As cloud service becomes more and more capable, available and powerful, wiseCIO has emerged from an innovative roadmap toward archival Content Management Service (aCMS) and massive Content Delivery Service (mCDS) in s...As cloud service becomes more and more capable, available and powerful, wiseCIO has emerged from an innovative roadmap toward archival Content Management Service (aCMS) and massive Content Delivery Service (mCDS) in support of Anything-as-a-Service (XaaS) via Digital Archiving and Transformed Analytics (DATA);DATA aims to automate UBC with FAST solutions throughout a feasible, analytical, scalable and testable approach. This paper, based on the novel wiseCIO (web-based intelligent service engaging Cloud Intelligence Outlet), presents digital archiving and transformed analytics via machine learning automata for intelligent UBC processes to liaise with Universal interface for human-computer interaction, enable Brewing aggregation (differing from traditional web browsing), and engage Centered user experience. As one of the most practical aspects of artificial intelligence, machine learning is applied to analytical model building and massive and/or multidimensional Online Analytical Processing (mOLAP) for more intelligent cloud service with little explicit coding required. DATA is central to useful information via archival transformation and analytics, and utilizable intelligence for Business, Education and Entertainment (iBEE) in support of decision-making. As a result, DATA orchestrates wiseCIO to promote ACTiVE XaaS that enables accessibility, contextuality and traceability of information for vast engagement with various cloud services, such as aCMS (archival Content Management Service), COSA (Context-Oriented Screening Aggregation), DASH (Deliveries Assembled for fast Search and Hits), OLAS (Online Learning via Analytical Synthesis), REAP (Rapid Extension and Active Presentation), and SPOT (Special Points On Top) with great ease.展开更多
The paper considers the modification or the manufacture error of cycloidal gear, then analyzes the relationship of pin circle meshed with the modified cycloidal gear, discuases the amount of error that leads to destro...The paper considers the modification or the manufacture error of cycloidal gear, then analyzes the relationship of pin circle meshed with the modified cycloidal gear, discuases the amount of error that leads to destroying conjugate action and results in the changes of tbe instantaneous velocity ratio and so as to affect the smooth operation of cycloidal pin gearing. The idea of the relationship between amount of modification aud manufacture error and the smooth operation can be gotten from the curve diagrams of the instantaneous velocity ratio. Therefore, the directions for improving the reature of the cycloidal pin gear transmission are clear.展开更多
Background: The purpose of this case series was to retrospectively compare radiological, clinical and functional outcomes and complications of diagnostic arthroscopy with open Latarjet procedures pre- and postoperativ...Background: The purpose of this case series was to retrospectively compare radiological, clinical and functional outcomes and complications of diagnostic arthroscopy with open Latarjet procedures pre- and postoperatively within one year after surgery. Additionally we compared the pathologic findings during diagnostic arthroscopy with the radiological findings in preoperative contrast enhanced CT or MRI scans. Methods: Between 07/2009 and 11/2013 46 cases with unidirectional antero-inferior shoulder instability were enrolled, 4 cases were lost during the follow-up within one year postoperatively. Plain radiographs, contrast enhanced multislice studies, Instability Severity Index, Constant, Duplay and Rowe Scores were obtained preoperatively. Diagnostic arthroscopy was performed in all cases prior to open Latarjet procedure. At one year follow-up Constant, Duplay and Rowe Scores were obtained;position and consolidation of the coracoid transfer were assessed by conventional x-ray studies. Results: At one year follow-up a significant improvement of all scores was recorded (Constant Score 95.8 vs. 86.7;Duplay Score 93.7 vs. 25.2, Rowe Score 98.1 vs. 31.7, (p Conclusion: The Latarjet procedure is a reliable technique with very good clinical outcomes. Diagnostic arthroscopy is a valuable tool to detect HAGL- and IGHL-lesions and to visualize the engaging potential of Hill-Sachs-lesions. An additional arthroscopy may help to indicate a Latarjet procedure and to address concomitant pathologies. Level of evidence: Level IV, case series.展开更多
