AIM:To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in 1990-2010.METHODS:A case of gastric glomus tumor was re-ported.Clinicopathological findings ...AIM:To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in 1990-2010.METHODS:A case of gastric glomus tumor was re-ported.Clinicopathological findings in 56 cases of gastric glomus tumor were analyzed.RESULTS:Gastric glomus tumor was far more common in women than in men with a female to male ratio of 1.6:1.The median age of the patients was 45 years(range 28-79 years).The patients often complained of epigastric pain and bloody stool.The tumor was located in antrum of the stomach.The greatest diameter of the tumor was 0.8-11cm.Histologically,the tumor was comprised of nests of glomus cells surrounding the capillaries.Glomus cells were small,uniform and round.Vimentin,smooth muscle actin and actin were expressed in the tumor.Other markers,including S-100 protein,CD34,CD117,desmin,CD56,synaptophysin,chromo-granin A,neuron specific enolase and cytokeratin were all negative.CONCLUSION:Gastric glomus tumor is a rare benign mesenchymal neoplasm.Its diagnosis depends on pathologic examination.Differential diagnosis includes gastrointestinal stromal tumor,paraganglioma and carcinoid tumor.展开更多
目的探讨ER、PR、HER-2、E-cadherin、CK5/6检测与浸润性乳腺癌(invasive breast cancer,IBC)临床预后关系。方法应用ER、PR、HER-2、E-cadherin、CK5/6抗体,对64例IBC患者进行免疫组化检测,检测结果后行统计学分析。结果 64例IBC中ER...目的探讨ER、PR、HER-2、E-cadherin、CK5/6检测与浸润性乳腺癌(invasive breast cancer,IBC)临床预后关系。方法应用ER、PR、HER-2、E-cadherin、CK5/6抗体,对64例IBC患者进行免疫组化检测,检测结果后行统计学分析。结果 64例IBC中ER、PR、HER-2、E-cadherin、CK5/6阳性表达率分别为60.93%、56.25%、37.50%、89.06%、10.94%。经统计学分析,ER与PR表达呈正相关(r=0.646,P=0.000);ER与HER-2、CK5/6表达呈负相关(r=-0.320,P=0.010;r=-0.385,P=0.002);PR与HER-2、CK5/6表达呈负相关(r=-0.392,P=0.013;r=-0.362,P=0.003)。采用χ2检验或Fisher精确概率法分析,ER、CK5/6在组织学分级中有统计学意义(P<0.05)。患者在不同年龄、是否绝经、肿瘤大小、组织学分级、有无淋巴结转移及肿瘤分期之间,PR、HER-2和E-cadherin均无统计学意义(P>0.05)。ER、CK5/6在患者的不同年龄、是否绝经、肿瘤大小、有无淋巴结转移及肿瘤分期之间的差异均无统计学意义(P>0.05)。采用Kaplan-Meier法,生存曲线间的比较采用Log-rank检验,总生存率(OS):HER-2或CK5/6阳性患者较阴性患者低(OS:P=0.048和P=0.041)。E-cadherin阳性患者较阴性患者总生存率(OS)高(OS:P=0.038)。但ER、PR的表达与总生存率相关性无统计学意义(OS:P>0.05)。患者的组织学分级越高,总生存率(OS)越低(OS:P=0.048)。患者在不同年龄、是否绝经、肿瘤大小、有无淋巴结转移、临床分期与总生存率(OS)相关性无统计学意义(OS:P>0.05)。结论 IBC中ER、PR、E-cadherin表达丧失,HER-2或CK5/6呈阳性表达,组织学分级呈高级别,提示IBC患者预后较差。联合检测IBC组织中ER、PR、HER-2、E-cadherin、CK5/6的表达,可为IBC临床预后评估提供有力依据。展开更多
文摘AIM:To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in 1990-2010.METHODS:A case of gastric glomus tumor was re-ported.Clinicopathological findings in 56 cases of gastric glomus tumor were analyzed.RESULTS:Gastric glomus tumor was far more common in women than in men with a female to male ratio of 1.6:1.The median age of the patients was 45 years(range 28-79 years).The patients often complained of epigastric pain and bloody stool.The tumor was located in antrum of the stomach.The greatest diameter of the tumor was 0.8-11cm.Histologically,the tumor was comprised of nests of glomus cells surrounding the capillaries.Glomus cells were small,uniform and round.Vimentin,smooth muscle actin and actin were expressed in the tumor.Other markers,including S-100 protein,CD34,CD117,desmin,CD56,synaptophysin,chromo-granin A,neuron specific enolase and cytokeratin were all negative.CONCLUSION:Gastric glomus tumor is a rare benign mesenchymal neoplasm.Its diagnosis depends on pathologic examination.Differential diagnosis includes gastrointestinal stromal tumor,paraganglioma and carcinoid tumor.
文摘目的探讨ER、PR、HER-2、E-cadherin、CK5/6检测与浸润性乳腺癌(invasive breast cancer,IBC)临床预后关系。方法应用ER、PR、HER-2、E-cadherin、CK5/6抗体,对64例IBC患者进行免疫组化检测,检测结果后行统计学分析。结果 64例IBC中ER、PR、HER-2、E-cadherin、CK5/6阳性表达率分别为60.93%、56.25%、37.50%、89.06%、10.94%。经统计学分析,ER与PR表达呈正相关(r=0.646,P=0.000);ER与HER-2、CK5/6表达呈负相关(r=-0.320,P=0.010;r=-0.385,P=0.002);PR与HER-2、CK5/6表达呈负相关(r=-0.392,P=0.013;r=-0.362,P=0.003)。采用χ2检验或Fisher精确概率法分析,ER、CK5/6在组织学分级中有统计学意义(P<0.05)。患者在不同年龄、是否绝经、肿瘤大小、组织学分级、有无淋巴结转移及肿瘤分期之间,PR、HER-2和E-cadherin均无统计学意义(P>0.05)。ER、CK5/6在患者的不同年龄、是否绝经、肿瘤大小、有无淋巴结转移及肿瘤分期之间的差异均无统计学意义(P>0.05)。采用Kaplan-Meier法,生存曲线间的比较采用Log-rank检验,总生存率(OS):HER-2或CK5/6阳性患者较阴性患者低(OS:P=0.048和P=0.041)。E-cadherin阳性患者较阴性患者总生存率(OS)高(OS:P=0.038)。但ER、PR的表达与总生存率相关性无统计学意义(OS:P>0.05)。患者的组织学分级越高,总生存率(OS)越低(OS:P=0.048)。患者在不同年龄、是否绝经、肿瘤大小、有无淋巴结转移、临床分期与总生存率(OS)相关性无统计学意义(OS:P>0.05)。结论 IBC中ER、PR、E-cadherin表达丧失,HER-2或CK5/6呈阳性表达,组织学分级呈高级别,提示IBC患者预后较差。联合检测IBC组织中ER、PR、HER-2、E-cadherin、CK5/6的表达,可为IBC临床预后评估提供有力依据。
