AIM:To evaluate the impact of long term permanent hypoxemia noticed in patients with non operated congenital cyanogenic cyanotic cardiopathy on liver stiffness.METHODS:We included ten adult patients with non operated ...AIM:To evaluate the impact of long term permanent hypoxemia noticed in patients with non operated congenital cyanogenic cyanotic cardiopathy on liver stiffness.METHODS:We included ten adult patients with non operated inoperate cyanotic cardiopathy and ten matched patients for age and gender admitted to the gastroenterology department for proctologic diseases;Clinical and laboratory data were collected[age,gender,body mass index,oxygen saturation,glutamate oxaloacetate transaminase(GOT),glutamate pyruvate transaminase(GPT),glycemia and cholesterol].Measurement of hepatic stiffness by transient elastography was carried out in all patients using the Fibroscan device.All patients underwent an echocardiography to eliminate congestive heart failure.RESULTS:Among the patients with cyanotic cardiopathy,median liver stiffness 5.9±1.3 kPa was greater than control group(4.7±0.4 kPa)(P=0.008).Median levels of GOT,GPT,gamma-glutamyltransferase,glycemia and cholesterol were comparable in cardiopathy and control group.In regression analysis including age,gender,body mass index,oxygen saturation,GOT,GPT,glycemia,cholesterol showed that only oxygen saturation was related to liver stiffness(r=-0.63 P=0.002).CONCLUSION:Chronic permanent hypoxemia can induce mild increase of liver stiffness,but further studies are needed to explore the histological aspects of liver injury induced by chronic permanent hypoxemia.展开更多
内质网(endoplasmic reticulum,ER)是细胞内蛋白质折叠、Ca2+储存和脂质生物合成的重要部位。氧化应激、缺血、Ca2+稳态的失衡都可以引起ER内非折叠蛋白的聚集,通过ER内的分子伴侣激活非折叠蛋白反应(unfolded protein response,UPR)可...内质网(endoplasmic reticulum,ER)是细胞内蛋白质折叠、Ca2+储存和脂质生物合成的重要部位。氧化应激、缺血、Ca2+稳态的失衡都可以引起ER内非折叠蛋白的聚集,通过ER内的分子伴侣激活非折叠蛋白反应(unfolded protein response,UPR)可促进细胞的生存,但是过度ER应激(endoplasmic reticulum stress,ERS)可以诱导凋亡信号起始,通过线粒体依赖或者非线粒体依赖途径导致细胞死亡。因此,近年来ER被认为是决定细胞生存与凋亡的重要器官。最近研究提示,ERS在多种心血管疾病的病生理机制中起着重要作用,包括心功能不全及缺血性心脏疾病等。对这些疾病分子机制的进一步认识,将有助于开发新的靶向药物并治疗疾病。本文将对ERS和其与心血管疾病的关系进行综述。展开更多
In this paper we present a signal processing method capable of detecting cardiopathies in electrocardiograms that was implemented in FPGA. The adopted procedure is based on fuzzy clustering to reduce the amount of dat...In this paper we present a signal processing method capable of detecting cardiopathies in electrocardiograms that was implemented in FPGA. The adopted procedure is based on fuzzy clustering to reduce the amount of data sampling, and a comparison with samples from a previously established database. By using the correlation method on the samples, it is possible to establish an initial indication of a cardiopathy. The reduced number of samples of the clustering process turns the processing simpler and allows its hardware implementation. According to the tests conducted, the method achieves 91% correct diagnoses.展开更多
Rheumatic involvement of all four heart valves is uncommon and its association with congenital heart disease is very rare. Tetralogy of Fallot is a frequent cyanotic congenital heart disease with a survival beyond mid...Rheumatic involvement of all four heart valves is uncommon and its association with congenital heart disease is very rare. Tetralogy of Fallot is a frequent cyanotic congenital heart disease with a survival beyond middle age. Background of this case report described the rheumatic involvement of all four heart valves (quadrivalvar rheumatic cardiopathy) with stenotic lesions of semilunar valves (aortic and pulmonary valves) and regurgitant lesions of atrioventricular valves (mitral and tricuspid valves) in Tetralogy of Fallot in a 48-year old asymptomatic female, detected by transthoracic two dimensional echocardiography in Thoothukudi region of India.展开更多
文摘AIM:To evaluate the impact of long term permanent hypoxemia noticed in patients with non operated congenital cyanogenic cyanotic cardiopathy on liver stiffness.METHODS:We included ten adult patients with non operated inoperate cyanotic cardiopathy and ten matched patients for age and gender admitted to the gastroenterology department for proctologic diseases;Clinical and laboratory data were collected[age,gender,body mass index,oxygen saturation,glutamate oxaloacetate transaminase(GOT),glutamate pyruvate transaminase(GPT),glycemia and cholesterol].Measurement of hepatic stiffness by transient elastography was carried out in all patients using the Fibroscan device.All patients underwent an echocardiography to eliminate congestive heart failure.RESULTS:Among the patients with cyanotic cardiopathy,median liver stiffness 5.9±1.3 kPa was greater than control group(4.7±0.4 kPa)(P=0.008).Median levels of GOT,GPT,gamma-glutamyltransferase,glycemia and cholesterol were comparable in cardiopathy and control group.In regression analysis including age,gender,body mass index,oxygen saturation,GOT,GPT,glycemia,cholesterol showed that only oxygen saturation was related to liver stiffness(r=-0.63 P=0.002).CONCLUSION:Chronic permanent hypoxemia can induce mild increase of liver stiffness,but further studies are needed to explore the histological aspects of liver injury induced by chronic permanent hypoxemia.
文摘In this paper we present a signal processing method capable of detecting cardiopathies in electrocardiograms that was implemented in FPGA. The adopted procedure is based on fuzzy clustering to reduce the amount of data sampling, and a comparison with samples from a previously established database. By using the correlation method on the samples, it is possible to establish an initial indication of a cardiopathy. The reduced number of samples of the clustering process turns the processing simpler and allows its hardware implementation. According to the tests conducted, the method achieves 91% correct diagnoses.
文摘Rheumatic involvement of all four heart valves is uncommon and its association with congenital heart disease is very rare. Tetralogy of Fallot is a frequent cyanotic congenital heart disease with a survival beyond middle age. Background of this case report described the rheumatic involvement of all four heart valves (quadrivalvar rheumatic cardiopathy) with stenotic lesions of semilunar valves (aortic and pulmonary valves) and regurgitant lesions of atrioventricular valves (mitral and tricuspid valves) in Tetralogy of Fallot in a 48-year old asymptomatic female, detected by transthoracic two dimensional echocardiography in Thoothukudi region of India.
