报道了采集自福建食用菌场的食用菌双翅目害虫共3亚目10科27种,并编制了其分科检索表.平菇厉眼蕈蚊(Lycoriella pleuroti Yang et Zhang)、沪菇迟眼蕈蚊(Bradysia hupleuroti Yang,Zhang et Tan)、黑腹果蝇(Drosophila melanogaster Mei...报道了采集自福建食用菌场的食用菌双翅目害虫共3亚目10科27种,并编制了其分科检索表.平菇厉眼蕈蚊(Lycoriella pleuroti Yang et Zhang)、沪菇迟眼蕈蚊(Bradysia hupleuroti Yang,Zhang et Tan)、黑腹果蝇(Drosophila melanogaster Meigen)、菇蛾蠓(Psychoda sp.)、东亚异蚤蝇(Megaselia spiracularis Schmitz)、真菌瘿蚊(Mycophila fungicola Felt)和广粪蚊[Cobolidia fuscipes(Meigen)]为常见种,并对其发生为害特点进行了描述.背黑狭胸步甲[Stenolophus connotatus(Bates)]和彩纹猎蝽[Euagoras plagiatus(Burmeister)]是眼蕈蚊的捕食性天敌.根据食用菌害虫的为害特点,探讨了防治对策.展开更多
Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in y-secretase component genes.We and other researchers showed that nicastrin (NCSTN) ...Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in y-secretase component genes.We and other researchers showed that nicastrin (NCSTN) is the most frequently mutated gene in familial AI.In this study,we generated a keratin 5-Cre-driven epidermis-specific Ncstn conditional knockout mutant in mice.We determined that this mutant recapitulated the major phenotypes of AI,including hyperkeratosis of hair follicles and inflammation.In Ncstnflox/flox;K5-Cre mice,the IL-36a expression level markedly increased starting from postnatal day 0 (P0),and this increase occurred much earlier than those of TNF-α,IL-23A,IL-1 3,and TLR4.RNA-Seq analysis indicated that Sprr2d,a member of the small proline-rich protein 2 family,in the skin tissues of the Ncstnflox/flox,;K5-Cre mice was also upregulated on P0.Quantitative reverse-transcription polymerase chain reaction showed that other Sprr2 genes had a similar expression pattern.Our findings suggested that IL-36a might be a key inflammatory cytokine in the pathophysiology of AI and implicate malfunction of the skin barrier in the pathogenesis of AI.展开更多
The Decision of CPC Central Committee and the State Council on Full Implementation of the Universal Two-child policy and Innovation and Improvement of Family Planning Service Management（Hereinafterreferred to as the ...The Decision of CPC Central Committee and the State Council on Full Implementation of the Universal Two-child policy and Innovation and Improvement of Family Planning Service Management（Hereinafterreferred to as the Decision）was announced on January 5,2016.China will implement a birth registration service system.展开更多
基金This work was financially supported by the National Key Research and Development Program of China(No.2016Y FC0905100)the CAMS Innovation Fund for Medical Sciences(No.2016-I2M-1-002)+3 种基金the National Natural Science Foundation of China(NSFCNos.81788101 and 81230015)the Beijing Municipal Science and Technology Commission(No.Z151100003915078)for Xue Zhangby the National NSFC(No.31271345)for Yaping Liu.
文摘Familial acne inversa (AI) is an autoinflammatory disorder that affects hair follicles and is caused by loss-of-function mutations in y-secretase component genes.We and other researchers showed that nicastrin (NCSTN) is the most frequently mutated gene in familial AI.In this study,we generated a keratin 5-Cre-driven epidermis-specific Ncstn conditional knockout mutant in mice.We determined that this mutant recapitulated the major phenotypes of AI,including hyperkeratosis of hair follicles and inflammation.In Ncstnflox/flox;K5-Cre mice,the IL-36a expression level markedly increased starting from postnatal day 0 (P0),and this increase occurred much earlier than those of TNF-α,IL-23A,IL-1 3,and TLR4.RNA-Seq analysis indicated that Sprr2d,a member of the small proline-rich protein 2 family,in the skin tissues of the Ncstnflox/flox,;K5-Cre mice was also upregulated on P0.Quantitative reverse-transcription polymerase chain reaction showed that other Sprr2 genes had a similar expression pattern.Our findings suggested that IL-36a might be a key inflammatory cytokine in the pathophysiology of AI and implicate malfunction of the skin barrier in the pathogenesis of AI.
文摘The Decision of CPC Central Committee and the State Council on Full Implementation of the Universal Two-child policy and Innovation and Improvement of Family Planning Service Management（Hereinafterreferred to as the Decision）was announced on January 5,2016.China will implement a birth registration service system.
