The Itmurundy Zone of Central Kazakhstan is a key structure in the core of the Kazakh Orocline representing a typical Pacific-type orogenic belt hosting accretionary complex,ophiolite massifs and serpentinite mél...The Itmurundy Zone of Central Kazakhstan is a key structure in the core of the Kazakh Orocline representing a typical Pacific-type orogenic belt hosting accretionary complex,ophiolite massifs and serpentinite mélange.The main controversies in the existing tectonic models of the Itmurundy Zone are about the timing of subduction and accretion,the direction and kinematics of subduction and the number of oceanic plates.A new model for the early Paleozoic tectonic story of the Itmurundy Zone is postulated in this paper,based on new detailed geological and U-Pb detrital zircon age data,combined with previously documented geological,U-Pb age,microfossil,geochemical and isotope data from igneous rocks,deep-sea sediments and greywacke sandstones.The present study employs the Ocean Plate Stratigraphy(OPS)model to explain the tectonic processes involved in the evolution of the Itmurundy Zone and to pre-sent a holistic story of Ordovician oceanic plate(s),which accretion formed an accretionary complex.The detailed mapping allows distinguishing three types of OPS assemblages:(1)Chert-dominated,(2)OIB-hosting,and(3)MORB-hosting.The U-Pb ages of detrital zircons from sandstones of OIB and Chert types show unimodal distributions with similar main peaks of magmatism at 460-455 Ma in the provenance,and their maximum depositional ages(MDA)span 455-433 Ma.Two samples from OPS Type 3 show the peaks of magmatism both at ca.460 Ma and the MDA of 452 Ma and 459 Ma,respectively.The MDA of sandstones and microfossils data from chert show the younging of strata to the south and SE in Types 1 and 2 and to NEE for Type 3(in present coordinates)suggesting double-sided subduction to the NNW and SEE and,accordingly,the co-existence of pieces of two oceanic plates in Ordovician time.The U-Pb zircon data from both igneous and clastic rocks indicate a period of subduction erosion in early Ordovician time.As a whole,the accreted OPS units of the Itmurundy Zone record the timing of subduction and accretion from the early Ordovician to the early Sil展开更多
The Luconia Province-offshore Sarawak-is a key geological unit for understanding the distribution of hydrocarbon resources in Malaysia. Nevertheless, little effort has been made to address the palaeoenvironmental char...The Luconia Province-offshore Sarawak-is a key geological unit for understanding the distribution of hydrocarbon resources in Malaysia. Nevertheless, little effort has been made to address the palaeoenvironmental characteristics of the Tertiary carbonates in the key sector of Central Luconia.We study the sedimentology and petrography of core samples from a well in Central Luconia, for which thirteen microfacies have been identified reflecting different depositional settings. This is the first microfacies scheme elaborated for Luconian carbonates. Lithofacies and microfacies distribution are compatible with deposition in a reef complex, originating around a framework reef, within the euphotic zone. Sediments were deposited in environments of backreef, reef crest, and forereef. The fair weather wave base is marked by the presence of coralline red algae, foraminifera, decreasing degree of bioclast fragmentation and other microfacies features. As a result, a depositional-environmental model is constructed, depicting a reef complex built around a framework reef developed on the margin of an isolated platform. In addition, an innovative, preliminary time series analysis of facies, microfacies and depositional environment data reveal the existence of seasonal cycles in the stacking patterns of facies and microfacies.展开更多
