AIM To assess the relationship between gastric acid output (GAO) and both pattern of gastroesophageal reflux (GER) and esophageal lesions, and to evaluate the role of GAO and other potential pathogenetic factors in t...AIM To assess the relationship between gastric acid output (GAO) and both pattern of gastroesophageal reflux (GER) and esophageal lesions, and to evaluate the role of GAO and other potential pathogenetic factors in the development of esophagitis. METHODS Gastric acid secretory testing and 24 h intraesophageal pH monitoring were performed in 31 patients with esophagitis and concomitant duodenal ulcer (E+DU) and compared with those of 72 patients with esophagitis (E) alone. RESULTS The GAO in patients with E+DU was significantly higher than in patients with E ( P <0 05). There was no significant difference between the two groups of patients as to endoscopicl findings and parameters of GER ( P >0 05). A multiple regression analysis with stepwise deletion showed that the pre sence of hiatal hernia (HH), GER in upright position and age appeared to correlate significantly with the presence of esophagitis. CONCLUSIONS No parallel relationship between GAO and severity of GER or esophageal lesions exists in patients with E+DU, and that GAO is not a major pathogenetic factor in GER disease.展开更多
目的探讨幽门螺杆菌(Hp)相关性十二指肠溃疡(DU)患者 Hp 根除前后胃黏膜及血中促胃液素(Gas)和生长抑素(SS)含量变化的意义。方法采用放射免疫分析法测定 Hp 相关性 DU 患者42例 Hp 根除前后及正常对照者20例胃黏膜及血中 Gas 和 SS 含...目的探讨幽门螺杆菌(Hp)相关性十二指肠溃疡(DU)患者 Hp 根除前后胃黏膜及血中促胃液素(Gas)和生长抑素(SS)含量变化的意义。方法采用放射免疫分析法测定 Hp 相关性 DU 患者42例 Hp 根除前后及正常对照者20例胃黏膜及血中 Gas 和 SS 含量。结果 Hp 相关性 DU 的患者胃黏膜及血中 Gas 的含量明显高于 Hp 阴性患者(黏膜:ng/g,226±65 vs 38±98;血清:ng/L,107±33 vs 50±8);而 Hp 根除后 Gas 含量明显下降。Hp 阳性者 SS 的含量低于 Hp 阴性患者(黏膜:ng/g,11±2 vs 42±8;血浆:ng/L,5.6±1.2 vs 10.2±2.3);Hp 根除后 SS 含量显著升高。Hp 感染时胃黏膜炎细胞浸润程度对 Gas 和 SS 的含量亦有一定影响。结论 Gas 和 SS 与 Hp 相关性是参与 DU 发病的重要因素之一。展开更多
文摘AIM To assess the relationship between gastric acid output (GAO) and both pattern of gastroesophageal reflux (GER) and esophageal lesions, and to evaluate the role of GAO and other potential pathogenetic factors in the development of esophagitis. METHODS Gastric acid secretory testing and 24 h intraesophageal pH monitoring were performed in 31 patients with esophagitis and concomitant duodenal ulcer (E+DU) and compared with those of 72 patients with esophagitis (E) alone. RESULTS The GAO in patients with E+DU was significantly higher than in patients with E ( P <0 05). There was no significant difference between the two groups of patients as to endoscopicl findings and parameters of GER ( P >0 05). A multiple regression analysis with stepwise deletion showed that the pre sence of hiatal hernia (HH), GER in upright position and age appeared to correlate significantly with the presence of esophagitis. CONCLUSIONS No parallel relationship between GAO and severity of GER or esophageal lesions exists in patients with E+DU, and that GAO is not a major pathogenetic factor in GER disease.
文摘目的探讨幽门螺杆菌(Hp)相关性十二指肠溃疡(DU)患者 Hp 根除前后胃黏膜及血中促胃液素(Gas)和生长抑素(SS)含量变化的意义。方法采用放射免疫分析法测定 Hp 相关性 DU 患者42例 Hp 根除前后及正常对照者20例胃黏膜及血中 Gas 和 SS 含量。结果 Hp 相关性 DU 的患者胃黏膜及血中 Gas 的含量明显高于 Hp 阴性患者(黏膜:ng/g,226±65 vs 38±98;血清:ng/L,107±33 vs 50±8);而 Hp 根除后 Gas 含量明显下降。Hp 阳性者 SS 的含量低于 Hp 阴性患者(黏膜:ng/g,11±2 vs 42±8;血浆:ng/L,5.6±1.2 vs 10.2±2.3);Hp 根除后 SS 含量显著升高。Hp 感染时胃黏膜炎细胞浸润程度对 Gas 和 SS 的含量亦有一定影响。结论 Gas 和 SS 与 Hp 相关性是参与 DU 发病的重要因素之一。