T cell engaging bispecific antibody(TCB)is an effective immunotherapy for cancer treatment.Through co-targeting CD3 and tumor-associated antigen(TAA),TCB can redirect CD3+T cells to eliminate tumor cells regardless of...T cell engaging bispecific antibody(TCB)is an effective immunotherapy for cancer treatment.Through co-targeting CD3 and tumor-associated antigen(TAA),TCB can redirect CD3+T cells to eliminate tumor cells regardless of the specificity of T cell receptor.Tissue factor(TF)is a TAA that involved in tumor progression.Here,we designed and characterized a novel TCB targeting TF(TF-TCB)for the treatment of TF-positive tumors.In vitro,robust T cell activation,tumor cell lysis and T cell proliferation were induced by TF-TCB.The tumor cell lysis activity was dependent upon both CD3 and TF binding moieties of the TF-TCB,and was related to TF expression level of tumor cells.In vivo,in both tumor cell/human peripheral blood mononuclear cells(PBMC)co-grafting model and established tumor models with poor T cell infiltration,tumor growth was strongly inhibited by TF-TCB.T cell infiltration into tumors was induced during the treatment.Furthermore,efficacy of TF-TCB was further improved by combination with immune checkpoint inhibitors.For the first time,our results validated the feasibility of using TF as a target for TCB and highlighted the potential for TF-TCB to demonstrate efficacy in solid tumor treatment.展开更多
Agency,learners’ability to act on their own learning through actively utilizing the resources and affordances in the learning environment,is of paramount importance to their success in language learning,especially wi...Agency,learners’ability to act on their own learning through actively utilizing the resources and affordances in the learning environment,is of paramount importance to their success in language learning,especially within the online learning environment in a world confronting COVID-19.This paper illustrates the concept of agency from a sociocultural perspective,discusses factors that affect agency development in language learning,and proposes five teaching principles that promote learner agency for teachers designing language lessons online and offline.展开更多
Sound structures are in place to improve the status of Chinese women, but challenges remain on the ground by Ni Yanshuo ONE of China’s most popular and financially successful movies of 2010 was Go Lala Go,a story abo...Sound structures are in place to improve the status of Chinese women, but challenges remain on the ground by Ni Yanshuo ONE of China’s most popular and financially successful movies of 2010 was Go Lala Go,a story about the rise of a determined female,Du Lala, from lowly office clerk to successful human resources manager in a global top 500 company.The movie’s central theme was to show that women can achieve anything展开更多
Is your business at the cutting edge of service delivery while making the property a cleaner, healthier and safer place to work and rest in If so, IH&RA wants to hear from you! Apply for the IH&RA Environmenta...Is your business at the cutting edge of service delivery while making the property a cleaner, healthier and safer place to work and rest in If so, IH&RA wants to hear from you! Apply for the IH&RA Environmental Award, now in its 14th year, and receive international recognition for your environmental best practices at the association’s Annual Congress, “Orient Express: Destination China! New Markets, New Competition” to be held 28-30 October in Beijing!展开更多
Apart from my personal experience in China about four decades ago, I would like to also share with readers my view on how to tell stories about China in a faithful and emotionally engaging way.
文摘As cloud service becomes more and more capable, available and powerful, wiseCIO has emerged from an innovative roadmap toward archival Content Management Service (aCMS) and massive Content Delivery Service (mCDS) in support of Anything-as-a-Service (XaaS) via Digital Archiving and Transformed Analytics (DATA);DATA aims to automate UBC with FAST solutions throughout a feasible, analytical, scalable and testable approach. This paper, based on the novel wiseCIO (web-based intelligent service engaging Cloud Intelligence Outlet), presents digital archiving and transformed analytics via machine learning automata for intelligent UBC processes to liaise with Universal interface for human-computer interaction, enable Brewing aggregation (differing from traditional web browsing), and engage Centered user experience. As one of the most practical aspects of artificial intelligence, machine learning is applied to analytical model building and massive and/or multidimensional Online Analytical Processing (mOLAP) for more intelligent cloud service with little explicit coding required. DATA is central to useful information via archival transformation and analytics, and utilizable intelligence for Business, Education and Entertainment (iBEE) in support of decision-making. As a result, DATA orchestrates wiseCIO to promote ACTiVE XaaS that enables accessibility, contextuality and traceability of information for vast engagement with various cloud services, such as aCMS (archival Content Management Service), COSA (Context-Oriented Screening Aggregation), DASH (Deliveries Assembled for fast Search and Hits), OLAS (Online Learning via Analytical Synthesis), REAP (Rapid Extension and Active Presentation), and SPOT (Special Points On Top) with great ease.
