Hepatitis B virus(HBV)infection remains a major global health problem because current therapies rarely eliminate the replicative template of HBV,which is the covalently closed circular DNA(ccc DNA).As an accurate and ...Hepatitis B virus(HBV)infection remains a major global health problem because current therapies rarely eliminate the replicative template of HBV,which is the covalently closed circular DNA(ccc DNA).As an accurate and efficient genome editing tool,clustered regularly interspaced palindromic repeat(CRISPR)-associated(Cas)9 system represents a very promising展开更多
文摘Hepatitis B virus(HBV)infection remains a major global health problem because current therapies rarely eliminate the replicative template of HBV,which is the covalently closed circular DNA(ccc DNA).As an accurate and efficient genome editing tool,clustered regularly interspaced palindromic repeat(CRISPR)-associated(Cas)9 system represents a very promising
