Objective： To investigate the relationship of insulin resistance and the polymorphisms of insulin receptor-related genes in essential hypertension patients of two different kinds of TCM constitution. Methods： Oral g...Objective： To investigate the relationship of insulin resistance and the polymorphisms of insulin receptor-related genes in essential hypertension patients of two different kinds of TCM constitution. Methods： Oral glucose tolerance test （OGTT） and insulin release test （InRT） were conducted in 217 essential hypertensive patients of either sluggish meticulous （SM） constitution （139 cases） or prosperous impetuous （PI） constitution （78 cases）, and the polymorphism of three genes, including insulin-like growth factor-1 receptor （IGF-1R）, insulin receptor substrate-1 （IRS-1） and 2 （IRS-2） genes were detected. Results： （1） OGTT, InRT and insulin resistance index （Homa-IR） were higher and insulin sensitive index （ISI） was lower in the patients of SM constitution than those in patients of PI constitution. （2） Significant difference of ISI and Homa-IR was shown in patients of both constitutions with genotype G of the 3 genes. Conclusion： Decrease of insulin sensitivity and increase of insulin resistance are more obvious in hypertensive patients with genotype G of the 3 genes of SM constitution than in those of PI constitution. Therefore, the difference in constitution might be one of the genetic characteristics for insulin resistance in hypertensive patients.展开更多
目的探讨60岁及以上老年人中医体质及体质指数(body mass index,BMI)与高血压之间的关系。方法整群抽样的方法抽取2018年1—6月在某社区卫生服务中心建档管理的60岁及以上老年人,用标准中医体质判定量表进行中医体质测评,测量身高体重计...目的探讨60岁及以上老年人中医体质及体质指数(body mass index,BMI)与高血压之间的关系。方法整群抽样的方法抽取2018年1—6月在某社区卫生服务中心建档管理的60岁及以上老年人,用标准中医体质判定量表进行中医体质测评,测量身高体重计算BMI,同时收集调查对象的基本信息,采用描述性统计、χ^2检验和多因素logistic回归等进行分析研究。结果共纳入2757名调查对象,平均年龄(72.21±7.41)岁,男性占45.77%,高血压患病率为59.09%。单因素分析显示,年龄、吸烟、饮酒、锻炼、BMI及中医体质均为高血压的影响因素。随着年龄增大,高血压患病率有升高趋势(χ^2=23.36,P<0.001);BMI越大,高血压的患病率越高(χ^2=58.62,P<0.001);不同中医体质的人群高血压患病率有差异(P<0.001),其中痰湿质(70.45%)、阳虚质(65.38%)和阴虚质(64.64%)人群的高血压患病率位列前三。多因素logistic回归示,年龄越大患高血压的危险越大,80岁~人群高血压患病率高于60岁~人群(OR=1.88,95%CI:1.48~2.38);超重(OR=1.41,95%CI:1.17~1.69)、肥胖(OR=1.59,95%CI:1.17~2.16)、痰湿质(OR=1.77,95%CI:1.45~2.16)、阳虚质(OR=1.60,95%CI:1.12~2.29)、阴虚质(OR=1.50,1.08~2.09)是高血压的危险因素。结论BMI升高是高血压的危险因素,痰湿质、阳虚质、阴虚质是高血压的易发体质,应针对此类体质的老年人开展针对性的健康宣教。展开更多
文摘Objective： To investigate the relationship of insulin resistance and the polymorphisms of insulin receptor-related genes in essential hypertension patients of two different kinds of TCM constitution. Methods： Oral glucose tolerance test （OGTT） and insulin release test （InRT） were conducted in 217 essential hypertensive patients of either sluggish meticulous （SM） constitution （139 cases） or prosperous impetuous （PI） constitution （78 cases）, and the polymorphism of three genes, including insulin-like growth factor-1 receptor （IGF-1R）, insulin receptor substrate-1 （IRS-1） and 2 （IRS-2） genes were detected. Results： （1） OGTT, InRT and insulin resistance index （Homa-IR） were higher and insulin sensitive index （ISI） was lower in the patients of SM constitution than those in patients of PI constitution. （2） Significant difference of ISI and Homa-IR was shown in patients of both constitutions with genotype G of the 3 genes. Conclusion： Decrease of insulin sensitivity and increase of insulin resistance are more obvious in hypertensive patients with genotype G of the 3 genes of SM constitution than in those of PI constitution. Therefore, the difference in constitution might be one of the genetic characteristics for insulin resistance in hypertensive patients.
文摘目的探讨60岁及以上老年人中医体质及体质指数(body mass index,BMI)与高血压之间的关系。方法整群抽样的方法抽取2018年1—6月在某社区卫生服务中心建档管理的60岁及以上老年人,用标准中医体质判定量表进行中医体质测评,测量身高体重计算BMI,同时收集调查对象的基本信息,采用描述性统计、χ^2检验和多因素logistic回归等进行分析研究。结果共纳入2757名调查对象,平均年龄(72.21±7.41)岁,男性占45.77%,高血压患病率为59.09%。单因素分析显示,年龄、吸烟、饮酒、锻炼、BMI及中医体质均为高血压的影响因素。随着年龄增大,高血压患病率有升高趋势(χ^2=23.36,P<0.001);BMI越大,高血压的患病率越高(χ^2=58.62,P<0.001);不同中医体质的人群高血压患病率有差异(P<0.001),其中痰湿质(70.45%)、阳虚质(65.38%)和阴虚质(64.64%)人群的高血压患病率位列前三。多因素logistic回归示,年龄越大患高血压的危险越大,80岁~人群高血压患病率高于60岁~人群(OR=1.88,95%CI:1.48~2.38);超重(OR=1.41,95%CI:1.17~1.69)、肥胖(OR=1.59,95%CI:1.17~2.16)、痰湿质(OR=1.77,95%CI:1.45~2.16)、阳虚质(OR=1.60,95%CI:1.12~2.29)、阴虚质(OR=1.50,1.08~2.09)是高血压的危险因素。结论BMI升高是高血压的危险因素,痰湿质、阳虚质、阴虚质是高血压的易发体质,应针对此类体质的老年人开展针对性的健康宣教。
