In this paper,the open-sourced computational fluid dynamics software,OpenFOAM~?,is used to study the fluctuation phenomenon of the water body inside a horizontally one-dimensional enclosed harbor basin with constant w...In this paper,the open-sourced computational fluid dynamics software,OpenFOAM~?,is used to study the fluctuation phenomenon of the water body inside a horizontally one-dimensional enclosed harbor basin with constant water depth triggered by falling wedges with various horizontal falling positions,initial falling velocities and masses.Based on both Fourier transfo rm analysis and wavelet spectrum analysis for the time series of the free surface elevations inside the harbor basin,it is found for the first time that the wedge falling inside the harbor can directly trigger harbor resonance.The influences of the three factors(including the horizontal falling position,the initial falling velocity,and the mass)on the response amplitudes of the lowest three resonant modes are also investigated.The results show that when the wedge falls on one of the nodal points of a resonant mode,the mode would be remarkably suppressed.Conversely,when the wedge falls on one of the anti-nodal points of a resonant mode,the mode would be evidently triggered.The initial falling velocity of the wedge mainly has a remarkable effect on the response amplitude of the most significant mode,and the latter shows a gradual increase trend with the increase of the former.While for the other two less significant modes,their response amplitudes fluctuate around certain constant values as the initial falling velocity rises.In general,the response amplitudes of all the lowest three modes are shown to gradually increase with the mass of the wedge.展开更多
目的:通过建立海港地区抑郁大鼠模型,探讨睡眠剥夺的快速抗抑郁机制。方法:将40只SD大鼠随机分为正常对照组、抑郁模型组、睡眠剥夺组及水环境对照组,每组10只。用慢性不可预见性应激抑郁模型方法结合孤养方式建立海港地区抑郁大鼠模型...目的:通过建立海港地区抑郁大鼠模型,探讨睡眠剥夺的快速抗抑郁机制。方法:将40只SD大鼠随机分为正常对照组、抑郁模型组、睡眠剥夺组及水环境对照组,每组10只。用慢性不可预见性应激抑郁模型方法结合孤养方式建立海港地区抑郁大鼠模型,采取改良多平台睡眠剥夺法实施睡眠剥夺,用旷场实验和强迫游泳实验对大鼠的行为变化进行测试,免疫组化法检测海马环磷腺苷效应元件结合蛋白(cAMP-response element binding protein,CREB)、磷酸化环磷腺苷反应元件结合蛋白(phosphorylation cyclic adenosinemonophosphate response element binding protein,p-CREB)的含量。结果:与抑郁模型组相比,睡眠剥夺组大鼠的旷场实验水平运动得分与垂直运动得分均明显升高,潜伏期明显缩短,强迫游泳实验不动时间明显减少(P<0.05或P<0.01)。抑郁模型组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著低于正常对照组(P<0.05),睡眠剥夺组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著高于抑郁模型组(P<0.05)。结论:睡眠剥夺可明显改善大鼠的抑郁样行为,其快速抗抑郁作用可能与海马部位CREB含量及活性的增高有关,可为海港地区抑郁症治疗提供依据。展开更多
基金financially supported by the National Natural Science Foundation of China (Grant No.51911530205)the Natural Science Foundation of Jiangsu Province (Grant No.BK20201455)+5 种基金the Guangdong Basic and Applied Basic Research Foundation (Grant No.2023A1515010890)the Key Laboratory of PortWaterway and Sedimentation Engineering of MOT (Grant No.YK222001-2)the Open Research Fund of Key Laboratory of Water Security Guarantee in Guangdong-Hong Kong-Marco Greater Bay Area of Ministry of Water Resources (Grant No.WSGBAKJ202309)the Qing Lan Project of Jiangsu Universitiesthe Royal Society (Grant No.IECNSFC181321)。
文摘In this paper,the open-sourced computational fluid dynamics software,OpenFOAM~?,is used to study the fluctuation phenomenon of the water body inside a horizontally one-dimensional enclosed harbor basin with constant water depth triggered by falling wedges with various horizontal falling positions,initial falling velocities and masses.Based on both Fourier transfo rm analysis and wavelet spectrum analysis for the time series of the free surface elevations inside the harbor basin,it is found for the first time that the wedge falling inside the harbor can directly trigger harbor resonance.The influences of the three factors(including the horizontal falling position,the initial falling velocity,and the mass)on the response amplitudes of the lowest three resonant modes are also investigated.The results show that when the wedge falls on one of the nodal points of a resonant mode,the mode would be remarkably suppressed.Conversely,when the wedge falls on one of the anti-nodal points of a resonant mode,the mode would be evidently triggered.The initial falling velocity of the wedge mainly has a remarkable effect on the response amplitude of the most significant mode,and the latter shows a gradual increase trend with the increase of the former.While for the other two less significant modes,their response amplitudes fluctuate around certain constant values as the initial falling velocity rises.In general,the response amplitudes of all the lowest three modes are shown to gradually increase with the mass of the wedge.
文摘目的:通过建立海港地区抑郁大鼠模型,探讨睡眠剥夺的快速抗抑郁机制。方法:将40只SD大鼠随机分为正常对照组、抑郁模型组、睡眠剥夺组及水环境对照组,每组10只。用慢性不可预见性应激抑郁模型方法结合孤养方式建立海港地区抑郁大鼠模型,采取改良多平台睡眠剥夺法实施睡眠剥夺,用旷场实验和强迫游泳实验对大鼠的行为变化进行测试,免疫组化法检测海马环磷腺苷效应元件结合蛋白(cAMP-response element binding protein,CREB)、磷酸化环磷腺苷反应元件结合蛋白(phosphorylation cyclic adenosinemonophosphate response element binding protein,p-CREB)的含量。结果:与抑郁模型组相比,睡眠剥夺组大鼠的旷场实验水平运动得分与垂直运动得分均明显升高,潜伏期明显缩短,强迫游泳实验不动时间明显减少(P<0.05或P<0.01)。抑郁模型组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著低于正常对照组(P<0.05),睡眠剥夺组海马CA1、CA3、DG区的CREB及p-CREB平均光密度值均显著高于抑郁模型组(P<0.05)。结论:睡眠剥夺可明显改善大鼠的抑郁样行为,其快速抗抑郁作用可能与海马部位CREB含量及活性的增高有关,可为海港地区抑郁症治疗提供依据。
