled Berotec with heliox driven, and the control group inhaled Berotec with compressed air driven Eight hospitalized patients in the respiratory department with severe exacerbation of asthma were enrolled The patients inhaled Berotec with heliox driven or compressed air driven in a random order Results The results of spirometric parameters and arterial blood gas analysis were measured In the mild to moderate asthma patients, no statistical differences between the two groups for forced vital capacity (FVC), forced expired volume in one second (FEV 1), and expiratory flow in 50% forced vital capacity (FEF 50 ) were presented But the severe patients showed significant differences between heliox driven and compressed air driven for FVC, FEV 1, FEF 50 and partial pressure of oxygen (PaO 2) Conclusions Compared with the traditional inhalation of β 2 agonist therapy using compressed air driven, the method of inhaling β 2 agonist with heliox driven has more obvious benefits for those suffering from severe asthma This is likely due to the cooperative effects between inhaling heliox on its physical gas properties and improving delivery of β 2 agonist in the treatment of exacerbation of severe asthma
文摘-The chief purpose of the research was to understand the physiological function change regularity, performance and adaptability of the human body living and working under high pressure for prolonged time.In January 1989, 4 naval divers entered the habital of NMRI's 500 msw saturation diving system after a series of adaptive diving training. The breathing mixture was helium-oxygen. After 55 h compression (including intermediate stages) the 350 msw depth was reached, where the divers lived and worked for 72 h 10 min. No sign of discomfort or significant HPNS was found in the 4 divers.The second and third day of the saturation exposure, the divers carried out 370 msw dry and wet chamber excursion diving 2 man-time each, the divers effectively carried out operational work under water, the total excursion time was 1 h each excursion dive.Saturation decompression started after 3-day storage exposure, the divers were gradually brought toward the surface 25 msw a day on the average by employing the linear steady rate of decompression. During decompression, no case of DCS occurred. Immediate post-dive medical check-ups shows that they were physically normal.More than 120 biomedical indices were monitored and measured on the divers at different period of the experiment. The organisms showed a good adaptability and certain operating capability, and both the compression and decompression profiles were proved to be satisfactory.The detailed experimental data obtained provided sound scientific basis for the practical application of future great depth open sea saturation diving.
文摘Four divers were compressed to 350 m to observe changes in hearing threshold, brainstem evoked response and acoustic impedance. The divers experienced no tinnitus, impairment of bearing, earache daring compression. Examination showed that the threshold of tower frequency range of hearing was elevated because of the masking effect of the noise in the hyperbaric chamber. Changes in waveform and latency of brainstem evoked response were due to changes in sound wave transmission affected by the chamber pressure and a poor ratio of signal to noise in the hyperbaric environment with heliox. All these changes were transient After leaving the chamber, the hearing threshold and brainstem evoked response returned to normal. Besides, there were no changes in tympanogram, acoustic compliance and stapedius reflex before and after diving. This indicated the designed speed of compression and decompression in the experiment caused no damage to the divers' acoustic system, and the functions of their Eustachain tubes, middle and inner ears were normal during the diving test
