Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 ...Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.展开更多
Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Met...Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.展开更多
The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut microbiota.Here we re-evaluated the link between exercise-induced microbia...The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut microbiota.Here we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and diabetes.We found that the relative abundances of substantial amounts of diabetes-associated metagenomic species associated negatively with physical fitness in a Chinese athlete students cohort.We additionally showed that those microbial changes correlated more with handgrip strength,a simple but valuable biomarker suggestive of the diabetes states,than maximum oxygen intake,one of the key surrogates for endurance training.Moreover,the causal relationships among exercise,risks for diabetes,and gut microbiota were explored based on mediation analysis.We propose that the protective roles of exercise against type 2 diabetes are mediated,at least partly,by the gut microbiota.展开更多
BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAF...BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAFLD in the general population in Korea.METHODS This nationwide representative cross-sectional study included 31649 individuals aged≥19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and 2018.Odds ratios(ORs)and 95%confidence intervals(95%CIs)for MAFLD according to sex-specific quartiles of muscle strength,defined by relative handgrip strength,were calculated using multivariable logistic regression analysis.Additionally,multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with MAFLD.RESULTS Of all the participants,29.3%had MAFLD.The prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants,sexes,and age groups(P<0.001).A 1.92-fold(OR=1.92,95%CI:1.70–2.16)and 3.12-fold(OR=3.12,95%CI:2.64–3.69)higher risk of MAFLD was observed in the lowest quartile(Q1)group than in the other groups(Q2–Q4)and the highest quartile(Q4)group,respectively.The ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner(P for trend<0.001).These associations persisted in both sexes.An inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age,obesity,and diabetes mellitus.In patients with MAFLD,the odds of severe liver fibrosis were higher in Q1(OR=1.83,95%CI:1.25–2.69)than in other groups(Q2–Q4).CONCLUSION Among Korean adults,low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD.展开更多
Background: Studies on physical activity during pregnancy and its impact on mother and fetus are still limited. International protocols consider only aerobic exercise and fail to provide information about other modali...Background: Studies on physical activity during pregnancy and its impact on mother and fetus are still limited. International protocols consider only aerobic exercise and fail to provide information about other modalities such as isometric exercise. Isometric exercise promotes cardiorespiratory resistance and muscle strengthening, but it is rarely tested on pregnant women because it increases maternal blood pressure and can subsequently affect placental circulation. Objectives: To assess the fetal response by use of Doppler study in diabetes pregnant women submitted to isometric exercise. Methods: A cross-sectional experimental study was conducted on 25 diabetes pregnant women with gestational age between 26 and 36 weeks. The patients were submitted to isometric handgrip, and data were collected from the mother (blood pressure, heart rate and Doppler velocimetry for the uterine arteries) and from the fetus (heart rate, Doppler velocimetry for the umbilical artery, middle cerebral artery and ductus venosus). All variables were collected before, during and after the isometric handgrip. Results: There was a significant reduction in the pulsatilityindex (average values pre 0.77 ± 0.30, trans 0.65 ± 0.22, and post 0.75 ± 0.22, with p = 0.001), resistance index (average values pre 0.49 ± 0.12, trans 0.44 ± 0.10, and post 0.48 ± 0.90, with p = </span.展开更多
Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip strength.Methods We used linear re...Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip strength.Methods We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip strength.Results In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(P<0.05).The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was−1.007(95%confidence interval:−1.362,−0.652;P<0.001)when each quartile of the mixture of the seven metals was increased.Bayesian kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength,with Cu,As and Sr being negatively associated with grip strength levels.In the total population,potential interactions were observed between As and Mn and between Cu and Mn(P_(interactions) of 0.003 and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip strength.Cu,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.展开更多
