目的探讨认知行为护理对乳腺癌化疗患者认知功能、心理状况及自我效能的影响。方法选取2016年8月至2017年8月本院收治的乳腺癌术后化疗患者76例,采用随机单盲法分为对照组和干预组,每组38例。对照组给予常规护理,干预组在对照组基础上...目的探讨认知行为护理对乳腺癌化疗患者认知功能、心理状况及自我效能的影响。方法选取2016年8月至2017年8月本院收治的乳腺癌术后化疗患者76例,采用随机单盲法分为对照组和干预组,每组38例。对照组给予常规护理,干预组在对照组基础上由经过培训的护理人员进行"一对一"的认知行为护理干预,每次30分钟,隔日一次,连续干预3个月。比较两组干预前后的癌症治疗功能评估-认知功能(functional assessment of cancer therapy-cognitive function,FACT-Cog)量表、中文版简式心境状态(profile of mood states,POMS)量表、健康促进策略(strategies used by people to promote health,SUPPH)量表评分情况。结果干预后两组FACT-Cog量表纠正认知障碍、认知能力、生命质量评分明显高于干预前,且干预组明显高于对照组,差异均有显著性(P<0.01)。对照组干预前后中文版简式POMS量表各项得分及总分比较差异均无显著性(P>0.05),干预组干预后中文版简式POMS量表压抑情绪、紧张情绪、愤怒情绪、劳累程度、恐慌程度及总分明显低于干预前及对照组干预后,精力状况、自尊感评分明显高于干预前及对照组干预后,差异均有显著性(P<0.01)。干预后两组SUPPH量表正面态度、自我减压、自我决策及总分均明显高于同组干预前,且干预组明显高于对照组,差异均有显著性(P<0.01)。结论认知行为护理可有效改善乳腺癌化疗患者的心理状况,提高患者的认知功能和自我效能。展开更多
目的探讨抑郁症患者治疗前及6个月后缓解者的认知功能特征。方法采用24项汉密尔顿抑郁量表(24-Items Hamilton Depression Scale,HAMD24)对103例抑郁症患者(抑郁症组)和与之相匹配的104名健康对照者(健康对照组)评定抑郁严重程...目的探讨抑郁症患者治疗前及6个月后缓解者的认知功能特征。方法采用24项汉密尔顿抑郁量表(24-Items Hamilton Depression Scale,HAMD24)对103例抑郁症患者(抑郁症组)和与之相匹配的104名健康对照者(健康对照组)评定抑郁严重程度。采用WSCT及神经认知功能评估工具中的Stroop色词测验、连线测验、词语流畅性测验、韦氏记忆量表评定抑郁症患者帕罗西汀治疗前及6个月后抑郁症缓解期患者(抑郁症缓解组)的认知功能特点及变化。采用方差分析和简单效应分析比较抑郁症缓解组和与之相匹配的健康对照随访者(对照随访组)认知因子变化差异。结果基线时,抑郁症组信息处理速度、词语流畅性、认知灵活性、学习记忆等方面各因子评分均显著低于健康对照组(t=-7.441--4.601,P〈0.01)。抑郁症缓解组(n=53)与对照随访组(n=31)各认知因子经两因素重复测量方差分析,词语流畅性[基线:(-0.81±0.93)分与(-0.13±1.12)分;6个月:(-0.38±0.87)分与(0.08±0.94)分]组别×时间无交互作用(F=0.625,P=0.432),组间差异有统计学意义(F=7.672,P=0.007),但时间点差异无统计学意义(F=1.484,P=0.227);其余认知因子组别×时间均存在交互作用(P〈0.05或P〈0.01);简单效应分析显示,基线时2组间认知因子比较差异均有统计学意义(P〈0.05或P〈0.01),但6个月时2组间差异均无统计学意义。结论抑郁症发病期患者存在认知功能损害,除词语流畅性外,其他认知因子在抑郁症缓解期恢复至健康水平,词语流畅性可能是抑郁症的内表型,而其他认知因子可能为抑郁症的状态型。展开更多
Our previous ifndings have demonstrated that acupuncture at the Taixi (KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acu...Our previous ifndings have demonstrated that acupuncture at the Taixi (KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acupoint in elderly patients with mild cognitive impairment can also activate neurons in these regions. Resting state and task-related functional magnetic resonance imaging showed that the pinprick senstation of acupuncture at the Taixi acupoint differed signiifcantly between elderly patients with mild cognitive impairment and healthy elderly controls. Results showed that 20 brain regions were activated in both groups of participants, including the bi-lateral anterior cingulate gyrus (Brodmann areas [BA] 32, 24), left medial frontal cortex (BA 9, 10, 11), left cuneus (BA 19), left middle frontal gyrus (BA 11), left lingual gyrus (BA 18), right medial frontal gyrus (BA 11), bilateral inferior frontal gyrus (BA 47), left superior frontal gyrus (BA11), right cuneus (BA 19, 18), right superior temporal gyrus (BA 38), left subcallosal gyrus (BA 47), bilateral precuneus (BA 19), right medial frontal gyrus (BA 10), right superior frontal (BA 11), left cingulate gyrus (BA 32), left precentral gyrus (BA 6), and right fusiform gyrus (BA 19). These results suggest that acupuncture at the Taixi acupoint in elderly patients with mild cogni-tive impairment can also activate some brain regions.展开更多
