Background: Antifungal resistance (AFR) is a global public health problem with devastating effects, especially among immunocompromised individuals. Addressing AFR requires a One Health approach including Antifungal St...Background: Antifungal resistance (AFR) is a global public health problem with devastating effects, especially among immunocompromised individuals. Addressing AFR requires a One Health approach including Antifungal Stewardship (AFS). This study aimed to comprehensively review global studies published on fungal infections and AFR and to recommend solutions to address this growing problem. Materials and Methods: This was a narrative review that was conducted using published papers on fungal infections, AFR, and AFS between January 1961 and March 2024. The literature was searched using PubMed, Google Scholar, Web of Science, and EMBASE. Results: This found that there has been an increase in fungal infections globally, especially among immunocompromised patients. Due to this increase in fungal infections, there has been a proportionate increase in the use of antifungal agents to prevent and treat fungal infections. This increased use of antifungal agents has worsened the problem of AFR contributing to increased morbidity and mortality. Globally, fungal infections have contributed to 150 million infections annually and 1.7 million deaths per year. By the year 2023, over 3.8 million people died from fungal infections. Addressing AFR remains a challenge because the treatment of antifungal-resistant infections is difficult. Finally, the treatment of fungal infections is a global challenge exacerbated by the limited number of antifungal agents to treat invasive fungal infections. Conclusion: The results of this study indicated that fungal infections and AFR are prevalent across humans, animals, agriculture, and the environment. Addressing this problem requires the provision of solutions such as improving the awareness of AFR, conducting further research on the discovery of new antifungal agents, and implementing AFS programs. If this global problem is not addressed, the morbidity and mortality associated with AFR will continue to rise in the future.展开更多
Background:Antimicrobial resistance(AMR)is one of the top ten global public health challenges.However,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based...Background:Antimicrobial resistance(AMR)is one of the top ten global public health challenges.However,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based system-wide evaluation tool on global AMR.Methods:We have further developed the three-hierarchical Global One Health Index(GOHI)-AMR indicator scheme,which consists of five key indicators,17 indicators,and 49 sub-indicators,by incorporating 146 countries'data from diverse authoritative databases,including WHO's Global Antimicrobial Resistance and Use Surveillance System(GLASS)and the European CDC.We investigated the overall-or sub-rankings of GOHI-AMR at the international/regional/national levels for data preprocessing and score calculation utilizing the existing GOHI methodology.Additionally,a correlation analysis was conducted between the GOHI-AMR and other socioeconomic factors.Results:The average GOHI-AMR score for 146 countries is 38.45.As expected,high-income countries(HICs)outperform the other three income groups on overall rankings and all five key indicators of GOHI-AMR,whereas lowincome countries unexpectedly outperform upper-middle-income countries and lower-middle-income countries on the antibiotics-resistant key indicator(ARR)and ARR-subordinate indicators,including carbapenem-,β-lactam-,and quinolone resistance,and even HICs on aminoglycoside resistance.There were no significant differences among the four groups on the environmental-monitoring indicator(P>0.05).GOHI-AMR was positively correlated with gross domestic product,life expectancy,and AMR-related publications,but negatively with natural growth rate and chronic respiratory disease.In contrast to Cyprus,the remarkably lower prevalence of"ESKAPE pathogens"in high-scoring Sweden and Denmark highlights Europe's huge gaps.China and Russia outperformed the other three BRICS countries on all key indicators,particularly India's ARR and Brazil's AMR laboratory network and coordination capacity.Furthermore,significant internal disparitie展开更多
Ongoing climate change is a major threat to biodiversity. However, although many species clearly suffer from ongoing climate change, others benefit from it, for exam- ple, by showing range expansions. However, which s...Ongoing climate change is a major threat to biodiversity. However, although many species clearly suffer from ongoing climate change, others benefit from it, for exam- ple, by showing range expansions. However, which specific features determine a species＇ vulnerability to climate change？ Phenotypic plasticity, which has been described as the first line of defence against environmental change, may be of utmost importance here. Against this background, we here compare plasticity in stress tolerance in 3 copper butter- fly species, which differ arguably in their vulnerability to climate change. Specifically, we investigated heat, cold and desiccation resistance after acclimatization to different temper- atures in the adult stage. We demonstrate that acclimation at a higher temperature increased heat but decreased cold tolerance and desiccation resistance. Contrary to our predictions, species did not show pronounced variation in stress resistance, though plastic capacities in temperature stress resistance did vary across species. Overall, our results seemed to reflect population--rather than species-specific patterns. We conclude that the geographical ori- gin of the populations used should be considered even in comparative studies. However, our results suggest that, in the 3 species studied here, vulnerability to climate change is not in the first place determined by stress resistance in the adult stage. As entomological studies focus all too often on adults only, we argue that more research effort should be dedicated to other developmental stages when trying to understand insect responses to environmental change.展开更多