文摘The paper considers the modification or the manufacture error of cycloidal gear, then analyzes the relationship of pin circle meshed with the modified cycloidal gear, discuases the amount of error that leads to destroying conjugate action and results in the changes of tbe instantaneous velocity ratio and so as to affect the smooth operation of cycloidal pin gearing. The idea of the relationship between amount of modification aud manufacture error and the smooth operation can be gotten from the curve diagrams of the instantaneous velocity ratio. Therefore, the directions for improving the reature of the cycloidal pin gear transmission are clear.
文摘Background: The purpose of this case series was to retrospectively compare radiological, clinical and functional outcomes and complications of diagnostic arthroscopy with open Latarjet procedures pre- and postoperatively within one year after surgery. Additionally we compared the pathologic findings during diagnostic arthroscopy with the radiological findings in preoperative contrast enhanced CT or MRI scans. Methods: Between 07/2009 and 11/2013 46 cases with unidirectional antero-inferior shoulder instability were enrolled, 4 cases were lost during the follow-up within one year postoperatively. Plain radiographs, contrast enhanced multislice studies, Instability Severity Index, Constant, Duplay and Rowe Scores were obtained preoperatively. Diagnostic arthroscopy was performed in all cases prior to open Latarjet procedure. At one year follow-up Constant, Duplay and Rowe Scores were obtained;position and consolidation of the coracoid transfer were assessed by conventional x-ray studies. Results: At one year follow-up a significant improvement of all scores was recorded (Constant Score 95.8 vs. 86.7;Duplay Score 93.7 vs. 25.2, Rowe Score 98.1 vs. 31.7, (p Conclusion: The Latarjet procedure is a reliable technique with very good clinical outcomes. Diagnostic arthroscopy is a valuable tool to detect HAGL- and IGHL-lesions and to visualize the engaging potential of Hill-Sachs-lesions. An additional arthroscopy may help to indicate a Latarjet procedure and to address concomitant pathologies. Level of evidence: Level IV, case series.
基金This work was supported by the National Natural Science Foundation of China(Nos.81773621 and 82073751)the National Science and Technology Major Project(No.2019ZX09201001,China).
文摘T cell engaging bispecific antibody(TCB)is an effective immunotherapy for cancer treatment.Through co-targeting CD3 and tumor-associated antigen(TAA),TCB can redirect CD3+T cells to eliminate tumor cells regardless of the specificity of T cell receptor.Tissue factor(TF)is a TAA that involved in tumor progression.Here,we designed and characterized a novel TCB targeting TF(TF-TCB)for the treatment of TF-positive tumors.In vitro,robust T cell activation,tumor cell lysis and T cell proliferation were induced by TF-TCB.The tumor cell lysis activity was dependent upon both CD3 and TF binding moieties of the TF-TCB,and was related to TF expression level of tumor cells.In vivo,in both tumor cell/human peripheral blood mononuclear cells(PBMC)co-grafting model and established tumor models with poor T cell infiltration,tumor growth was strongly inhibited by TF-TCB.T cell infiltration into tumors was induced during the treatment.Furthermore,efficacy of TF-TCB was further improved by combination with immune checkpoint inhibitors.For the first time,our results validated the feasibility of using TF as a target for TCB and highlighted the potential for TF-TCB to demonstrate efficacy in solid tumor treatment.
文摘Agency,learners’ability to act on their own learning through actively utilizing the resources and affordances in the learning environment,is of paramount importance to their success in language learning,especially within the online learning environment in a world confronting COVID-19.This paper illustrates the concept of agency from a sociocultural perspective,discusses factors that affect agency development in language learning,and proposes five teaching principles that promote learner agency for teachers designing language lessons online and offline.
文摘Sound structures are in place to improve the status of Chinese women, but challenges remain on the ground by Ni Yanshuo ONE of China’s most popular and financially successful movies of 2010 was Go Lala Go,a story about the rise of a determined female,Du Lala, from lowly office clerk to successful human resources manager in a global top 500 company.The movie’s central theme was to show that women can achieve anything
文摘Is your business at the cutting edge of service delivery while making the property a cleaner, healthier and safer place to work and rest in If so, IH&RA wants to hear from you! Apply for the IH&RA Environmental Award, now in its 14th year, and receive international recognition for your environmental best practices at the association’s Annual Congress, “Orient Express: Destination China! New Markets, New Competition” to be held 28-30 October in Beijing!
文摘Apart from my personal experience in China about four decades ago, I would like to also share with readers my view on how to tell stories about China in a faithful and emotionally engaging way.