Neoarchean metamorphic mafic rocks in the lower and the middle Wutai Complex mainly comprise metamorphic gabbros, amphibolites and chlorite schists. They can be subdivided into three groups according to chondrite norm...Neoarchean metamorphic mafic rocks in the lower and the middle Wutai Complex mainly comprise metamorphic gabbros, amphibolites and chlorite schists. They can be subdivided into three groups according to chondrite normalized REE patterns. Rocks in Group #1 are characterized by nearly flat REE patterns （Lan/Ybn=0.86-1.3）, the lowest total REEs （29-52 ppm）, and weak negative to positive Eu anomalies （Eun/Eun=0.84-1.02）, nearly flat primitive mantle normalized patterns and strong negative Zr（Hf） anomalies. Their geochemical characteristics in REEs and trace elements are similar to those of ocean plateau tholeiite, which imply that this group of rocks can represent remnants of Archean oceanic crust derived from a mantle plume. Rocks in Group #2 are characterized by moderate total REEs （34-116 ppm）, LREE-enriched （Lan/Ybn=1.76-4.34） chondrite normalized REE patterns with weak Eu anomalies （Eun/Eun=0.76-1.16）, and negative Nb, Ta, Zr（Hf）, Ti anomalies in the primitive mantle normalized spider diagram. The REE and trace element characteristics indicate that they represent arc magmas originating from a sub-arc mantle wedge metasomatized by slab-derived fluids. Rocks in Group #3 are characterized by the highest total REEs （61-192 ppm）, the strongest LREEs enrichment （Lan/Ybn=7.12-16） with slightly negative Eu anomalies （Eun/Eun=0.81-0.95） in the chondrite normalized diagram. In the primitive mantle normalized diagram, these rocks are characterized by large negative anomalies in Nb, Ta, Ti, negative to no Zr anomalies. They represent arc magmas originating from a sub-arc mantle wedge enriched in slab-derived melts. The three groups of rocks imply that the formation of the Neoarchean Wutai Complex is related to mantle plumes and island-arc interaction.展开更多
Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that ...Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that the specialized pro-resolving lipid mediator resolvin E1 promotes relief of pathologic pain by binding to chemerin receptor 23 in the nervous system.However,whether the resolvin E1-chemerin receptor 23 axis is involved in exercise-induced analgesia in complex regional pain syndrome type-Ⅰ has not been demonstrated.In the present study,a mouse model of chronic post-ischemia pain was established to mimic complex regional pain syndrome type-Ⅰ and subjected to an intervention involving swimming at different intensities.Chronic pain was reduced only in mice that engaged in high-intensity swimming.The resolvin E1-chemerin receptor 23 axis was clearly downregulated in the spinal cord of mice with chronic pain,while high-intensity swimming restored expression of resolvin E1 and chemerin receptor 23.Finally,shRNA-mediated silencing of chemerin receptor 23in the spinal cord reve rsed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammato ry pola rization of microglia in the dorsal horn of the spinal cord.These findings suggest that high-intensity swimming can decrease chronic pain via the endogenous resolvin E1-chemerin receptor 23 axis in the spinal cord.展开更多
目的:评价实体瘤中心变性粉碎引流术(the method of solid tumors center’s denaturation,smashing and drainage,TCDSD)的疗效及安全性。方法:采用腹水型Walker 256乳腺癌细胞接种雄性SD大鼠腋下形成实体瘤模型,分别设模型对照组(A组...目的:评价实体瘤中心变性粉碎引流术(the method of solid tumors center’s denaturation,smashing and drainage,TCDSD)的疗效及安全性。方法:采用腹水型Walker 256乳腺癌细胞接种雄性SD大鼠腋下形成实体瘤模型,分别设模型对照组(A组)、实体瘤中心热变性组(B组)、热变性+中心粉碎+引流(TCDSD)组(C组)、TCDSD后粉碎腔内阿霉素和预知子种子醇提物复合给药组(D组)。分别予相应干预,并分析各组大鼠肿瘤生长及肿瘤空腔重构情况,比较大鼠荷瘤体质量及对肝、肾、脾的影响。结果:瘤质量见C组<D组<B组<A组的趋势;抑瘤率见C组>D组>B组的趋势;C、D组大鼠肿瘤粉碎腔均被肿瘤及变性后肿瘤组织填满,实现术区重构;各组大鼠荷瘤体质量、去瘤体质量、肝肾脾质量差异均无统计学意义(P>0.05),肝肾脾外观无明显差别,提示各治疗组均未见毒副作用。结论:TCDSD治疗实体瘤安全有效,是对完善和优化现有肿瘤治疗方案的积极探索。展开更多
In the economic field, along the Yalu River, there are one economic and technological development zone, two new and high-tech development zones, one industrial processing zone and one border trade zone, all approved b...In the economic field, along the Yalu River, there are one economic and technological development zone, two new and high-tech development zones, one industrial processing zone and one border trade zone, all approved by the state, and seven other development zones that展开更多
基金supported by the Russian Science Foundation(#21-77-20022,stratigraphy,geochronology,geochemistry)Fundamental Research Funds for the Central Universities of China(2682023CX016,paper preparation)Ministry of Science and Higher Education of Russia,State Assignment Projects(122041400044-2 and FSUS-2020-0039)(petrography,isotopes,geodynamic implications).