Based on the new large de formation theory of Stokes-Chen Strain-Rotation Decomposition Theorem and study on shear-tensile deformation of bolts (Chen Zhida, 1979), a new method of determining bolt’s large de formatio...Based on the new large de formation theory of Stokes-Chen Strain-Rotation Decomposition Theorem and study on shear-tensile deformation of bolts (Chen Zhida, 1979), a new method of determining bolt’s large de formation based on the measurement or displacement has been prerented. Theoretical formulas of global resistance on bolted joints under shear-tensile load have also been proposed. The validity of the theory has ben conflrmed by experimental results iu lab.展开更多
In this paper,epidemnic diseases among pests are assumed to occur,so pests are divided into susceptible pests and infected pests,and only susceptible pests are harmful to crops.Considering spraying pesticides and rele...In this paper,epidemnic diseases among pests are assumed to occur,so pests are divided into susceptible pests and infected pests,and only susceptible pests are harmful to crops.Considering spraying pesticides and releasing of natural enermies and infected pests to control pests,as well as the long-term application of the same pesticide to induce resistance,an integrated pest management with pesticide resistance is established.The pollution emission model is introduced to model the action process of pesticides,which well reflects its residual and delay effects.By using comparison theorem of impulsive differential equation and analysis method,the threshold condition for eradication of susceptible pests is obtained.Then we analyze the frequency of spraying pesticide on the success of pests control.It shows that it is not that the more frequently pesticides are applied,the better the result of the susceptible pests control is.From the sensitivity analysis,the key factors on the threshold are obtained.Finally,the strategies to control susceptible pests are given,including switching pesticides and releasing infected pests and natural enemies elastically.展开更多
The ice resistance on a ship hull affects the safety of the hull structure and the ship maneuvering performance in icecovered regions.In this paper,the discrete element method(DEM)is adopted to simulate the interactio...The ice resistance on a ship hull affects the safety of the hull structure and the ship maneuvering performance in icecovered regions.In this paper,the discrete element method(DEM)is adopted to simulate the interaction between level ice and ship hull.The level ice is modeled with 3D bonded spherical elements considering the buoyancy and drag force of the water.The parallel bonding approach and the de-bonding criterion are adopted to model the freezing and breakage of level ice.The ship hull is constructed with rigid triangle elements.To improve computational efficiency,the GPU-based parallel computational algorithm was developed for the DEM simulations.During the interaction between the ship hull and level ice,the ice cover is broken into small blocks when the interparticle stress approaches the bonding strength.The global ice resistance on the hull is calculated through the contacts between ice elements and hull elements during the navigation process.The influences of the ice thickness and navigation speed on the dynamic ice force are analyzed considering the breakage mechanism of ice cover.The Lindqvist and Riska formulas for the determination of ice resistance on ship hull are employed to validate the DEM simulation.The comparison of results of DEM,Lindqvist,and Riska formula show that the DEM result is between those the Lindqvist formula and Riska formula.Therefore the proposed DEM is an effective approach to determine the ice resistance on the ship hull.This work can be aided in the hull structure design and the navigation operation in ice-covered fields.展开更多
A cell is a house to myriad biochemical reactions composed in a symphony of various pathways,both survival and apoptotic.Apoptosis is of fundamental significance to an organ by replacing weary and senile cells with ju...A cell is a house to myriad biochemical reactions composed in a symphony of various pathways,both survival and apoptotic.Apoptosis is of fundamental significance to an organ by replacing weary and senile cells with juvenile cells.展开更多
In the aftermath of the global financial crisis of 2008, China witnessed gradual shrinkage of cities in the Pearl River Delta(PRD). In this study, we introduce the concept of economic resilience to analyse urban growt...In the aftermath of the global financial crisis of 2008, China witnessed gradual shrinkage of cities in the Pearl River Delta(PRD). In this study, we introduce the concept of economic resilience to analyse urban growth and shrinkage in the context of a rapidly-urbanising region. Multiple regression analysis is performed to explore the determinants of economic resilience in the PRD. By measuring resistance in the shrinking phase and recoverability in the growing phase in a group of cities in the PRD, this study distinguishes four scenarios and investigates their characteristics from a spatial perspective. The results demonstrate that the financial crisis had a severe and asymmetric influence on this area, indicating more than 15% of cities are faced with shrinking. The spatial distribution of economic resilience indicates a centre-periphery pattern, that is, high economic resilience in the inner ring and low economic resilience in the outer ring of the PRD. The service economy is found to play a significant role in promoting urban economic resilience. Results imply that sound economic policies for enhancing resilience: both poor local financial status and a high degree of export concentration adversely impact resistance, while upgrading the manufacturing economy and stimulating of industrial innovation are conducive to improve recoverability.展开更多
