人参皂苷是人参中的主要活性成分,具有抗氧化、抗肿瘤、提高免疫功能和改善神经系统等作用。为进一步研究人参皂苷对神经系统调节方面的基础研究和临床应用,本研究以"人参皂苷、活性、神经系统"等为关键词,检索1990年~2020年W...人参皂苷是人参中的主要活性成分,具有抗氧化、抗肿瘤、提高免疫功能和改善神经系统等作用。为进一步研究人参皂苷对神经系统调节方面的基础研究和临床应用,本研究以"人参皂苷、活性、神经系统"等为关键词,检索1990年~2020年Web of Science、PubMed、中国万方和中国知网等数据库,检索结果为中文文献265篇,外文文献50篇。通过对检索文献的查阅及整理,分类并总结了人参皂苷在神经系统调控方面的药理活性。检索发现人参皂苷对神经系统的调节作用广泛,包括神经保护作用、抗抑郁作用、改善认知功能和改善学习记忆功能等方面。本研究可为人参皂苷在神经系统疾病方面开拓药用范围,进一步明确药效机制,为人参皂苷在神经系统调节领域的研究打开思路。展开更多
Degenerative disc disease is a multifaceted progressive irreversible condition and an inevitable part of aging,which has been found to be a contributing factor for low back pain and might cause radiculopathy,myelopath...Degenerative disc disease is a multifaceted progressive irreversible condition and an inevitable part of aging,which has been found to be a contributing factor for low back pain and might cause radiculopathy,myelopathy,spinal stenosis,degenerative spondylolisthesis,and herniations.Its etiology is complex and multifactorial.Although genetics influence more dominant,the occupational and mechanical influences still persist as a major risk factor.This review emphasizes up-to-date knowledge regarding etiology of disc degeneration with special consideration on occupational,lifestyle factors,and genetic polymorphisms.展开更多
Degenerative disease of the lumbar spine is a common and increasingly prevalent condition that is often implicated as the primary reason for chronic low back pain and the leading cause of disability in the western wor...Degenerative disease of the lumbar spine is a common and increasingly prevalent condition that is often implicated as the primary reason for chronic low back pain and the leading cause of disability in the western world. Surgical management of lumbar degenerative disease has historically been approached by way of open surgical procedures aimed at decompressing and/or stabilizing the lumbar spine. Advances in technology andsurgical instrumentation have led to minimally invasive surgical techniques being developed and increasingly used in the treatment of lumbar degenerative disease. Compared to the traditional open spine surgery, minimally invasive techniques require smaller incisions and decrease approach-related morbidity by avoiding muscle crush injury by self-retaining retractors, preventing the disruption of tendon attachment sites of important muscles at the spinous processes, using known anatomic neurovascular and muscle planes, and minimizing collateral soft-tissue injury by limiting the width of the surgical corridor. The theoretical benefits of minimally invasive surgery over traditional open surgery include reduced blood loss, decreased postoperative pain and narcotics use, shorter hospital length of stay, faster recover and quicker return to work and normal activity. This paper describes the different minimally invasive techniques that are currently available for the treatment of degenerative disease of the lumbar spine.展开更多
文摘人参皂苷是人参中的主要活性成分,具有抗氧化、抗肿瘤、提高免疫功能和改善神经系统等作用。为进一步研究人参皂苷对神经系统调节方面的基础研究和临床应用,本研究以"人参皂苷、活性、神经系统"等为关键词,检索1990年~2020年Web of Science、PubMed、中国万方和中国知网等数据库,检索结果为中文文献265篇,外文文献50篇。通过对检索文献的查阅及整理,分类并总结了人参皂苷在神经系统调控方面的药理活性。检索发现人参皂苷对神经系统的调节作用广泛,包括神经保护作用、抗抑郁作用、改善认知功能和改善学习记忆功能等方面。本研究可为人参皂苷在神经系统疾病方面开拓药用范围,进一步明确药效机制,为人参皂苷在神经系统调节领域的研究打开思路。
文摘Degenerative disc disease is a multifaceted progressive irreversible condition and an inevitable part of aging,which has been found to be a contributing factor for low back pain and might cause radiculopathy,myelopathy,spinal stenosis,degenerative spondylolisthesis,and herniations.Its etiology is complex and multifactorial.Although genetics influence more dominant,the occupational and mechanical influences still persist as a major risk factor.This review emphasizes up-to-date knowledge regarding etiology of disc degeneration with special consideration on occupational,lifestyle factors,and genetic polymorphisms.
文摘Degenerative disease of the lumbar spine is a common and increasingly prevalent condition that is often implicated as the primary reason for chronic low back pain and the leading cause of disability in the western world. Surgical management of lumbar degenerative disease has historically been approached by way of open surgical procedures aimed at decompressing and/or stabilizing the lumbar spine. Advances in technology andsurgical instrumentation have led to minimally invasive surgical techniques being developed and increasingly used in the treatment of lumbar degenerative disease. Compared to the traditional open spine surgery, minimally invasive techniques require smaller incisions and decrease approach-related morbidity by avoiding muscle crush injury by self-retaining retractors, preventing the disruption of tendon attachment sites of important muscles at the spinous processes, using known anatomic neurovascular and muscle planes, and minimizing collateral soft-tissue injury by limiting the width of the surgical corridor. The theoretical benefits of minimally invasive surgery over traditional open surgery include reduced blood loss, decreased postoperative pain and narcotics use, shorter hospital length of stay, faster recover and quicker return to work and normal activity. This paper describes the different minimally invasive techniques that are currently available for the treatment of degenerative disease of the lumbar spine.