Objectives:The objective of this study is to assess the handgrip strength(HGS)in patients with type 2 diabetes,compare it with nondiabetes age-matched individuals,and assess the correlation between diabetic status and...Objectives:The objective of this study is to assess the handgrip strength(HGS)in patients with type 2 diabetes,compare it with nondiabetes age-matched individuals,and assess the correlation between diabetic status and HGS among diabetic patients.Materials and Methods:A community-based cross-sectional study was conducted in rural Mysore,India,for 4 months.Fifty-eight clinically diagnosed type 2 diabetics and 58 nondiabetics participated in the study.The handheld dynamometer was used to test the HGS of all subjects in their dominant hand.Independent t-test was used to analyze the differences in HGS between patients with and without diabetes.Results:The mean dynamometer reading among diabetics was 19.08±7.51,whereas that in nondiabetics was 27.474±13.11.There was a significant difference in HGSs between diabetics and nondiabetics(P<0.01).Conclusion:Decreased muscle strength and quality in the upper extremities are associated with type 2 diabetes and can lead to functional and physical limitations.Diabetic patients’HGS should be evaluated promptly to identify any disabilities and plan for appropriate therapy.展开更多
Purpose: To establish a relationship between falls and handgrip strength (GS) in communitydwelling senior citizens in Egypt. Subjects: Crosssectional study enrolling 132 subjects, all ≥60 years old. Materials and Met...Purpose: To establish a relationship between falls and handgrip strength (GS) in communitydwelling senior citizens in Egypt. Subjects: Crosssectional study enrolling 132 subjects, all ≥60 years old. Materials and Methods: History of falls in the past year and their number as well as GS measurement in both hands using Baseline? pneumatic squeeze handheld dynamometer. Results: There is a highly significant difference between the GS of fallers and non-fallers in both hands (P = 0.000). There is a highly significant negative correlation between the mean GS and the number of falls (P = 0.003). There is a highly significant positive correlation between GS of the right hand with the number of falls (R = 0.226, P = 0.009), as for the correlation with the left GS it was a weaker positive correlation (R = 0.209, P = 0.16). Conclusion: Seniors with history of falls have a lower GS in both dominant and nondominant hands and it is directly related to the number of falls. GS is decreased in senior fallers even if within the normal range.展开更多
The effects of combined training(CT)on improving general health are well known,however,few studies have investigated the effects of low-volume CT.So,the aim of this study is to investigate the effects of 6 weeks of lo...The effects of combined training(CT)on improving general health are well known,however,few studies have investigated the effects of low-volume CT.So,the aim of this study is to investigate the effects of 6 weeks of lowvolume CT on body composition,handgrip strength(HGS),cardiorespiratory fitness(CRF)and affective response(AR)to exercise.Eighteen healthy,active young adult man(meanSD,[20.061.66]years;[22.232.76]kg/m2)performed either a low-volume CT(EG,n?9),or maintained a normal life(CG,n?9).The CT was composed of three resistance exercises followed by a high intensity-interval training(HIIT)on cycle ergometer performed twice a week.The measures of the body composition,HGS,maximal oxygen consumption(V_O2max)and AR to exercise were taken at baseline and after training for analysis.Furthermore,an ANOVA test of repeated measures and t-test paired samples were used with a p0.05.The results showed that EG improved HGS(pre:[45.6711.84]kg vs.post:[52.4411.90]kg,p<0.01)and V_O2max(pre:[41.365.16]ml⋅kg-1⋅min-1 vs.post:[44.075.98]ml⋅kg-1⋅min-1,p<0.01).Although,for all measures the body composition had not significant differences between weeks(p>0.05),nevertheless the feeling scale was positive in all weeks and without significant differences between them(p>0.05).Lastly,for active young adults,the low-volume CT improved HGS,CRF and had a positive outcome in AR,with less volume and time spent than traditional exercise recommendations.展开更多
Introduction: <span style="font-family:""><span style="font-family:Verdana;">Some somatic and psychological disorders have been associated with handgrip strength, which is an easy,...Introduction: <span style="font-family:""><span style="font-family:Verdana;">Some somatic and psychological disorders have been associated with handgrip strength, which is an easy, inexpensive and noninvasive method for assessment of muscle strength. We conducted a cross-sectional </span><span style="font-family:Verdana;">study to clarify the relationship of handgrip strength and menstruation-related </span><span style="font-family:Verdana;">symptoms. </span><b><span style="font-family:Verdana;">Material and Methods:</span></b><span style="font-family:Verdana;"> Handgrip strength was measured and a self-administered questionnaire was performed in female university students in Japan. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Handgrip strength did not significantly differ among the menstrual phases. The mean handgrip strength level (n = 260) was 26.0 ± 3.9 kg. We divided the subjects into three groups according to the handgrip strength level. Handgrip strength was associated with degrees of depression and anxiety during menstruation.</span><b><span style="font-family:Verdana;"> Conclusion: </span></b><span style="font-family:Verdana;">This can be used as fundamental data in further clarifying the relationship between muscle strength and menstruation-related symptoms.</span></span>展开更多
Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Agi...Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study.Cognitive impairment was assessed by the Chinese Mini-Mental State Examination.Handgrip strength was calculated from the means of the right and left hand values.Calf circumference was measured at the site of maximum circumference of the non-dominant leg.The formula developed by Ishii was used to define sarcopenia.Multiple logistic regression was performed to evaluate the associations of sarcopenia,handgrip strength,and calf circumference with cognitive impairment.Results The prevalence of cognitive impairment was 34.36%.The adjusted odds ratio(OR)for cognitive impairment in individuals with sarcopenia was 2.55[95% confidence interval(95%CI):1.86-3.50].Compared with individuals in the first quartile(Q1)of calf circumference,the adjusted ORs in the second,third,and fourth quartiles(Q_(2),Q_(3),and Q_(4))were 0.75(95% CI:0.58-0.96),0.59(95% CI:0.44-0.79),and 0.62(95% CI:0.45-0.8),respectively.Compared with individuals in Q1 of handgrip strength,the adjusted ORs for Q_(2),Q_(3),and Q_(4) were 0.49(95%CI:0.38-0.62),0.31(95% CI:0.23-0.41),and 0.30(95%CI:0.21-0.44),respectively.Conclusion Sarcopenia,identified by low handgrip strength and low calf circumference,was positively associated with cognitive impairment.展开更多
Objective: Handgrip strength (HGS) exercise has been reported to reduce blood pressure in both hypertensive and normotensive patients. In this study, we evaluated the association of HGS with hypertension in a Chinese ...Objective: Handgrip strength (HGS) exercise has been reported to reduce blood pressure in both hypertensive and normotensive patients. In this study, we evaluated the association of HGS with hypertension in a Chinese Han Population. Methods: A total of 11,151 subjects mainly consisting of a rural population were recruited with a multi-stage sampling method in Jurong city, Jiangsu Province, China. Besides hypertension and diabetes, major chronic diseases were excluded. HGS was categorized into tertiles by age and gender. Logistic regression was used to estimate the association of HGS and hypertension with the odds ratio (OR) and 95% confidence interval (Cl). Results: From low to high tertiles of HGS, diastolic blood pressure (DBP) was significantly increased (74.52 ± 7.39,74.70 ± 7.03, and 75.54 ± 7.01 mmHg, respectively;Ptrend=0.001), as well as in females (Ptrend=0.003). The differences in DBP among the tertiles of HGS were still significant in females even after adjusting for covariates (Ptrend=0.048). No significant differences in systolic blood pressure (SBP) were observed among the tertiles of HGS (P>0.05). Compared to low HGS, high HGS was significantly associated with hypertension after adjustment for age and gender (adjusted OR,1.19;95% CI, 1.06-1.34;P=0.004). A stratified analysis showed that the significant association of high HGS and hypertension was also observed with the following factors even after adjusting for age and gender: female gender (adjusted OR, 1.25;95% CI, 1.08-1.46;P=0.004), ages of 60-69 years (adjusted OR, 1.29;95% CI, 1.06-1.57;P=O.O11), and married (adjusted OR,1.20;95% CI, 1.06-1.37;P=0.005). However, no significant associations were found after adjusting for age, gender, smoking status, drinking status, body mass index, physical activity level, glucose, high-and low-density lipoprotein cholesterol, total cholesterol, and triglyceride (P>0.05).Conclusion: The findings of the current study suggest that HGS was positively correlated with DBP in a rural population, and high HGS was展开更多
This study examines gender differences and laterality in maximal handgrip strength and controlled force exertion (CFE) in young adults. The subjects were 75 healthy young males (mean age 19.6 ± 1.6 yrs.) and 50 h...This study examines gender differences and laterality in maximal handgrip strength and controlled force exertion (CFE) in young adults. The subjects were 75 healthy young males (mean age 19.6 ± 1.6 yrs.) and 50 healthy young females (mean age 20.9 ± 1.9 yrs.). Maximal handgrip strength was measured twice. The subjects performed the CFE test three times after one practice trial. They matched their handgrip strengths to the demand values, which constantly changed and ranged from 5 to 25% of maximal handgrip strength. The difference between the demand value and the grip exertion value was used as an estimate of CFE. Maximal handgrip strength was significantly larger in males than in females in both the dominant and non-dominant hands, and was significantly larger in the dominant hand in both males and females. Insignificant gender differences were found in CFE of both hands. CFE was significantly superior in the dominant hand in both genders. In conclusions, gender differences are present in maximal handgrip strength of the dominant and non-dominant hands in young adults, but not in CFE of both hands. Laterality exists in maximal handgrip strength and in CFE for both genders.展开更多
