BACKGROUND Depression affects more than 350 million people worldwide.In China,4.2%(54 million people)of the total population suffers from depression.Psychotherapy has been shown to change cognition,improve personality...BACKGROUND Depression affects more than 350 million people worldwide.In China,4.2%(54 million people)of the total population suffers from depression.Psychotherapy has been shown to change cognition,improve personality,and enhance the ability to cope with difficulties and setbacks.While pharmacotherapy can reduce symptoms,it is also associated with adverse reactions and relapse after drug withdrawal.Therefore,there has been an increasing emphasis placed on the use of non-pharmacological therapies for depression.The hypothesis of this study was that acupuncture at ghost points combined with fluoxetine would be more effective than fluoxetine alone for the treatment of depression.AIM To investigate the efficacy of acupuncture at ghost points combined with fluoxetine for the treatment of patients with depression.METHODS This randomized controlled trial included patients with mild to moderate depression(n=160).Patients received either acupuncture at ghost points combined with fluoxetine(n=80)or fluoxetine alone(control group,n=80).Needles were retained in place for 30 min,5 times a week;three treatment cycles were administered.The Mann–Whitney U test was used to compare functional magnet resonance imaging parameters,Hamilton depression rating scale(HAMD)scores,and self-rating depression scale(SDS)scores between the acupuncture group and control group.RESULTS There were no significant differences in HAMD or SDS scores between the acupuncture group and control group,before or after 4 wk of treatment.The acupuncture group exhibited significantly lower HAMD and SDS scores than the control group after 8 wk of treatment(P<0.05).The acupuncture group had significantly lower fractional Amplitude of Low Frequency Fluctuations values for the left anterior wedge leaf,left posterior cingulate gyrus,left middle occipital gyrus,and left inferior occipital gyrus after 8 wk.The acupuncture group also had significantly higher values for the right inferior frontal gyrus,right insula,and right hippocampus(P<0.05).After 8 wk of treatmen展开更多
针对一维带有不连续系数和奇异源项的椭圆型方程,采用匹配界面和边界(MIB,matched interface and boundary)方法进行求解.该方法对微分方程和跳跃条件的离散是分别进行的,通过在界面附近构造虚拟点达到提高差分格式整体精度的目的,文中...针对一维带有不连续系数和奇异源项的椭圆型方程,采用匹配界面和边界(MIB,matched interface and boundary)方法进行求解.该方法对微分方程和跳跃条件的离散是分别进行的,通过在界面附近构造虚拟点达到提高差分格式整体精度的目的,文中对Neumann边界也给出了处理办法.通过数值算例对文中构造的差分方法进行了验证,并与文献中的浸入界面方法进行了对比,数值结果证明了方法的有效性和可行性.展开更多
基金Supported by Shanghai Science and Technology Commission TCM Guidance Project,No.19401935500Shanghai University of Traditional Chinese Medicine Budget Scientific Research Project,No.2020LK079Medical Innovation Research Special General Project of Shanghai Science and Technology Commission,No.21Y11923500.
文摘BACKGROUND Depression affects more than 350 million people worldwide.In China,4.2%(54 million people)of the total population suffers from depression.Psychotherapy has been shown to change cognition,improve personality,and enhance the ability to cope with difficulties and setbacks.While pharmacotherapy can reduce symptoms,it is also associated with adverse reactions and relapse after drug withdrawal.Therefore,there has been an increasing emphasis placed on the use of non-pharmacological therapies for depression.The hypothesis of this study was that acupuncture at ghost points combined with fluoxetine would be more effective than fluoxetine alone for the treatment of depression.AIM To investigate the efficacy of acupuncture at ghost points combined with fluoxetine for the treatment of patients with depression.METHODS This randomized controlled trial included patients with mild to moderate depression(n=160).Patients received either acupuncture at ghost points combined with fluoxetine(n=80)or fluoxetine alone(control group,n=80).Needles were retained in place for 30 min,5 times a week;three treatment cycles were administered.The Mann–Whitney U test was used to compare functional magnet resonance imaging parameters,Hamilton depression rating scale(HAMD)scores,and self-rating depression scale(SDS)scores between the acupuncture group and control group.RESULTS There were no significant differences in HAMD or SDS scores between the acupuncture group and control group,before or after 4 wk of treatment.The acupuncture group exhibited significantly lower HAMD and SDS scores than the control group after 8 wk of treatment(P<0.05).The acupuncture group had significantly lower fractional Amplitude of Low Frequency Fluctuations values for the left anterior wedge leaf,left posterior cingulate gyrus,left middle occipital gyrus,and left inferior occipital gyrus after 8 wk.The acupuncture group also had significantly higher values for the right inferior frontal gyrus,right insula,and right hippocampus(P<0.05).After 8 wk of treatmen
文摘针对一维带有不连续系数和奇异源项的椭圆型方程,采用匹配界面和边界(MIB,matched interface and boundary)方法进行求解.该方法对微分方程和跳跃条件的离散是分别进行的,通过在界面附近构造虚拟点达到提高差分格式整体精度的目的,文中对Neumann边界也给出了处理办法.通过数值算例对文中构造的差分方法进行了验证,并与文献中的浸入界面方法进行了对比,数值结果证明了方法的有效性和可行性.
