主要研究了扩展有限元法(extended finite element method,XFEM)在处理弱不连续问题时不同改进函数形式对XFEM数值求解精度的影响,阐述了各种改进函数影响XFEM求解精度的关键因素,指出校正的扩展有限元法(corrected-XFEM)能够提高数值...主要研究了扩展有限元法(extended finite element method,XFEM)在处理弱不连续问题时不同改进函数形式对XFEM数值求解精度的影响,阐述了各种改进函数影响XFEM求解精度的关键因素,指出校正的扩展有限元法(corrected-XFEM)能够提高数值求解精度的实质在于它拓展了改进结点域,即将常规扩展有限元法(standard-XFEM)的改进结点域增加一层作为corrected-XFEM的改进结点域,文中建议延拓corrected-XFEM的改进结点域,即在corrected-XFEM的改进结点域基础上再增加一层改进结点.利用水平集函数表征材料内部的不连续界面,推导了XFEM求解的支配方程,给出了一种改进单元的数值积分方案以及改进单元处高精度应力的求解方法.含夹杂问题的数值计算结果表明:建议的延拓corrected-XFEM改进结点域的方法能够明显提高XFEM的数值求解精度.展开更多
Previous studies have reported age-specific pathological and functional outcomes in young and aged patients suffering spinal cord injury,but the mechanisms remain poorly understood. In this study, we examined mice wit...Previous studies have reported age-specific pathological and functional outcomes in young and aged patients suffering spinal cord injury,but the mechanisms remain poorly understood. In this study, we examined mice with spinal cord injury. Gene expression profiles from the Gene Expression Omnibus database （accession number GSE93561） were used, including spinal cord samples from 3 young injured mice （2–3-months old, induced by Impactor at Th9 level） and 3 control mice （2–3-months old, no treatment）, as well as 2 aged injured mice （15–18-months old, induced by Impactor at Th9 level） and 2 control mice （15–18-months old, no treatment）. Differentially expressed genes （DEGs） in spinal cord tissue from injured and control mice were identified using the Linear Models for Microarray data method,with a threshold of adjusted P 〈 0.05 and ｜logFC（fold change）｜ 〉 1.5. Protein–protein interaction networks were constructed using data from the STRING database, followed by module analysis by Cytoscape software to screen crucial genes. Kyoto encyclopedia of genes and genomes pathway and Gene Ontology enrichment analyses were performed to investigate the underlying functions of DEGs using Database for Annotation, Visualization and Integrated Discovery. Consequently, 1,604 and 1,153 DEGs were identified between injured and normal control mice in spinal cord tissue of aged and young mice, respectively. Furthermore, a Venn diagram showed that 960 DEGs were shared among aged and young mice, while 644 and 193 DEGs were specific to aged and young mice, respectively. Functional enrichment indicates that shared DEGs are involved in osteoclast differentiation, extracellular matrix–receptor interaction, nuclear factor-kappa B signaling pathway, and focal adhesion. Unique genes for aged and young injured groups were involved in the cell cycle （upregulation of PLK1） and complement （upregulation of C3） activation, respectively. These findings were confirmed by functional analysis of genes i展开更多
Hot air sintering technology is used to improve the quality and production efficiency of sintered ore.However,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air si...Hot air sintering technology is used to improve the quality and production efficiency of sintered ore.However,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering layer.Therefore,it is considered to use oxygen enrichment sintering to improve the environment of hot air sintering.Traditional sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was clarified.Hot air reduced the vertical sintering velocity,while improved the yield and tumbler index.Oxygen-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production efficiency.Under the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was prolonged.After oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.展开更多
Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in...Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whether ts RNAs are involved in traumatic brain injury-induced secondary injury remains poorly understood. In this study, a mouse controlled cortical impact model of traumatic brain injury was established, and integrated ts RNA and messenger RNA(m RNA) transcriptome sequencing were used. The results revealed that 103 ts RNAs were differentially expressed in the mouse model of traumatic brain injury at 72 hours, of which 56 ts RNAs were upregulated and 47 ts RNAs were downregulated. Based on micro RNA-like seed matching and Pearson correlation analysis, 57 differentially expressed ts RNA-m RNA interaction pairs were identified, including 29 ts RNAs and 26 m RNAs. Moreover, Gene Ontology annotation of target genes revealed that the significantly enriched terms were primarily associated with inflammation and synaptic function. Collectively, our findings suggest that ts RNAs may be associated with traumatic brain injury-induced secondary brain injury, and are thus a potential therapeutic target for traumatic brain injury. The study was approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No. 20190411) on April 11, 2019.展开更多
