Background： The Composite International Diagnostic Interview-3.0 （CIDI-3.0） is a fully structured lay-administered diagnostic interview for the assessment of mental disorders according to ICD-10 and Diagnostic and ...Background： The Composite International Diagnostic Interview-3.0 （CIDI-3.0） is a fully structured lay-administered diagnostic interview for the assessment of mental disorders according to ICD-10 and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition （DSM-IV） criteria. The aim of the study was to investigate the concurrent validity of the Chinese CIDI in diagnosing mental disorders in psychiatric settings. Methods： We recruited 208 participants, of whom 148 were patients from two psychiatric hospitals and 60 healthy people from communities. These participants were administered with CIDI by six trained lay interviewers and the Structured Clinical Interview for DSM-IV Axis I Disorders （SCID-I, gold standard） by two psychiatrists. Agreement between CIDI and SCID-I was assessed with sensitivity, specificity, positive predictive value and negative predictive value. Individual-level CIDI-SCID diagnostic concordance was evaluated using the area under the receiver operator characteristic curve and Cohen＇s K. Results： Substantial to excellent CIDI to SCID concordance was found for any substance use disorder （area under the receiver operator characteristic curve [AUC] = 0.926）, any anxiety disorder （AUC = 0.807） and any mood disorder （AUC = 0.806）. The concordance between the CIDI and the SCID for psychotic and eating disorders is moderate. However, for individual mental disorders, the CIDI-SCID concordance for bipolar disorders （AUC = 0.55） and anorexia nervosa （AUC = 0.50） was insufficient. Conclusions： Overall, the Chinese version of ClDI-3.0 has acceptable validity in diagnosing the substance use disorder, anxiety disorder and mood disorder among Chinese adult population. However, we should be cautious when using it for bipolar disorders and anorexia nervosa.展开更多
Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the co...Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high vs.low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals.展开更多
目的:探讨药物利用指数(d DUI/c DUI)与药品说明书评价结果相关性。方法:以6种中药注射剂为例,分层随机抽取某医院使用该品种中药注射剂病例120例,采用d DUI/c DUI与药品说明书(给药剂量/给药浓度合理性百分率)评价中药注射剂临床使用...目的:探讨药物利用指数(d DUI/c DUI)与药品说明书评价结果相关性。方法:以6种中药注射剂为例,分层随机抽取某医院使用该品种中药注射剂病例120例,采用d DUI/c DUI与药品说明书(给药剂量/给药浓度合理性百分率)评价中药注射剂临床使用合理性与安全性,并探讨两者评价结果相关性与一致性。结果:相关分析提示,除注射用丹参(冻干)外,其他5种中药注射剂药物利用指数c DUI与药品说明书(给药浓度)评价尚具有较好相关性(热毒宁注射液:Spearman=-0.7507,P<0.05;疏血通注射液:Spearman=-0.7723,P<0.05;血塞通注射液:Spearman=-0.8911,P<0.05;银杏内酯注射液:Spearman=0.7283,P<0.05;灯盏细辛注射液:S p e a r m a n=-0.5854,P<0.05);κ参数提示,c DUI与给药浓度仅银杏内酯注射液尚具有较好一致性(κ=0.613,P<0.05)。结论:药物利用指数与药品说明书评价相关性受多因素影响,其中从给药浓度角度评价中药注射剂临床使用合理性与安全性尚可接受,但应注意临床严重超剂量、超浓度使用等实际因素的影响。展开更多
Qinghai Lake Watershed （QLW） is a hot place of a series of ecological restoration and environmental remediation programs nowadays.However,little information is available on change of ecosystem service and economic p...Qinghai Lake Watershed （QLW） is a hot place of a series of ecological restoration and environmental remediation programs nowadays.However,little information is available on change of ecosystem service and economic practice in this area.As ecosystem service and natural capital are closely related with social and economic development,an index of concordance between environment and economy （ICEE） has been proposed to compare the annual variation rate of ecosystem service value （RESV） with that of gross domestic product （RGDP）.Using this Index,we have assessed concordance between environment and economy （CEE） for the QLW in the period 1977-2004.The result showed that from 1977 to 2004,the ecosystem service value in the QLW descended from 128.81×10 8 yuan to 127.32×10 8 yuan;In contrast,the GDP increased from 0.931×10 8 yuan to 8.856×10 8 yuan.The values of the I CEE were -1.14,-0.22,and -0.14 in the stages of 1977-1987,1987-2000 and 2000-2004,respectively.The result indicated that during the first stage 1977-1987,the relationship between environment and economy in the QLW was not concordant but at a high conflict;from 1987 to 2004,there was a low conflict between environment and economy,and the CEE appeared to increase slowly.Analysis of the assessment results showed that the national policies and industrial adjustment practice play an important role in the CEE changes.展开更多
