Objectives Cardiovascular risk factors lead to pathogenesis of atherosclerosis and its clinical events by impairing vascular wall. Endothelial dysfunction is the earliest marker for vascular wall injuries. Development...Objectives Cardiovascular risk factors lead to pathogenesis of atherosclerosis and its clinical events by impairing vascular wall. Endothelial dysfunction is the earliest marker for vascular wall injuries. Development of new method to detect early vascular wall damage has an important clinical implication for the prevention and treatment of cardiovascular diseases. Therefore, the present study was performed to evaluate effect of aging and hypertension, two independent risk factors for cardiovascular diseases, on arterial elasticity by using pulse waveform analysis and investigate whether the changes in arterial elasticity can be used as a risk marker for vascular structural and functional abnormalities. Methods Using modified Windkessel model of the circulation and pulse waveform analysis, C1 large artery and C2 small artery elasticity indices of 204 Chinese normal healthy subjects （ age 15-80 years） and 46 Chinese essential hypertensive patients （age 35-70 years） were measured. Age- and hypertension-related arterial elasticity changes were examined. Results C1 large artery and C2 small artery elasticity indices were reduced with advancing age in healthy subjects. C1 large artery and C2 small artery elasticity indices were negatively correlated with age （r=-0.628, P〈0.001; r=-0.595, P〈0.001）. C1 large artery and C2 small artery elasticity indices in patients with essential hypertension compared with the agematched healthy subjects were （9.31±3.85 ml/mm Hg × 10 versus 15.13±4.14 ml/mmHg × 10, P〈0.001） and （3.57 ± 1.62 ml/mm Hg x 100 versus 7.89±2.91 ml/ mmHg × 100 P 〈0.001）, respectively, and were significantly lower than the corresponding healthy subjects. There were negative association between C1 large artery and C2 small artery elasticity indices and systolic blood pressure （r=-0.37, P〈0.05; r=-0.39, P〈0.05） and pulse pressure （r=-0.39, P〈0.05; r=- 0.43,P〈0.05） in patients with essential hypertension. Conclusions Advancing age and essential hypertension lead展开更多
文摘Objectives Cardiovascular risk factors lead to pathogenesis of atherosclerosis and its clinical events by impairing vascular wall. Endothelial dysfunction is the earliest marker for vascular wall injuries. Development of new method to detect early vascular wall damage has an important clinical implication for the prevention and treatment of cardiovascular diseases. Therefore, the present study was performed to evaluate effect of aging and hypertension, two independent risk factors for cardiovascular diseases, on arterial elasticity by using pulse waveform analysis and investigate whether the changes in arterial elasticity can be used as a risk marker for vascular structural and functional abnormalities. Methods Using modified Windkessel model of the circulation and pulse waveform analysis, C1 large artery and C2 small artery elasticity indices of 204 Chinese normal healthy subjects （ age 15-80 years） and 46 Chinese essential hypertensive patients （age 35-70 years） were measured. Age- and hypertension-related arterial elasticity changes were examined. Results C1 large artery and C2 small artery elasticity indices were reduced with advancing age in healthy subjects. C1 large artery and C2 small artery elasticity indices were negatively correlated with age （r=-0.628, P〈0.001; r=-0.595, P〈0.001）. C1 large artery and C2 small artery elasticity indices in patients with essential hypertension compared with the agematched healthy subjects were （9.31±3.85 ml/mm Hg × 10 versus 15.13±4.14 ml/mmHg × 10, P〈0.001） and （3.57 ± 1.62 ml/mm Hg x 100 versus 7.89±2.91 ml/ mmHg × 100 P 〈0.001）, respectively, and were significantly lower than the corresponding healthy subjects. There were negative association between C1 large artery and C2 small artery elasticity indices and systolic blood pressure （r=-0.37, P〈0.05; r=-0.39, P〈0.05） and pulse pressure （r=-0.39, P〈0.05; r=- 0.43,P〈0.05） in patients with essential hypertension. Conclusions Advancing age and essential hypertension lead