【目的】研究乌鲁木齐市快速路侧绿化树种的重金属污染情况,并对不同树种的修复潜力进行评价,初步对城市快速路环境作出评估,为乌鲁木齐市城市快速路绿化树种健康管理和城市道路绿化方案的优化提供科学依据。【方法】植物样品采用HNO_(3...【目的】研究乌鲁木齐市快速路侧绿化树种的重金属污染情况,并对不同树种的修复潜力进行评价,初步对城市快速路环境作出评估,为乌鲁木齐市城市快速路绿化树种健康管理和城市道路绿化方案的优化提供科学依据。【方法】植物样品采用HNO_(3)-HClO_(4)(4∶1)消解法进行消解;土壤样品采用HF-HClO_(4)(1∶1)消解法进行消解。通过电感耦合等离子体发射光谱仪(ICP-OES)测定绿化树种各部位重金属(Pb、Zn、Cd、Cr、Cu、Ni)含量,并通过隶属函数法对研究区的富集能力进行综合评价。【结果】北美海棠(North American Begonia)、白榆(Ulmus pumila L.)、大叶白蜡(Fraxinus rhynchophylla)、新疆杨(Populus alba var.pyramidalis)4种绿化树种中Zn浓度最大,Cd浓度最小,重金属元素主要分布于树皮和根系,叶片中浓度较小。各部位富集系数总体表现为树皮>根系>树枝>叶片,其中大叶白蜡树皮和根系对Cu的富集系数分别为1.897、1.068,表现出高富集特点。北美海棠对Cr、Cu、Pb的转运系数均大于其余树种,白榆对Zn的转运能力最强,新疆杨对Cd的转运能力最强。北美海棠根际土壤污染程度最小,属于轻度污染,白榆和大叶白蜡根际土壤属于中度污染,新疆杨根际土壤属于重度污染。6种重金属均表现出不同程度的污染,含量均高于背景值,Cd污染最为严重。Pb和Cd变异系数较大,分别为11.44%和12.50%,表明其含量在整个研究区分布差异性较大。【结论】重金属元素在不同绿化树种中和同一绿化树种不同部位中分布均存在明显差异;北美海棠的综合富集能力最强,可作为研究区土壤重金属污染修复的首选树种;快速路侧土壤重金属整体上呈中度污染(P=2.20)。展开更多
文摘主要研究了扩展有限元法(extended finite element method,XFEM)在处理弱不连续问题时不同改进函数形式对XFEM数值求解精度的影响,阐述了各种改进函数影响XFEM求解精度的关键因素,指出校正的扩展有限元法(corrected-XFEM)能够提高数值求解精度的实质在于它拓展了改进结点域,即将常规扩展有限元法(standard-XFEM)的改进结点域增加一层作为corrected-XFEM的改进结点域,文中建议延拓corrected-XFEM的改进结点域,即在corrected-XFEM的改进结点域基础上再增加一层改进结点.利用水平集函数表征材料内部的不连续界面,推导了XFEM求解的支配方程,给出了一种改进单元的数值积分方案以及改进单元处高精度应力的求解方法.含夹杂问题的数值计算结果表明:建议的延拓corrected-XFEM改进结点域的方法能够明显提高XFEM的数值求解精度.
基金supported by the National Science Fund for Distinguished Young Scientists of China,No.81601052
文摘Previous studies have reported age-specific pathological and functional outcomes in young and aged patients suffering spinal cord injury,but the mechanisms remain poorly understood. In this study, we examined mice with spinal cord injury. Gene expression profiles from the Gene Expression Omnibus database （accession number GSE93561） were used, including spinal cord samples from 3 young injured mice （2–3-months old, induced by Impactor at Th9 level） and 3 control mice （2–3-months old, no treatment）, as well as 2 aged injured mice （15–18-months old, induced by Impactor at Th9 level） and 2 control mice （15–18-months old, no treatment）. Differentially expressed genes （DEGs） in spinal cord tissue from injured and control mice were identified using the Linear Models for Microarray data method,with a threshold of adjusted P 〈 0.05 and ｜logFC（fold change）｜ 〉 1.5. Protein–protein interaction networks were constructed using data from the STRING database, followed by module analysis by Cytoscape software to screen crucial genes. Kyoto encyclopedia of genes and genomes pathway and Gene Ontology enrichment analyses were performed to investigate the underlying functions of DEGs using Database for Annotation, Visualization and Integrated Discovery. Consequently, 1,604 and 1,153 DEGs were identified between injured and normal control mice in spinal cord tissue of aged and young mice, respectively. Furthermore, a Venn diagram showed that 960 DEGs were shared among aged and young mice, while 644 and 193 DEGs were specific to aged and young mice, respectively. Functional enrichment indicates that shared DEGs are involved in osteoclast differentiation, extracellular matrix–receptor interaction, nuclear factor-kappa B signaling pathway, and focal adhesion. Unique genes for aged and young injured groups were involved in the cell cycle （upregulation of PLK1） and complement （upregulation of C3） activation, respectively. These findings were confirmed by functional analysis of genes i
基金supported by the National Natural Science Foundation of China(Nos.51974371 and 52274344)the Science and Technology Innovation Program of Hunan Province(No.2023RC3042)+1 种基金Provincial Natural Science Foundation of Hunan(Nos.2023JJ20068 and 2022JJ30723)China Baowu Low Carbon Metallurgy Innovation Foundation(BWLCF202118).