文摘Background: Antifungal resistance (AFR) is a global public health problem with devastating effects, especially among immunocompromised individuals. Addressing AFR requires a One Health approach including Antifungal Stewardship (AFS). This study aimed to comprehensively review global studies published on fungal infections and AFR and to recommend solutions to address this growing problem. Materials and Methods: This was a narrative review that was conducted using published papers on fungal infections, AFR, and AFS between January 1961 and March 2024. The literature was searched using PubMed, Google Scholar, Web of Science, and EMBASE. Results: This found that there has been an increase in fungal infections globally, especially among immunocompromised patients. Due to this increase in fungal infections, there has been a proportionate increase in the use of antifungal agents to prevent and treat fungal infections. This increased use of antifungal agents has worsened the problem of AFR contributing to increased morbidity and mortality. Globally, fungal infections have contributed to 150 million infections annually and 1.7 million deaths per year. By the year 2023, over 3.8 million people died from fungal infections. Addressing AFR remains a challenge because the treatment of antifungal-resistant infections is difficult. Finally, the treatment of fungal infections is a global challenge exacerbated by the limited number of antifungal agents to treat invasive fungal infections. Conclusion: The results of this study indicated that fungal infections and AFR are prevalent across humans, animals, agriculture, and the environment. Addressing this problem requires the provision of solutions such as improving the awareness of AFR, conducting further research on the discovery of new antifungal agents, and implementing AFS programs. If this global problem is not addressed, the morbidity and mortality associated with AFR will continue to rise in the future.
文摘Background:Antimicrobial resistance(AMR)is one of the top ten global public health challenges.However,given the lack of a comprehensive assessment of worldwide AMR status,our objective is to develop a One Health-based system-wide evaluation tool on global AMR.Methods:We have further developed the three-hierarchical Global One Health Index(GOHI)-AMR indicator scheme,which consists of five key indicators,17 indicators,and 49 sub-indicators,by incorporating 146 countries'data from diverse authoritative databases,including WHO's Global Antimicrobial Resistance and Use Surveillance System(GLASS)and the European CDC.We investigated the overall-or sub-rankings of GOHI-AMR at the international/regional/national levels for data preprocessing and score calculation utilizing the existing GOHI methodology.Additionally,a correlation analysis was conducted between the GOHI-AMR and other socioeconomic factors.Results:The average GOHI-AMR score for 146 countries is 38.45.As expected,high-income countries(HICs)outperform the other three income groups on overall rankings and all five key indicators of GOHI-AMR,whereas lowincome countries unexpectedly outperform upper-middle-income countries and lower-middle-income countries on the antibiotics-resistant key indicator(ARR)and ARR-subordinate indicators,including carbapenem-,β-lactam-,and quinolone resistance,and even HICs on aminoglycoside resistance.There were no significant differences among the four groups on the environmental-monitoring indicator(P>0.05).GOHI-AMR was positively correlated with gross domestic product,life expectancy,and AMR-related publications,but negatively with natural growth rate and chronic respiratory disease.In contrast to Cyprus,the remarkably lower prevalence of"ESKAPE pathogens"in high-scoring Sweden and Denmark highlights Europe's huge gaps.China and Russia outperformed the other three BRICS countries on all key indicators,particularly India's ARR and Brazil's AMR laboratory network and coordination capacity.Furthermore,significant internal disparitie
文摘Ongoing climate change is a major threat to biodiversity. However, although many species clearly suffer from ongoing climate change, others benefit from it, for exam- ple, by showing range expansions. However, which specific features determine a species＇ vulnerability to climate change？ Phenotypic plasticity, which has been described as the first line of defence against environmental change, may be of utmost importance here. Against this background, we here compare plasticity in stress tolerance in 3 copper butter- fly species, which differ arguably in their vulnerability to climate change. Specifically, we investigated heat, cold and desiccation resistance after acclimatization to different temper- atures in the adult stage. We demonstrate that acclimation at a higher temperature increased heat but decreased cold tolerance and desiccation resistance. Contrary to our predictions, species did not show pronounced variation in stress resistance, though plastic capacities in temperature stress resistance did vary across species. Overall, our results seemed to reflect population--rather than species-specific patterns. We conclude that the geographical ori- gin of the populations used should be considered even in comparative studies. However, our results suggest that, in the 3 species studied here, vulnerability to climate change is not in the first place determined by stress resistance in the adult stage. As entomological studies focus all too often on adults only, we argue that more research effort should be dedicated to other developmental stages when trying to understand insect responses to environmental change.
