Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kid...Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable.展开更多
目的:分析尿常规与尿微量白蛋白检测在糖尿病早期肾损伤中的诊断价值。方法:2018年2月-2019年2月收治糖尿病患者42例作为分析组,另外选择同期的健康体检人员42名作为参照组。对两组进行尿常规及尿微量白蛋白检测结果进行比较。结果:分...目的:分析尿常规与尿微量白蛋白检测在糖尿病早期肾损伤中的诊断价值。方法:2018年2月-2019年2月收治糖尿病患者42例作为分析组,另外选择同期的健康体检人员42名作为参照组。对两组进行尿常规及尿微量白蛋白检测结果进行比较。结果:分析组尿微量白蛋白检测阳性率低于参照组,分析组24 h mALB检测结果高于参照组,差异有统计学意义(P<0.05)。结论:尿常规与尿微量白蛋白检测应用于糖尿病患者诊断中,利于检测出患者早期肾损伤情况。展开更多
文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable.
文摘目的:分析尿常规与尿微量白蛋白检测在糖尿病早期肾损伤中的诊断价值。方法:2018年2月-2019年2月收治糖尿病患者42例作为分析组,另外选择同期的健康体检人员42名作为参照组。对两组进行尿常规及尿微量白蛋白检测结果进行比较。结果:分析组尿微量白蛋白检测阳性率低于参照组,分析组24 h mALB检测结果高于参照组,差异有统计学意义(P<0.05)。结论:尿常规与尿微量白蛋白检测应用于糖尿病患者诊断中,利于检测出患者早期肾损伤情况。
