Background The correct diagnosis of sputum smear-negative pulmonary tuberculosis in AIDS patients is very important to their therapy. We aimed to assess the value of the computed tomography （CT） and clinical finding...Background The correct diagnosis of sputum smear-negative pulmonary tuberculosis in AIDS patients is very important to their therapy. We aimed to assess the value of the computed tomography （CT） and clinical findings in predicting smear- negative pulmonary tuberculosis in AIDS patients. Methods A total of 121 AIDS patients suspected of smear-negative pulmonary tuberculosis by clinical and radiographic findings were recruited. Pulmonary tuberculosis was diagnosed in 57 （47.1%） patients. The CT and clinical predictors were selected to diagnose AIDS-related pulmonary tuberculosis through univariate and multivariate Logistic analysis. Results Multivariate analysis showed that five variables, including weight loss, presence of miliary nodules, necrotic lymph node, Iobular consolidation, tree-in-bud sign, were independent predictors of pulmonary tuberculosis in AIDS patients. Predicted scores based on the five variables were used to identify pulmonary tuberculosis. If the predicted score of 3 was taken as the ideal cut-off point in the diagnosis of AIDS-related smear-negative pulmonary tuberculosis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 84.2%, 81.2%, 80.0%, 85.2%, and 82.6%, respectively. Conclusion The prediction method based on five key factors of clinical and CT findings are useful in guiding the diagnosis of smear-negative pulmonary tuberculosis in AIDS patients.展开更多
·AIM:To report ocular symptoms,funduscopic findings and demographic distribution of ocular toxoplasmosis in Iran·METHODS:In this cross-sectional study,a total of 40 patients with ocular toxoplasmosis (24 fem...·AIM:To report ocular symptoms,funduscopic findings and demographic distribution of ocular toxoplasmosis in Iran·METHODS:In this cross-sectional study,a total of 40 patients with ocular toxoplasmosis (24 female,16 male) were enrolled.The distribution of symptoms and funduscopic findings were studied.·RESULTS:The patients’ age was in the range of 13-52 with the most common age of 19 years old.Twenty-four patients were female (60.0%).The most common presenting sign was visual loss.There was anterior chamber (AC) inflammation in 23 patients (57.5%).Vitritis was presented in 36 patients (90.0%).In 35 patients (87.5%),the retinal lesion was central.In patients with peripheral lesion,3 patients (60.0%) had flashing vs 12.5% chance of flashing in all patients.Older patients had larger lesion (P =0.04).·CONCLUSION:Ocular toxoplasmosis substantially varies among patients with different age,gender,status of immunity,site of lesion and other undetermined factors.One of ocular symptoms,flashing,may necessitate a more precise peripheral fundus examination.·展开更多
文摘Background The correct diagnosis of sputum smear-negative pulmonary tuberculosis in AIDS patients is very important to their therapy. We aimed to assess the value of the computed tomography （CT） and clinical findings in predicting smear- negative pulmonary tuberculosis in AIDS patients. Methods A total of 121 AIDS patients suspected of smear-negative pulmonary tuberculosis by clinical and radiographic findings were recruited. Pulmonary tuberculosis was diagnosed in 57 （47.1%） patients. The CT and clinical predictors were selected to diagnose AIDS-related pulmonary tuberculosis through univariate and multivariate Logistic analysis. Results Multivariate analysis showed that five variables, including weight loss, presence of miliary nodules, necrotic lymph node, Iobular consolidation, tree-in-bud sign, were independent predictors of pulmonary tuberculosis in AIDS patients. Predicted scores based on the five variables were used to identify pulmonary tuberculosis. If the predicted score of 3 was taken as the ideal cut-off point in the diagnosis of AIDS-related smear-negative pulmonary tuberculosis, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 84.2%, 81.2%, 80.0%, 85.2%, and 82.6%, respectively. Conclusion The prediction method based on five key factors of clinical and CT findings are useful in guiding the diagnosis of smear-negative pulmonary tuberculosis in AIDS patients.
文摘·AIM:To report ocular symptoms,funduscopic findings and demographic distribution of ocular toxoplasmosis in Iran·METHODS:In this cross-sectional study,a total of 40 patients with ocular toxoplasmosis (24 female,16 male) were enrolled.The distribution of symptoms and funduscopic findings were studied.·RESULTS:The patients’ age was in the range of 13-52 with the most common age of 19 years old.Twenty-four patients were female (60.0%).The most common presenting sign was visual loss.There was anterior chamber (AC) inflammation in 23 patients (57.5%).Vitritis was presented in 36 patients (90.0%).In 35 patients (87.5%),the retinal lesion was central.In patients with peripheral lesion,3 patients (60.0%) had flashing vs 12.5% chance of flashing in all patients.Older patients had larger lesion (P =0.04).·CONCLUSION:Ocular toxoplasmosis substantially varies among patients with different age,gender,status of immunity,site of lesion and other undetermined factors.One of ocular symptoms,flashing,may necessitate a more precise peripheral fundus examination.·