文摘Based on the new large de formation theory of Stokes-Chen Strain-Rotation Decomposition Theorem and study on shear-tensile deformation of bolts (Chen Zhida, 1979), a new method of determining bolt’s large de formation based on the measurement or displacement has been prerented. Theoretical formulas of global resistance on bolted joints under shear-tensile load have also been proposed. The validity of the theory has ben conflrmed by experimental results iu lab.
基金This work was supported by the National Natural Science Foundation of China(11371030)the Natural Science Foundation of Liaoning Province(20170540001)。
文摘In this paper,epidemnic diseases among pests are assumed to occur,so pests are divided into susceptible pests and infected pests,and only susceptible pests are harmful to crops.Considering spraying pesticides and releasing of natural enermies and infected pests to control pests,as well as the long-term application of the same pesticide to induce resistance,an integrated pest management with pesticide resistance is established.The pollution emission model is introduced to model the action process of pesticides,which well reflects its residual and delay effects.By using comparison theorem of impulsive differential equation and analysis method,the threshold condition for eradication of susceptible pests is obtained.Then we analyze the frequency of spraying pesticide on the success of pests control.It shows that it is not that the more frequently pesticides are applied,the better the result of the susceptible pests control is.From the sensitivity analysis,the key factors on the threshold are obtained.Finally,the strategies to control susceptible pests are given,including switching pesticides and releasing infected pests and natural enemies elastically.
基金This study is financially supported by the National Key Research and Development Program of China(Grant Nos.2017YFE0111400 and 2016YCF1401505)the National Natural Science Foundation of China(Grant Nos.41576179 and 51639004)the China Postdoctoral Science Foundation(Grant No.2020M670746).
文摘The ice resistance on a ship hull affects the safety of the hull structure and the ship maneuvering performance in icecovered regions.In this paper,the discrete element method(DEM)is adopted to simulate the interaction between level ice and ship hull.The level ice is modeled with 3D bonded spherical elements considering the buoyancy and drag force of the water.The parallel bonding approach and the de-bonding criterion are adopted to model the freezing and breakage of level ice.The ship hull is constructed with rigid triangle elements.To improve computational efficiency,the GPU-based parallel computational algorithm was developed for the DEM simulations.During the interaction between the ship hull and level ice,the ice cover is broken into small blocks when the interparticle stress approaches the bonding strength.The global ice resistance on the hull is calculated through the contacts between ice elements and hull elements during the navigation process.The influences of the ice thickness and navigation speed on the dynamic ice force are analyzed considering the breakage mechanism of ice cover.The Lindqvist and Riska formulas for the determination of ice resistance on ship hull are employed to validate the DEM simulation.The comparison of results of DEM,Lindqvist,and Riska formula show that the DEM result is between those the Lindqvist formula and Riska formula.Therefore the proposed DEM is an effective approach to determine the ice resistance on the ship hull.This work can be aided in the hull structure design and the navigation operation in ice-covered fields.
文摘A cell is a house to myriad biochemical reactions composed in a symphony of various pathways,both survival and apoptotic.Apoptosis is of fundamental significance to an organ by replacing weary and senile cells with juvenile cells.
基金National Natural Science Foundation of China,No.41801122GDAS’ Special Project of Science and Technology Development,No.2016GDASRC-0101,No.2018GDASCX-0901
文摘In the aftermath of the global financial crisis of 2008, China witnessed gradual shrinkage of cities in the Pearl River Delta(PRD). In this study, we introduce the concept of economic resilience to analyse urban growth and shrinkage in the context of a rapidly-urbanising region. Multiple regression analysis is performed to explore the determinants of economic resilience in the PRD. By measuring resistance in the shrinking phase and recoverability in the growing phase in a group of cities in the PRD, this study distinguishes four scenarios and investigates their characteristics from a spatial perspective. The results demonstrate that the financial crisis had a severe and asymmetric influence on this area, indicating more than 15% of cities are faced with shrinking. The spatial distribution of economic resilience indicates a centre-periphery pattern, that is, high economic resilience in the inner ring and low economic resilience in the outer ring of the PRD. The service economy is found to play a significant role in promoting urban economic resilience. Results imply that sound economic policies for enhancing resilience: both poor local financial status and a high degree of export concentration adversely impact resistance, while upgrading the manufacturing economy and stimulating of industrial innovation are conducive to improve recoverability.
