目的:探讨18F-FDG-PET/CT显像在初诊结外NK/T细胞淋巴瘤(ENKTL)中的应用价值。方法:回顾性分析43例初诊ENKTL患者的PET/CT及CT资料,比较两种影像方法对病灶位置、病变范围、分型、分期及治疗方案的影响,分析18F-FDG最大标准摄取值(SUVm...目的:探讨18F-FDG-PET/CT显像在初诊结外NK/T细胞淋巴瘤(ENKTL)中的应用价值。方法:回顾性分析43例初诊ENKTL患者的PET/CT及CT资料,比较两种影像方法对病灶位置、病变范围、分型、分期及治疗方案的影响,分析18F-FDG最大标准摄取值(SUVmax)与分型、分期及全身症状的关系。结果:病变部位处于前4位的分别为鼻(76.74%)、鼻咽部(41.86%)、咽淋巴环(30.23%)及副鼻窦(27.91%),有4例患者上呼吸消化道部位未发现18F-FD G摄取;PET/C T分期与全身症状关系有显著相关性(P<0.01);43例患者S U Vm ax为13.65±6.35,比较早期(Ⅰ/Ⅱ期)与进展期(Ⅲ/Ⅳ期)、Ⅰ期局限型与超腔型、是否合并全身症状等患者的S U Vm ax值差异有统计学意义;PET/CT分期与传统CT相比有21例不同,其中14例对制定治疗方案有影响;8例CT判断为早期,而PET/CT更改为进展期,21例早期病例中有6例如果应用PET/CT,则应更改放疗方案。结论:PET/CT能更准确显示ENKTL的病灶位置及范围,较传统CT分期方法更准确可靠,对治疗方案制定有较大的指导价值,值得临床推广应用。展开更多
As the chemotherapeutic resistance of extranodal NK/T-cell lymphoma(ENKTL) rises year by year, searching for novel chemoprevention compounds has become imminent. Gambogic acid(GA) has recently been shown to have anti-...As the chemotherapeutic resistance of extranodal NK/T-cell lymphoma(ENKTL) rises year by year, searching for novel chemoprevention compounds has become imminent. Gambogic acid(GA) has recently been shown to have anti-tumor effects, but its role and underling mechanism in ENKTL are rather elusive. In the present study, we showed that GA inhibited the cell growth and potently induced the apoptosis of ENKTL cells in vitro in a time-and concentration-dependent manner. Furthermore, GA induced cell death through endoplasmic reticulum stress(ERS) mediated suppression of Akt signaling pathways and finally the release of the caspase-3 proteases. Overall, our data provided evidences supporting GA as a potential therapeutic agent for ENKTL, which may facilitate further preclinical development of anti-tumor drugs.展开更多
文摘目的:探讨18F-FDG-PET/CT显像在初诊结外NK/T细胞淋巴瘤(ENKTL)中的应用价值。方法:回顾性分析43例初诊ENKTL患者的PET/CT及CT资料,比较两种影像方法对病灶位置、病变范围、分型、分期及治疗方案的影响,分析18F-FDG最大标准摄取值(SUVmax)与分型、分期及全身症状的关系。结果:病变部位处于前4位的分别为鼻(76.74%)、鼻咽部(41.86%)、咽淋巴环(30.23%)及副鼻窦(27.91%),有4例患者上呼吸消化道部位未发现18F-FD G摄取;PET/C T分期与全身症状关系有显著相关性(P<0.01);43例患者S U Vm ax为13.65±6.35,比较早期(Ⅰ/Ⅱ期)与进展期(Ⅲ/Ⅳ期)、Ⅰ期局限型与超腔型、是否合并全身症状等患者的S U Vm ax值差异有统计学意义;PET/CT分期与传统CT相比有21例不同,其中14例对制定治疗方案有影响;8例CT判断为早期,而PET/CT更改为进展期,21例早期病例中有6例如果应用PET/CT,则应更改放疗方案。结论:PET/CT能更准确显示ENKTL的病灶位置及范围,较传统CT分期方法更准确可靠,对治疗方案制定有较大的指导价值,值得临床推广应用。
基金supported by the National Natural Science Foundation of China(Nos.81502588 and 81370673)Agency of Jiangsu Province Science and Technology(Nos.2013035 and BK20151018)+2 种基金the Key Medical subjects of Jiangsu Province(No.BL2014078)Research Office of Jiangsu Cancer Hospital(No.ZK201401)the Key Discipline of Jiangsu Province(2016-2020)
文摘As the chemotherapeutic resistance of extranodal NK/T-cell lymphoma(ENKTL) rises year by year, searching for novel chemoprevention compounds has become imminent. Gambogic acid(GA) has recently been shown to have anti-tumor effects, but its role and underling mechanism in ENKTL are rather elusive. In the present study, we showed that GA inhibited the cell growth and potently induced the apoptosis of ENKTL cells in vitro in a time-and concentration-dependent manner. Furthermore, GA induced cell death through endoplasmic reticulum stress(ERS) mediated suppression of Akt signaling pathways and finally the release of the caspase-3 proteases. Overall, our data provided evidences supporting GA as a potential therapeutic agent for ENKTL, which may facilitate further preclinical development of anti-tumor drugs.
