In this paper,algebraic criteria are established to determine whether or not a real coefficient polynomial has one or two pairs of conjugate complex roots whose moduli are equal to 1 and the other roots have moduli le...In this paper,algebraic criteria are established to determine whether or not a real coefficient polynomial has one or two pairs of conjugate complex roots whose moduli are equal to 1 and the other roots have moduli less than 1 directly from its coefficients.The form and the function of the criteria are similar to those of the Jury criterion which can be used to determine whether or not all the moduli of the roots of a real coefficient polynomial are less than 1.展开更多
RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases.These include antisense oligonucleotides(ASOs),s...RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases.These include antisense oligonucleotides(ASOs),small interfering RNAs(siRNAs),endogenous microRNAs(miRNAs),messenger RNAs(mRNAs),clustered regularly interspersed short palindromic repeats-associated protein 9(CRISPR/Cas9),single guide RNAs(sgRNAs),as well as RNA aptamers.These therapeutic agents exert their effects through various mechanisms such as gene inhibition,addition,replacement,and editing.The advancement of RNA biology and the field of RNA therapy has paved the way for the development and utilization of RNA-based nanomedicine in human healthcare.One remarkable example of RNA-based nanomedicine is the mRNA-based vaccines including mRNA-1273(Moderna)and BNT162b2(Pfizer/BioNTech)that have been successfully employed in response to the coronavirus disease 2019(COVID-19)pandemic.This review aims to highlight the advantages of RNA-based nanomedicines,provides an overview of significant developments in delivery systems,elucidates the molecular mechanisms of action underlying RNA-based nanomedicines,and discusses their clinical applications.Additionally,the review will address the existing challenges and innovations in delivery platforms while exploring the future possibilities for these promising RNA-based nanomedicines.展开更多
A novel building integrated photovoltaic thermal(BIPVT)roofing panel has been designed considering both solar energy harvesting efficiency and thermal performance.The thermal system reduces the operating temperature o...A novel building integrated photovoltaic thermal(BIPVT)roofing panel has been designed considering both solar energy harvesting efficiency and thermal performance.The thermal system reduces the operating temperature of the cells by means of a hydronic loop integrated into the backside of the panel,thus resulting in maintaining the efficiency of the solar panels at their feasible peak while also harvesting the generated heat for use in the building.The performance of the proposed system has been evaluated using physical experiments by conducting case studies to investigate the energy harvesting efficiency,thermal performance of the panel,and temperature differences of inlet/outlet working liquid with various liquid flow rates.The physical experiments have been simulated by coupling the finite element method(FEM)and finite volume method(FVM)for heat and mass transfer in the operation.Results show that the thermal system successfully reduced the surface temperature of the solar module from 88℃to as low as 55℃.Accordingly,the output power that has been decreased from 14.89 W to 10.69 W can be restored by 30.2%to achieve 13.92 W.On the other hand,the outlet water from this hydronic system reaches 45.4℃which can be used to partially heat domestic water use.Overall,this system provides a versatile framework for the design and optimization of the BIPVT systems.展开更多
The SE Tibetan Plateau,tectonically situated in the eastern India-Eurasia oblique convergence zone,has experienced multiple stages of deformation since the Cenozoic.Three major tectonic boundaries—the Ailaoshan-Red R...The SE Tibetan Plateau,tectonically situated in the eastern India-Eurasia oblique convergence zone,has experienced multiple stages of deformation since the Cenozoic.Three major tectonic boundaries—the Ailaoshan-Red River,ChongshanLincang-Inthanon,and Gaoligong-Mogok shear zones—delineate the first-order tectonic framework in this region.The most striking structural features in the block interiors are a series of NW-and NE-trending fault systems,such as the Dayingjiang,Longlin-Ruili,Nantinghe,Red River,Weixi-Qiaohou,and Lancang-Genma faults,which have conjugate geometric relationships.In this study,we review these structures’geometric and kinematic characteristics and deformation histories.A synthesis of existing geological observations,geomorphological analyses,and chronological data reveals three major Cenozoic tectonothermal events,including crustal shortening,strike-slip shearing,and kinematic reversal.The boundary structures controlled the tectonic extrusion of plateau material during the early Oligocene-early Miocene.In the mid-late Miocene,NW-and NE-trending fault systems mostly experienced diachronous slip-sense inversions.The onset and spatial trend of regional kinematic reversal are constrained by existing chronologic data.Together with geophysical and geodetic observations,the activity and geodynamic drivers of the major fault systems and regional deformation styles are explored,revealing that the SE Tibetan Plateau underwent a transition from discrete(lateral block extrusion)to diffuse deformation in the mid-late Miocene.The intracontinental crustal deformation and its coupling with dynamic processes at depth during the plateau growth are discussed in the context of the IndiaEurasia convergence.展开更多
