Recently,research on hydrogel materials with a porous structure and superior water absorption capabilities significantly grown.However,the hydrogel under gravity-driven separation conditions often exhibit an unstable ...Recently,research on hydrogel materials with a porous structure and superior water absorption capabilities significantly grown.However,the hydrogel under gravity-driven separation conditions often exhibit an unstable pore structure,poor mechanical properties,and limited functionality.To this end,this work presents a novel approach that combines a macro-micro double bionic strategy with a triple crosslinking method to develop a multifunctional alginate composite hydrogel filter(2%-SA-κCG-PVA-Ca^(2+),2%-SKP-Ca^(2+)for short)with a stable pore structure and superior mechanical properties,which possessed an umbrella-shaped structure resembling that of jellyfish.The 2%-SKPCa^(2+)filter was synthesized using polyvinyl alcohol(PVA)as a stable structure-directing agent,and sodium alginate(SA)andκ-carrageenan(κ-CG)as polymer hydrogels.The distinctive umbrellashaped hydrogel of 2%-SKP-Ca^(2+)filter,formed through the triple crosslinking method,overcomes the limitations of unstable pore structure and poor durability seen in hydrogels prepared by traditional crosslinking methods.Furthermore,the utilization of the 2%-SKP-Ca^(2+)filter in water treatment demonstrates its good selective permeability,excellent resistance to fouling,and extended longevity,which enables it to simultaneously achieve the multifunctional water purification and the coating of multi-substrate anti-fouling coatings.Therefore,not only does this research provide an efficient,multifunctional,highly pollution-resistant preparation method for designing a new filter,but it also confirms the application prospect of the macro-micro dual bionic strategy developed in this study in complex water treatment.展开更多
Decellularization method based on trypsin-digestion is widely used to construct small diameter vascular grafts.However,this method will reduce the opening angle of the blood vessel and result in the reduction of resid...Decellularization method based on trypsin-digestion is widely used to construct small diameter vascular grafts.However,this method will reduce the opening angle of the blood vessel and result in the reduction of residual stress.Residual stress reduced has an adverse effect on the compliance and permeability of small diameter vascular grafts.To improve the situation,acellular blood vessels were treated with glutaraldehyde and photooxidation crosslinking respectively,and the changes of opening angle,circumferential residual strain of native blood vessels,decellularized arteries and crosslinked blood vessels were measured by means of histological examination,scanning electron microscopy(SEM)and transmission electron microscopy(TEM)in this study.The opening angle of decellularized arteries significantly restored after photooxidation crosslinking(P紏0.0216),while that of glutaraldehyde crosslinking blood vessels reduced.The elastic fibers inside the blood vessels became densely rearranged after photooxidation crosslinking.The results of finite element simulation showed that the residual stress increased with the increase of opening angle.In this study,we found at the first time that photooxidation crosslinking method could significantly increase the residual stress of decellularized vessels,which provides biomechanical support for the development of new biomaterials of vascular grafts.展开更多
基金received generous support from multiple sources,including the Zhejiang Provincial Natural Science Foundation of China(No.LY23D060004)the Science and Technology Planning Project of Zhoushan,China(Nos.2022C41005 and 2019C21007)the National Natural Science Foundation of China(No.51606168).
文摘Recently,research on hydrogel materials with a porous structure and superior water absorption capabilities significantly grown.However,the hydrogel under gravity-driven separation conditions often exhibit an unstable pore structure,poor mechanical properties,and limited functionality.To this end,this work presents a novel approach that combines a macro-micro double bionic strategy with a triple crosslinking method to develop a multifunctional alginate composite hydrogel filter(2%-SA-κCG-PVA-Ca^(2+),2%-SKP-Ca^(2+)for short)with a stable pore structure and superior mechanical properties,which possessed an umbrella-shaped structure resembling that of jellyfish.The 2%-SKPCa^(2+)filter was synthesized using polyvinyl alcohol(PVA)as a stable structure-directing agent,and sodium alginate(SA)andκ-carrageenan(κ-CG)as polymer hydrogels.The distinctive umbrellashaped hydrogel of 2%-SKP-Ca^(2+)filter,formed through the triple crosslinking method,overcomes the limitations of unstable pore structure and poor durability seen in hydrogels prepared by traditional crosslinking methods.Furthermore,the utilization of the 2%-SKP-Ca^(2+)filter in water treatment demonstrates its good selective permeability,excellent resistance to fouling,and extended longevity,which enables it to simultaneously achieve the multifunctional water purification and the coating of multi-substrate anti-fouling coatings.Therefore,not only does this research provide an efficient,multifunctional,highly pollution-resistant preparation method for designing a new filter,but it also confirms the application prospect of the macro-micro dual bionic strategy developed in this study in complex water treatment.
基金This work was supported by grants from the National Key R&D Program(2016YFC1101101,2016YFC1102305)Preface Technology Project of Chongqing(cstc2018jcyjAX0530,cstc2019jcyj-msxmX0329)+2 种基金Fundamental Research Funds for Central Universities(2018CDXYSW0023)the National Natural Science Foundation of China(30570453,31971242)We are also thankful for the support from the Chongqing Engineering Laboratory in Vascular Implants,the Public Experiment Center of State Bioindustrial Base(Chongqing),China.
文摘Decellularization method based on trypsin-digestion is widely used to construct small diameter vascular grafts.However,this method will reduce the opening angle of the blood vessel and result in the reduction of residual stress.Residual stress reduced has an adverse effect on the compliance and permeability of small diameter vascular grafts.To improve the situation,acellular blood vessels were treated with glutaraldehyde and photooxidation crosslinking respectively,and the changes of opening angle,circumferential residual strain of native blood vessels,decellularized arteries and crosslinked blood vessels were measured by means of histological examination,scanning electron microscopy(SEM)and transmission electron microscopy(TEM)in this study.The opening angle of decellularized arteries significantly restored after photooxidation crosslinking(P紏0.0216),while that of glutaraldehyde crosslinking blood vessels reduced.The elastic fibers inside the blood vessels became densely rearranged after photooxidation crosslinking.The results of finite element simulation showed that the residual stress increased with the increase of opening angle.In this study,we found at the first time that photooxidation crosslinking method could significantly increase the residual stress of decellularized vessels,which provides biomechanical support for the development of new biomaterials of vascular grafts.
