Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings.Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia.Dynamin-related protein 1(Drp1)regulates ...Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings.Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia.Dynamin-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury.However,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic target.Here,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia.Additionally,potential clinical translation prospects for targeting Drp1 are discussed.This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.展开更多
目的系统评价动力相关蛋白1(DRP1)的表达对肿瘤患者预后的评估价值,以期为肿瘤患者预测预后和治疗提供新的靶点。方法计算机检索PubMed、EMBASE、Web of Science、CNKI及万方等数据库,检索时间为建库至2020年10月,按照文献纳入与排除标...目的系统评价动力相关蛋白1(DRP1)的表达对肿瘤患者预后的评估价值,以期为肿瘤患者预测预后和治疗提供新的靶点。方法计算机检索PubMed、EMBASE、Web of Science、CNKI及万方等数据库,检索时间为建库至2020年10月,按照文献纳入与排除标准筛选文献并提取数据,根据Newcastle-Ottawa Scale(NOS)量表评估文献质量,采用Review Maneger5.3软件进行Meta分析。结果共纳入10篇研究共1138例患者。Meta分析结果显示DRP1高表达与肿瘤患者OS有关(HR=1.46,95%CI为1.11~1.92,P<0.001)。亚组分析结果显示,DRP1高表达与消化系统恶性肿瘤患者OS相关(HR=1.61,95%CI为1.12~2.31,P<0.001),与肿瘤患者淋巴结转移发生率相关(OR=3.24,95%CI为1.85~5.67,P<0.001)。结论DRP1高表达的肿瘤患者预后较差,且与淋巴结转移发生相关,可以作为肿瘤预测预后及治疗的新靶点。展开更多
基金This work was supported by the National Natural Science Foundation of China(82272252,82270378)the Senior Medical Talents Program of Chongqing for Young and Middle-agedthe Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.
文摘Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings.Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia.Dynamin-related protein 1(Drp1)regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications,which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury.However,there is active controversy and gaps in knowledge regarding the modification,protein interaction,and functions of Drp1,which both hinder and promote development of Drp1 as a novel therapeutic target.Here,we summarize recent findings on the oligomeric changes,modification types,and protein interactions of Drp1 in various hypoxic-ischemic diseases,as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia.Additionally,potential clinical translation prospects for targeting Drp1 are discussed.This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.
文摘目的系统评价动力相关蛋白1(DRP1)的表达对肿瘤患者预后的评估价值,以期为肿瘤患者预测预后和治疗提供新的靶点。方法计算机检索PubMed、EMBASE、Web of Science、CNKI及万方等数据库,检索时间为建库至2020年10月,按照文献纳入与排除标准筛选文献并提取数据,根据Newcastle-Ottawa Scale(NOS)量表评估文献质量,采用Review Maneger5.3软件进行Meta分析。结果共纳入10篇研究共1138例患者。Meta分析结果显示DRP1高表达与肿瘤患者OS有关(HR=1.46,95%CI为1.11~1.92,P<0.001)。亚组分析结果显示,DRP1高表达与消化系统恶性肿瘤患者OS相关(HR=1.61,95%CI为1.12~2.31,P<0.001),与肿瘤患者淋巴结转移发生率相关(OR=3.24,95%CI为1.85~5.67,P<0.001)。结论DRP1高表达的肿瘤患者预后较差,且与淋巴结转移发生相关,可以作为肿瘤预测预后及治疗的新靶点。