文摘The Itmurundy Zone of Central Kazakhstan is a key structure in the core of the Kazakh Orocline representing a typical Pacific-type orogenic belt hosting accretionary complex,ophiolite massifs and serpentinite mélange.The main controversies in the existing tectonic models of the Itmurundy Zone are about the timing of subduction and accretion,the direction and kinematics of subduction and the number of oceanic plates.A new model for the early Paleozoic tectonic story of the Itmurundy Zone is postulated in this paper,based on new detailed geological and U-Pb detrital zircon age data,combined with previously documented geological,U-Pb age,microfossil,geochemical and isotope data from igneous rocks,deep-sea sediments and greywacke sandstones.The present study employs the Ocean Plate Stratigraphy(OPS)model to explain the tectonic processes involved in the evolution of the Itmurundy Zone and to pre-sent a holistic story of Ordovician oceanic plate(s),which accretion formed an accretionary complex.The detailed mapping allows distinguishing three types of OPS assemblages:(1)Chert-dominated,(2)OIB-hosting,and(3)MORB-hosting.The U-Pb ages of detrital zircons from sandstones of OIB and Chert types show unimodal distributions with similar main peaks of magmatism at 460-455 Ma in the provenance,and their maximum depositional ages(MDA)span 455-433 Ma.Two samples from OPS Type 3 show the peaks of magmatism both at ca.460 Ma and the MDA of 452 Ma and 459 Ma,respectively.The MDA of sandstones and microfossils data from chert show the younging of strata to the south and SE in Types 1 and 2 and to NEE for Type 3(in present coordinates)suggesting double-sided subduction to the NNW and SEE and,accordingly,the co-existence of pieces of two oceanic plates in Ordovician time.The U-Pb zircon data from both igneous and clastic rocks indicate a period of subduction erosion in early Ordovician time.As a whole,the accreted OPS units of the Itmurundy Zone record the timing of subduction and accretion from the early Ordovician to the early Sil
基金financial assistance throughout the research under the grant YUTP 0153AAA14financial support from UTP through the grant URIF 2014-00735
文摘The Luconia Province-offshore Sarawak-is a key geological unit for understanding the distribution of hydrocarbon resources in Malaysia. Nevertheless, little effort has been made to address the palaeoenvironmental characteristics of the Tertiary carbonates in the key sector of Central Luconia.We study the sedimentology and petrography of core samples from a well in Central Luconia, for which thirteen microfacies have been identified reflecting different depositional settings. This is the first microfacies scheme elaborated for Luconian carbonates. Lithofacies and microfacies distribution are compatible with deposition in a reef complex, originating around a framework reef, within the euphotic zone. Sediments were deposited in environments of backreef, reef crest, and forereef. The fair weather wave base is marked by the presence of coralline red algae, foraminifera, decreasing degree of bioclast fragmentation and other microfacies features. As a result, a depositional-environmental model is constructed, depicting a reef complex built around a framework reef developed on the margin of an isolated platform. In addition, an innovative, preliminary time series analysis of facies, microfacies and depositional environment data reveal the existence of seasonal cycles in the stacking patterns of facies and microfacies.
基金The National Natural Science Foundation of. China （Grant No.40420120135 and 40472096） are thankefl for the fthancial support.
