Background In China,the prevalence of chronic kidney disease has increased significantly.Many studies shows that the spectrum of kidney disease had changed in recent years.We retrospectively analyzed the pathological ...Background In China,the prevalence of chronic kidney disease has increased significantly.Many studies shows that the spectrum of kidney disease had changed in recent years.We retrospectively analyzed the pathological types of renal biopsy and its spectrum change at the General Hospital of the Chinese People＇s Liberation Army from December 1987 to December 2012,in order to offer new supporting evidences for further specifying the distribution of renal pathological types in China.Methods According to the ＂Revised Protocol for the Histological Typing of Glomerulopathy＂ （WHO,1995）,pathological diagnosis of renal biopsy was classified,detection rate of each pathological type was summarized （i.e.,percentage of total renal biopsy cases）,study period was divided at an interval of 5 years,and age-stratified distribution change of main pathological types was analyzed.Results The proportion of pathological types in 11 618 cases of renal biopsy was as follows：primary glomerulonephritis （PGN,70.7％）,secondary glomerulonephritis （SGN,20.7％）,tubular-interstitial nephropathy （4.0％）,hereditary/rare nephropathy （0.3％）,end-stage renal disease （0.9％）,and unclassified renal disease （3.3％）.Among PGN,there was IgA nephropathy （IgAN,37.0％）,membranous nephropathy （MN,11.8％）,mesangial proliferative glomerulonephritis （MsPGN,8.9％）,minimal change disease （MCD,6.6％）,and focal segmental glomerulosclerosis （3.9％）.Among SGN there was lupus nephritis （LN,5.5％）,Henoch-Sch（o）nlein purpura glomerulonephritis （5.3％）,hepatitis B virus-associated nephritis （HBVAN,3.03％）,diabetic nephropathy （2.2％）,and hypertension/malignant hypertension-associated renal damage （1.9％）.Pathological data were analyzed from 1987-1992 to 2008-2012 （after age adjustment）.Detection rate of IgAN tended to rise （P ＜0.001）.Detection rates of MN and MCD rose significantly （P ＜0.001）,but detection rate of MsPGN dropped significantly （P ＜0.001）.A展开更多
基金This study was supported by the Twelfth Five-Year Plan （No. 2011BAI10B08, 2011BAI10B03）, 863 program （No. 2012AA02A512）, National Natural Science Foundation （No. 81330019, 81270794, 81370867）, and Scientific Program of Beijing （No. D131100004713003, D131100005313006）.
文摘Background In China,the prevalence of chronic kidney disease has increased significantly.Many studies shows that the spectrum of kidney disease had changed in recent years.We retrospectively analyzed the pathological types of renal biopsy and its spectrum change at the General Hospital of the Chinese People＇s Liberation Army from December 1987 to December 2012,in order to offer new supporting evidences for further specifying the distribution of renal pathological types in China.Methods According to the ＂Revised Protocol for the Histological Typing of Glomerulopathy＂ （WHO,1995）,pathological diagnosis of renal biopsy was classified,detection rate of each pathological type was summarized （i.e.,percentage of total renal biopsy cases）,study period was divided at an interval of 5 years,and age-stratified distribution change of main pathological types was analyzed.Results The proportion of pathological types in 11 618 cases of renal biopsy was as follows：primary glomerulonephritis （PGN,70.7％）,secondary glomerulonephritis （SGN,20.7％）,tubular-interstitial nephropathy （4.0％）,hereditary/rare nephropathy （0.3％）,end-stage renal disease （0.9％）,and unclassified renal disease （3.3％）.Among PGN,there was IgA nephropathy （IgAN,37.0％）,membranous nephropathy （MN,11.8％）,mesangial proliferative glomerulonephritis （MsPGN,8.9％）,minimal change disease （MCD,6.6％）,and focal segmental glomerulosclerosis （3.9％）.Among SGN there was lupus nephritis （LN,5.5％）,Henoch-Sch（o）nlein purpura glomerulonephritis （5.3％）,hepatitis B virus-associated nephritis （HBVAN,3.03％）,diabetic nephropathy （2.2％）,and hypertension/malignant hypertension-associated renal damage （1.9％）.Pathological data were analyzed from 1987-1992 to 2008-2012 （after age adjustment）.Detection rate of IgAN tended to rise （P ＜0.001）.Detection rates of MN and MCD rose significantly （P ＜0.001）,but detection rate of MsPGN dropped significantly （P ＜0.001）.A