Sensitivity to cold, which is a popular symptom in Japanese women, is associated with various symptoms such as shoulder stiffness and general fatigue. However, an association of sensitivity to cold with muscle strengt...Sensitivity to cold, which is a popular symptom in Japanese women, is associated with various symptoms such as shoulder stiffness and general fatigue. However, an association of sensitivity to cold with muscle strength has not been reported. The aim of the study was to clarify the associations of sensitivity to cold with handgrip strength and with menstruation-related symptoms in female university students in Japan. We recruited 278 female university students in Japan. Sensitivity to cold and menstruation-related symptoms including physical and psychological symptoms were assessed by using a self-administered questionnaire that we designed. Handgrip strength was measured by using a handgrip strength dynamometer. We received responses from 269 students. The prevalence rate of sensitivity to cold in the subjects was 54.3%. The students who had sensitivity to cold had a lower handgrip strength level (25.5 ± 3.8 kg) than did the students who did not have sensitivity to cold (26.7 ± 3.9 kg) (p = 0.017). Sensitivity to cold was associated with low body mass index. In addition, the students who had sensitivity to cold tended to have low back pain and constipation during menstruation. In conclusion, sensitivity to cold is an important symptom associated with muscle strength as well as menstruation-related symptoms for young women.展开更多
Background:Pancreatitis patients are at an increased risk of malnutrition due to impaired digestion,absorption,and metabolism.The degree of malnutrition is dependent on the duration,viz.acute or chronic.Studies on nut...Background:Pancreatitis patients are at an increased risk of malnutrition due to impaired digestion,absorption,and metabolism.The degree of malnutrition is dependent on the duration,viz.acute or chronic.Studies on nutritional status in patients with pancreatitis are limited.Prevalence of nutritional status,physical functioning,and muscle strength among the subjects are scarce globally.The main aim of this study was to screen the status of malnutrition using appropriate screening tools and to assess hand muscle strength among subjects.Method:A cross-sectional study was conducted on 64 subjects(18–80 years old,59 males and 5 females)in Mysore city,Karnataka.The patients were screened for malnutrition using a standard tool Patient-Generated Subjective Global Assessment(PG-SGA)and handgrip strength on both dominant and nondominant hands.Results:The majority of patients(n=44)were categorized as moderately malnourished/suspected malnutrition(Stage B)according to PG-SGA.A significant difference(p<0.005)in handgrip strength was seen in men aged 31–40(t=?3.287)and 41–50(t=?5.487)years compared to healthy adults.Conclusion:This study was able to identify patients at risk of malnutrition when the PG-SGA tool was used along with handgrip strength and other anthropometric parameters.展开更多
Purpose:This study examined the effect of handgrip exercise on hemodynamic indices to determine the most effective regimen for promoting blood circulation.Methods:Healthy individuals were divided into three treatment ...Purpose:This study examined the effect of handgrip exercise on hemodynamic indices to determine the most effective regimen for promoting blood circulation.Methods:Healthy individuals were divided into three treatment groups with each performing exercises using an electronic handgrip.Groups performed exercises to determine the most appropriate tap position,frequency,and duration.The hemodynamic indices were measured by Doppler ultrasound.Results:The best handgrip position was the weak tap position.Venous blood flow velocity and blood flow increased significantly with each exercise relative to the resting state(p<0.01).Venous blood flow velocity and blood flow peaked with handgrip exercise frequency of 25 times/min for 2 min(p<0.01).No significant differences were observed between sexes.Conclusion:Handgrip exercise is an effective method for improving blood circulation in the upper extremities.展开更多
Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen character...Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen characteristics have not been explored.We recruited 1382 eligible men at the Hubei Province Human Sperm Bank(Wuhan,China)who had their handgrip strength measured at recruitment and provided 6458 repeated semen specimens within a 6-month period.Semen characteristics,including semen volume,sperm motility parameters(immotility,nonprogressive motility,and progressive motility),and sperm concentration,were assessed.Mixed-effect models and restricted cubic spline functions were applied to investigate the relationship of handgrip strength with repeated measurements of semen characteristics.After adjusting for confounding factors,the mixed-effect models revealed that handgrip strength was positively associated with semen volume,sperm concentration,progressive motility,total motility,and total count(all P for trend<0.05).Compared to men in the lowest quartile,those in the highest quartile of handgrip strength had higher semen volume,sperm concentration,progressive motility,total motility,and total count,with measurements of 14.2%(95%confidence interval[CI]:5.9%-23.2%),19.5%(95%CI:7.3%-33.1%),9.5%(95%CI:3.4%-15.9%),8.8%(95%CI:3.2%-14.6%),and 36.4%(95%CI:18.9%-56.5%),respectively.These positive dose-response relationships were further confirmed in restricted cubic splines,where handgrip strength was modeled as a continuous variable.Handgrip strength,as an indicator of muscular function and strength,was positively associated with semen characteristics in a dose-dependentmanner.展开更多
文摘Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.
文摘Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.