文摘Neoarchean metamorphic mafic rocks in the lower and the middle Wutai Complex mainly comprise metamorphic gabbros, amphibolites and chlorite schists. They can be subdivided into three groups according to chondrite normalized REE patterns. Rocks in Group #1 are characterized by nearly flat REE patterns （Lan/Ybn=0.86-1.3）, the lowest total REEs （29-52 ppm）, and weak negative to positive Eu anomalies （Eun/Eun=0.84-1.02）, nearly flat primitive mantle normalized patterns and strong negative Zr（Hf） anomalies. Their geochemical characteristics in REEs and trace elements are similar to those of ocean plateau tholeiite, which imply that this group of rocks can represent remnants of Archean oceanic crust derived from a mantle plume. Rocks in Group #2 are characterized by moderate total REEs （34-116 ppm）, LREE-enriched （Lan/Ybn=1.76-4.34） chondrite normalized REE patterns with weak Eu anomalies （Eun/Eun=0.76-1.16）, and negative Nb, Ta, Zr（Hf）, Ti anomalies in the primitive mantle normalized spider diagram. The REE and trace element characteristics indicate that they represent arc magmas originating from a sub-arc mantle wedge metasomatized by slab-derived fluids. Rocks in Group #3 are characterized by the highest total REEs （61-192 ppm）, the strongest LREEs enrichment （Lan/Ybn=7.12-16） with slightly negative Eu anomalies （Eun/Eun=0.81-0.95） in the chondrite normalized diagram. In the primitive mantle normalized diagram, these rocks are characterized by large negative anomalies in Nb, Ta, Ti, negative to no Zr anomalies. They represent arc magmas originating from a sub-arc mantle wedge enriched in slab-derived melts. The three groups of rocks imply that the formation of the Neoarchean Wutai Complex is related to mantle plumes and island-arc interaction.
基金National Key R&D Program of China,Nos.2019YFA0110300 (to LZ),2021YFA1201400 (to LZ)Natural Science Foundation of Shanghai,No.21ZR1468600 (to LZ)Open Fund of the Key Laboratory of Cellular Physiology (Shanxi Medical University),Ministry of Education,No.KLMEC/SXMU-201910 (to XJ)。
文摘Physical exe rcise effectively alleviates chronic pain associated with complex regional pain syndrome type-Ⅰ.However,the mechanism of exe rcise-induced analgesia has not been clarified.Recent studies have shown that the specialized pro-resolving lipid mediator resolvin E1 promotes relief of pathologic pain by binding to chemerin receptor 23 in the nervous system.However,whether the resolvin E1-chemerin receptor 23 axis is involved in exercise-induced analgesia in complex regional pain syndrome type-Ⅰ has not been demonstrated.In the present study,a mouse model of chronic post-ischemia pain was established to mimic complex regional pain syndrome type-Ⅰ and subjected to an intervention involving swimming at different intensities.Chronic pain was reduced only in mice that engaged in high-intensity swimming.The resolvin E1-chemerin receptor 23 axis was clearly downregulated in the spinal cord of mice with chronic pain,while high-intensity swimming restored expression of resolvin E1 and chemerin receptor 23.Finally,shRNA-mediated silencing of chemerin receptor 23in the spinal cord reve rsed the analgesic effect of high-intensity swimming exercise on chronic post-ischemic pain and the anti-inflammato ry pola rization of microglia in the dorsal horn of the spinal cord.These findings suggest that high-intensity swimming can decrease chronic pain via the endogenous resolvin E1-chemerin receptor 23 axis in the spinal cord.
文摘目的:评价实体瘤中心变性粉碎引流术(the method of solid tumors center’s denaturation,smashing and drainage,TCDSD)的疗效及安全性。方法:采用腹水型Walker 256乳腺癌细胞接种雄性SD大鼠腋下形成实体瘤模型,分别设模型对照组(A组)、实体瘤中心热变性组(B组)、热变性+中心粉碎+引流(TCDSD)组(C组)、TCDSD后粉碎腔内阿霉素和预知子种子醇提物复合给药组(D组)。分别予相应干预,并分析各组大鼠肿瘤生长及肿瘤空腔重构情况,比较大鼠荷瘤体质量及对肝、肾、脾的影响。结果:瘤质量见C组<D组<B组<A组的趋势;抑瘤率见C组>D组>B组的趋势;C、D组大鼠肿瘤粉碎腔均被肿瘤及变性后肿瘤组织填满,实现术区重构;各组大鼠荷瘤体质量、去瘤体质量、肝肾脾质量差异均无统计学意义(P>0.05),肝肾脾外观无明显差别,提示各治疗组均未见毒副作用。结论:TCDSD治疗实体瘤安全有效,是对完善和优化现有肿瘤治疗方案的积极探索。
文摘In the economic field, along the Yalu River, there are one economic and technological development zone, two new and high-tech development zones, one industrial processing zone and one border trade zone, all approved by the state, and seven other development zones that
