Background The mechanism of acupuncture analgesia in craniotomy has been widely studied. However, the theoretical basis for selection of acupoints has not been examined. In this study, we used the regional homogeneit...Background The mechanism of acupuncture analgesia in craniotomy has been widely studied. However, the theoretical basis for selection of acupoints has not been examined. In this study, we used the regional homogeneity method blood oxygen level-dependent （BOLD） signals to determine changes in brain activity in response to transcutaneous electrical stimulation on acupoints and non-acupoints in resting state functional magnetic resonance imaging （fMRI）.Methods Twelve healthy volunteers were enrolled in this study. BOLD fMRI scanning of the brain was performed for 306 seconds before and 30 minutes after transcutaneous electrical stimulation on acupoints UB63 （Jinmen）, LV3 （Tai chong）, ST36 （Zusanli）, and GB40 （Qiuxu）. The procedure was repeated after one week with stimulation on non-acupoints （one was 9 above BL67, the second was 12 above BL67 （Kunlun）, the third was 7 above KI3, and the fourth was 10 above KI3 （Taixi））.Results The regional homogeneity in the acupoint group was increased in the left thalamus, caudate, putamen, lentiform nucleus （BA19, 30, 39）, postcentral gyrus, precentral gyrus （BA3, 4, 30, 32）, calcarine fissure, middle temporal gyrus （BA30）, right superior temporal gyrus, inferior temporal gyrus （BA38）, cuneus, and precuneus （BA7, 19） when compared to the non-acupoint group. The regional homogeneity of the acupoint group was decreased in the left cerebellum posterior lobe, middle frontal gyrus （BA10）, double-side precuneus （BA7）, and the postcentral gyrus （BA40）.Conclusions The brain region activated following acupoint stimulation is the ipsilateral pain-related brain region, which may relate to the therapeutic effect of acupuncture on pain relief. Further acupoint stimulation causes different central nervous responses compared to non-acupoint stimulation.展开更多
The reinforcing effect of transcutaneous acupoint electric stimulation(TAES)on enflurane anesthesia during craniotomy was studied.One hundred and ten neurosurgical patientswere randomly divided into three groups.Anest...The reinforcing effect of transcutaneous acupoint electric stimulation(TAES)on enflurane anesthesia during craniotomy was studied.One hundred and ten neurosurgical patientswere randomly divided into three groups.Anesthesia was maintained with enflurane in Group A(n=40).In Group B,enflurane anesthesia was supplemented by TAES with Han’s acupoint nerve stimu-lator(HANS)at Hegu(LI 4),Yuyao(EX-HN 4)and Fengchi(GB 20)points on the operated side(n=40).In Group C,enflurane anesthesia was supplemented by TAES and scalp infiltration with 0.5％procaine solution(n=30).The results showed that the minimum alveolar concentration(MAC)of enflurane in Group B and C decreased by 37.8-47.0％and 42.1-66.1％respectively than thatin Group A.The hemodynamics was more stable during operation,and the patients recovered after operation in group B and C.It was concluded that TAES with HANS significantly the anesthetic effect and decreased the side effects of enflurane during operation,and that the triplecombination of TAES,enflurane and scalp infiltration with procaine appeared to be a better anestheticmethod for craniotomy.展开更多
基金This work was supported by the grants from the National Key Basic Research and Development Program ＂973＂ Project （No. 2007CB512503）, and the China Postdoctoral Science Foundation （No. 20070420403）.Acknowledgements： The authors are highly grateful to Professor ZANG Yu-feng （State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University） for software support.
文摘Background The mechanism of acupuncture analgesia in craniotomy has been widely studied. However, the theoretical basis for selection of acupoints has not been examined. In this study, we used the regional homogeneity method blood oxygen level-dependent （BOLD） signals to determine changes in brain activity in response to transcutaneous electrical stimulation on acupoints and non-acupoints in resting state functional magnetic resonance imaging （fMRI）.Methods Twelve healthy volunteers were enrolled in this study. BOLD fMRI scanning of the brain was performed for 306 seconds before and 30 minutes after transcutaneous electrical stimulation on acupoints UB63 （Jinmen）, LV3 （Tai chong）, ST36 （Zusanli）, and GB40 （Qiuxu）. The procedure was repeated after one week with stimulation on non-acupoints （one was 9 above BL67, the second was 12 above BL67 （Kunlun）, the third was 7 above KI3, and the fourth was 10 above KI3 （Taixi））.Results The regional homogeneity in the acupoint group was increased in the left thalamus, caudate, putamen, lentiform nucleus （BA19, 30, 39）, postcentral gyrus, precentral gyrus （BA3, 4, 30, 32）, calcarine fissure, middle temporal gyrus （BA30）, right superior temporal gyrus, inferior temporal gyrus （BA38）, cuneus, and precuneus （BA7, 19） when compared to the non-acupoint group. The regional homogeneity of the acupoint group was decreased in the left cerebellum posterior lobe, middle frontal gyrus （BA10）, double-side precuneus （BA7）, and the postcentral gyrus （BA40）.Conclusions The brain region activated following acupoint stimulation is the ipsilateral pain-related brain region, which may relate to the therapeutic effect of acupuncture on pain relief. Further acupoint stimulation causes different central nervous responses compared to non-acupoint stimulation.
文摘The reinforcing effect of transcutaneous acupoint electric stimulation(TAES)on enflurane anesthesia during craniotomy was studied.One hundred and ten neurosurgical patientswere randomly divided into three groups.Anesthesia was maintained with enflurane in Group A(n=40).In Group B,enflurane anesthesia was supplemented by TAES with Han’s acupoint nerve stimu-lator(HANS)at Hegu(LI 4),Yuyao(EX-HN 4)and Fengchi(GB 20)points on the operated side(n=40).In Group C,enflurane anesthesia was supplemented by TAES and scalp infiltration with 0.5％procaine solution(n=30).The results showed that the minimum alveolar concentration(MAC)of enflurane in Group B and C decreased by 37.8-47.0％and 42.1-66.1％respectively than thatin Group A.The hemodynamics was more stable during operation,and the patients recovered after operation in group B and C.It was concluded that TAES with HANS significantly the anesthetic effect and decreased the side effects of enflurane during operation,and that the triplecombination of TAES,enflurane and scalp infiltration with procaine appeared to be a better anestheticmethod for craniotomy.