The paper reports the dynamical study of a three-dimensional quadratic autonomous chaotic system with only two quadratic nonlinearities, which is a special case of the so-called conjugate Lue system. Basic properties ...The paper reports the dynamical study of a three-dimensional quadratic autonomous chaotic system with only two quadratic nonlinearities, which is a special case of the so-called conjugate Lue system. Basic properties of this system are analyzed by means of Lyapunov exponent spectrum and bifurcation diagram. The analysis shows that the system has complex dynamics with some interesting characteristics in which there are several periodic regions, but each of them has quite different periodic orbits.展开更多
A conjugate gradient method （CGM） based on the inverse algorithm is used to estimate the unknown fouling-layer profile on the inner wall of a pipe system using simulated temperature measurements taken within the pip...A conjugate gradient method （CGM） based on the inverse algorithm is used to estimate the unknown fouling-layer profile on the inner wall of a pipe system using simulated temperature measurements taken within the pipe wall. It is assumed that no prior information is available about the functional form of the unknown profile. Therefore, the procedure is classified as the function estimation in inverse calculation. The temperature data obtained from the direct problem are used to simulate the temperature measurements. The accuracy of the inverse analysis is examined using the simulated exact and inexact temperature measurements. The results show that the excellent estimation of the fouling-layer profile can be obtained for the test case considered in this study. The technique presented in this study can be used in a warning system to call for pipe maintenance when the thickness of fouling exceeds a predefined criterion.展开更多
Minor self conjugate (msc) and skewpositive semidefinite (ssd) solutions to the system of matrix equations over skew fields [A mn X nn =A mn ,B sn X nn =O sn ] are considered. Necessary and su...Minor self conjugate (msc) and skewpositive semidefinite (ssd) solutions to the system of matrix equations over skew fields [A mn X nn =A mn ,B sn X nn =O sn ] are considered. Necessary and sufficient conditions for the existence of and the expressions for the msc solutions and the ssd solutions are obtained for the system.展开更多
The crystal structure and molecular structures of the title compound were determined using Xray analysis.The crystal belongs to monoclinic system with the space group P21/c,C21H20N4O2,with Mr=358...The crystal structure and molecular structures of the title compound were determined using Xray analysis.The crystal belongs to monoclinic system with the space group P21/c,C21H20N4O2,with Mr=35839,a=12845(3),b=19334(4),c=073112(5)nm,β=9443(3)°,V=18103(4)nm3,Z=4,DC=132Mg·m-3,μ=0088mm-1,and F(000)=752.The final discrepancy factor R1=01508,and S=0942.The result showed that the dihedral angles between the two pyrazolinone rings and phenyl rings were 1267 and 798°,which indicated that these two planes roughly coplanar to each other forming a big conjugate system.展开更多
基金supported by National Natural Science Foundation of China (Grant No.10891056)
文摘In this paper,algebraic criteria are established to determine whether or not a real coefficient polynomial has one or two pairs of conjugate complex roots whose moduli are equal to 1 and the other roots have moduli less than 1 directly from its coefficients.The form and the function of the criteria are similar to those of the Jury criterion which can be used to determine whether or not all the moduli of the roots of a real coefficient polynomial are less than 1.
基金supported by the National Natural Science Foundation of China(No.32371458)the Key Research and Development Programs of the Ministry of Science and Technology(No.2022YFA1205700)+1 种基金the Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei(Nos.H_(2)022205047,22JCZXJC00060,and E3B33911DF)funding from the National Center for Nanoscience and Technology and Chinese Academy of Sciences.
文摘RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases.These include antisense oligonucleotides(ASOs),small interfering RNAs(siRNAs),endogenous microRNAs(miRNAs),messenger RNAs(mRNAs),clustered regularly interspersed short palindromic repeats-associated protein 9(CRISPR/Cas9),single guide RNAs(sgRNAs),as well as RNA aptamers.These therapeutic agents exert their effects through various mechanisms such as gene inhibition,addition,replacement,and editing.The advancement of RNA biology and the field of RNA therapy has paved the way for the development and utilization of RNA-based nanomedicine in human healthcare.One remarkable example of RNA-based nanomedicine is the mRNA-based vaccines including mRNA-1273(Moderna)and BNT162b2(Pfizer/BioNTech)that have been successfully employed in response to the coronavirus disease 2019(COVID-19)pandemic.This review aims to highlight the advantages of RNA-based nanomedicines,provides an overview of significant developments in delivery systems,elucidates the molecular mechanisms of action underlying RNA-based nanomedicines,and discusses their clinical applications.Additionally,the review will address the existing challenges and innovations in delivery platforms while exploring the future possibilities for these promising RNA-based nanomedicines.
基金the National Science Foundation IIP#1941244,CMMI#1762891U.S.Department of Agriculture NIFA#2021-67021-34201,whose support is gratefully acknowledged.