基金supported in part by the National Key Research and Development Program of China(2020YFA0803800,2019YFA0801900,2018YFA0800300,and 2022YFA0806400)the National Natural Science Foundation of China(31971097,31671242,32150610475,and 31971074)+4 种基金Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202001)Shanghai Frontiers Science Research Base of Exercise and Metabolic Healththe Construction Project of High-Level Local Universities in ShanghaiShanghai“Science and Technology Innovation Action Plan”Social Development Science and Technology Reach Project(22dz1204600)Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)。
文摘The metabolic benefits associated with long-term physical activity are well appreciated and growing evidence suggests that it involves the gut microbiota.Here we re-evaluated the link between exercise-induced microbial changes and those associated with prediabetes and diabetes.We found that the relative abundances of substantial amounts of diabetes-associated metagenomic species associated negatively with physical fitness in a Chinese athlete students cohort.We additionally showed that those microbial changes correlated more with handgrip strength,a simple but valuable biomarker suggestive of the diabetes states,than maximum oxygen intake,one of the key surrogates for endurance training.Moreover,the causal relationships among exercise,risks for diabetes,and gut microbiota were explored based on mediation analysis.We propose that the protective roles of exercise against type 2 diabetes are mediated,at least partly,by the gut microbiota.
文摘BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAFLD in the general population in Korea.METHODS This nationwide representative cross-sectional study included 31649 individuals aged≥19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and 2018.Odds ratios(ORs)and 95%confidence intervals(95%CIs)for MAFLD according to sex-specific quartiles of muscle strength,defined by relative handgrip strength,were calculated using multivariable logistic regression analysis.Additionally,multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with MAFLD.RESULTS Of all the participants,29.3%had MAFLD.The prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants,sexes,and age groups(P<0.001).A 1.92-fold(OR=1.92,95%CI:1.70–2.16)and 3.12-fold(OR=3.12,95%CI:2.64–3.69)higher risk of MAFLD was observed in the lowest quartile(Q1)group than in the other groups(Q2–Q4)and the highest quartile(Q4)group,respectively.The ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner(P for trend<0.001).These associations persisted in both sexes.An inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age,obesity,and diabetes mellitus.In patients with MAFLD,the odds of severe liver fibrosis were higher in Q1(OR=1.83,95%CI:1.25–2.69)than in other groups(Q2–Q4).CONCLUSION Among Korean adults,low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD.
文摘Background: Studies on physical activity during pregnancy and its impact on mother and fetus are still limited. International protocols consider only aerobic exercise and fail to provide information about other modalities such as isometric exercise. Isometric exercise promotes cardiorespiratory resistance and muscle strengthening, but it is rarely tested on pregnant women because it increases maternal blood pressure and can subsequently affect placental circulation. Objectives: To assess the fetal response by use of Doppler study in diabetes pregnant women submitted to isometric exercise. Methods: A cross-sectional experimental study was conducted on 25 diabetes pregnant women with gestational age between 26 and 36 weeks. The patients were submitted to isometric handgrip, and data were collected from the mother (blood pressure, heart rate and Doppler velocimetry for the uterine arteries) and from the fetus (heart rate, Doppler velocimetry for the umbilical artery, middle cerebral artery and ductus venosus). All variables were collected before, during and after the isometric handgrip. Results: There was a significant reduction in the pulsatilityindex (average values pre 0.77 ± 0.30, trans 0.65 ± 0.22, and post 0.75 ± 0.22, with p = 0.001), resistance index (average values pre 0.49 ± 0.12, trans 0.44 ± 0.10, and post 0.48 ± 0.90, with p = </span.
基金supported by the National Natural Science Foundation of China[rant Nos.81960583,81760577,81560523 and 82260629]Major Science and Technology Projects in Guangxi[GKAA22399 and AA22096026]+3 种基金the Guangxi Science and Technology Development Project[Grant Nos.AD 17129003 and 18050005]the Guangxi Natural Science Foundation for Innovation Research Team[2019GXNSFGA245002]the Innovation Platform and Talent Plan in Guilin[20220120-2]the Guangxi Scholarship Fund of Guangxi Education Department of China。
文摘Objective This study aimed to investigate the potential relationship between urinary metals copper(Cu),arsenic(As),strontium(Sr),barium(Ba),iron(Fe),lead(Pb)and manganese(Mn)and grip strength.Methods We used linear regression models,quantile g-computation and Bayesian kernel machine regression(BKMR)to assess the relationship between metals and grip strength.Results In the multimetal linear regression,Cu(β=−2.119),As(β=−1.318),Sr(β=−2.480),Ba(β=0.781),Fe(β=1.130)and Mn(β=−0.404)were significantly correlated with grip strength(P<0.05).The results of the quantile g-computation showed that the risk of occurrence of grip strength reduction was−1.007(95%confidence interval:−1.362,−0.652;P<0.001)when each quartile of the mixture of the seven metals was increased.Bayesian kernel function regression model analysis showed that mixtures of the seven metals had a negative overall effect on grip strength,with Cu,As and Sr being negatively associated with grip strength levels.In the total population,potential interactions were observed between As and Mn and between Cu and Mn(P_(interactions) of 0.003 and 0.018,respectively).Conclusion In summary,this study suggests that combined exposure to metal mixtures is negatively associated with grip strength.Cu,Sr and As were negatively correlated with grip strength levels,and there were potential interactions between As and Mn and between Cu and Mn.