文摘Hot air sintering technology is used to improve the quality and production efficiency of sintered ore.However,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering layer.Therefore,it is considered to use oxygen enrichment sintering to improve the environment of hot air sintering.Traditional sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was clarified.Hot air reduced the vertical sintering velocity,while improved the yield and tumbler index.Oxygen-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production efficiency.Under the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was prolonged.After oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.
基金supported by grants from the National Natural Science Foundation of China,Nos.81471238,81771327Construction of Central Nervous System Injury Basic Science and Clinical Translational Research Platform,Budget of Beijing Municipal Health Commission 2020,No.PXM2020_026280_000002(all to BYL)。
文摘Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whether ts RNAs are involved in traumatic brain injury-induced secondary injury remains poorly understood. In this study, a mouse controlled cortical impact model of traumatic brain injury was established, and integrated ts RNA and messenger RNA(m RNA) transcriptome sequencing were used. The results revealed that 103 ts RNAs were differentially expressed in the mouse model of traumatic brain injury at 72 hours, of which 56 ts RNAs were upregulated and 47 ts RNAs were downregulated. Based on micro RNA-like seed matching and Pearson correlation analysis, 57 differentially expressed ts RNA-m RNA interaction pairs were identified, including 29 ts RNAs and 26 m RNAs. Moreover, Gene Ontology annotation of target genes revealed that the significantly enriched terms were primarily associated with inflammation and synaptic function. Collectively, our findings suggest that ts RNAs may be associated with traumatic brain injury-induced secondary brain injury, and are thus a potential therapeutic target for traumatic brain injury. The study was approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No. 20190411) on April 11, 2019.
文摘【目的】研究乌鲁木齐市快速路侧绿化树种的重金属污染情况,并对不同树种的修复潜力进行评价,初步对城市快速路环境作出评估,为乌鲁木齐市城市快速路绿化树种健康管理和城市道路绿化方案的优化提供科学依据。【方法】植物样品采用HNO_(3)-HClO_(4)(4∶1)消解法进行消解;土壤样品采用HF-HClO_(4)(1∶1)消解法进行消解。通过电感耦合等离子体发射光谱仪(ICP-OES)测定绿化树种各部位重金属(Pb、Zn、Cd、Cr、Cu、Ni)含量,并通过隶属函数法对研究区的富集能力进行综合评价。【结果】北美海棠(North American Begonia)、白榆(Ulmus pumila L.)、大叶白蜡(Fraxinus rhynchophylla)、新疆杨(Populus alba var.pyramidalis)4种绿化树种中Zn浓度最大,Cd浓度最小,重金属元素主要分布于树皮和根系,叶片中浓度较小。各部位富集系数总体表现为树皮>根系>树枝>叶片,其中大叶白蜡树皮和根系对Cu的富集系数分别为1.897、1.068,表现出高富集特点。北美海棠对Cr、Cu、Pb的转运系数均大于其余树种,白榆对Zn的转运能力最强,新疆杨对Cd的转运能力最强。北美海棠根际土壤污染程度最小,属于轻度污染,白榆和大叶白蜡根际土壤属于中度污染,新疆杨根际土壤属于重度污染。6种重金属均表现出不同程度的污染,含量均高于背景值,Cd污染最为严重。Pb和Cd变异系数较大,分别为11.44%和12.50%,表明其含量在整个研究区分布差异性较大。【结论】重金属元素在不同绿化树种中和同一绿化树种不同部位中分布均存在明显差异;北美海棠的综合富集能力最强,可作为研究区土壤重金属污染修复的首选树种;快速路侧土壤重金属整体上呈中度污染(P=2.20)。
