We report herein the use of p-dodecylbenzenesulfonic acid（DBSA） as a catalyst for a one-pot Biginelli reaction to afford 3,4- dihydropyrimidinone derivatives in good to excellent yields.This reaction proceeds effici...We report herein the use of p-dodecylbenzenesulfonic acid（DBSA） as a catalyst for a one-pot Biginelli reaction to afford 3,4- dihydropyrimidinone derivatives in good to excellent yields.This reaction proceeds efficiently in water and under solvent free conditions.Comparisons of results indicate that although the yields are high and comparable for both methods,the reaction times are considerably shorter under solvent free conditions.展开更多
基金Supported by the National Natural Science Foundation of China(No.21273101)the Key Scientific Research Project of Higher Education of He'nan(No.16A150036)+1 种基金the Program for Science&Technology Innovation Talents in Universities of He'nan Province(No.2014HASTIT014)the Excellent Youth Foundation of He'nan Scientific Committee(No.164100510012)~~
基金the faculty of chemistry of Tarbiat Moallem University for supporting this work
文摘We report herein the use of p-dodecylbenzenesulfonic acid（DBSA） as a catalyst for a one-pot Biginelli reaction to afford 3,4- dihydropyrimidinone derivatives in good to excellent yields.This reaction proceeds efficiently in water and under solvent free conditions.Comparisons of results indicate that although the yields are high and comparable for both methods,the reaction times are considerably shorter under solvent free conditions.