文摘A novel building integrated photovoltaic thermal(BIPVT)roofing panel has been designed considering both solar energy harvesting efficiency and thermal performance.The thermal system reduces the operating temperature of the cells by means of a hydronic loop integrated into the backside of the panel,thus resulting in maintaining the efficiency of the solar panels at their feasible peak while also harvesting the generated heat for use in the building.The performance of the proposed system has been evaluated using physical experiments by conducting case studies to investigate the energy harvesting efficiency,thermal performance of the panel,and temperature differences of inlet/outlet working liquid with various liquid flow rates.The physical experiments have been simulated by coupling the finite element method(FEM)and finite volume method(FVM)for heat and mass transfer in the operation.Results show that the thermal system successfully reduced the surface temperature of the solar module from 88℃to as low as 55℃.Accordingly,the output power that has been decreased from 14.89 W to 10.69 W can be restored by 30.2%to achieve 13.92 W.On the other hand,the outlet water from this hydronic system reaches 45.4℃which can be used to partially heat domestic water use.Overall,this system provides a versatile framework for the design and optimization of the BIPVT systems.
基金supported by the Natural Science Foundation of Guangdong Province(Grant Nos.2021A1515011631,202102020490 and 2019B1515120019)the National Natural Science Foundation of China(Grant Nos.U1701641 and41802213)+1 种基金the Second Tibetan Plateau Scientific Expedition and Research Program(STEP,Grant No.2019QZKK0703)Guangdong Province Introduced Innovative and R&D Team of Geological Processes and Natural Disasters around the South China Sea(Grant No.2016ZT06N331)。
文摘The SE Tibetan Plateau,tectonically situated in the eastern India-Eurasia oblique convergence zone,has experienced multiple stages of deformation since the Cenozoic.Three major tectonic boundaries—the Ailaoshan-Red River,ChongshanLincang-Inthanon,and Gaoligong-Mogok shear zones—delineate the first-order tectonic framework in this region.The most striking structural features in the block interiors are a series of NW-and NE-trending fault systems,such as the Dayingjiang,Longlin-Ruili,Nantinghe,Red River,Weixi-Qiaohou,and Lancang-Genma faults,which have conjugate geometric relationships.In this study,we review these structures’geometric and kinematic characteristics and deformation histories.A synthesis of existing geological observations,geomorphological analyses,and chronological data reveals three major Cenozoic tectonothermal events,including crustal shortening,strike-slip shearing,and kinematic reversal.The boundary structures controlled the tectonic extrusion of plateau material during the early Oligocene-early Miocene.In the mid-late Miocene,NW-and NE-trending fault systems mostly experienced diachronous slip-sense inversions.The onset and spatial trend of regional kinematic reversal are constrained by existing chronologic data.Together with geophysical and geodetic observations,the activity and geodynamic drivers of the major fault systems and regional deformation styles are explored,revealing that the SE Tibetan Plateau underwent a transition from discrete(lateral block extrusion)to diffuse deformation in the mid-late Miocene.The intracontinental crustal deformation and its coupling with dynamic processes at depth during the plateau growth are discussed in the context of the IndiaEurasia convergence.
文摘The paper reports the dynamical study of a three-dimensional quadratic autonomous chaotic system with only two quadratic nonlinearities, which is a special case of the so-called conjugate Lue system. Basic properties of this system are analyzed by means of Lyapunov exponent spectrum and bifurcation diagram. The analysis shows that the system has complex dynamics with some interesting characteristics in which there are several periodic regions, but each of them has quite different periodic orbits.
基金Project supported by the National Science Council of Taiwan of China(No.NSC 97-2221-E-168-039)
文摘A conjugate gradient method （CGM） based on the inverse algorithm is used to estimate the unknown fouling-layer profile on the inner wall of a pipe system using simulated temperature measurements taken within the pipe wall. It is assumed that no prior information is available about the functional form of the unknown profile. Therefore, the procedure is classified as the function estimation in inverse calculation. The temperature data obtained from the direct problem are used to simulate the temperature measurements. The accuracy of the inverse analysis is examined using the simulated exact and inexact temperature measurements. The results show that the excellent estimation of the fouling-layer profile can be obtained for the test case considered in this study. The technique presented in this study can be used in a warning system to call for pipe maintenance when the thickness of fouling exceeds a predefined criterion.
文摘Minor self conjugate (msc) and skewpositive semidefinite (ssd) solutions to the system of matrix equations over skew fields [A mn X nn =A mn ,B sn X nn =O sn ] are considered. Necessary and sufficient conditions for the existence of and the expressions for the msc solutions and the ssd solutions are obtained for the system.
文摘The crystal structure and molecular structures of the title compound were determined using Xray analysis.The crystal belongs to monoclinic system with the space group P21/c,C21H20N4O2,with Mr=35839,a=12845(3),b=19334(4),c=073112(5)nm,β=9443(3)°,V=18103(4)nm3,Z=4,DC=132Mg·m-3,μ=0088mm-1,and F(000)=752.The final discrepancy factor R1=01508,and S=0942.The result showed that the dihedral angles between the two pyrazolinone rings and phenyl rings were 1267 and 798°,which indicated that these two planes roughly coplanar to each other forming a big conjugate system.
