The insulin sensitivity in hypertensive patients with normal glucose tolerance(NGT) , impaired glucose tolerance (IGT) and type 2 diabetes m ellitus (DM) and the insulin resistance (IR) under the disorder of glucose...The insulin sensitivity in hypertensive patients with normal glucose tolerance(NGT) , impaired glucose tolerance (IGT) and type 2 diabetes m ellitus (DM) and the insulin resistance (IR) under the disorder of glucose metabolism and hypertension were studied. By glucose toler- ance test and insulin release test,insulin sensitivity index (ISI) and the ratio of area under glucose tolerance curve(AUCG) to area under insulin release curve(AU CI) were calculated and analyzed. The results showed that ISI was decreased to varying degrees in the patients with hypertension, the m ildest in the group of NGT with hypertension,followed by the group of IGT without hyper- tension,the group of IGT with hypertension and DM(P=0 ) .There was very significant differ- ence in the ratio of AUCG/ AUCI between the hypertensive patients with NGT and controls (P= 0 ) .It was concluded that a significant IR existed during the development of IGT both in hyperten- sion and nonhypertension.The increase of total insulin secretion (AUCI) was associated with non- hypertension sim ultaneously.IR of the hypertensive patients even existed in NGT and was wors- ened with the deterioration of glucose metabolism disorder,but the AUCI in the HT group changed slightly.A relative deficiency of insulin secretion or dysfunction ofβ- cell of isletexisted in IGT and DM of the hypertensive patients.展开更多
文摘The insulin sensitivity in hypertensive patients with normal glucose tolerance(NGT) , impaired glucose tolerance (IGT) and type 2 diabetes m ellitus (DM) and the insulin resistance (IR) under the disorder of glucose metabolism and hypertension were studied. By glucose toler- ance test and insulin release test,insulin sensitivity index (ISI) and the ratio of area under glucose tolerance curve(AUCG) to area under insulin release curve(AU CI) were calculated and analyzed. The results showed that ISI was decreased to varying degrees in the patients with hypertension, the m ildest in the group of NGT with hypertension,followed by the group of IGT without hyper- tension,the group of IGT with hypertension and DM(P=0 ) .There was very significant differ- ence in the ratio of AUCG/ AUCI between the hypertensive patients with NGT and controls (P= 0 ) .It was concluded that a significant IR existed during the development of IGT both in hyperten- sion and nonhypertension.The increase of total insulin secretion (AUCI) was associated with non- hypertension sim ultaneously.IR of the hypertensive patients even existed in NGT and was wors- ened with the deterioration of glucose metabolism disorder,but the AUCI in the HT group changed slightly.A relative deficiency of insulin secretion or dysfunction ofβ- cell of isletexisted in IGT and DM of the hypertensive patients.
