Twelve known compounds, colchicine, 2-demethylcolchicine, 2-demethyldemecolcine, 2-demethylcolchifoline, 2-demethyl-lumicolchicine, lumicolchicine, demecolcine, luteolin, apigenin, n-hentriacontane, n-triacontanol and...Twelve known compounds, colchicine, 2-demethylcolchicine, 2-demethyldemecolcine, 2-demethylcolchifoline, 2-demethyl-lumicolchicine, lumicolchicine, demecolcine, luteolin, apigenin, n-hentriacontane, n-triacontanol and sitosterol were isolated from cormsand flowers of colchicum autumnale Liliaceae which was introduced from Europe and cultivated in Zhaotong Yunnan, China The contents ofcolchicine in corms and flowers of colchicum autumnale were 0.015% and 0.04% respectively, and the content of demecolcine in corms was0.043%.展开更多
Demecolcine was synthesized from colchicine in two steps. The methylation of colchicine with （iodomethane） was carried out in a THF solution of potassium t-butoxide at -20 ℃ for 4 h. The product was （isolated） on...Demecolcine was synthesized from colchicine in two steps. The methylation of colchicine with （iodomethane） was carried out in a THF solution of potassium t-butoxide at -20 ℃ for 4 h. The product was （isolated） on a silica gel flash column with a yield of over 78%. N-Methylcolchicine was then （hydrolyzed） in （i-propanol） and aqueous solution of sodium hydroxide under refluxing temperature to give （demecolcine）. The （overall） yield was 69%. The structures of the two products were confirmed by IR and 1H NMR.展开更多
文摘Twelve known compounds, colchicine, 2-demethylcolchicine, 2-demethyldemecolcine, 2-demethylcolchifoline, 2-demethyl-lumicolchicine, lumicolchicine, demecolcine, luteolin, apigenin, n-hentriacontane, n-triacontanol and sitosterol were isolated from cormsand flowers of colchicum autumnale Liliaceae which was introduced from Europe and cultivated in Zhaotong Yunnan, China The contents ofcolchicine in corms and flowers of colchicum autumnale were 0.015% and 0.04% respectively, and the content of demecolcine in corms was0.043%.
文摘Demecolcine was synthesized from colchicine in two steps. The methylation of colchicine with （iodomethane） was carried out in a THF solution of potassium t-butoxide at -20 ℃ for 4 h. The product was （isolated） on a silica gel flash column with a yield of over 78%. N-Methylcolchicine was then （hydrolyzed） in （i-propanol） and aqueous solution of sodium hydroxide under refluxing temperature to give （demecolcine）. The （overall） yield was 69%. The structures of the two products were confirmed by IR and 1H NMR.
