ABA triblock copolymers were synthesized by dihydroxyl-capped PEO initiated enzymatic ring-opening polymerization (eROP) of ε-CL in the presence of biocatalyst Novozyme 435. The chains ended with hydroxyl of ...ABA triblock copolymers were synthesized by dihydroxyl-capped PEO initiated enzymatic ring-opening polymerization (eROP) of ε-CL in the presence of biocatalyst Novozyme 435. The chains ended with hydroxyl of block copolymers were modified by the esterification of 2,2-dichloro acetyl chloride (DCAC) to obtain the tetrafunctional macroinitiator, which was used in the ATRP of 4-vinylpyridine (4-VP). CuCl/HMTETA was used as the catalyst system in the ATRP of 4-VP to acquire the H-shaped block copolymers (PVP)<sub>2</sub>-b-PCL-b-PEG-b-PCL-b-(PVP)<sub>2</sub>. The H-shaped block copolymers were characterized by FTIR, NMR, and GPC. Copolymers with high molecular weights (M <sub>n</sub> = 46121 g/mol) and low polydispersities (M <sub>w</sub>/M <sub>n</sub> = 1.30) were prepared. Moreover, the morphology of the copolymer was examined with dynamic light scattering (DLS) and atomic force microscopy (AFM). Spherical micelles with a diameter of 70 nm in aqueous solution were obtained.展开更多
采用新型化学酶法——开环易位聚合反应(ROMP)与酶促开环聚合反应(eROP)联用合成嵌段聚合物PCL-b-PB-b-PCL,用核磁共振氢谱(1 H NMR)、凝胶渗透色谱(GPC)和差示扫描量热法(DSC)表征产物的结构并进行性能测试.结果表明:GPC数据向高分子...采用新型化学酶法——开环易位聚合反应(ROMP)与酶促开环聚合反应(eROP)联用合成嵌段聚合物PCL-b-PB-b-PCL,用核磁共振氢谱(1 H NMR)、凝胶渗透色谱(GPC)和差示扫描量热法(DSC)表征产物的结构并进行性能测试.结果表明:GPC数据向高分子量移动,即成功合成了嵌段聚合物;嵌段聚合物可完全水解,且GPC数据向低分子量移动,表明该方法可行、有效.展开更多
文摘ABA triblock copolymers were synthesized by dihydroxyl-capped PEO initiated enzymatic ring-opening polymerization (eROP) of ε-CL in the presence of biocatalyst Novozyme 435. The chains ended with hydroxyl of block copolymers were modified by the esterification of 2,2-dichloro acetyl chloride (DCAC) to obtain the tetrafunctional macroinitiator, which was used in the ATRP of 4-vinylpyridine (4-VP). CuCl/HMTETA was used as the catalyst system in the ATRP of 4-VP to acquire the H-shaped block copolymers (PVP)<sub>2</sub>-b-PCL-b-PEG-b-PCL-b-(PVP)<sub>2</sub>. The H-shaped block copolymers were characterized by FTIR, NMR, and GPC. Copolymers with high molecular weights (M <sub>n</sub> = 46121 g/mol) and low polydispersities (M <sub>w</sub>/M <sub>n</sub> = 1.30) were prepared. Moreover, the morphology of the copolymer was examined with dynamic light scattering (DLS) and atomic force microscopy (AFM). Spherical micelles with a diameter of 70 nm in aqueous solution were obtained.
文摘采用新型化学酶法——开环易位聚合反应(ROMP)与酶促开环聚合反应(eROP)联用合成嵌段聚合物PCL-b-PB-b-PCL,用核磁共振氢谱(1 H NMR)、凝胶渗透色谱(GPC)和差示扫描量热法(DSC)表征产物的结构并进行性能测试.结果表明:GPC数据向高分子量移动,即成功合成了嵌段聚合物;嵌段聚合物可完全水解,且GPC数据向低分子量移动,表明该方法可行、有效.
