Composite microspheres composed of monodispersed poly（St-co-MAA） latices with diameter about 260 nm as core and Ag nanocrystals as shell were prepared by an in situ reduction method. The shell thickness could be con...Composite microspheres composed of monodispersed poly（St-co-MAA） latices with diameter about 260 nm as core and Ag nanocrystals as shell were prepared by an in situ reduction method. The shell thickness could be controlled in the range of 15--45 nm by this coating process. The structure and the composition of the core-shell microspheres were characterized by transmission electron microscopy （TEM）, X-ray diffractometry （XRD）, X-ray photoelectron spectroscopy （XPS）, and thermogravimetric analysis （TG）. The formation of the composite microspheres is explained by the nucleation of silver on the surface of the latices followed by growth of the silver shell.展开更多
文摘以低度交联的单分散三聚氰胺甲醛(MF)微球作为胶体模板,采用逐层静电自组装技术,交替组装正负聚电解质,得到具有核壳结构的复合微球,然后利用盐酸溶液分解掉模板MF,从而形成均匀的空腔胶囊;并以盐酸阿霉素为例,对空腔胶囊的载药量及缓释性进行了初步研究. 结果显示,胶囊载药量可达27.07 mg/mL,胶囊对药物具有显著的缓释作用,释放半衰期t1/2=17.5 h.
基金Project supported by the National Natural Science Foundation of China （No. 20271016）.
文摘Composite microspheres composed of monodispersed poly（St-co-MAA） latices with diameter about 260 nm as core and Ag nanocrystals as shell were prepared by an in situ reduction method. The shell thickness could be controlled in the range of 15--45 nm by this coating process. The structure and the composition of the core-shell microspheres were characterized by transmission electron microscopy （TEM）, X-ray diffractometry （XRD）, X-ray photoelectron spectroscopy （XPS）, and thermogravimetric analysis （TG）. The formation of the composite microspheres is explained by the nucleation of silver on the surface of the latices followed by growth of the silver shell.
