稀土在工业、医药领域、基础研究以及在我国的广泛农用引起了人们对其生物效应机理以及可能毒性的关注.在稀土生物学效应机理及毒性的研究中,无论是在动物水平还是细胞层次,引起生物学效应的稀土物种都是一个关键问题,一直存在争议.本...稀土在工业、医药领域、基础研究以及在我国的广泛农用引起了人们对其生物效应机理以及可能毒性的关注.在稀土生物学效应机理及毒性的研究中,无论是在动物水平还是细胞层次,引起生物学效应的稀土物种都是一个关键问题,一直存在争议.本文对以动物、细胞为模型的生物效应研究中的实验条件进行分析,对生理条件下引起稀土生物学效应的可能物种提出"稀土离子池"(rare earth ion pool)模型,并对其引起生物学效应的活性物种以及与细胞膜相互作用的方式进行了探讨,以期为阐明复杂生物学体系中稀土化合物的作用机制提供思路.展开更多
The chemical decomposition of glutamine is a first-order reaction. Its reaction constants under storage and culture conditions were determined as 0 0009 h\+\{-1\} and 0 0032 h\+\{-1\} respectively. Batch culture of hy...The chemical decomposition of glutamine is a first-order reaction. Its reaction constants under storage and culture conditions were determined as 0 0009 h\+\{-1\} and 0 0032 h\+\{-1\} respectively. Batch culture of hybridoma cell C50 with different initial contents of glutamine helped to understand its real metabolic characteristic. The results show that when the initial concentration of glutamine is lower than 5 mmol/L, more than 80% is used by cells. And the lower the initial content, the more being used. As the initial glutamine concentration increases, the ratio of its utilization decreases. When it reaches 10 mmol/L, the ratio decreases dramatically.展开更多
Ten compounds were isolated from the leaves of Rhizophora stylosa,one kind of mangrove plants distributed in the tropical and subtropical areas of the world.Their structures were identified as taraxerone（1）,taraxero...Ten compounds were isolated from the leaves of Rhizophora stylosa,one kind of mangrove plants distributed in the tropical and subtropical areas of the world.Their structures were identified as taraxerone（1）,taraxerol（2）,β-sitosterol（3）,careaborin（4）,cis-careaborin（5）,β-daucosterol（6）,isovanillic acid（7）,protocatechuic acid（8）,astilbin（9） and rutin（10）,among which compound 9 and 10 were reported in this plant for the first time.Of these compounds,compound 2 has been confirmed to have the abilities to inhibit the growth of Hela and BGC-823 with IC50 of 73.4 μmol·L-1 and 73.3 μmol·L-1,respectively.Compound 5 could inhibit the growth of BGC-823 and MCF-7 with IC50 of 45.9 μmol·L-1 and 116.0 μmol·L-1,respectively.Compound 9 and 10 were firstly reported to stimulate the proliferation of mice splenic lymphocytes markedly in a dose-dependent manner.展开更多
文摘稀土在工业、医药领域、基础研究以及在我国的广泛农用引起了人们对其生物效应机理以及可能毒性的关注.在稀土生物学效应机理及毒性的研究中,无论是在动物水平还是细胞层次,引起生物学效应的稀土物种都是一个关键问题,一直存在争议.本文对以动物、细胞为模型的生物效应研究中的实验条件进行分析,对生理条件下引起稀土生物学效应的可能物种提出"稀土离子池"(rare earth ion pool)模型,并对其引起生物学效应的活性物种以及与细胞膜相互作用的方式进行了探讨,以期为阐明复杂生物学体系中稀土化合物的作用机制提供思路.
文摘The chemical decomposition of glutamine is a first-order reaction. Its reaction constants under storage and culture conditions were determined as 0 0009 h\+\{-1\} and 0 0032 h\+\{-1\} respectively. Batch culture of hybridoma cell C50 with different initial contents of glutamine helped to understand its real metabolic characteristic. The results show that when the initial concentration of glutamine is lower than 5 mmol/L, more than 80% is used by cells. And the lower the initial content, the more being used. As the initial glutamine concentration increases, the ratio of its utilization decreases. When it reaches 10 mmol/L, the ratio decreases dramatically.
文摘Ten compounds were isolated from the leaves of Rhizophora stylosa,one kind of mangrove plants distributed in the tropical and subtropical areas of the world.Their structures were identified as taraxerone（1）,taraxerol（2）,β-sitosterol（3）,careaborin（4）,cis-careaborin（5）,β-daucosterol（6）,isovanillic acid（7）,protocatechuic acid（8）,astilbin（9） and rutin（10）,among which compound 9 and 10 were reported in this plant for the first time.Of these compounds,compound 2 has been confirmed to have the abilities to inhibit the growth of Hela and BGC-823 with IC50 of 73.4 μmol·L-1 and 73.3 μmol·L-1,respectively.Compound 5 could inhibit the growth of BGC-823 and MCF-7 with IC50 of 45.9 μmol·L-1 and 116.0 μmol·L-1,respectively.Compound 9 and 10 were firstly reported to stimulate the proliferation of mice splenic lymphocytes markedly in a dose-dependent manner.