文摘Background： The Composite International Diagnostic Interview-3.0 （CIDI-3.0） is a fully structured lay-administered diagnostic interview for the assessment of mental disorders according to ICD-10 and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition （DSM-IV） criteria. The aim of the study was to investigate the concurrent validity of the Chinese CIDI in diagnosing mental disorders in psychiatric settings. Methods： We recruited 208 participants, of whom 148 were patients from two psychiatric hospitals and 60 healthy people from communities. These participants were administered with CIDI by six trained lay interviewers and the Structured Clinical Interview for DSM-IV Axis I Disorders （SCID-I, gold standard） by two psychiatrists. Agreement between CIDI and SCID-I was assessed with sensitivity, specificity, positive predictive value and negative predictive value. Individual-level CIDI-SCID diagnostic concordance was evaluated using the area under the receiver operator characteristic curve and Cohen＇s K. Results： Substantial to excellent CIDI to SCID concordance was found for any substance use disorder （area under the receiver operator characteristic curve [AUC] = 0.926）, any anxiety disorder （AUC = 0.807） and any mood disorder （AUC = 0.806）. The concordance between the CIDI and the SCID for psychotic and eating disorders is moderate. However, for individual mental disorders, the CIDI-SCID concordance for bipolar disorders （AUC = 0.55） and anorexia nervosa （AUC = 0.50） was insufficient. Conclusions： Overall, the Chinese version of ClDI-3.0 has acceptable validity in diagnosing the substance use disorder, anxiety disorder and mood disorder among Chinese adult population. However, we should be cautious when using it for bipolar disorders and anorexia nervosa.
基金supported by the National Key R&D Program of China (2017YFC1309902 to CGY)National Basic Research Program (2015CB351702 to XNZ)+4 种基金the Natural Science Foundation of China (81671774 and 81630031 to CGY, 81471740, 81220108014 to XNZ)the Hundred Talents Program of the Chinese Academy of Sciences (Y5CX072006 to CGY)Beijing Municipal Science & Technology Commission (Z161100000216152 to CGY)the National Institutes of Health (U01MH099059 to MPM)the Child Mind Institute (1FDN2012-1 to MPM)
文摘Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high vs.low concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals.
文摘目的:探讨药物利用指数(d DUI/c DUI)与药品说明书评价结果相关性。方法:以6种中药注射剂为例,分层随机抽取某医院使用该品种中药注射剂病例120例,采用d DUI/c DUI与药品说明书(给药剂量/给药浓度合理性百分率)评价中药注射剂临床使用合理性与安全性,并探讨两者评价结果相关性与一致性。结果:相关分析提示,除注射用丹参(冻干)外,其他5种中药注射剂药物利用指数c DUI与药品说明书(给药浓度)评价尚具有较好相关性(热毒宁注射液:Spearman=-0.7507,P<0.05;疏血通注射液:Spearman=-0.7723,P<0.05;血塞通注射液:Spearman=-0.8911,P<0.05;银杏内酯注射液:Spearman=0.7283,P<0.05;灯盏细辛注射液:S p e a r m a n=-0.5854,P<0.05);κ参数提示,c DUI与给药浓度仅银杏内酯注射液尚具有较好一致性(κ=0.613,P<0.05)。结论:药物利用指数与药品说明书评价相关性受多因素影响,其中从给药浓度角度评价中药注射剂临床使用合理性与安全性尚可接受,但应注意临床严重超剂量、超浓度使用等实际因素的影响。
基金New Century Excellent Talents in University, No.NCET-08-0056 National Natural Science Foundation of China, No.40971110 National Key Technologies R＆D Program, No.2007BAC30B02
文摘Qinghai Lake Watershed （QLW） is a hot place of a series of ecological restoration and environmental remediation programs nowadays.However,little information is available on change of ecosystem service and economic practice in this area.As ecosystem service and natural capital are closely related with social and economic development,an index of concordance between environment and economy （ICEE） has been proposed to compare the annual variation rate of ecosystem service value （RESV） with that of gross domestic product （RGDP）.Using this Index,we have assessed concordance between environment and economy （CEE） for the QLW in the period 1977-2004.The result showed that from 1977 to 2004,the ecosystem service value in the QLW descended from 128.81×10 8 yuan to 127.32×10 8 yuan;In contrast,the GDP increased from 0.931×10 8 yuan to 8.856×10 8 yuan.The values of the I CEE were -1.14,-0.22,and -0.14 in the stages of 1977-1987,1987-2000 and 2000-2004,respectively.The result indicated that during the first stage 1977-1987,the relationship between environment and economy in the QLW was not concordant but at a high conflict;from 1987 to 2004,there was a low conflict between environment and economy,and the CEE appeared to increase slowly.Analysis of the assessment results showed that the national policies and industrial adjustment practice play an important role in the CEE changes.