文摘Objectives:The objective of this study is to assess the handgrip strength(HGS)in patients with type 2 diabetes,compare it with nondiabetes age-matched individuals,and assess the correlation between diabetic status and HGS among diabetic patients.Materials and Methods:A community-based cross-sectional study was conducted in rural Mysore,India,for 4 months.Fifty-eight clinically diagnosed type 2 diabetics and 58 nondiabetics participated in the study.The handheld dynamometer was used to test the HGS of all subjects in their dominant hand.Independent t-test was used to analyze the differences in HGS between patients with and without diabetes.Results:The mean dynamometer reading among diabetics was 19.08±7.51,whereas that in nondiabetics was 27.474±13.11.There was a significant difference in HGSs between diabetics and nondiabetics(P<0.01).Conclusion:Decreased muscle strength and quality in the upper extremities are associated with type 2 diabetes and can lead to functional and physical limitations.Diabetic patients’HGS should be evaluated promptly to identify any disabilities and plan for appropriate therapy.
文摘Purpose: To establish a relationship between falls and handgrip strength (GS) in communitydwelling senior citizens in Egypt. Subjects: Crosssectional study enrolling 132 subjects, all ≥60 years old. Materials and Methods: History of falls in the past year and their number as well as GS measurement in both hands using Baseline? pneumatic squeeze handheld dynamometer. Results: There is a highly significant difference between the GS of fallers and non-fallers in both hands (P = 0.000). There is a highly significant negative correlation between the mean GS and the number of falls (P = 0.003). There is a highly significant positive correlation between GS of the right hand with the number of falls (R = 0.226, P = 0.009), as for the correlation with the left GS it was a weaker positive correlation (R = 0.209, P = 0.16). Conclusion: Seniors with history of falls have a lower GS in both dominant and nondominant hands and it is directly related to the number of falls. GS is decreased in senior fallers even if within the normal range.
文摘The effects of combined training(CT)on improving general health are well known,however,few studies have investigated the effects of low-volume CT.So,the aim of this study is to investigate the effects of 6 weeks of lowvolume CT on body composition,handgrip strength(HGS),cardiorespiratory fitness(CRF)and affective response(AR)to exercise.Eighteen healthy,active young adult man(meanSD,[20.061.66]years;[22.232.76]kg/m2)performed either a low-volume CT(EG,n?9),or maintained a normal life(CG,n?9).The CT was composed of three resistance exercises followed by a high intensity-interval training(HIIT)on cycle ergometer performed twice a week.The measures of the body composition,HGS,maximal oxygen consumption(V_O2max)and AR to exercise were taken at baseline and after training for analysis.Furthermore,an ANOVA test of repeated measures and t-test paired samples were used with a p0.05.The results showed that EG improved HGS(pre:[45.6711.84]kg vs.post:[52.4411.90]kg,p<0.01)and V_O2max(pre:[41.365.16]ml⋅kg-1⋅min-1 vs.post:[44.075.98]ml⋅kg-1⋅min-1,p<0.01).Although,for all measures the body composition had not significant differences between weeks(p>0.05),nevertheless the feeling scale was positive in all weeks and without significant differences between them(p>0.05).Lastly,for active young adults,the low-volume CT improved HGS,CRF and had a positive outcome in AR,with less volume and time spent than traditional exercise recommendations.
