Immunotherapy is emerging as a powerful tool for combating many human diseases.However,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly restricted.The major obstacle ...Immunotherapy is emerging as a powerful tool for combating many human diseases.However,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly restricted.The major obstacle is the lack of effective technologies for transporting therapeutic agents across the blood-brain barrier(BBB)and achieving targeted delivery to specific cells once across the BBB.Ferritin,an iron storage protein,traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1(TfR1)overexpressed on BBB endothelial cells.Here,we developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse model.We fused different glioma-targeting moieties on self-assembled ferritin nanoparticles via genetic engineering,and RGE fusion protein nanoparticles(RGE-HFn NPs)were identified as the best candidate.Furthermore,RGE-HFn NPs encapsulating a stimulator of interferon genes(STING)agonist(SR717@RGE-HFn NPs)maintained stable self-assembled structure and targeting properties even after traversing the BBB.In the glioma-bearing mouse model,SR717@RGE-HFn NPs elicited a potent local innate immune response in the tumor microenvironment,resulting in significant tumor growth inhibition and prolonged survival.Overall,this biomimetic brain delivery platform offers new opportunities to overcome the BBB and provides a promising approach for brain drug delivery and immunotherapy in patients with glioma.展开更多
The correlation between the microstructure and soft magnetic properties under the direct current(DC)mode of dual-phase FeCoNi(CuAl)_(0.8)RE_(0.05)(RE=Nd,Y)high-entropy alloys(HEAs)was investigated.Xray diffraction(XRD...The correlation between the microstructure and soft magnetic properties under the direct current(DC)mode of dual-phase FeCoNi(CuAl)_(0.8)RE_(0.05)(RE=Nd,Y)high-entropy alloys(HEAs)was investigated.Xray diffraction(XRD)and electron backscattered diffraction(EBSD)results show that all samples consist of face-centered cubic(FCC)and body-centered cubic(BCC)phases.In comparison to the volume fraction of BCC phase of the RE-free HEA(25.3%),Nd and Y additions dramatically increase it to 42.0%and 43.3%,which leads to an increase of the saturation magnetization.RE addition reduces the average grain size from 7.26 wm of the RE-free HEA to 5.42μm of RE=Nd HEA and 4.88μm of RE=Y HEA.Stripe magnetic domain structure is observed in both FCC and BCC phases in the RE-free and RE-containing HEAs.The additives of Nd and Y both decrease the stripe pattern width in FCC and BCC phases.The refined structure and finely spaced stripe domain by RE addition can decrease the remanence.Compared with the RE-free HEA,RE addition can effectively enhance the DC soft magnetic property by decreasing the remanence,the coercivity,and the hysteresis loss.展开更多
This study deals with the dynamic property of threshold cryptosystem. A dynamic threshold cryptosystem allows the sender to choose the authorized decryption group and the threshold value for each message dynamically. ...This study deals with the dynamic property of threshold cryptosystem. A dynamic threshold cryptosystem allows the sender to choose the authorized decryption group and the threshold value for each message dynamically. We first introduce an identity based dynamic threshold cryptosystem, and then use the CanettiHalevi-Katz(CHK) transformation to transform it into a fully secure system in the traditional public key setting.Finally, the elegant dual system encryption technique is applied to constructing a fully secure dynamic threshold cryptosystem with adaptive security.展开更多
In June 2013, the U.S. National Security Agency proposed two families of lightweight block ciphers, called SIMON and SPECK respectively. These ciphers are designed to perform excellently on both hardware and software ...In June 2013, the U.S. National Security Agency proposed two families of lightweight block ciphers, called SIMON and SPECK respectively. These ciphers are designed to perform excellently on both hardware and software platforms. In this paper, we mainly present zero-correlation linear cryptanalysis on various versions of SIMON. Firstly, by using miss- in-the-middle approach, we construct zero-correlation linear distinguishers of SIMON, and zero-correlation linear attacks are presented based oi1 careful analysis of key recovery phase. Secondly, multidimensional zero-correlation linear attacks are used to reduce the data complexity. Our zero-correlation linear attacks perform better than impossible differential attacks proposed by Abed et al. in ePrint Report 2013/568. Finally, we also use the divide-and-conquer technique to improve the results of linear cryptanalysis proposed by Javad et al. in ePrint Report 2013/663.展开更多
Based on pre punching to hot rolled martensitic and bainitic dual phase steels with similar elongation and work hardening index （n）, as well as similar thickness and hole expansion test using taper die, analysis of ...Based on pre punching to hot rolled martensitic and bainitic dual phase steels with similar elongation and work hardening index （n）, as well as similar thickness and hole expansion test using taper die, analysis of the hole expansion rate indicated significant difference in their flanging performance. The results indicated that mechanical property was not the only major factor that influenced flanging. Further analysis of the hole border microstructure, work hardening condition, and fracture property showed that the fracture property of sheets was the major factor that influenced flanging performance.展开更多
基金funded by the Interdisciplinary Program of Shanghai Jiao Tong University(project number ZH2018ZDA36(19X190020006))Shanghai Jiao Tong University Scientific and Technological Innovation Funds(2019TPA10)+1 种基金the Foundation of National Facility for Translational Medicine(Shanghai)(TMSK-2020-008).X.X.acknowledges support from the National Science Foundation(2001606)the Gustavus and Louise Pfeiffer Research Foundation Award.We greatly thank Xiyun Yan(Institute of Biophysics,CAS)for her generous gift of the pET-HFn plasmid.We also thank Kelong Fan(Institute of Biophysics,CAS)for his professional suggestions on protein purification.