文摘目的探讨认知行为护理对乳腺癌化疗患者认知功能、心理状况及自我效能的影响。方法选取2016年8月至2017年8月本院收治的乳腺癌术后化疗患者76例,采用随机单盲法分为对照组和干预组,每组38例。对照组给予常规护理,干预组在对照组基础上由经过培训的护理人员进行"一对一"的认知行为护理干预,每次30分钟,隔日一次,连续干预3个月。比较两组干预前后的癌症治疗功能评估-认知功能(functional assessment of cancer therapy-cognitive function,FACT-Cog)量表、中文版简式心境状态(profile of mood states,POMS)量表、健康促进策略(strategies used by people to promote health,SUPPH)量表评分情况。结果干预后两组FACT-Cog量表纠正认知障碍、认知能力、生命质量评分明显高于干预前,且干预组明显高于对照组,差异均有显著性(P<0.01)。对照组干预前后中文版简式POMS量表各项得分及总分比较差异均无显著性(P>0.05),干预组干预后中文版简式POMS量表压抑情绪、紧张情绪、愤怒情绪、劳累程度、恐慌程度及总分明显低于干预前及对照组干预后,精力状况、自尊感评分明显高于干预前及对照组干预后,差异均有显著性(P<0.01)。干预后两组SUPPH量表正面态度、自我减压、自我决策及总分均明显高于同组干预前,且干预组明显高于对照组,差异均有显著性(P<0.01)。结论认知行为护理可有效改善乳腺癌化疗患者的心理状况,提高患者的认知功能和自我效能。
文摘目的探讨抑郁症患者治疗前及6个月后缓解者的认知功能特征。方法采用24项汉密尔顿抑郁量表(24-Items Hamilton Depression Scale,HAMD24)对103例抑郁症患者(抑郁症组)和与之相匹配的104名健康对照者(健康对照组)评定抑郁严重程度。采用WSCT及神经认知功能评估工具中的Stroop色词测验、连线测验、词语流畅性测验、韦氏记忆量表评定抑郁症患者帕罗西汀治疗前及6个月后抑郁症缓解期患者(抑郁症缓解组)的认知功能特点及变化。采用方差分析和简单效应分析比较抑郁症缓解组和与之相匹配的健康对照随访者(对照随访组)认知因子变化差异。结果基线时,抑郁症组信息处理速度、词语流畅性、认知灵活性、学习记忆等方面各因子评分均显著低于健康对照组(t=-7.441--4.601,P〈0.01)。抑郁症缓解组(n=53)与对照随访组(n=31)各认知因子经两因素重复测量方差分析,词语流畅性[基线:(-0.81±0.93)分与(-0.13±1.12)分;6个月:(-0.38±0.87)分与(0.08±0.94)分]组别×时间无交互作用(F=0.625,P=0.432),组间差异有统计学意义(F=7.672,P=0.007),但时间点差异无统计学意义(F=1.484,P=0.227);其余认知因子组别×时间均存在交互作用(P〈0.05或P〈0.01);简单效应分析显示,基线时2组间认知因子比较差异均有统计学意义(P〈0.05或P〈0.01),但6个月时2组间差异均无统计学意义。结论抑郁症发病期患者存在认知功能损害,除词语流畅性外,其他认知因子在抑郁症缓解期恢复至健康水平,词语流畅性可能是抑郁症的内表型,而其他认知因子可能为抑郁症的状态型。
基金supported by the National Natural Science Foundation of China,No.81173354the Natural Science Foundation of Guangdong Province,No.10451810101005862+1 种基金a grant from Guangdong Administration of Traditional Chinese Medicine,No.20111032,20132019the Science and Technology Plan Project of Baoan District,Shenzhen City,No.200902159
文摘Our previous ifndings have demonstrated that acupuncture at the Taixi (KI3) acupoint in healthy youths can activate neurons in cognitive-related cerebral cortex. Here, we investigated whether acupuncture at this acupoint in elderly patients with mild cognitive impairment can also activate neurons in these regions. Resting state and task-related functional magnetic resonance imaging showed that the pinprick senstation of acupuncture at the Taixi acupoint differed signiifcantly between elderly patients with mild cognitive impairment and healthy elderly controls. Results showed that 20 brain regions were activated in both groups of participants, including the bi-lateral anterior cingulate gyrus (Brodmann areas [BA] 32, 24), left medial frontal cortex (BA 9, 10, 11), left cuneus (BA 19), left middle frontal gyrus (BA 11), left lingual gyrus (BA 18), right medial frontal gyrus (BA 11), bilateral inferior frontal gyrus (BA 47), left superior frontal gyrus (BA11), right cuneus (BA 19, 18), right superior temporal gyrus (BA 38), left subcallosal gyrus (BA 47), bilateral precuneus (BA 19), right medial frontal gyrus (BA 10), right superior frontal (BA 11), left cingulate gyrus (BA 32), left precentral gyrus (BA 6), and right fusiform gyrus (BA 19). These results suggest that acupuncture at the Taixi acupoint in elderly patients with mild cogni-tive impairment can also activate some brain regions.