文摘Introduction: <span style="font-family:""><span style="font-family:Verdana;">Some somatic and psychological disorders have been associated with handgrip strength, which is an easy, inexpensive and noninvasive method for assessment of muscle strength. We conducted a cross-sectional </span><span style="font-family:Verdana;">study to clarify the relationship of handgrip strength and menstruation-related </span><span style="font-family:Verdana;">symptoms. </span><b><span style="font-family:Verdana;">Material and Methods:</span></b><span style="font-family:Verdana;"> Handgrip strength was measured and a self-administered questionnaire was performed in female university students in Japan. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Handgrip strength did not significantly differ among the menstrual phases. The mean handgrip strength level (n = 260) was 26.0 ± 3.9 kg. We divided the subjects into three groups according to the handgrip strength level. Handgrip strength was associated with degrees of depression and anxiety during menstruation.</span><b><span style="font-family:Verdana;"> Conclusion: </span></b><span style="font-family:Verdana;">This can be used as fundamental data in further clarifying the relationship between muscle strength and menstruation-related symptoms.</span></span>
基金supported by National Natural Science Foundation of China[82025030,81941023,81872707,81273160 and 81573247]National Science and Technology Planning Project[2018YFC2000300]NIH/NIA P30AG028716。
文摘Objective To evaluate the associations of sarcopenia,handgrip strength and calf circumference with cognitive impairment among Chinese older adults.Methods Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study.Cognitive impairment was assessed by the Chinese Mini-Mental State Examination.Handgrip strength was calculated from the means of the right and left hand values.Calf circumference was measured at the site of maximum circumference of the non-dominant leg.The formula developed by Ishii was used to define sarcopenia.Multiple logistic regression was performed to evaluate the associations of sarcopenia,handgrip strength,and calf circumference with cognitive impairment.Results The prevalence of cognitive impairment was 34.36%.The adjusted odds ratio(OR)for cognitive impairment in individuals with sarcopenia was 2.55[95% confidence interval(95%CI):1.86-3.50].Compared with individuals in the first quartile(Q1)of calf circumference,the adjusted ORs in the second,third,and fourth quartiles(Q_(2),Q_(3),and Q_(4))were 0.75(95% CI:0.58-0.96),0.59(95% CI:0.44-0.79),and 0.62(95% CI:0.45-0.8),respectively.Compared with individuals in Q1 of handgrip strength,the adjusted ORs for Q_(2),Q_(3),and Q_(4) were 0.49(95%CI:0.38-0.62),0.31(95% CI:0.23-0.41),and 0.30(95%CI:0.21-0.44),respectively.Conclusion Sarcopenia,identified by low handgrip strength and low calf circumference,was positively associated with cognitive impairment.
基金grants from the Social Development Guidance Project of Zhenjiang (FZ2015064)the Livelihood Science and Technology Plan Project of Science and Technology Bureau in Jurong (SF2016896226)+1 种基金the National Natural Science Foundation of China (81573232)the Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine).
文摘Objective: Handgrip strength (HGS) exercise has been reported to reduce blood pressure in both hypertensive and normotensive patients. In this study, we evaluated the association of HGS with hypertension in a Chinese Han Population. Methods: A total of 11,151 subjects mainly consisting of a rural population were recruited with a multi-stage sampling method in Jurong city, Jiangsu Province, China. Besides hypertension and diabetes, major chronic diseases were excluded. HGS was categorized into tertiles by age and gender. Logistic regression was used to estimate the association of HGS and hypertension with the odds ratio (OR) and 95% confidence interval (Cl). Results: From low to high tertiles of HGS, diastolic blood pressure (DBP) was significantly increased (74.52 ± 7.39,74.70 ± 7.03, and 75.54 ± 7.01 mmHg, respectively;Ptrend=0.001), as well as in females (Ptrend=0.003). The differences in DBP among the tertiles of HGS were still significant in females even after adjusting for covariates (Ptrend=0.048). No significant differences in systolic blood pressure (SBP) were observed among the tertiles of HGS (P>0.05). Compared to low HGS, high HGS was significantly associated with hypertension after adjustment for age and gender (adjusted OR,1.19;95% CI, 1.06-1.34;P=0.004). A stratified analysis showed that the significant association of high HGS and hypertension was also observed with the following factors even after adjusting for age and gender: female gender (adjusted OR, 1.25;95% CI, 1.08-1.46;P=0.004), ages of 60-69 years (adjusted OR, 1.29;95% CI, 1.06-1.57;P=O.O11), and married (adjusted OR,1.20;95% CI, 1.06-1.37;P=0.005). However, no significant associations were found after adjusting for age, gender, smoking status, drinking status, body mass index, physical activity level, glucose, high-and low-density lipoprotein cholesterol, total cholesterol, and triglyceride (P>0.05).Conclusion: The findings of the current study suggest that HGS was positively correlated with DBP in a rural population, and high HGS was
文摘This study examines gender differences and laterality in maximal handgrip strength and controlled force exertion (CFE) in young adults. The subjects were 75 healthy young males (mean age 19.6 ± 1.6 yrs.) and 50 healthy young females (mean age 20.9 ± 1.9 yrs.). Maximal handgrip strength was measured twice. The subjects performed the CFE test three times after one practice trial. They matched their handgrip strengths to the demand values, which constantly changed and ranged from 5 to 25% of maximal handgrip strength. The difference between the demand value and the grip exertion value was used as an estimate of CFE. Maximal handgrip strength was significantly larger in males than in females in both the dominant and non-dominant hands, and was significantly larger in the dominant hand in both males and females. Insignificant gender differences were found in CFE of both hands. CFE was significantly superior in the dominant hand in both genders. In conclusions, gender differences are present in maximal handgrip strength of the dominant and non-dominant hands in young adults, but not in CFE of both hands. Laterality exists in maximal handgrip strength and in CFE for both genders.