文摘Immunotherapy is emerging as a powerful tool for combating many human diseases.However,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly restricted.The major obstacle is the lack of effective technologies for transporting therapeutic agents across the blood-brain barrier(BBB)and achieving targeted delivery to specific cells once across the BBB.Ferritin,an iron storage protein,traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1(TfR1)overexpressed on BBB endothelial cells.Here,we developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse model.We fused different glioma-targeting moieties on self-assembled ferritin nanoparticles via genetic engineering,and RGE fusion protein nanoparticles(RGE-HFn NPs)were identified as the best candidate.Furthermore,RGE-HFn NPs encapsulating a stimulator of interferon genes(STING)agonist(SR717@RGE-HFn NPs)maintained stable self-assembled structure and targeting properties even after traversing the BBB.In the glioma-bearing mouse model,SR717@RGE-HFn NPs elicited a potent local innate immune response in the tumor microenvironment,resulting in significant tumor growth inhibition and prolonged survival.Overall,this biomimetic brain delivery platform offers new opportunities to overcome the BBB and provides a promising approach for brain drug delivery and immunotherapy in patients with glioma.
基金the National Natural Science Foundation of China(51971125)。
文摘The correlation between the microstructure and soft magnetic properties under the direct current(DC)mode of dual-phase FeCoNi(CuAl)_(0.8)RE_(0.05)(RE=Nd,Y)high-entropy alloys(HEAs)was investigated.Xray diffraction(XRD)and electron backscattered diffraction(EBSD)results show that all samples consist of face-centered cubic(FCC)and body-centered cubic(BCC)phases.In comparison to the volume fraction of BCC phase of the RE-free HEA(25.3%),Nd and Y additions dramatically increase it to 42.0%and 43.3%,which leads to an increase of the saturation magnetization.RE addition reduces the average grain size from 7.26 wm of the RE-free HEA to 5.42μm of RE=Nd HEA and 4.88μm of RE=Y HEA.Stripe magnetic domain structure is observed in both FCC and BCC phases in the RE-free and RE-containing HEAs.The additives of Nd and Y both decrease the stripe pattern width in FCC and BCC phases.The refined structure and finely spaced stripe domain by RE addition can decrease the remanence.Compared with the RE-free HEA,RE addition can effectively enhance the DC soft magnetic property by decreasing the remanence,the coercivity,and the hysteresis loss.
基金the National Natural Science Foundation of China(Nos.61202023,60903189 and 61133014)
文摘This study deals with the dynamic property of threshold cryptosystem. A dynamic threshold cryptosystem allows the sender to choose the authorized decryption group and the threshold value for each message dynamically. We first introduce an identity based dynamic threshold cryptosystem, and then use the CanettiHalevi-Katz(CHK) transformation to transform it into a fully secure system in the traditional public key setting.Finally, the elegant dual system encryption technique is applied to constructing a fully secure dynamic threshold cryptosystem with adaptive security.
基金This work was supported by the National Basic Research 973 Program of China under Grant No. 2013CB338002 and the National Natural Science Foundation of China under Grant Nos. 61272476, 61202420, and 61232009.
文摘In June 2013, the U.S. National Security Agency proposed two families of lightweight block ciphers, called SIMON and SPECK respectively. These ciphers are designed to perform excellently on both hardware and software platforms. In this paper, we mainly present zero-correlation linear cryptanalysis on various versions of SIMON. Firstly, by using miss- in-the-middle approach, we construct zero-correlation linear distinguishers of SIMON, and zero-correlation linear attacks are presented based oi1 careful analysis of key recovery phase. Secondly, multidimensional zero-correlation linear attacks are used to reduce the data complexity. Our zero-correlation linear attacks perform better than impossible differential attacks proposed by Abed et al. in ePrint Report 2013/568. Finally, we also use the divide-and-conquer technique to improve the results of linear cryptanalysis proposed by Javad et al. in ePrint Report 2013/663.
基金Sponsored by National Natural Science Foundation of China(51275003)
文摘Based on pre punching to hot rolled martensitic and bainitic dual phase steels with similar elongation and work hardening index （n）, as well as similar thickness and hole expansion test using taper die, analysis of the hole expansion rate indicated significant difference in their flanging performance. The results indicated that mechanical property was not the only major factor that influenced flanging. Further analysis of the hole border microstructure, work hardening condition, and fracture property showed that the fracture property of sheets was the major factor that influenced flanging performance.
