Background Variation in prostate cancer incidence between different racial groups has been well documented, for which genetic polymorphisms are hypothesized to be an explanation. We evaluated the association between p...Background Variation in prostate cancer incidence between different racial groups has been well documented, for which genetic polymorphisms are hypothesized to be an explanation. We evaluated the association between polymorphisms in the cytochrome P-450 CYP1A1 （CYP1A1） and glutathione S-transferase M1 （GSTM1） genes and genetic susceptibility to prostate cancer in Chinese men.Methods TWO hundred and eight prostate cancer patients and 230 age matched controls were enrolled in this study. All DNA samples from peripheral blood lymphocytes were genotyped for common genetic polymorphisms of the CYP1A1 and GSTM1 genes using the oligonucleotide microarray （DNA chip） technique and the polymorphism results confirmed by sequencing. The different polymorphisms in prostate cancer patients were also analyzed according to age at diagnosis, prostate specific antigen level, cancer stage and grade （Gleason score）.Results The prevalence of the GSTM1 （0/0） genotype was significantly higher in prostate cancer patients （58.2%） than in controls （41.7%, P〈0.05）. Further analysis demonstrated that the prostate cancer patients with a GSTM1 （0/0） genotype were younger than those with the GSTM1 （＋/＋） genotype （P=-0.024）. No significant differences in the frequency distributions of CYP1A1 polymorphisms were observed between prostate cancer patients and controls.Conclusion GSTM1 （0/0）-gene polymorphism may be linked to prostate cancer risk and early age of Onset in Chinese.展开更多
【目的】探讨CYP1A2＊1F基因多态性与肺癌易感性之间的关系。【方法】收集CYP1A2 163A／C基因多态性与肺癌易感性文献6篇，累计肺癌病例1033例，对照1626例，应用Meta分析探讨CYP1A2＊1F基因多态性与肺癌易感性之间的关系。【结果】CYP...【目的】探讨CYP1A2＊1F基因多态性与肺癌易感性之间的关系。【方法】收集CYP1A2 163A／C基因多态性与肺癌易感性文献6篇，累计肺癌病例1033例，对照1626例，应用Meta分析探讨CYP1A2＊1F基因多态性与肺癌易感性之间的关系。【结果】CYP1A2＊1F基因多态性中CCVSAA的OR值为1．04，95％可信区间为0．54～2．02；ACVSAA的OR值为0．85，95％可信区间为，0．61～1．20；CC＋ACVSAA的OR值为0．88，95％可信区间为0．60～1．27；CC vs AA＋AC的OR值为0．83；95％可信区间为0．54～1．28。【结论】CYP1A2＊1F基因多态性不增加肺癌的患病风险。展开更多
文摘Background Variation in prostate cancer incidence between different racial groups has been well documented, for which genetic polymorphisms are hypothesized to be an explanation. We evaluated the association between polymorphisms in the cytochrome P-450 CYP1A1 （CYP1A1） and glutathione S-transferase M1 （GSTM1） genes and genetic susceptibility to prostate cancer in Chinese men.Methods TWO hundred and eight prostate cancer patients and 230 age matched controls were enrolled in this study. All DNA samples from peripheral blood lymphocytes were genotyped for common genetic polymorphisms of the CYP1A1 and GSTM1 genes using the oligonucleotide microarray （DNA chip） technique and the polymorphism results confirmed by sequencing. The different polymorphisms in prostate cancer patients were also analyzed according to age at diagnosis, prostate specific antigen level, cancer stage and grade （Gleason score）.Results The prevalence of the GSTM1 （0/0） genotype was significantly higher in prostate cancer patients （58.2%） than in controls （41.7%, P〈0.05）. Further analysis demonstrated that the prostate cancer patients with a GSTM1 （0/0） genotype were younger than those with the GSTM1 （＋/＋） genotype （P=-0.024）. No significant differences in the frequency distributions of CYP1A1 polymorphisms were observed between prostate cancer patients and controls.Conclusion GSTM1 （0/0）-gene polymorphism may be linked to prostate cancer risk and early age of Onset in Chinese.
文摘【目的】探讨CYP1A2＊1F基因多态性与肺癌易感性之间的关系。【方法】收集CYP1A2 163A／C基因多态性与肺癌易感性文献6篇，累计肺癌病例1033例，对照1626例，应用Meta分析探讨CYP1A2＊1F基因多态性与肺癌易感性之间的关系。【结果】CYP1A2＊1F基因多态性中CCVSAA的OR值为1．04，95％可信区间为0．54～2．02；ACVSAA的OR值为0．85，95％可信区间为，0．61～1．20；CC＋ACVSAA的OR值为0．88，95％可信区间为0．60～1．27；CC vs AA＋AC的OR值为0．83；95％可信区间为0．54～1．28。【结论】CYP1A2＊1F基因多态性不增加肺癌的患病风险。