文摘Sensitivity to cold, which is a popular symptom in Japanese women, is associated with various symptoms such as shoulder stiffness and general fatigue. However, an association of sensitivity to cold with muscle strength has not been reported. The aim of the study was to clarify the associations of sensitivity to cold with handgrip strength and with menstruation-related symptoms in female university students in Japan. We recruited 278 female university students in Japan. Sensitivity to cold and menstruation-related symptoms including physical and psychological symptoms were assessed by using a self-administered questionnaire that we designed. Handgrip strength was measured by using a handgrip strength dynamometer. We received responses from 269 students. The prevalence rate of sensitivity to cold in the subjects was 54.3%. The students who had sensitivity to cold had a lower handgrip strength level (25.5 ± 3.8 kg) than did the students who did not have sensitivity to cold (26.7 ± 3.9 kg) (p = 0.017). Sensitivity to cold was associated with low body mass index. In addition, the students who had sensitivity to cold tended to have low back pain and constipation during menstruation. In conclusion, sensitivity to cold is an important symptom associated with muscle strength as well as menstruation-related symptoms for young women.
基金University grants Commission-Junior Research Fellowship(Grant/Award Number:190520419587)。
文摘Background:Pancreatitis patients are at an increased risk of malnutrition due to impaired digestion,absorption,and metabolism.The degree of malnutrition is dependent on the duration,viz.acute or chronic.Studies on nutritional status in patients with pancreatitis are limited.Prevalence of nutritional status,physical functioning,and muscle strength among the subjects are scarce globally.The main aim of this study was to screen the status of malnutrition using appropriate screening tools and to assess hand muscle strength among subjects.Method:A cross-sectional study was conducted on 64 subjects(18–80 years old,59 males and 5 females)in Mysore city,Karnataka.The patients were screened for malnutrition using a standard tool Patient-Generated Subjective Global Assessment(PG-SGA)and handgrip strength on both dominant and nondominant hands.Results:The majority of patients(n=44)were categorized as moderately malnourished/suspected malnutrition(Stage B)according to PG-SGA.A significant difference(p<0.005)in handgrip strength was seen in men aged 31–40(t=?3.287)and 41–50(t=?5.487)years compared to healthy adults.Conclusion:This study was able to identify patients at risk of malnutrition when the PG-SGA tool was used along with handgrip strength and other anthropometric parameters.
基金supported by a grant from the Medicine and Health Science Technology Development Program of Shandong(No.2014WS0481).
文摘Purpose:This study examined the effect of handgrip exercise on hemodynamic indices to determine the most effective regimen for promoting blood circulation.Methods:Healthy individuals were divided into three treatment groups with each performing exercises using an electronic handgrip.Groups performed exercises to determine the most appropriate tap position,frequency,and duration.The hemodynamic indices were measured by Doppler ultrasound.Results:The best handgrip position was the weak tap position.Venous blood flow velocity and blood flow increased significantly with each exercise relative to the resting state(p<0.01).Venous blood flow velocity and blood flow peaked with handgrip exercise frequency of 25 times/min for 2 min(p<0.01).No significant differences were observed between sexes.Conclusion:Handgrip exercise is an effective method for improving blood circulation in the upper extremities.
基金supported by the National Natural Science Foundation of China(No.81903281)the National Postdoctoral Program for Innovative Talents(No.BX201700087)the Health Commission of Hubei Province Scientific Research Project(No.WJ2019H270).
文摘Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen characteristics have not been explored.We recruited 1382 eligible men at the Hubei Province Human Sperm Bank(Wuhan,China)who had their handgrip strength measured at recruitment and provided 6458 repeated semen specimens within a 6-month period.Semen characteristics,including semen volume,sperm motility parameters(immotility,nonprogressive motility,and progressive motility),and sperm concentration,were assessed.Mixed-effect models and restricted cubic spline functions were applied to investigate the relationship of handgrip strength with repeated measurements of semen characteristics.After adjusting for confounding factors,the mixed-effect models revealed that handgrip strength was positively associated with semen volume,sperm concentration,progressive motility,total motility,and total count(all P for trend<0.05).Compared to men in the lowest quartile,those in the highest quartile of handgrip strength had higher semen volume,sperm concentration,progressive motility,total motility,and total count,with measurements of 14.2%(95%confidence interval[CI]:5.9%-23.2%),19.5%(95%CI:7.3%-33.1%),9.5%(95%CI:3.4%-15.9%),8.8%(95%CI:3.2%-14.6%),and 36.4%(95%CI:18.9%-56.5%),respectively.These positive dose-response relationships were further confirmed in restricted cubic splines,where handgrip strength was modeled as a continuous variable.Handgrip strength,as an indicator of muscular function and strength,was positively associated with semen characteristics in a dose-dependentmanner.
