With high water content(～90 wt%) and significantly improved mechanical strength(～MPa),double network(DN) hydrogels have emerged as promising biomaterials with widespread applications in biomedicine.In recent years,D...With high water content(～90 wt%) and significantly improved mechanical strength(～MPa),double network(DN) hydrogels have emerged as promising biomaterials with widespread applications in biomedicine.In recent years,DN hydrogels with extremely high mechanical strength have achieved great advance,and scientists have designed a series of natural and biomimetic DN hydrogels with novel functions including low friction,low wear,mechanical anisotropy and cell compatibility.These advances have also led to new design of biocompatible DN hydrogels for regeneration of tissues such as cartilage.In this paper,we reviewed the strategies of designing high-strength DN hydrogel and analyzed the factors that affect DN hydrogel properties.We also discussed the challenges and future development of the DN hydrogel in view of its potential as biomaterials for their biomedical applications.展开更多
Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical implementation.Given the antibacterial and cardiovas-cular...Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical implementation.Given the antibacterial and cardiovas-cular biological benefits of Cu^(2+)and titanium-nitride-oxide(TiN x O y)coatings,a Cu_(2)O/CuO-TiN x O y coating with upregulated Cu^(2+)release was successfully deposited on Ti-5Cu alloy for the first time using oxygen and nitrogen plasma-based surface modification.The superhydrophilic and nanostructured Cu_(2)O/CuO-TiN x O y coating had a dense structure and was well bonded to the substrate,resulting in enhanced cor-rosion resistance,while CuO/Cu_(2)O in the coating released Cu^(2+)faster than Ti_(2)Cu phase in the matrix.More gratifying,the coating demonstrated perfect antibacterial properties(R>99.9%against S.aureus),owing primarily to direct contact sterilization of Cu_(2)O/CuO.The most encouraging phenomenon was that the coating dramatically accelerated HUVEC adhesion(1.4 times),proliferation(RGR:106%-116%),and particularly migration(RMR:158%-247%)compared with the control Ti.The coating extract also signifi-cantly stimulated in vitro angiogenesis capacity.The rapid endothelialization for Cu_(2)O/CuO-TiN x O y coating was attributed to the surface nanostructure and Cu^(2+)/NO_(2)−release,which upregulated the angiogenesis-related gene expression of HIF-1α,VEGF,and eNOS to increase VEGF secretion and NO production.All of the findings indicated that the Cu_(2)O/CuO-TiN x O y coating could enhance the corrosion resistance,an-tibacterial properties,and endothelialization potential of Ti-Cu alloy,displaying great clinical potential in cardiovascular applications.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 51073127,51173144 )the Higher School Specialized Research Fund for the Doctoral Program FundingIssue (Grant No. 20100201110040 )+1 种基金the Operation Expenses for Universities’ Basic Scientific Research of Central Authorities (Grant No. 0109-08140018 )the New Research Support Project (Grant No. 08141001) from Xi’an Jiaotong University,P. R. China
文摘With high water content(～90 wt%) and significantly improved mechanical strength(～MPa),double network(DN) hydrogels have emerged as promising biomaterials with widespread applications in biomedicine.In recent years,DN hydrogels with extremely high mechanical strength have achieved great advance,and scientists have designed a series of natural and biomimetic DN hydrogels with novel functions including low friction,low wear,mechanical anisotropy and cell compatibility.These advances have also led to new design of biocompatible DN hydrogels for regeneration of tissues such as cartilage.In this paper,we reviewed the strategies of designing high-strength DN hydrogel and analyzed the factors that affect DN hydrogel properties.We also discussed the challenges and future development of the DN hydrogel in view of its potential as biomaterials for their biomedical applications.
基金supported by the National Key R&D Program of China(No.2022YFB3804400)and(No.2022YFE0122800)Research Program(No.62602010113)+1 种基金Na-tional Natural Science Foundation of China(No.31971253/C1002)Beijing Municipal Health Commission(Nos.BMHC-2021-6,BMHC-2019-9,PXM 2020_026275_000002).
文摘Antibacterial Ti-5Cu alloy is a promising substitute material for Ti-made cardiovascular implants,so its surface engineering is crucial to expediting clinical implementation.Given the antibacterial and cardiovas-cular biological benefits of Cu^(2+)and titanium-nitride-oxide(TiN x O y)coatings,a Cu_(2)O/CuO-TiN x O y coating with upregulated Cu^(2+)release was successfully deposited on Ti-5Cu alloy for the first time using oxygen and nitrogen plasma-based surface modification.The superhydrophilic and nanostructured Cu_(2)O/CuO-TiN x O y coating had a dense structure and was well bonded to the substrate,resulting in enhanced cor-rosion resistance,while CuO/Cu_(2)O in the coating released Cu^(2+)faster than Ti_(2)Cu phase in the matrix.More gratifying,the coating demonstrated perfect antibacterial properties(R>99.9%against S.aureus),owing primarily to direct contact sterilization of Cu_(2)O/CuO.The most encouraging phenomenon was that the coating dramatically accelerated HUVEC adhesion(1.4 times),proliferation(RGR:106%-116%),and particularly migration(RMR:158%-247%)compared with the control Ti.The coating extract also signifi-cantly stimulated in vitro angiogenesis capacity.The rapid endothelialization for Cu_(2)O/CuO-TiN x O y coating was attributed to the surface nanostructure and Cu^(2+)/NO_(2)−release,which upregulated the angiogenesis-related gene expression of HIF-1α,VEGF,and eNOS to increase VEGF secretion and NO production.All of the findings indicated that the Cu_(2)O/CuO-TiN x O y coating could enhance the corrosion resistance,an-tibacterial properties,and endothelialization potential of Ti-Cu alloy,displaying great clinical potential in cardiovascular applications.
